| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Caligan Partners LP | 0 | 6,075,028 | +6,075,028 | 0.00 | 1.96 | +1.96 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,104,996 | 6,029,775 | +4,924,779 | 0.00 | 0.04 | +0.04 | buy |
| Boxer Capital Management, LLC | 0 | 2,250,000 | +2,250,000 | 0.00 | 1.34 | +1.34 | buy |
| MARSHALL WACE, LLP | 157,648 | 2,313,380 | +2,155,732 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 40,000 | 1,849,004 | +1,809,004 | 0.01 | 0.51 | +0.50 | buy |
| Woodline Partners LP | 0 | 1,354,030 | +1,354,030 | 0.00 | 0.02 | +0.02 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 1,189,113 | +1,189,113 | 0.00 | 0.12 | +0.12 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.03 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,002,550 | 2,630,432 | +627,882 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 201,635 | 823,383 | +621,748 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 388,491 | +388,491 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 326,809 | +326,809 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 0 | 324,340 | +324,340 | 0.00 | 0.36 | +0.36 | buy |
| UBS Group AG | 0 | 257,649 | +257,649 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 158,103 | +158,103 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 0 | 143,796 | +143,796 | 0.00 | 0.01 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 9,063 | 82,480 | +73,417 | 0.00 | 0.01 | +0.01 | buy |
| Stonepine Capital Management, LLC | 0 | 68,688 | +68,688 | 0.00 | 0.27 | +0.27 | buy |
| HRT FINANCIAL LP | 0 | 67,663 | +67,663 | 0.00 | 0.00 | +0.00 | buy |
| Palogic Value Management, L.P. | 0 | 65,000 | +65,000 | 0.00 | 0.13 | +0.13 | buy |
| Brevan Howard Capital Management LP | 0 | 61,313 | +61,313 | 0.00 | 0.00 | +0.00 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 41,717 | +41,717 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 35,000 | +35,000 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 504,983 | 538,347 | +33,364 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 28,741 | +28,741 | 0.00 | 0.00 | +0.00 | buy |
| nVerses Capital, LLC | 0 | 28,564 | +28,564 | 0.00 | 0.12 | +0.12 | buy |
| STATE STREET CORP | 173,253 | 199,953 | +26,700 | 0.00 | 0.00 | +0.00 | buy |
| Regency Capital Management Inc.\DE | 46,000 | 68,000 | +22,000 | 0.04 | 0.14 | +0.10 | buy |
| Persistent Asset Partners Ltd | 0 | 17,919 | +17,919 | 0.00 | 0.03 | +0.03 | buy |
| SANDERS MORRIS HARRIS LLC | 0 | 12,000 | +12,000 | 0.00 | 0.01 | +0.01 | buy |
| Miller Financial Services LLC | 10,000 | 22,000 | +12,000 | 0.02 | 0.11 | +0.09 | buy |
| GROUP ONE TRADING LLC | 0 | 10,594 | +10,594 | 0.00 | 0.00 | +0.00 | buy |
| Texas Capital Bank Wealth Management Services Inc | 78,000 | 88,500 | +10,500 | 0.01 | 0.02 | +0.01 | buy |
| NORTHERN TRUST CORP | 87,447 | 94,415 | +6,968 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 141,897 | 147,740 | +5,843 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 2,300 | +2,300 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 42,065 | 42,065 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 2,718,029 | 2,718,029 | 0 | 0.01 | 0.02 | +0.01 | hold |
| First City Capital Management, Inc. | 11,836 | 11,836 | 0 | 0.01 | 0.03 | +0.02 | hold |
| CAPTRUST FINANCIAL ADVISORS | 32,000 | 32,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Creative Planning | 128,366 | 128,366 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Empowered Funds, LLC | 42,065 | 42,065 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Opaleye Management Inc. | 1,120,000 | 1,120,000 | 0 | 0.30 | 0.30 | -0.00 | hold |
| NewEdge Advisors, LLC | 16,364 | 16,364 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bedel Financial Consulting, Inc. | 15,000 | 15,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Bleichroeder LP | 736,842 | 736,842 | 0 | 0.26 | 0.58 | +0.32 | hold |
| Stokes Family Office, LLC | 12,120 | 12,120 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Annandale Capital, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| BIOS Capital Management, LP | 3,683,429 | 3,683,429 | 0 | 8.96 | 31.70 | +22.74 | hold |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 521 | 521 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Reliant Investment Partners, LLC | 10,000 | 10,000 | 0 | 0.02 | 0.04 | +0.02 | hold |
| BARCLAYS PLC | 1,900 | 1,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JAMES INVESTMENT RESEARCH, INC. | 16,364 | 16,364 | 0 | 0.00 | 0.01 | +0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 2,014 | 2,014 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Allworth Financial LP | 5 | 0 | -5 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 496 | 0 | -496 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 20,508 | 19,508 | -1,000 | 0.00 | 0.00 | +0.00 | sell |
| SBI Securities Co., Ltd. | 2,574 | 530 | -2,044 | 0.00 | 0.00 | -0.00 | sell |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 16,000 | 12,800 | -3,200 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 23,737 | 16,704 | -7,033 | 0.00 | 0.00 | +0.00 | sell |
| OCCUDO QUANTITATIVE STRATEGIES LP | 12,205 | 0 | -12,205 | 0.00 | 0.00 | -0.00 | sell |
| BLAIR WILLIAM & CO/IL | 27,466 | 12,466 | -15,000 | 0.00 | 0.00 | +0.00 | sell |
| Virtu Financial LLC | 16,810 | 0 | -16,810 | 0.00 | 0.00 | -0.00 | sell |
| JOHNSON INVESTMENT COUNSEL INC | 20,000 | 0 | -20,000 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 39,978 | 0 | -39,978 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 151,312 | 108,641 | -42,671 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 87,900 | 41,600 | -46,300 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 126,309 | 73,209 | -53,100 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 180,721 | 120,900 | -59,821 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 241,871 | 0 | -241,871 | 0.00 | 0.00 | -0.00 | sell |
| Voss Capital, LP | 441,891 | 0 | -441,891 | 0.05 | 0.00 | -0.05 | sell |
| Mink Brook Asset Management LLC | 1,665,631 | 590,552 | -1,075,079 | 2.12 | 1.50 | -0.62 | sell |
| PERCEPTIVE ADVISORS LLC | 4,325,000 | 1,835,842 | -2,489,158 | 0.16 | 0.16 | +0.01 | sell |
| Nantahala Capital Management, LLC | 4,781,330 | 1,681,330 | -3,100,000 | 0.57 | 0.48 | -0.10 | sell |