| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 4,325,000 | 4,325,000 | 0 | 0.15 | 0.21 | +0.05 | hold |
| BIOS Capital Management, LP | 3,683,429 | 3,683,429 | 0 | 4.77 | 7.42 | +2.64 | hold |
| Nantahala Capital Management, LLC | 3,345,923 | 3,345,923 | 0 | 0.22 | 0.34 | +0.12 | hold |
| VANGUARD GROUP INC | 992,200 | 1,342,025 | +349,825 | 0.00 | 0.00 | +0.00 | buy |
| Mink Brook Asset Management LLC | 1,197,616 | 1,237,947 | +40,331 | 0.98 | 1.38 | +0.40 | buy |
| Opaleye Management Inc. | 1,220,000 | 1,100,000 | -120,000 | 0.23 | 0.26 | +0.02 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 954,996 | +954,996 | 0.00 | 0.00 | +0.00 | buy |
| Bleichroeder LP | 736,842 | 736,842 | 0 | 0.17 | 0.24 | +0.07 | hold |
| Voss Capital, LP | 541,159 | 562,377 | +21,218 | 0.04 | 0.05 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 355,677 | 468,937 | +113,260 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 153,309 | 173,809 | +20,500 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 70,473 | 145,873 | +75,400 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 128,366 | +128,366 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 40,190 | 108,338 | +68,148 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 68,228 | 68,228 | 0 | 0.00 | 0.00 | +0.00 | hold |
| XTX Topco Ltd | 15,808 | 51,757 | +35,949 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 46,094 | 46,094 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 42,065 | 42,065 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Empowered Funds, LLC | 42,065 | 42,065 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIMPLEX TRADING, LLC | 0 | 32,847 | +32,847 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 32,000 | 32,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BLAIR WILLIAM & CO/IL | 24,466 | 24,466 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RAYMOND JAMES FINANCIAL INC | 0 | 22,508 | +22,508 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 20,677 | +20,677 | 0.00 | 0.00 | +0.00 | buy |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 19,000 | 19,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TWO SIGMA SECURITIES, LLC | 0 | 17,746 | +17,746 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Advisors, LLC | 16,364 | 16,364 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JAMES INVESTMENT RESEARCH, INC. | 16,364 | 16,364 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bedel Financial Consulting, Inc. | 15,000 | 15,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 0 | 13,100 | +13,100 | 0.00 | 0.00 | +0.00 | buy |
| Stokes Family Office, LLC | 12,120 | 12,120 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMERICA BANK | 12,000 | 12,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TWO SIGMA ADVISERS, LP | 0 | 10,200 | +10,200 | 0.00 | 0.00 | +0.00 | buy |
| Annandale Capital, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Reliant Investment Partners, LLC | 10,000 | 10,000 | 0 | 0.01 | 0.01 | +0.01 | hold |
| SBI Securities Co., Ltd. | 3,582 | 2,582 | -1,000 | 0.00 | 0.00 | +0.00 | sell |
| NATIONAL BANK OF CANADA /FI/ | 2,014 | 2,014 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 1,900 | 1,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MAI Capital Management | 123 | 123 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MILLENNIUM MANAGEMENT LLC | 127,844 | 0 | -127,844 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 6,698 | 0 | -6,698 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 79,346 | 0 | -79,346 | 0.00 | 0.00 | -0.00 | sell |
| CarsonAllaria Wealth Management, Ltd. | 1,000 | 0 | -1,000 | 0.00 | 0.00 | -0.00 | sell |