| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BALYASNY ASSET MANAGEMENT L.P. | 111,715 | 1,510,033 | +1,398,318 | 0.00 | 0.05 | +0.05 | buy |
| Boxer Capital Management, LLC | 0 | 453,686 | +453,686 | 0.00 | 1.09 | +1.09 | buy |
| TANG CAPITAL MANAGEMENT LLC | 872,398 | 1,160,000 | +287,602 | 0.51 | 1.08 | +0.57 | buy |
| MILLENNIUM MANAGEMENT LLC | 61,882 | 323,553 | +261,671 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 25,245 | 228,475 | +203,230 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 21,826 | 200,780 | +178,954 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 57,048 | 213,635 | +156,587 | 0.00 | 0.01 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 153,191 | +153,191 | 0.00 | 1.66 | +1.66 | buy |
| JENNISON ASSOCIATES LLC | 0 | 152,974 | +152,974 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 1,178,300 | 1,312,615 | +134,315 | 1.84 | 3.18 | +1.33 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 130,500 | +130,500 | 0.00 | 0.28 | +0.28 | buy |
| Hudson Bay Capital Management LP | 0 | 88,867 | +88,867 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 0 | 82,706 | +82,706 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 30,189 | +30,189 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 29,277 | +29,277 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 25,000 | +25,000 | 0.00 | 0.02 | +0.02 | buy |
| CITIGROUP INC | 623 | 20,169 | +19,546 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 19,530 | +19,530 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 23,339 | 41,004 | +17,665 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 13,806 | +13,806 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 91,079 | 104,221 | +13,142 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 26,217 | 39,067 | +12,850 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 3,585 | 15,694 | +12,109 | 0.00 | 0.00 | +0.00 | buy |
| Cannon Global Investment Management, LLC | 0 | 10,200 | +10,200 | 0.00 | 0.45 | +0.45 | buy |
| Quadrature Capital Ltd | 13,246 | 20,917 | +7,671 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 109,230 | 115,725 | +6,495 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 11,600 | 17,800 | +6,200 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 264 | +264 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 161 | +161 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 40 | +40 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 2,748,763 | 2,748,763 | 0 | 1.10 | 1.61 | +0.51 | hold |
| MOORE CAPITAL MANAGEMENT, LP | 25,000 | 25,000 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Alyeska Investment Group, L.P. | 264,000 | 264,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| RTW INVESTMENTS, LP | 372,856 | 372,856 | 0 | 0.04 | 0.07 | +0.02 | hold |
| Point72 Asset Management, L.P. | 300,000 | 300,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| VR Adviser, LLC | 2,133,576 | 2,133,576 | 0 | 1.25 | 1.46 | +0.21 | hold |
| Woodline Partners LP | 74,000 | 74,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Fairmount Funds Management LLC | 2,747,866 | 2,747,866 | 0 | 2.48 | 3.65 | +1.17 | hold |
| SBI Securities Co., Ltd. | 68 | 68 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Deep Track Capital, LP | 453,686 | 453,686 | 0 | 0.12 | 0.17 | +0.05 | hold |
| Burkehill Global Management, LP | 74,000 | 74,000 | 0 | 0.06 | 0.07 | +0.01 | hold |
| Vestal Point Capital, LP | 1,500,000 | 1,500,000 | 0 | 0.65 | 0.77 | +0.12 | hold |
| FCPM III SERVICES B.V. | 1,677,852 | 1,677,852 | 0 | 2.61 | 4.27 | +1.66 | hold |
| FMR LLC | 4,133,514 | 4,133,514 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHERN TRUST CORP | 17,229 | 17,229 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 24,903 | 24,903 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 4 | 0 | -4 | 0.00 | 0.00 | -0.00 | sell |
| Avion Wealth | 40 | 0 | -40 | 0.00 | 0.00 | 0.00 | sell |
| Tower Research Capital LLC (TRC) | 409 | 0 | -409 | 0.00 | 0.00 | -0.00 | sell |
| Stonepine Capital Management, LLC | 87,682 | 85,000 | -2,682 | 0.82 | 1.37 | +0.55 | sell |
| TWO SIGMA INVESTMENTS, LP | 125,224 | 115,828 | -9,396 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 13,083 | 0 | -13,083 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 46,700 | 24,262 | -22,438 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 22,965 | 0 | -22,965 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 32,500 | 0 | -32,500 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 338,125 | 303,551 | -34,574 | 0.00 | 0.00 | +0.00 | sell |
| Jefferies Financial Group Inc. | 64,244 | 0 | -64,244 | 0.01 | 0.00 | -0.01 | sell |
| Blackstone Inc. | 75,614 | 0 | -75,614 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 600,000 | 482,500 | -117,500 | 0.47 | 0.46 | -0.02 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 143,412 | 0 | -143,412 | 0.00 | 0.00 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 453,686 | 206,942 | -246,744 | 0.10 | 0.08 | -0.02 | sell |
| HEIGHTS CAPITAL MANAGEMENT, INC | 264,000 | 0 | -264,000 | 1.18 | 0.00 | -1.18 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 302,457 | 0 | -302,457 | 0.02 | 0.00 | -0.02 | sell |
| Boxer Capital Management, LLC | 453,686 | 0 | -453,686 | 1.18 | 0.00 | -1.18 | sell |
| ADAR1 Capital Management, LLC | 606,000 | 50,273 | -555,727 | 0.54 | 0.06 | -0.48 | sell |