| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 0 | 1,414,190 | +1,414,190 | 0.00 | 0.00 | +0.00 | buy |
| Fairmount Funds Management LLC | 0 | 1,387,866 | +1,387,866 | 0.00 | 2.90 | +2.90 | buy |
| VR Adviser, LLC | 0 | 1,387,864 | +1,387,864 | 0.00 | 1.68 | +1.68 | buy |
| BVF INC/IL | 0 | 1,387,863 | +1,387,863 | 0.00 | 0.80 | +0.80 | buy |
| Paradigm Biocapital Advisors LP | 0 | 642,721 | +642,721 | 0.00 | 0.44 | +0.44 | buy |
| Logos Global Management LP | 0 | 553,686 | +553,686 | 0.00 | 1.19 | +1.19 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 453,686 | +453,686 | 0.00 | 0.27 | +0.27 | buy |
| Commodore Capital LP | 0 | 453,686 | +453,686 | 0.00 | 0.52 | +0.52 | buy |
| Deep Track Capital, LP | 0 | 453,686 | +453,686 | 0.00 | 0.24 | +0.24 | buy |
| Boxer Capital Management, LLC | 0 | 453,686 | +453,686 | 0.00 | 3.69 | +3.69 | buy |
| Frazier Life Sciences Management, L.P. | 0 | 453,685 | +453,685 | 0.00 | 0.29 | +0.29 | buy |
| Soleus Capital Management, L.P. | 0 | 400,000 | +400,000 | 0.00 | 0.45 | +0.45 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 302,457 | +302,457 | 0.00 | 0.04 | +0.04 | buy |
| Affinity Asset Advisors, LLC | 0 | 280,031 | +280,031 | 0.00 | 0.67 | +0.67 | buy |
| BRAIDWELL LP | 0 | 261,504 | +261,504 | 0.00 | 0.14 | +0.14 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 179,886 | +179,886 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 100,912 | +100,912 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 0 | 75,614 | +75,614 | 0.00 | 0.01 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 50,152 | +50,152 | 0.00 | 0.04 | +0.04 | buy |
| Jefferies Financial Group Inc. | 0 | 27,096 | +27,096 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 0 | 6,051 | +6,051 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 286 | +286 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 162 | +162 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 0 | 68 | +68 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |