| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Logos Global Management LP | 482,500 | 1,900,000 | +1,417,500 | 0.46 | 1.47 | +1.02 | buy |
| BlackRock, Inc. | 115,725 | 1,271,762 | +1,156,037 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 302,568 | +302,568 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 104,221 | 384,576 | +280,355 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 39,067 | 315,587 | +276,520 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 152,974 | 378,507 | +225,533 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 182,382 | +182,382 | 0.00 | 0.57 | +0.57 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,510,033 | 1,662,917 | +152,884 | 0.05 | 0.05 | +0.00 | buy |
| Vestal Point Capital, LP | 1,500,000 | 1,630,000 | +130,000 | 0.77 | 0.69 | -0.08 | buy |
| NORTHERN TRUST CORP | 17,229 | 138,778 | +121,549 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 121,300 | +121,300 | 0.00 | 1.52 | +1.52 | buy |
| UBS Group AG | 82,706 | 175,182 | +92,476 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 323,553 | 403,859 | +80,306 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 115,828 | 186,874 | +71,046 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 0 | 62,647 | +62,647 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 50,824 | +50,824 | 0.00 | 0.02 | +0.02 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 50,258 | +50,258 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 50,258 | +50,258 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 47,629 | +47,629 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 45,778 | +45,778 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 25,487 | +25,487 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 24,166 | +24,166 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 22,805 | +22,805 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 74,000 | 94,488 | +20,488 | 0.01 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 19,700 | +19,700 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 18,258 | +18,258 | 0.00 | 0.08 | +0.08 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 14,600 | +14,600 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 13,768 | +13,768 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 200,780 | 214,300 | +13,520 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 0 | 12,780 | +12,780 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 11,731 | +11,731 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 10,968 | +10,968 | 0.00 | 0.06 | +0.06 | buy |
| XTX Topco Ltd | 0 | 10,564 | +10,564 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 9,901 | +9,901 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 7,600 | +7,600 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 1,312,615 | 1,319,351 | +6,736 | 3.18 | 2.15 | -1.03 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 6,369 | +6,369 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 2,097 | +2,097 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 1,761 | +1,761 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 403 | +403 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 297 | +297 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 76 | +76 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 29 | +29 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 4 | 21 | +17 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 2,748,763 | 2,748,763 | 0 | 1.61 | 1.27 | -0.34 | hold |
| PERCEPTIVE ADVISORS LLC | 206,942 | 206,942 | 0 | 0.08 | 0.06 | -0.02 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,160,000 | 1,160,000 | 0 | 1.08 | 0.95 | -0.13 | hold |
| MOORE CAPITAL MANAGEMENT, LP | 25,000 | 25,000 | 0 | 0.02 | 0.01 | -0.01 | hold |
| RTW INVESTMENTS, LP | 372,856 | 372,856 | 0 | 0.07 | 0.06 | -0.01 | hold |
| Allworth Financial LP | 161 | 161 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Point72 Asset Management, L.P. | 300,000 | 300,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| VR Adviser, LLC | 2,133,576 | 2,133,576 | 0 | 1.46 | 1.16 | -0.30 | hold |
| Parallel Advisors, LLC | 264 | 264 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Fairmount Funds Management LLC | 2,747,866 | 2,747,866 | 0 | 3.65 | 3.27 | -0.38 | hold |
| SBI Securities Co., Ltd. | 68 | 68 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Burkehill Global Management, LP | 74,000 | 74,000 | 0 | 0.07 | 0.05 | -0.02 | hold |
| Fortitude Family Office, LLC | 40 | 40 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FCPM III SERVICES B.V. | 1,677,852 | 1,677,852 | 0 | 4.27 | 4.02 | -0.24 | hold |
| Boxer Capital Management, LLC | 453,686 | 453,686 | 0 | 1.09 | 0.62 | -0.48 | hold |
| FMR LLC | 4,133,514 | 4,133,514 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Quadrature Capital Ltd | 20,917 | 19,227 | -1,690 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 29,277 | 25,821 | -3,456 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 24,903 | 17,755 | -7,148 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 20,169 | 10,141 | -10,028 | 0.00 | 0.00 | -0.00 | sell |
| Cannon Global Investment Management, LLC | 10,200 | 0 | -10,200 | 0.45 | 0.00 | -0.45 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 15,694 | 3,303 | -12,391 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 13,806 | 0 | -13,806 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 17,800 | 0 | -17,800 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 19,530 | 0 | -19,530 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 24,262 | 0 | -24,262 | 0.00 | 0.00 | -0.00 | sell |
| Lighthouse Investment Partners, LLC | 25,000 | 0 | -25,000 | 0.02 | 0.00 | -0.02 | sell |
| Exome Asset Management LLC | 153,191 | 127,769 | -25,422 | 1.66 | 1.42 | -0.24 | sell |
| BARCLAYS PLC | 30,189 | 4,462 | -25,727 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 303,551 | 275,581 | -27,970 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 41,004 | 9,020 | -31,984 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 50,273 | 18,275 | -31,998 | 0.06 | 0.02 | -0.04 | sell |
| Stonepine Capital Management, LLC | 85,000 | 40,000 | -45,000 | 1.37 | 0.55 | -0.83 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 130,500 | 59,104 | -71,396 | 0.28 | 0.12 | -0.16 | sell |
| Hudson Bay Capital Management LP | 88,867 | 0 | -88,867 | 0.01 | 0.00 | -0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 213,635 | 0 | -213,635 | 0.01 | 0.00 | -0.01 | sell |
| GOLDMAN SACHS GROUP INC | 228,475 | 0 | -228,475 | 0.00 | 0.00 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 264,000 | 0 | -264,000 | 0.01 | 0.00 | -0.01 | sell |
| Deep Track Capital, LP | 453,686 | 0 | -453,686 | 0.17 | 0.00 | -0.17 | sell |