| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 0 | 657,900 | +657,900 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 50,152 | 679,824 | +629,672 | 0.04 | 0.31 | +0.27 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 383,595 | +383,595 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 6,051 | 109,115 | +103,064 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 100,912 | 200,005 | +99,093 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 27,096 | 102,714 | +75,618 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 69,134 | +69,134 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 553,686 | 600,000 | +46,314 | 1.19 | 0.70 | -0.49 | buy |
| MARSHALL WACE, LLP | 0 | 43,694 | +43,694 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 36,975 | +36,975 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 28,318 | +28,318 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 26,900 | +26,900 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 25,593 | +25,593 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 24,923 | +24,923 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 18,617 | +18,617 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 16,816 | +16,816 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 798 | +798 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,414,190 | 1,414,680 | +490 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 1,387,863 | 1,387,863 | 0 | 0.80 | 0.67 | -0.13 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 4 | 4 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 453,686 | 453,686 | 0 | 0.27 | 0.16 | -0.12 | hold |
| Blackstone Inc. | 75,614 | 75,614 | 0 | 0.01 | 0.00 | -0.00 | hold |
| VR Adviser, LLC | 1,387,864 | 1,387,864 | 0 | 1.68 | 0.93 | -0.75 | hold |
| Fairmount Funds Management LLC | 1,387,866 | 1,387,866 | 0 | 2.90 | 1.48 | -1.42 | hold |
| SBI Securities Co., Ltd. | 68 | 68 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Deep Track Capital, LP | 453,686 | 453,686 | 0 | 0.24 | 0.15 | -0.08 | hold |
| Boxer Capital Management, LLC | 453,686 | 453,686 | 0 | 3.69 | 1.72 | -1.97 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 302,457 | 302,457 | 0 | 0.04 | 0.03 | -0.01 | hold |
| GROUP ONE TRADING LLC | 162 | 82 | -80 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 286 | 0 | -286 | 0.00 | 0.00 | -0.00 | sell |
| Commodore Capital LP | 453,686 | 450,829 | -2,857 | 0.52 | 0.26 | -0.26 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 179,886 | 17,698 | -162,188 | 0.00 | 0.00 | -0.00 | sell |
| Frazier Life Sciences Management, L.P. | 453,685 | 272,951 | -180,734 | 0.29 | 0.10 | -0.20 | sell |
| Soleus Capital Management, L.P. | 400,000 | 200,000 | -200,000 | 0.45 | 0.13 | -0.32 | sell |
| BRAIDWELL LP | 261,504 | 0 | -261,504 | 0.14 | 0.00 | -0.14 | sell |
| Affinity Asset Advisors, LLC | 280,031 | 17,998 | -262,033 | 0.67 | 0.02 | -0.65 | sell |
| Paradigm Biocapital Advisors LP | 642,721 | 0 | -642,721 | 0.44 | 0.00 | -0.44 | sell |