| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 1,414,680 | 4,133,514 | +2,718,834 | 0.00 | 0.00 | +0.00 | buy |
| FCPM III SERVICES B.V. | 0 | 1,677,852 | +1,677,852 | 0.00 | 2.61 | +2.61 | buy |
| Vestal Point Capital, LP | 0 | 1,500,000 | +1,500,000 | 0.00 | 0.65 | +0.65 | buy |
| BVF INC/IL | 1,387,863 | 2,748,763 | +1,360,900 | 0.67 | 1.10 | +0.43 | buy |
| Fairmount Funds Management LLC | 1,387,866 | 2,747,866 | +1,360,000 | 1.48 | 2.48 | +1.00 | buy |
| Opaleye Management Inc. | 0 | 1,178,300 | +1,178,300 | 0.00 | 1.84 | +1.84 | buy |
| VR Adviser, LLC | 1,387,864 | 2,133,576 | +745,712 | 0.93 | 1.25 | +0.32 | buy |
| ADAR1 Capital Management, LLC | 0 | 606,000 | +606,000 | 0.00 | 0.54 | +0.54 | buy |
| RTW INVESTMENTS, LP | 0 | 372,856 | +372,856 | 0.00 | 0.04 | +0.04 | buy |
| Point72 Asset Management, L.P. | 0 | 300,000 | +300,000 | 0.00 | 0.01 | +0.01 | buy |
| HEIGHTS CAPITAL MANAGEMENT, INC | 0 | 264,000 | +264,000 | 0.00 | 1.18 | +1.18 | buy |
| Alyeska Investment Group, L.P. | 0 | 264,000 | +264,000 | 0.00 | 0.01 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 679,824 | 872,398 | +192,574 | 0.31 | 0.51 | +0.20 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 17,698 | 143,412 | +125,714 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 111,715 | +111,715 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 28,318 | 125,224 | +96,906 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 87,682 | +87,682 | 0.00 | 0.82 | +0.82 | buy |
| Woodline Partners LP | 0 | 74,000 | +74,000 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 0 | 74,000 | +74,000 | 0.00 | 0.06 | +0.06 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 61,882 | +61,882 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 57,048 | +57,048 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 32,500 | +32,500 | 0.00 | 0.00 | +0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 25,000 | +25,000 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 0 | 23,339 | +23,339 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 22,965 | +22,965 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 69,134 | 91,079 | +21,945 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 26,900 | 46,700 | +19,800 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 13,246 | +13,246 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 13,083 | +13,083 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 11,600 | +11,600 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 18,617 | 26,217 | +7,600 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 4 | 3,585 | +3,581 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 16,816 | 17,229 | +413 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 200 | 409 | +209 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 109,115 | 109,230 | +115 | 0.00 | 0.00 | -0.00 | buy |
| Avion Wealth | 0 | 40 | +40 | 0.00 | 0.00 | 0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 453,686 | 453,686 | 0 | 0.16 | 0.10 | -0.06 | hold |
| Blackstone Inc. | 75,614 | 75,614 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Logos Global Management LP | 600,000 | 600,000 | 0 | 0.70 | 0.47 | -0.23 | hold |
| SBI Securities Co., Ltd. | 68 | 68 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Deep Track Capital, LP | 453,686 | 453,686 | 0 | 0.15 | 0.12 | -0.03 | hold |
| Boxer Capital Management, LLC | 453,686 | 453,686 | 0 | 1.72 | 1.18 | -0.54 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 302,457 | 302,457 | 0 | 0.03 | 0.02 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 24,923 | 24,903 | -20 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 82 | 4 | -78 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 798 | 623 | -175 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 36,975 | 25,245 | -11,730 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 17,998 | 0 | -17,998 | 0.02 | 0.00 | -0.02 | sell |
| MARSHALL WACE, LLP | 43,694 | 21,826 | -21,868 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 25,593 | 0 | -25,593 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 102,714 | 64,244 | -38,470 | 0.01 | 0.01 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 383,595 | 338,125 | -45,470 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 657,900 | 557,506 | -100,394 | 0.00 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 200,000 | 0 | -200,000 | 0.13 | 0.00 | -0.13 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 200,005 | 0 | -200,005 | 0.00 | 0.00 | -0.00 | sell |
| Frazier Life Sciences Management, L.P. | 272,951 | 0 | -272,951 | 0.10 | 0.00 | -0.10 | sell |
| Commodore Capital LP | 450,829 | 0 | -450,829 | 0.26 | 0.00 | -0.26 | sell |