| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Tidal Investments LLC | 0 | 7,887,228 | +7,887,228 | 0.00 | 0.33 | +0.33 | buy |
| Capital World Investors | 7,468,145 | 13,025,313 | +5,557,168 | 0.10 | 0.15 | +0.05 | buy |
| JUPITER ASSET MANAGEMENT LTD | 6,734,991 | 10,781,056 | +4,046,065 | 0.13 | 0.25 | +0.12 | buy |
| MARSHALL WACE, LLP | 1,530,721 | 5,144,374 | +3,613,653 | 0.01 | 0.02 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 225,427 | 2,946,523 | +2,721,096 | 0.02 | 0.17 | +0.16 | buy |
| Holocene Advisors, LP | 378,350 | 2,498,373 | +2,120,023 | 0.11 | 0.64 | +0.53 | buy |
| Champlain Investment Partners, LLC | 820,225 | 2,258,235 | +1,438,010 | 0.36 | 0.89 | +0.53 | buy |
| VAN ECK ASSOCIATES CORP | 9,572,679 | 10,810,119 | +1,237,440 | 0.03 | 0.04 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 6,522 | 760,845 | +754,323 | 0.00 | 0.13 | +0.13 | buy |
| Iron Triangle Partners LP | 0 | 700,000 | +700,000 | 0.00 | 5.00 | +5.00 | buy |
| Point72 Asset Management, L.P. | 1,289,191 | 1,969,774 | +680,583 | 0.29 | 0.39 | +0.11 | buy |
| SPROTT INC. | 0 | 657,684 | +657,684 | 0.00 | 0.11 | +0.11 | buy |
| CITIGROUP INC | 181,103 | 770,384 | +589,281 | 0.02 | 0.06 | +0.04 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 780,839 | 1,314,470 | +533,631 | 0.02 | 0.03 | +0.01 | buy |
| C WorldWide Group Holding A/S | 632,173 | 1,137,970 | +505,797 | 0.63 | 0.90 | +0.27 | buy |
| PURA VIDA INVESTMENTS, LLC | 0 | 481,910 | +481,910 | 0.00 | 22.65 | +22.65 | buy |
| FMR LLC | 882,726 | 1,334,926 | +452,200 | 0.01 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 647,139 | 1,069,083 | +421,944 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 10,280,814 | 10,679,839 | +399,025 | 0.14 | 0.13 | -0.01 | buy |
| ROYAL BANK OF CANADA | 0 | 339,975 | +339,975 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 329,929 | +329,929 | 0.00 | 0.63 | +0.63 | buy |
| NORGES BANK | 1,626,228 | 1,931,673 | +305,445 | 0.02 | 0.02 | +0.00 | buy |
| Spyglass Capital Management LLC | 758,598 | 1,060,648 | +302,050 | 4.04 | 4.88 | +0.84 | buy |
| Ensign Peak Advisors, Inc | 1,524,903 | 1,815,744 | +290,841 | 0.22 | 0.23 | +0.01 | buy |
| Global Assets Advisory, LLC | 0 | 261,714 | +261,714 | 0.00 | 0.17 | +0.17 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 55,431 | 293,987 | +238,556 | 0.01 | 0.03 | +0.02 | buy |
| Neuberger Berman Group LLC | 14,951 | 248,468 | +233,517 | 0.00 | 0.01 | +0.01 | buy |
| Casdin Capital, LLC | 420,000 | 650,000 | +230,000 | 3.06 | 3.34 | +0.28 | buy |
| Sofinnova Investments, Inc. | 0 | 229,481 | +229,481 | 0.00 | 0.94 | +0.94 | buy |
| GLENVIEW CAPITAL MANAGEMENT, LLC | 0 | 227,565 | +227,565 | 0.00 | 0.31 | +0.31 | buy |
| MACQUARIE GROUP LTD | 256,144 | 481,747 | +225,603 | 0.02 | 0.04 | +0.02 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 885,916 | 1,095,246 | +209,330 | 0.04 | 0.04 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 695,542 | 894,488 | +198,946 | 0.02 | 0.02 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 5,160,727 | 5,349,514 | +188,787 | 0.02 | 0.04 | +0.02 | buy |
| VANGUARD GROUP INC | 17,559,751 | 17,740,092 | +180,341 | 0.03 | 0.02 | -0.00 | buy |
| MORGAN STANLEY | 595,344 | 750,182 | +154,838 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 0 | 140,400 | +140,400 | 0.00 | 0.18 | +0.18 | buy |
| JANE STREET GROUP, LLC | 206,473 | 344,735 | +138,262 | 0.02 | 0.03 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 136,800 | +136,800 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 52,141 | 186,358 | +134,217 | 3.90 | 0.60 | -3.30 | buy |
| Centiva Capital, LP | 0 | 130,345 | +130,345 | 0.00 | 0.02 | +0.02 | buy |
| FEDERATED HERMES, INC. | 429,292 | 558,231 | +128,939 | 0.08 | 0.09 | +0.01 | buy |
| Eagle Health Investments LP | 0 | 121,000 | +121,000 | 0.00 | 1.59 | +1.59 | buy |
| HSBC HOLDINGS PLC | 75,004 | 192,560 | +117,556 | 0.01 | 0.01 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 115,800 | +115,800 | 0.00 | 0.21 | +0.21 | buy |
| FRANKLIN RESOURCES INC | 31,496 | 144,348 | +112,852 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 15,789 | 117,868 | +102,079 | 0.04 | 0.24 | +0.20 | buy |
| Vestal Point Capital, LP | 0 | 100,000 | +100,000 | 0.00 | 0.57 | +0.57 | buy |
| BANK OF AMERICA CORP /DE/ | 1,195,899 | 1,295,047 | +99,148 | 0.01 | 0.01 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 22,747 | 121,874 | +99,127 | 0.00 | 0.01 | +0.01 | buy |
| RTW INVESTMENTS, LP | 0 | 95,000 | +95,000 | 0.00 | 0.10 | +0.10 | buy |
| Atika Capital Management LLC | 122,000 | 215,000 | +93,000 | 1.28 | 1.67 | +0.38 | buy |
| Bellevue Group AG | 1,047,786 | 1,138,526 | +90,740 | 1.19 | 1.20 | +0.01 | buy |
| Virtu Financial LLC | 57,028 | 147,287 | +90,259 | 0.01 | 0.03 | +0.02 | buy |
| Tri Locum Partners LP | 0 | 90,000 | +90,000 | 0.00 | 2.16 | +2.16 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,880,262 | 2,969,890 | +89,628 | 0.02 | 0.02 | -0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 149,400 | 227,200 | +77,800 | 0.01 | 0.02 | +0.00 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 582,221 | 656,056 | +73,835 | 0.44 | 0.42 | -0.01 | buy |
| STATE STREET CORP | 5,020,742 | 5,093,647 | +72,905 | 0.02 | 0.02 | -0.00 | buy |
| HRT FINANCIAL LP | 4,770 | 77,232 | +72,462 | 0.00 | 0.03 | +0.03 | buy |
| HighTower Advisors, LLC | 14,500 | 84,500 | +70,000 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 64,100 | +64,100 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 63,490 | +63,490 | 0.00 | 0.00 | +0.00 | buy |
| JUPITER ASSET MANAGEMENT LTD | 345,339 | 407,417 | +62,078 | 0.25 | 0.27 | +0.02 | buy |
| EULAV Asset Management | 257,000 | 318,000 | +61,000 | 0.59 | 0.60 | +0.02 | buy |
| Jefferies Financial Group Inc. | 7,000 | 67,458 | +60,458 | 0.01 | 0.09 | +0.09 | buy |
| ARDSLEY ADVISORY PARTNERS LP | 0 | 60,000 | +60,000 | 0.00 | 0.60 | +0.60 | buy |
| Blue Water Life Science Advisors, LP | 0 | 57,343 | +57,343 | 0.00 | 3.72 | +3.72 | buy |
| Simplify Asset Management Inc. | 8,981 | 64,027 | +55,046 | 0.10 | 0.42 | +0.32 | buy |
| Cetera Investment Advisers | 53,035 | 107,667 | +54,632 | 0.03 | 0.02 | -0.01 | buy |
| Mariner, LLC | 0 | 50,169 | +50,169 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 215,824 | 261,931 | +46,107 | 0.01 | 0.01 | -0.00 | buy |
| Erste Asset Management GmbH | 282,928 | 323,928 | +41,000 | 0.31 | 0.30 | -0.00 | buy |
| iA Global Asset Management Inc. | 0 | 40,820 | +40,820 | 0.00 | 0.06 | +0.06 | buy |
| Rock Springs Capital Management LP | 1,019,500 | 1,059,750 | +40,250 | 1.86 | 1.86 | -0.00 | buy |
| WASATCH ADVISORS LP | 261,580 | 299,248 | +37,668 | 0.11 | 0.11 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 950,904 | 987,904 | +37,000 | 0.11 | 0.11 | -0.00 | buy |
| ROYAL BANK OF CANADA | 183,705 | 218,780 | +35,075 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 915,765 | 950,537 | +34,772 | 0.01 | 0.01 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 70,041 | 103,453 | +33,412 | 0.00 | 0.01 | +0.00 | buy |
| GRANDFIELD & DODD, LLC | 22,771 | 55,224 | +32,453 | 0.12 | 0.24 | +0.12 | buy |
| JANE STREET GROUP, LLC | 745,075 | 777,413 | +32,338 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 162,544 | 194,274 | +31,730 | 0.13 | 0.12 | -0.01 | buy |
| Bank Pictet & Cie (Europe) AG | 133,300 | 164,639 | +31,339 | 0.29 | 0.30 | +0.00 | buy |
| EFG Asset Management (North America) Corp. | 49,268 | 79,833 | +30,565 | 0.69 | 0.95 | +0.26 | buy |
| SIMPLEX TRADING, LLC | 36,007 | 66,070 | +30,063 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 195,275 | 222,060 | +26,785 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 26,700 | +26,700 | 0.00 | 1.58 | +1.58 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 25,824 | +25,824 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 196,616 | 221,241 | +24,625 | 0.03 | 0.02 | -0.00 | buy |
| BlueCrest Capital Management Ltd | 0 | 23,700 | +23,700 | 0.00 | 0.39 | +0.39 | buy |
| Vident Advisory, LLC | 0 | 23,610 | +23,610 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,167,909 | 1,190,366 | +22,457 | 0.02 | 0.02 | -0.00 | buy |
| WINTON GROUP Ltd | 0 | 22,340 | +22,340 | 0.00 | 0.11 | +0.11 | buy |
| SIT INVESTMENT ASSOCIATES INC | 44,025 | 66,252 | +22,227 | 0.08 | 0.11 | +0.03 | buy |
| Savant Capital, LLC | 2,864 | 23,729 | +20,865 | 0.00 | 0.02 | +0.02 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 67,785 | 87,898 | +20,113 | 0.02 | 0.02 | +0.00 | buy |
| Cetera Investment Advisers | 0 | 19,910 | +19,910 | 0.00 | 0.00 | +0.00 | buy |
| Belpointe Asset Management LLC | 21,470 | 41,245 | +19,775 | 0.14 | 0.21 | +0.07 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 182,776 | 202,488 | +19,712 | 0.24 | 0.23 | -0.01 | buy |