| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VAN ECK ASSOCIATES CORP | 10,810,119 | 24,467,240 | +13,657,121 | 0.04 | 0.12 | +0.08 | buy |
| VANGUARD GROUP INC | 17,740,092 | 18,175,271 | +435,179 | 0.02 | 0.01 | -0.01 | buy |
| Capital World Investors | 13,025,313 | 16,501,346 | +3,476,033 | 0.15 | 0.11 | -0.04 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 10,679,839 | 14,788,411 | +4,108,572 | 0.13 | 0.11 | -0.02 | buy |
| FMR LLC | 1,334,926 | 13,624,036 | +12,289,110 | 0.01 | 0.04 | +0.03 | buy |
| JUPITER ASSET MANAGEMENT LTD | 10,781,056 | 10,781,056 | 0 | 0.25 | 0.36 | +0.11 | hold |
| Tidal Investments LLC | 7,887,228 | 8,669,868 | +782,640 | 0.33 | 0.42 | +0.10 | buy |
| STATE STREET CORP | 5,093,647 | 8,210,058 | +3,116,411 | 0.02 | 0.02 | -0.00 | buy |
| JPMORGAN CHASE & CO | 12,384,516 | 4,334,890 | -8,049,626 | 0.08 | 0.02 | -0.06 | sell |
| Holocene Advisors, LP | 2,498,373 | 4,038,634 | +1,540,261 | 0.64 | 0.71 | +0.08 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 3,934,900 | +3,934,900 | 0.00 | 0.06 | +0.06 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 0 | 3,879,195 | +3,879,195 | 0.00 | 0.43 | +0.43 | buy |
| Artisan Partners Limited Partnership | 3,111,931 | 3,805,389 | +693,458 | 0.31 | 0.24 | -0.07 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,969,890 | 3,098,097 | +128,207 | 0.02 | 0.01 | -0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 2,938,502 | 2,941,202 | +2,700 | 0.12 | 0.08 | -0.05 | buy |
| TD ASSET MANAGEMENT INC | 0 | 2,689,003 | +2,689,003 | 0.00 | 0.01 | +0.01 | buy |
| Champlain Investment Partners, LLC | 2,258,235 | 2,248,500 | -9,735 | 0.89 | 0.58 | -0.31 | sell |
| AMERIPRISE FINANCIAL INC | 2,259,982 | 2,214,730 | -45,252 | 0.04 | 0.03 | -0.02 | sell |
| Ensign Peak Advisors, Inc | 1,815,744 | 1,815,137 | -607 | 0.23 | 0.14 | -0.09 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,314,470 | 1,763,545 | +449,075 | 0.03 | 0.02 | -0.01 | buy |
| MACQUARIE GROUP LTD | 481,747 | 1,541,559 | +1,059,812 | 0.04 | 0.07 | +0.04 | buy |
| C WorldWide Group Holding A/S | 1,137,970 | 1,504,355 | +366,385 | 0.90 | 0.69 | -0.21 | buy |
| MORGAN STANLEY | 1,305,429 | 1,469,126 | +163,697 | 0.01 | 0.00 | -0.00 | buy |
| BAILLIE GIFFORD & CO | 1,701,988 | 1,426,617 | -275,371 | 0.09 | 0.05 | -0.04 | sell |
| Spyglass Capital Management LLC | 1,060,648 | 1,418,591 | +357,943 | 4.88 | 4.39 | -0.49 | buy |
| ARMISTICE CAPITAL, LLC | 730,648 | 1,400,086 | +669,438 | 1.34 | 1.55 | +0.20 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,095,246 | 1,303,887 | +208,641 | 0.04 | 0.03 | -0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,190,366 | 1,247,075 | +56,709 | 0.02 | 0.01 | -0.01 | buy |
| NORGES BANK | 1,931,673 | 1,242,102 | -689,571 | 0.02 | 0.01 | -0.01 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,084,722 | 1,231,728 | +147,006 | 1.18 | 0.89 | -0.28 | buy |
| MILLENNIUM MANAGEMENT LLC | 3,816,046 | 1,203,796 | -2,612,250 | 0.01 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,345,238 | 1,185,123 | -160,115 | 0.01 | 0.01 | -0.01 | sell |
| Bellevue Group AG | 1,138,526 | 1,158,880 | +20,354 | 1.20 | 0.80 | -0.40 | buy |
| BANK OF AMERICA CORP /DE/ | 1,295,047 | 1,153,343 | -141,704 | 0.01 | 0.00 | -0.00 | sell |
| Sumitomo Mitsui Trust Group, Inc. | 1,973,592 | 1,142,776 | -830,816 | 0.09 | 0.04 | -0.06 | sell |
| BRAIDWELL LP | 0 | 1,141,678 | +1,141,678 | 0.00 | 1.51 | +1.51 | buy |
| TWO SIGMA INVESTMENTS, LP | 741,178 | 1,112,518 | +371,340 | 0.00 | 0.01 | +0.00 | buy |
| Rock Springs Capital Management LP | 1,059,750 | 1,081,500 | +21,750 | 1.86 | 1.38 | -0.48 | buy |
| GOLDMAN SACHS GROUP INC | 950,537 | 1,067,073 | +116,536 | 0.01 | 0.01 | -0.01 | buy |
| NORTHERN TRUST CORP | 989,211 | 1,038,425 | +49,214 | 0.01 | 0.01 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,069,083 | 1,031,116 | -37,967 | 0.00 | 0.01 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 970,462 | 1,027,962 | +57,500 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 894,488 | 1,002,784 | +108,296 | 0.02 | 0.01 | -0.01 | buy |
| JPMORGAN CHASE & CO | 0 | 980,372 | +980,372 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 750,182 | 972,213 | +222,031 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 999,660 | 963,888 | -35,772 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 79,695 | 958,369 | +878,674 | 0.00 | 0.01 | +0.01 | buy |
| Vestal Point Capital, LP | 100,000 | 925,000 | +825,000 | 0.57 | 2.91 | +2.34 | buy |
| JENNISON ASSOCIATES LLC | 633,629 | 915,434 | +281,805 | 0.03 | 0.02 | -0.00 | buy |
| SPROTT INC. | 657,684 | 888,202 | +230,518 | 0.11 | 0.23 | +0.12 | buy |
| DEUTSCHE BANK AG\ | 594,423 | 814,477 | +220,054 | 0.02 | 0.02 | -0.00 | buy |
| Legal & General Group Plc | 859,216 | 806,290 | -52,926 | 0.02 | 0.01 | -0.01 | sell |
| Bank of New York Mellon Corp | 753,358 | 785,023 | +31,665 | 0.01 | 0.01 | -0.00 | buy |
| Sculptor Capital LP | 0 | 776,788 | +776,788 | 0.00 | 0.68 | +0.68 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 654,593 | 768,640 | +114,047 | 1.30 | 0.95 | -0.35 | buy |
| Nikko Asset Management Americas, Inc. | 1,527,926 | 721,088 | -806,838 | 1.05 | 0.35 | -0.70 | sell |
| SAMLYN CAPITAL, LLC | 0 | 720,147 | +720,147 | 0.00 | 0.52 | +0.52 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 656,056 | 705,468 | +49,412 | 0.42 | 0.30 | -0.13 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,946,523 | 674,856 | -2,271,667 | 0.17 | 0.02 | -0.15 | sell |
| ORBIMED ADVISORS LLC | 140,400 | 672,416 | +532,016 | 0.18 | 0.56 | +0.39 | buy |
| Casdin Capital, LLC | 650,000 | 650,000 | 0 | 3.34 | 2.10 | -1.24 | hold |
| GLENVIEW CAPITAL MANAGEMENT, LLC | 227,565 | 629,455 | +401,890 | 0.31 | 0.56 | +0.26 | buy |
| BAMCO INC /NY/ | 10,000 | 628,000 | +618,000 | 0.00 | 0.08 | +0.07 | buy |
| AXA S.A. | 476,510 | 614,952 | +138,442 | 0.10 | 0.08 | -0.02 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 600,000 | 600,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Eagle Health Investments LP | 121,000 | 544,200 | +423,200 | 1.59 | 4.11 | +2.52 | buy |
| Swiss National Bank | 541,580 | 535,080 | -6,500 | 0.03 | 0.02 | -0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 987,904 | 510,704 | -477,200 | 0.11 | 0.04 | -0.07 | sell |
| FIRST TRUST ADVISORS LP | 850,956 | 508,911 | -342,045 | 0.06 | 0.02 | -0.04 | sell |
| HighTower Advisors, LLC | 516,440 | 507,396 | -9,044 | 0.06 | 0.03 | -0.02 | sell |
| WASATCH ADVISORS LP | 299,248 | 507,187 | +207,939 | 0.11 | 0.11 | +0.01 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 479,300 | 496,300 | +17,000 | 0.02 | 0.02 | -0.01 | buy |
| Swiss National Bank | 0 | 476,100 | +476,100 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 2,054,197 | 461,342 | -1,592,855 | 0.14 | 0.02 | -0.12 | sell |
| BLAIR WILLIAM & CO/IL | 346,869 | 446,686 | +99,817 | 0.08 | 0.06 | -0.02 | buy |
| Rafferty Asset Management, LLC | 152,740 | 442,592 | +289,852 | 0.04 | 0.07 | +0.03 | buy |
| NATIONAL BANK OF CANADA /FI/ | 7,520 | 438,794 | +431,274 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 344,735 | 429,673 | +84,938 | 0.03 | 0.02 | -0.01 | buy |
| UBS Group AG | 261,931 | 429,145 | +167,214 | 0.01 | 0.01 | -0.00 | buy |
| CITIGROUP INC | 770,384 | 383,806 | -386,578 | 0.06 | 0.02 | -0.04 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 369,636 | 369,729 | +93 | 0.12 | 0.07 | -0.05 | buy |
| MARSHALL WACE, LLP | 5,144,374 | 367,043 | -4,777,331 | 0.02 | 0.00 | -0.02 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 95,982 | 364,391 | +268,409 | 0.01 | 0.02 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 379,712 | 362,974 | -16,738 | 0.02 | 0.01 | -0.01 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 51,583 | 361,500 | +309,917 | 0.00 | 0.02 | +0.01 | buy |
| JANE STREET GROUP, LLC | 777,413 | 358,221 | -419,192 | 0.00 | 0.00 | -0.00 | sell |
| PCJ Investment Counsel Ltd. | 200,000 | 351,330 | +151,330 | 0.16 | 0.51 | +0.35 | buy |
| ARK Investment Management LLC | 3,267,648 | 344,487 | -2,923,161 | 1.56 | 0.13 | -1.43 | sell |
| Avidity Partners Management LP | 0 | 338,500 | +338,500 | 0.00 | 0.61 | +0.61 | buy |
| GROUP ONE TRADING LLC | 131,641 | 329,157 | +197,516 | 0.01 | 0.04 | +0.03 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 337,736 | 326,910 | -10,826 | 0.01 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 760,845 | 325,668 | -435,177 | 0.13 | 0.04 | -0.10 | sell |
| GUGGENHEIM CAPITAL LLC | 195,486 | 324,490 | +129,004 | 0.00 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 294,041 | 312,778 | +18,737 | 0.03 | 0.02 | -0.01 | buy |
| SEI INVESTMENTS CO | 379,743 | 308,325 | -71,418 | 0.04 | 0.02 | -0.02 | sell |
| Erste Asset Management GmbH | 323,928 | 306,132 | -17,796 | 0.30 | 0.17 | -0.13 | sell |
| BARCLAYS PLC | 226,939 | 305,284 | +78,345 | 0.01 | 0.01 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 282,657 | 290,594 | +7,937 | 0.02 | 0.02 | -0.01 | buy |
| EULAV Asset Management | 318,000 | 285,000 | -33,000 | 0.60 | 0.33 | -0.28 | sell |
| Baird Financial Group, Inc. | 296,877 | 283,374 | -13,503 | 0.04 | 0.02 | -0.02 | sell |