| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 13,624,036 | 21,648,467 | +8,024,431 | 0.04 | 0.09 | +0.05 | buy |
| AMERIPRISE FINANCIAL INC | 2,214,730 | 4,525,434 | +2,310,704 | 0.03 | 0.08 | +0.05 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,185,123 | 3,298,076 | +2,112,953 | 0.01 | 0.03 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 221,624 | 2,183,545 | +1,961,921 | 0.00 | 0.01 | +0.01 | buy |
| MACKENZIE FINANCIAL CORP | 11,535 | 1,405,452 | +1,393,917 | 0.00 | 0.13 | +0.13 | buy |
| JPMORGAN CHASE & CO | 4,334,890 | 5,256,283 | +921,393 | 0.02 | 0.03 | +0.01 | buy |
| VAN ECK ASSOCIATES CORP | 24,467,240 | 25,125,455 | +658,215 | 0.12 | 0.17 | +0.05 | buy |
| MILLENNIUM MANAGEMENT LLC | 674,856 | 1,238,785 | +563,929 | 0.02 | 0.07 | +0.05 | buy |
| AMERICAN CENTURY COMPANIES INC | 167,500 | 720,423 | +552,923 | 0.00 | 0.00 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 2,941,202 | 3,392,838 | +451,636 | 0.08 | 0.14 | +0.06 | buy |
| ArrowMark Colorado Holdings LLC | 0 | 419,959 | +419,959 | 0.00 | 0.37 | +0.37 | buy |
| Granahan Investment Management, LLC | 0 | 410,241 | +410,241 | 0.00 | 1.10 | +1.10 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 3,879,195 | 4,284,953 | +405,758 | 0.43 | 0.72 | +0.29 | buy |
| SPROTT INC. | 888,202 | 1,288,211 | +400,009 | 0.23 | 0.33 | +0.09 | buy |
| Iron Triangle Partners LP | 0 | 399,871 | +399,871 | 0.00 | 3.83 | +3.83 | buy |
| CITADEL ADVISORS LLC | 218,621 | 579,428 | +360,807 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 353,824 | +353,824 | 0.00 | 0.00 | +0.00 | buy |
| U S GLOBAL INVESTORS INC | 0 | 350,000 | +350,000 | 0.00 | 0.13 | +0.13 | buy |
| Invesco Ltd. | 0 | 336,247 | +336,247 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 56,460 | 391,455 | +334,995 | 0.02 | 0.23 | +0.20 | buy |
| Rhenman & Partners Asset Management AB | 145,000 | 465,000 | +320,000 | 0.59 | 2.57 | +1.98 | buy |
| FIRST TRUST ADVISORS LP | 508,911 | 827,621 | +318,710 | 0.02 | 0.05 | +0.03 | buy |
| MORGAN STANLEY | 1,469,126 | 1,780,084 | +310,958 | 0.00 | 0.01 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 364,391 | 670,717 | +306,326 | 0.02 | 0.05 | +0.03 | buy |
| Bellevue Group AG | 1,158,880 | 1,449,465 | +290,585 | 0.80 | 1.60 | +0.80 | buy |
| JANE STREET GROUP, LLC | 358,221 | 617,658 | +259,437 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 338,500 | 588,000 | +249,500 | 0.61 | 2.04 | +1.44 | buy |
| Champlain Investment Partners, LLC | 2,248,500 | 2,494,480 | +245,980 | 0.58 | 1.03 | +0.44 | buy |
| AlphaQuest LLC | 0 | 244,567 | +244,567 | 0.00 | 0.09 | +0.09 | buy |
| Candriam S.C.A. | 212,527 | 456,591 | +244,064 | 0.05 | 0.18 | +0.12 | buy |
| Aquatic Capital Management LLC | 0 | 211,700 | +211,700 | 0.00 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 1,027,962 | 1,229,545 | +201,583 | 0.00 | 0.00 | +0.00 | buy |
| Eschler Asset Management LLP | 0 | 199,467 | +199,467 | 0.00 | 1.17 | +1.17 | buy |
| Blue Water Life Science Advisors, LP | 57,343 | 255,243 | +197,900 | 2.36 | 15.29 | +12.94 | buy |
| HSBC HOLDINGS PLC | 84,218 | 275,160 | +190,942 | 0.00 | 0.01 | +0.01 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 14,986 | 187,807 | +172,821 | 0.00 | 0.03 | +0.03 | buy |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 0 | 165,259 | +165,259 | 0.00 | 0.01 | +0.01 | buy |
| SOROS FUND MANAGEMENT LLC | 225,000 | 378,590 | +153,590 | 0.21 | 0.51 | +0.30 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 210,513 | 335,705 | +125,192 | 0.04 | 0.11 | +0.07 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 125,000 | +125,000 | 0.00 | 0.18 | +0.18 | buy |
| TD ASSET MANAGEMENT INC | 362,974 | 477,756 | +114,782 | 0.01 | 0.03 | +0.01 | buy |
| Artemis Investment Management LLP | 0 | 106,775 | +106,775 | 0.00 | 0.11 | +0.11 | buy |
| DEUTSCHE BANK AG\ | 814,477 | 916,872 | +102,395 | 0.02 | 0.03 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 101,500 | +101,500 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 153,598 | 254,658 | +101,060 | 0.01 | 0.02 | +0.01 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 35,035 | 133,859 | +98,824 | 0.03 | 0.20 | +0.17 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 361,500 | 451,183 | +89,683 | 0.02 | 0.03 | +0.02 | buy |
| Erste Asset Management GmbH | 306,132 | 392,139 | +86,007 | 0.17 | 0.32 | +0.15 | buy |
| TWINBEECH CAPITAL LP | 0 | 84,870 | +84,870 | 0.00 | 0.11 | +0.11 | buy |
| ROYAL BANK OF CANADA | 79,987 | 164,302 | +84,315 | 0.00 | 0.00 | +0.00 | buy |
| Pier Capital, LLC | 0 | 81,036 | +81,036 | 0.00 | 0.78 | +0.78 | buy |
| Integral Health Asset Management, LLC | 0 | 80,000 | +80,000 | 0.00 | 0.64 | +0.64 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 75,599 | +75,599 | 0.00 | 0.00 | +0.00 | buy |
| BRITISH COLUMBIA INVESTMENT MANAGEMENT Corp | 34,787 | 109,815 | +75,028 | 0.01 | 0.04 | +0.04 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 0 | 70,835 | +70,835 | 0.00 | 0.21 | +0.21 | buy |
| LMR Partners LLP | 0 | 69,412 | +69,412 | 0.00 | 0.10 | +0.10 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 66,080 | +66,080 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 1,081,500 | 1,147,500 | +66,000 | 1.38 | 2.54 | +1.16 | buy |
| HRT FINANCIAL LP | 0 | 64,952 | +64,952 | 0.00 | 0.02 | +0.02 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 62,062 | +62,062 | 0.00 | 0.02 | +0.02 | buy |
| ExodusPoint Capital Management, LP | 0 | 60,546 | +60,546 | 0.00 | 0.04 | +0.04 | buy |
| TRILLIUM ASSET MANAGEMENT, LLC | 0 | 58,621 | +58,621 | 0.00 | 0.10 | +0.10 | buy |
| BARCLAYS PLC | 3 | 51,904 | +51,901 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 228,057 | 279,859 | +51,802 | 0.00 | 0.00 | +0.00 | buy |
| SOROS CAPITAL MANAGEMENT LLC | 0 | 51,700 | +51,700 | 0.00 | 0.85 | +0.85 | buy |
| Polar Asset Management Partners Inc. | 22,500 | 68,300 | +45,800 | 0.02 | 0.11 | +0.09 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,247,075 | 1,292,090 | +45,015 | 0.01 | 0.02 | +0.01 | buy |
| PDT Partners, LLC | 0 | 44,810 | +44,810 | 0.00 | 0.27 | +0.27 | buy |
| Vident Advisory, LLC | 184,088 | 228,602 | +44,514 | 0.02 | 0.02 | +0.00 | buy |
| Baird Financial Group, Inc. | 283,374 | 326,935 | +43,561 | 0.02 | 0.04 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 2,689,003 | 2,732,376 | +43,373 | 0.01 | 0.01 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 39,298 | +39,298 | 0.00 | 0.05 | +0.05 | buy |
| FORSTA AP-FONDEN | 0 | 38,800 | +38,800 | 0.00 | 0.02 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 100,665 | 136,592 | +35,927 | 0.00 | 0.01 | +0.00 | buy |
| Verition Fund Management LLC | 4,926 | 40,815 | +35,889 | 0.00 | 0.02 | +0.02 | buy |
| B. Metzler seel. Sohn & Co. AG | 0 | 32,194 | +32,194 | 0.00 | 0.02 | +0.02 | buy |
| Cambridge Investment Research Advisors, Inc. | 47,543 | 78,693 | +31,150 | 0.00 | 0.00 | +0.00 | buy |
| Gotham Asset Management, LLC | 131,549 | 162,422 | +30,873 | 0.07 | 0.11 | +0.04 | buy |
| ZACKS INVESTMENT MANAGEMENT | 0 | 30,579 | +30,579 | 0.00 | 0.02 | +0.02 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 30,536 | +30,536 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 111,364 | 140,857 | +29,493 | 0.01 | 0.01 | +0.00 | buy |
| Hartree Partners, LP | 0 | 28,507 | +28,507 | 0.00 | 0.03 | +0.03 | buy |
| Walleye Capital LLC | 0 | 28,128 | +28,128 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 51,367 | 79,168 | +27,801 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 785,023 | 812,760 | +27,737 | 0.01 | 0.01 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 52,988 | 80,405 | +27,417 | 0.01 | 0.01 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 25,415 | +25,415 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 179,542 | 203,809 | +24,267 | 0.00 | 0.00 | +0.00 | buy |
| GRANDFIELD & DODD, LLC | 79,896 | 103,999 | +24,103 | 0.21 | 0.42 | +0.21 | buy |
| Brevan Howard Capital Management LP | 0 | 22,895 | +22,895 | 0.00 | 0.08 | +0.08 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 22,700 | +22,700 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 308,325 | 330,270 | +21,945 | 0.02 | 0.03 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,067,073 | 1,088,843 | +21,770 | 0.01 | 0.01 | +0.01 | buy |
| Tidal Investments LLC | 12,592 | 34,275 | +21,683 | 0.01 | 0.03 | +0.02 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 20,341 | +20,341 | 0.00 | 0.02 | +0.02 | buy |
| Virtu Financial LLC | 0 | 20,230 | +20,230 | 0.00 | 0.00 | +0.00 | buy |
| EULAV Asset Management | 285,000 | 305,000 | +20,000 | 0.33 | 0.51 | +0.18 | buy |
| B. Riley Wealth Advisors, Inc. | 118,100 | 137,300 | +19,200 | 0.01 | 0.02 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 89,203 | 107,831 | +18,628 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 0 | 15,934 | +15,934 | 0.00 | 0.00 | +0.00 | buy |