| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Connor, Clark & Lunn Investment Management Ltd. | 3,934,900 | 2,933,900 | +1,001,000 | 0.06 | 0.06 | -0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 2,941,202 | 3,392,838 | +451,636 | 0.08 | 0.14 | +0.06 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 3,879,195 | 4,284,953 | +405,758 | 0.43 | 0.72 | +0.29 | buy |
| SPROTT INC. | 888,202 | 1,288,211 | +400,009 | 0.23 | 0.33 | +0.09 | buy |
| Woodline Partners LP | 56,460 | 391,455 | +334,995 | 0.02 | 0.23 | +0.20 | buy |
| Rhenman & Partners Asset Management AB | 145,000 | 465,000 | +320,000 | 0.59 | 2.57 | +1.98 | buy |
| Bellevue Group AG | 1,158,880 | 1,449,465 | +290,585 | 0.80 | 1.60 | +0.80 | buy |
| Avidity Partners Management LP | 338,500 | 588,000 | +249,500 | 0.61 | 2.04 | +1.44 | buy |
| Champlain Investment Partners, LLC | 2,248,500 | 2,494,480 | +245,980 | 0.58 | 1.03 | +0.44 | buy |
| Candriam S.C.A. | 212,527 | 456,591 | +244,064 | 0.05 | 0.18 | +0.12 | buy |
| Blue Water Life Science Advisors, LP | 57,343 | 255,243 | +197,900 | 2.36 | 15.29 | +12.94 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 14,986 | 187,807 | +172,821 | 0.00 | 0.03 | +0.03 | buy |
| SOROS FUND MANAGEMENT LLC | 225,000 | 378,590 | +153,590 | 0.17 | 0.37 | +0.20 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 35,035 | 133,859 | +98,824 | 0.03 | 0.20 | +0.17 | buy |
| Erste Asset Management GmbH | 306,132 | 392,139 | +86,007 | 0.17 | 0.32 | +0.15 | buy |
| BRITISH COLUMBIA INVESTMENT MANAGEMENT Corp | 34,787 | 109,815 | +75,028 | 0.01 | 0.04 | +0.04 | buy |
| Rock Springs Capital Management LP | 1,081,500 | 1,147,500 | +66,000 | 1.38 | 2.54 | +1.17 | buy |
| Polar Asset Management Partners Inc. | 22,500 | 68,300 | +45,800 | 0.02 | 0.10 | +0.08 | buy |
| Vident Advisory, LLC | 184,088 | 228,602 | +44,514 | 0.02 | 0.02 | 0.00 | buy |
| TD ASSET MANAGEMENT INC | 2,689,003 | 2,732,376 | +43,373 | 0.01 | 0.01 | +0.00 | buy |
| ALPS ADVISORS INC | 51,367 | 79,168 | +27,801 | 0.00 | 0.00 | +0.00 | buy |
| GRANDFIELD & DODD, LLC | 79,896 | 103,999 | +24,103 | 0.21 | 0.42 | +0.21 | buy |
| EULAV Asset Management | 285,000 | 305,000 | +20,000 | 0.33 | 0.51 | +0.18 | buy |
| ADAR1 Capital Management, LLC | 600 | 15,200 | +14,600 | 0.01 | 0.17 | +0.17 | buy |
| Achmea Investment Management B.V. | 10,665 | 24,125 | +13,460 | 0.01 | 0.03 | +0.02 | buy |
| Simplify Asset Management Inc. | 17,477 | 29,277 | +11,800 | 0.06 | 0.14 | +0.07 | buy |
| THOMPSON INVESTMENT MANAGEMENT, INC. | 194,071 | 205,269 | +11,198 | 1.27 | 2.00 | +0.73 | buy |
| Artisan Partners Limited Partnership | 3,805,389 | 3,814,526 | +9,137 | 0.24 | 0.39 | +0.15 | buy |
| ORBIMED ADVISORS LLC | 672,416 | 679,816 | +7,400 | 0.56 | 0.85 | +0.28 | buy |
| Ameritas Advisory Services, LLC | 23,500 | 30,500 | +7,000 | 0.00 | 0.01 | +0.00 | buy |
| BANQUE PICTET & CIE SA | 183,034 | 189,233 | +6,199 | 0.07 | 0.10 | +0.03 | buy |
| MAIRS & POWER INC | 38,525 | 43,710 | +5,185 | 0.02 | 0.03 | +0.01 | buy |
| CHICAGO TRUST Co NA | 6,495 | 11,045 | +4,550 | 0.06 | 0.13 | +0.07 | buy |
| Rathbones Group PLC | 22,950 | 27,200 | +4,250 | 0.00 | 0.00 | +0.00 | buy |
| Slow Capital, Inc. | 72,812 | 76,655 | +3,843 | 0.50 | 0.80 | +0.30 | buy |
| PATTEN & PATTEN INC/TN | 22,555 | 25,693 | +3,138 | 0.07 | 0.12 | +0.05 | buy |
| iA Global Asset Management Inc. | 66,582 | 69,642 | +3,060 | 0.05 | 0.08 | +0.03 | buy |
| Cascade Financial Partners, LLC | 32,900 | 35,900 | +3,000 | 0.02 | 0.02 | +0.01 | buy |
| Korea Investment CORP | 33,174 | 36,066 | +2,892 | 0.00 | 0.01 | +0.00 | buy |
| Asset Management One Co., Ltd. | 65,778 | 68,615 | +2,837 | 0.01 | 0.02 | +0.01 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 24,226 | 26,491 | +2,265 | 0.09 | 0.18 | +0.10 | buy |
| MOODY NATIONAL BANK TRUST DIVISION | 9,573 | 11,764 | +2,191 | 0.03 | 0.09 | +0.05 | buy |
| AIA Group Ltd | 28,552 | 30,731 | +2,179 | 0.04 | 0.05 | +0.02 | buy |
| Values First Advisors, Inc. | 7,701 | 9,558 | +1,857 | 0.19 | 0.35 | +0.16 | buy |
| Diversified Trust Co | 10,337 | 11,931 | +1,594 | 0.01 | 0.02 | +0.01 | buy |
| Livforsakringsbolaget Skandia, Omsesidigt | 200 | 1,600 | +1,400 | 0.00 | 0.01 | +0.01 | buy |
| HOHIMER WEALTH MANAGEMENT, LLC | 11,925 | 13,000 | +1,075 | 0.01 | 0.01 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 9,788 | 10,753 | +965 | 0.00 | 0.01 | +0.00 | buy |
| NISSAY ASSET MANAGEMENT CORP /JAPAN | 21,114 | 22,066 | +952 | 0.01 | 0.01 | +0.00 | buy |
| Curi Capital, LLC | 23,714 | 24,468 | +754 | 0.02 | 0.04 | +0.01 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 237,956 | 238,622 | +666 | 0.17 | 0.26 | +0.09 | buy |
| MONETA GROUP INVESTMENT ADVISORS LLC | 11,640 | 12,220 | +580 | 0.01 | 0.01 | +0.00 | buy |
| Elo Mutual Pension Insurance Co | 15,840 | 16,391 | +551 | 0.02 | 0.02 | +0.01 | buy |
| Crescent Grove Advisors, LLC | 13,545 | 14,045 | +500 | 0.06 | 0.10 | +0.03 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,231,728 | 1,232,119 | +391 | 0.89 | 1.45 | +0.56 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 21,896 | 22,229 | +333 | 0.01 | 0.01 | +0.01 | buy |
| Operose Advisors LLC | 5,486 | 5,775 | +289 | 0.08 | 0.13 | +0.05 | buy |
| TOWARZYSTWO FUNDUSZY INWESTYCYJNYCH PZU SA | 370 | 650 | +280 | 0.01 | 0.02 | +0.01 | buy |
| Utah Retirement Systems | 29,986 | 30,186 | +200 | 0.02 | 0.02 | +0.01 | buy |
| Chicago Partners Investment Group LLC | 9,103 | 9,261 | +158 | 0.02 | 0.02 | +0.01 | buy |
| Perigon Wealth Management, LLC | 8,023 | 8,172 | +149 | 0.01 | 0.01 | +0.00 | buy |
| Itau Unibanco Holding S.A. | 689 | 828 | +139 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Advisors Network LLC | 5,271 | 5,381 | +110 | 0.01 | 0.02 | +0.01 | buy |
| KING LUTHER CAPITAL MANAGEMENT CORP | 32,695 | 32,749 | +54 | 0.01 | 0.01 | +0.00 | buy |
| SIT INVESTMENT ASSOCIATES INC | 66,740 | 66,775 | +35 | 0.06 | 0.10 | +0.04 | buy |
| Goldstein Advisors, LLC | 6,436 | 6,457 | +21 | 0.05 | 0.07 | +0.02 | buy |
| BAKER TILLY WEALTH MANAGEMENT, LLC | 5,471 | 5,484 | +13 | 0.09 | 0.17 | +0.07 | buy |
| Strategic Blueprint, LLC | 5,714 | 5,713 | -1 | 0.02 | 0.02 | +0.01 | sell |
| MEEDER ASSET MANAGEMENT INC | 80 | 64 | -16 | 0.00 | 0.00 | +0.00 | sell |
| Concord Wealth Partners | 129 | 100 | -29 | 0.00 | 0.00 | +0.00 | sell |
| Activest Wealth Management | 97 | 57 | -40 | 0.00 | 0.00 | -0.00 | sell |
| Sumitomo Mitsui DS Asset Management Company, Ltd | 14,071 | 14,025 | -46 | 0.01 | 0.01 | +0.00 | sell |
| Wealthfront Advisers LLC | 5,589 | 5,500 | -89 | 0.00 | 0.00 | +0.00 | sell |
| CarsonAllaria Wealth Management, Ltd. | 344 | 246 | -98 | 0.01 | 0.01 | +0.00 | sell |
| Johnson Financial Group, Inc. | 349 | 235 | -114 | 0.00 | 0.00 | +0.00 | sell |
| IAG Wealth Partners, LLC | 1,740 | 1,615 | -125 | 0.01 | 0.02 | +0.01 | sell |
| EMERALD ADVISERS, LLC | 5,363 | 5,234 | -129 | 0.01 | 0.01 | +0.00 | sell |
| GREAT VALLEY ADVISOR GROUP, INC. | 8,691 | 8,534 | -157 | 0.01 | 0.01 | +0.00 | sell |
| OAK RIDGE INVESTMENTS LLC | 10,635 | 10,400 | -235 | 0.04 | 0.06 | +0.02 | sell |
| Register Financial Advisors LLC | 3,235 | 2,985 | -250 | 0.07 | 0.10 | +0.04 | sell |
| Riverview Trust Co | 264 | 8 | -256 | 0.01 | 0.00 | -0.01 | sell |
| Plato Investment Management Ltd | 8,118 | 7,856 | -262 | 0.03 | 0.04 | +0.01 | sell |
| Regal Investment Advisors LLC | 8,346 | 8,060 | -286 | 0.02 | 0.04 | +0.02 | sell |
| FIRST COMMUNITY TRUST NA | 625 | 325 | -300 | 0.02 | 0.02 | -0.00 | sell |
| Silvant Capital Management LLC | 14,846 | 14,438 | -408 | 0.03 | 0.04 | +0.02 | sell |
| GILDER GAGNON HOWE & CO LLC | 23,631 | 23,206 | -425 | 0.01 | 0.02 | +0.01 | sell |
| Walkner Condon Financial Advisors LLC | 8,441 | 7,983 | -458 | 0.08 | 0.10 | +0.02 | sell |
| ACORN FINANCIAL ADVISORY SERVICES INC /ADV | 17,136 | 16,674 | -462 | 0.14 | 0.20 | +0.07 | sell |
| Northstar Group, Inc. | 4,821 | 4,321 | -500 | 0.04 | 0.05 | +0.01 | sell |
| Gulf International Bank (UK) Ltd | 14,846 | 14,224 | -622 | 0.02 | 0.02 | +0.01 | sell |
| Quantum Private Wealth, LLC | 62,974 | 62,274 | -700 | 0.94 | 1.44 | +0.49 | sell |
| Frazier Financial Advisors, LLC | 1,369 | 498 | -871 | 0.05 | 0.03 | -0.02 | sell |
| PERRITT CAPITAL MANAGEMENT INC | 235,825 | 234,948 | -877 | 0.45 | 0.48 | +0.02 | sell |
| GREAT LAKES ADVISORS, LLC | 5,725 | 4,813 | -912 | 0.00 | 0.00 | +0.00 | sell |
| 1492 Capital Management LLC | 83,767 | 82,841 | -926 | 2.00 | 2.82 | +0.82 | sell |
| One River Asset Management, LLC | 1,004 | 60 | -944 | 0.00 | 0.00 | -0.00 | sell |
| Resona Asset Management Co.,Ltd. | 55,892 | 54,908 | -984 | 0.01 | 0.02 | +0.01 | sell |
| Marex Group plc | 4,989 | 3,705 | -1,284 | 0.01 | 0.01 | +0.00 | sell |
| IFM Investors Pty Ltd | 38,008 | 36,570 | -1,438 | 0.02 | 0.02 | +0.01 | sell |
| BNP Paribas Asset Management Holding S.A. | 7,658 | 6,166 | -1,492 | 0.00 | 0.00 | +0.00 | sell |