| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 0 | 8,902,972 | +8,902,972 | 0.00 | 0.32 | +0.32 | buy |
| Avidity Partners Management LP | 0 | 8,902,972 | +8,902,972 | 0.00 | 0.42 | +0.42 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 6,993,007 | +6,993,007 | 0.00 | 0.01 | +0.01 | buy |
| Soleus Capital Management, L.P. | 300,000 | 7,293,007 | +6,993,007 | 0.05 | 0.85 | +0.80 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 5,594,406 | +5,594,406 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 1,691,000 | 3,394,047 | +1,703,047 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 1,612,378 | +1,612,378 | 0.00 | 0.58 | +0.58 | buy |
| 683 Capital Management, LLC | 0 | 699,301 | +699,301 | 0.00 | 0.09 | +0.09 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 74,806 | 747,271 | +672,465 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 417,613 | 895,646 | +478,033 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 81,091 | 423,522 | +342,431 | 0.00 | 0.02 | +0.01 | buy |
| RTW INVESTMENTS, LP | 4,335,255 | 4,567,717 | +232,462 | 0.10 | 0.09 | -0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 116,494 | 254,613 | +138,119 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 120,054 | +120,054 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 164,439 | 240,238 | +75,799 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 59,544 | +59,544 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 52,275 | +52,275 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 4,711 | 42,582 | +37,871 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 31,324 | +31,324 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 19,279 | 49,529 | +30,250 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 29,764 | +29,764 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 147,418 | 173,318 | +25,900 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 42,281 | 61,695 | +19,414 | 0.01 | 0.01 | -0.00 | buy |
| Virtu Financial LLC | 0 | 19,088 | +19,088 | 0.00 | 0.00 | +0.00 | buy |
| Summit Trail Advisors, LLC | 0 | 18,600 | +18,600 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 13,814 | +13,814 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 11,215 | +11,215 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 27,038 | 31,778 | +4,740 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 125,803 | 130,503 | +4,700 | 0.00 | 0.00 | -0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 1,500 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 250 | +250 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 42 | +42 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 6 | 6 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Private Advisor Group, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Omega Fund Management, LLC | 1,788,160 | 1,788,160 | 0 | 2.17 | 1.52 | -0.65 | hold |
| Parallel Advisors, LLC | 2 | 2 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LEVEL FOUR ADVISORY SERVICES, LLC | 11,775 | 11,775 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BFSG, LLC | 3,000 | 3,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Logos Global Management LP | 421,184 | 421,184 | 0 | 0.07 | 0.06 | -0.01 | hold |
| Balboa Wealth Partners | 12,000 | 12,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 28,873 | 28,873 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALDWELL SUTTER CAPITAL, INC. | 5 | 5 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERICAN CENTURY COMPANIES INC | 20,942 | 20,942 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Qube Research & Technologies Ltd | 58 | 0 | -58 | 0.00 | 0.00 | -0.00 | sell |
| Newbridge Financial Services Group, Inc. | 500 | 0 | -500 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 614 | 0 | -614 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 112,800 | 102,800 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| WOLVERINE TRADING, LLC | 10,925 | 0 | -10,925 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 129,700 | 53,000 | -76,700 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 102,256 | 0 | -102,256 | 0.02 | 0.00 | -0.02 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 334,953 | 132,450 | -202,503 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 559,305 | 239,962 | -319,343 | 0.00 | 0.00 | -0.00 | sell |
| SIERRA SUMMIT ADVISORS LLC | 324,829 | 0 | -324,829 | 0.14 | 0.00 | -0.14 | sell |
| Connective Capital Management, LLC | 328,699 | 0 | -328,699 | 0.42 | 0.00 | -0.42 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 600,234 | 167,685 | -432,549 | 0.03 | 0.01 | -0.02 | sell |