| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Aberdeen Group plc | 0 | 1,059,484 | +1,059,484 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 2,168,353 | 2,583,457 | +415,104 | 0.01 | 0.01 | +0.00 | buy |
| Laurion Capital Management LP | 0 | 228,431 | +228,431 | 0.00 | 0.02 | +0.02 | buy |
| JANE STREET GROUP, LLC | 0 | 207,401 | +207,401 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 700,000 | 900,000 | +200,000 | 0.07 | 0.10 | +0.03 | buy |
| MARSHALL WACE, LLP | 417,883 | 563,543 | +145,660 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 566,623 | 669,464 | +102,841 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 883,738 | 949,648 | +65,910 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 115,942 | 177,381 | +61,439 | 0.01 | 0.02 | +0.01 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 55,114 | +55,114 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 45,774 | +45,774 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 44,536 | +44,536 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 36,622 | +36,622 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 952,290 | 976,152 | +23,862 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 14,573 | +14,573 | 0.00 | 0.00 | +0.00 | buy |
| Retirement Planning Group, LLC | 0 | 10,417 | +10,417 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Advisor Solutions LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Crescent Grove Advisors, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 3,923,763 | 3,931,548 | +7,785 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 2,209 | 3,594 | +1,385 | 0.00 | 0.00 | +0.00 | buy |
| Rise Advisors, LLC | 0 | 862 | +862 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 8,902,972 | 8,902,972 | 0 | 0.30 | 0.40 | +0.09 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 1,500 | 1,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,398,600 | 1,398,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 6 | 6 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bank of New York Mellon Corp | 31,778 | 31,778 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CWM, LLC | 8,642 | 8,642 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Creative Planning | 35,000 | 35,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Private Advisor Group, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Omega Fund Management, LLC | 1,788,160 | 1,788,160 | 0 | 1.16 | 1.15 | -0.01 | hold |
| Parallel Advisors, LLC | 2 | 2 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LEVEL FOUR ADVISORY SERVICES, LLC | 11,167 | 11,167 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Soleus Capital Management, L.P. | 7,293,007 | 7,293,007 | 0 | 0.55 | 0.62 | +0.07 | hold |
| Addison Advisors LLC | 5,200 | 5,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Balboa Wealth Partners | 12,000 | 12,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PFG Investments, LLC | 10,500 | 10,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Marex Group plc | 22,500 | 22,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ring Mountain Capital, LLC | 18,039 | 18,039 | 0 | 0.01 | 0.01 | +0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 27,521 | 27,521 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALDWELL SUTTER CAPITAL, INC. | 5 | 5 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHERN TRUST CORP | 231,218 | 231,218 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 303,945 | 303,945 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 250 | 0 | -250 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 36,811 | 35,409 | -1,402 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 1,433 | 0 | -1,433 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 115,962 | 114,253 | -1,709 | 0.00 | 0.00 | +0.00 | sell |
| BFSG, LLC | 3,000 | 0 | -3,000 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 23,312 | 14,742 | -8,570 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 8,660 | 0 | -8,660 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 10,718 | 0 | -10,718 | 0.00 | 0.00 | -0.00 | sell |
| Ground Swell Capital, LLC | 11,357 | 0 | -11,357 | 0.02 | 0.00 | -0.02 | sell |
| GROUP ONE TRADING LLC | 73,906 | 61,850 | -12,056 | 0.00 | 0.00 | +0.00 | sell |
| Virtu Financial LLC | 12,128 | 0 | -12,128 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 15,684 | 0 | -15,684 | 0.00 | 0.00 | -0.00 | sell |
| WOLVERINE TRADING, LLC | 16,789 | 0 | -16,789 | 0.00 | 0.00 | -0.00 | sell |
| HB Wealth Management, LLC | 78,400 | 52,400 | -26,000 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 784,213 | 757,128 | -27,085 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 84,299 | 56,287 | -28,012 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 159,167 | 120,027 | -39,140 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 215,000 | 115,000 | -100,000 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 165,761 | 34,989 | -130,772 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 204,579 | 48,865 | -155,714 | 0.01 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 157,204 | 0 | -157,204 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 425,314 | 240,873 | -184,441 | 0.01 | 0.01 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 579,683 | 100,916 | -478,767 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 1,614,170 | 914,170 | -700,000 | 0.46 | 0.32 | -0.14 | sell |
| JANUS HENDERSON GROUP PLC | 2,689,082 | 0 | -2,689,082 | 0.00 | 0.00 | -0.00 | sell |
| Avidity Partners Management LP | 7,966,400 | 4,454,408 | -3,511,992 | 0.79 | 1.00 | +0.21 | sell |
| RTW INVESTMENTS, LP | 4,567,717 | 0 | -4,567,717 | 0.07 | 0.00 | -0.07 | sell |