| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Soleus Capital Management, L.P. | 0 | 4,500,000 | +4,500,000 | 0.00 | 0.20 | +0.20 | buy |
| MORGAN STANLEY | 0 | 3,288,540 | +3,288,540 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 0 | 2,450,000 | +2,450,000 | 0.00 | 0.25 | +0.25 | buy |
| Propel Bio Management, LLC | 0 | 2,344,779 | +2,344,779 | 0.00 | 1.65 | +1.65 | buy |
| Avidity Partners Management LP | 4,699,411 | 6,699,411 | +2,000,000 | 0.72 | 1.51 | +0.78 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 1,028,256 | +1,028,256 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 967,152 | +967,152 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 952,966 | +952,966 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 919,164 | +919,164 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 659,153 | +659,153 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 522,797 | +522,797 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 493,393 | +493,393 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 0 | 438,932 | +438,932 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 3,419,299 | 3,779,922 | +360,623 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,176,285 | 1,525,769 | +349,484 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 717,470 | 964,230 | +246,760 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 331,945 | 565,645 | +233,700 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 213,017 | +213,017 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 168,300 | +168,300 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 26 | 121,850 | +121,824 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 113,366 | +113,366 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 0 | 111,460 | +111,460 | 0.00 | 0.00 | +0.00 | buy |
| MML INVESTORS SERVICES, LLC | 0 | 90,630 | +90,630 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 25,000 | 85,000 | +60,000 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 0 | 48,500 | +48,500 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 45,843 | +45,843 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 220,727 | 263,328 | +42,601 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 33,297 | +33,297 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 30,000 | +30,000 | 0.00 | 0.00 | 0.00 | buy |
| Quadrature Capital Ltd | 0 | 29,627 | +29,627 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,841 | 32,868 | +29,027 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 28,300 | +28,300 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 26,635 | +26,635 | 0.00 | 0.02 | +0.02 | buy |
| CTC Alternative Strategies, Ltd. | 0 | 24,390 | +24,390 | 0.00 | 0.06 | +0.06 | buy |
| Corient Private Wealth LLC | 0 | 22,100 | +22,100 | 0.00 | 0.00 | +0.00 | buy |
| LINCOLN CAPITAL CORP | 0 | 20,400 | +20,400 | 0.00 | 0.01 | +0.01 | buy |
| AXQ CAPITAL, LP | 0 | 18,151 | +18,151 | 0.00 | 0.00 | +0.00 | buy |
| Baader Bank Aktiengesellschaft | 0 | 11,281 | +11,281 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 10,360 | +10,360 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 406 | 2,428 | +2,022 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 1,702 | +1,702 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 3,605 | 3,765 | +160 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 35,000 | 35,022 | +22 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 1,500 | 1,505 | +5 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| CALDWELL SUTTER CAPITAL, INC. | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 7,652,972 | 7,652,972 | 0 | 0.14 | 0.27 | +0.13 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,398,600 | 1,398,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Laurion Capital Management LP | 3,882,162 | 3,882,162 | 0 | 0.14 | 0.40 | +0.26 | hold |
| CWM, LLC | 8,642 | 8,642 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Private Advisor Group, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Dynamic Advisor Solutions LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Crescent Grove Advisors, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Aberdeen Group plc | 8,243,941 | 8,243,941 | 0 | 0.01 | 0.01 | +0.01 | hold |
| Rockefeller Capital Management L.P. | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ikarian Capital, LLC | 674,662 | 674,662 | 0 | 0.05 | 0.11 | +0.06 | hold |
| HB Wealth Management, LLC | 91,450 | 91,450 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Balboa Wealth Partners | 12,000 | 12,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Strategies Wealth Advisors, LLC | 100,000 | 100,000 | 0 | 0.01 | 0.01 | +0.01 | hold |
| Smartleaf Asset Management LLC | 21 | 21 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Parallel Advisors, LLC | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| CALDWELL SUTTER CAPITAL, INC. | 3 | 0 | -3 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 842 | 0 | -842 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 30,456 | 28,358 | -2,098 | 0.00 | 0.00 | +0.00 | sell |
| Addison Advisors LLC | 5,200 | 0 | -5,200 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 76,186 | 67,186 | -9,000 | 0.00 | 0.00 | +0.00 | sell |
| Retirement Planning Group, LLC | 10,417 | 0 | -10,417 | 0.00 | 0.00 | -0.00 | sell |
| PFG Investments, LLC | 10,500 | 0 | -10,500 | 0.00 | 0.00 | -0.00 | sell |
| LEVEL FOUR ADVISORY SERVICES, LLC | 10,780 | 0 | -10,780 | 0.00 | 0.00 | -0.00 | sell |
| StoneX Group Inc. | 20,540 | 0 | -20,540 | 0.00 | 0.00 | -0.00 | sell |
| Marex Group plc | 32,700 | 0 | -32,700 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 40,000 | 0 | -40,000 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 130,585 | 0 | -130,585 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 225,271 | 30,824 | -194,447 | 0.00 | 0.00 | -0.00 | sell |
| Connective Capital Management, LLC | 301,296 | 0 | -301,296 | 0.09 | 0.00 | -0.09 | sell |
| Squarepoint Ops LLC | 352,875 | 0 | -352,875 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 527,455 | 0 | -527,455 | 0.02 | 0.00 | -0.02 | sell |
| MARSHALL WACE, LLP | 1,019,983 | 0 | -1,019,983 | 0.00 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 4,378,406 | 2,506,491 | -1,871,915 | 0.14 | 0.17 | +0.03 | sell |
| Focus Partners Wealth | 2,622,462 | 0 | -2,622,462 | 0.00 | 0.00 | -0.00 | sell |