| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 3,394,047 | 3,740,047 | +346,000 | 0.00 | 0.00 | -0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 331,774 | +331,774 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 284,109 | +284,109 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 116,765 | +116,765 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 6,993,007 | 7,073,844 | +80,837 | 0.01 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 132,450 | 193,769 | +61,319 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 895,646 | 936,258 | +40,612 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 130,503 | 155,503 | +25,000 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 240,238 | 264,968 | +24,730 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 29,764 | 37,187 | +7,423 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 11,215 | 17,107 | +5,892 | 0.00 | 0.00 | +0.00 | buy |
| Summit Trail Advisors, LLC | 18,600 | 21,600 | +3,000 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 61,695 | 62,145 | +450 | 0.01 | 0.01 | -0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 59,544 | 59,874 | +330 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 25,000 | 25,100 | +100 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 51 | +51 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 8,902,972 | 8,902,972 | 0 | 0.32 | 0.28 | -0.05 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 102,800 | 102,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 1,500 | 1,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,594,406 | 5,594,406 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 6 | 6 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bank of New York Mellon Corp | 31,778 | 31,778 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 683 Capital Management, LLC | 699,301 | 699,301 | 0 | 0.09 | 0.08 | -0.01 | hold |
| RTW INVESTMENTS, LP | 4,567,717 | 4,567,717 | 0 | 0.09 | 0.08 | -0.01 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 423,522 | 423,522 | 0 | 0.02 | 0.01 | -0.00 | hold |
| Private Advisor Group, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Omega Fund Management, LLC | 1,788,160 | 1,788,160 | 0 | 1.52 | 1.47 | -0.05 | hold |
| Parallel Advisors, LLC | 2 | 2 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BFSG, LLC | 3,000 | 3,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avidity Partners Management LP | 8,902,972 | 8,902,972 | 0 | 0.42 | 0.42 | +0.00 | hold |
| Soleus Capital Management, L.P. | 7,293,007 | 7,293,007 | 0 | 0.85 | 0.71 | -0.13 | hold |
| CALDWELL SUTTER CAPITAL, INC. | 5 | 5 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 250 | 250 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GROUP ONE TRADING LLC | 42 | 42 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LEVEL FOUR ADVISORY SERVICES, LLC | 11,775 | 11,167 | -608 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 28,873 | 27,521 | -1,352 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 31,324 | 22,054 | -9,270 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 49,529 | 39,621 | -9,908 | 0.00 | 0.00 | -0.00 | sell |
| Vontobel Holding Ltd. | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| Balboa Wealth Partners | 12,000 | 0 | -12,000 | 0.01 | 0.00 | -0.01 | sell |
| GOLDMAN SACHS GROUP INC | 13,814 | 0 | -13,814 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 19,088 | 0 | -19,088 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 20,942 | 0 | -20,942 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 53,000 | 28,200 | -24,800 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 42,582 | 16,974 | -25,608 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 167,685 | 117,685 | -50,000 | 0.01 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 52,275 | 0 | -52,275 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 120,054 | 29,674 | -90,380 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 254,613 | 157,542 | -97,071 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 173,318 | 47,718 | -125,600 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 239,962 | 0 | -239,962 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 421,184 | 0 | -421,184 | 0.06 | 0.00 | -0.06 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 747,271 | 291,087 | -456,184 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 1,612,378 | 493,496 | -1,118,882 | 0.58 | 0.17 | -0.41 | sell |