| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Focus Partners Wealth | 0 | 2,144,743 | +2,144,743 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 3,740,047 | 4,700,016 | +959,969 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 193,769 | 711,810 | +518,041 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 39,621 | 466,287 | +426,666 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 240,057 | +240,057 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 51 | 174,961 | +174,910 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 118,652 | +118,652 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 108,187 | +108,187 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 157,542 | 262,875 | +105,333 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 291,087 | 389,081 | +97,994 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 96,548 | +96,548 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 102,800 | 192,800 | +90,000 | 0.00 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 29,674 | 99,837 | +70,163 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 59,874 | 102,257 | +42,383 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 41,062 | +41,062 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 30,359 | +30,359 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 13,000 | +13,000 | 0.00 | 0.00 | +0.00 | buy |
| Balboa Wealth Partners | 0 | 12,000 | +12,000 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 0 | 11,693 | +11,693 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 155,503 | 167,145 | +11,642 | 0.00 | 0.00 | +0.00 | buy |
| PFG Investments, LLC | 0 | 10,500 | +10,500 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 936,258 | 945,533 | +9,275 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 47,718 | 51,718 | +4,000 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 17,107 | 19,884 | +2,777 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 21 | +21 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 8,902,972 | 8,902,972 | 0 | 0.28 | 0.43 | +0.15 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 1,500 | 1,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,594,406 | 5,594,406 | 0 | 0.01 | 0.02 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 6 | 6 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bank of New York Mellon Corp | 31,778 | 31,778 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RTW INVESTMENTS, LP | 4,567,717 | 4,567,717 | 0 | 0.08 | 0.11 | +0.03 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 423,522 | 423,522 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Private Advisor Group, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Omega Fund Management, LLC | 1,788,160 | 1,788,160 | 0 | 1.47 | 1.84 | +0.37 | hold |
| Parallel Advisors, LLC | 2 | 2 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LEVEL FOUR ADVISORY SERVICES, LLC | 11,167 | 11,167 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BFSG, LLC | 3,000 | 3,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ikarian Capital, LLC | 493,496 | 493,496 | 0 | 0.17 | 0.25 | +0.08 | hold |
| Soleus Capital Management, L.P. | 7,293,007 | 7,293,007 | 0 | 0.71 | 1.00 | +0.29 | hold |
| DIMENSIONAL FUND ADVISORS LP | 27,521 | 27,521 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALDWELL SUTTER CAPITAL, INC. | 5 | 5 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 250 | 250 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 42 | 0 | -42 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 25,100 | 25,000 | -100 | 0.00 | 0.00 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 37,187 | 36,507 | -680 | 0.00 | 0.00 | +0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 117,685 | 107,685 | -10,000 | 0.00 | 0.00 | +0.00 | sell |
| Schonfeld Strategic Advisors LLC | 28,200 | 16,600 | -11,600 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 16,974 | 3,925 | -13,049 | 0.00 | 0.00 | -0.00 | sell |
| 683 Capital Management, LLC | 699,301 | 684,651 | -14,650 | 0.08 | 0.12 | +0.03 | sell |
| Summit Trail Advisors, LLC | 21,600 | 0 | -21,600 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 22,054 | 0 | -22,054 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 62,145 | 28,957 | -33,188 | 0.01 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 264,968 | 231,585 | -33,383 | 0.00 | 0.00 | +0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 116,765 | 32,766 | -83,999 | 0.01 | 0.00 | -0.01 | sell |
| BANK OF MONTREAL /CAN/ | 284,109 | 0 | -284,109 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 331,774 | 0 | -331,774 | 0.01 | 0.00 | -0.01 | sell |
| Avidity Partners Management LP | 8,902,972 | 8,266,000 | -636,972 | 0.42 | 0.70 | +0.28 | sell |
| JANUS HENDERSON GROUP PLC | 7,073,844 | 5,099,278 | -1,974,566 | 0.00 | 0.00 | +0.00 | sell |