| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Ikarian Capital, LLC | 493,496 | 1,614,170 | +1,120,674 | 0.25 | 0.46 | +0.21 | buy |
| MILLENNIUM MANAGEMENT LLC | 99,837 | 579,683 | +479,846 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 389,081 | 566,623 | +177,542 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 711,810 | 883,738 | +171,928 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 167,145 | 303,945 | +136,800 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 684,663 | 784,213 | +99,550 | 0.00 | 0.00 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 107,685 | 204,579 | +96,894 | 0.00 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 0 | 84,299 | +84,299 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 32,766 | 115,942 | +83,176 | 0.00 | 0.01 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 36,507 | 115,962 | +79,455 | 0.00 | 0.00 | +0.00 | buy |
| HB Wealth Management, LLC | 0 | 78,400 | +78,400 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 73,906 | +73,906 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 102,257 | 159,167 | +56,910 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 0 | 36,811 | +36,811 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 35,000 | +35,000 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 2,144,743 | 2,168,353 | +23,610 | 0.01 | 0.01 | -0.01 | buy |
| Marex Group plc | 0 | 22,500 | +22,500 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 192,800 | 215,000 | +22,200 | 0.01 | 0.00 | -0.00 | buy |
| 683 Capital Management, LLC | 684,651 | 700,000 | +15,349 | 0.12 | 0.07 | -0.05 | buy |
| Ground Swell Capital, LLC | 0 | 11,357 | +11,357 | 0.00 | 0.02 | +0.02 | buy |
| CWM, LLC | 0 | 8,642 | +8,642 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 945,533 | 952,290 | +6,757 | 0.00 | 0.00 | -0.00 | buy |
| Addison Advisors LLC | 0 | 5,200 | +5,200 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 11,693 | 16,789 | +5,096 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,925 | 8,660 | +4,735 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 423,522 | 425,314 | +1,792 | 0.02 | 0.01 | -0.01 | buy |
| BVF INC/IL | 8,902,972 | 8,902,972 | 0 | 0.43 | 0.30 | -0.13 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 1,500 | 1,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 6 | 6 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bank of New York Mellon Corp | 31,778 | 31,778 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RTW INVESTMENTS, LP | 4,567,717 | 4,567,717 | 0 | 0.11 | 0.07 | -0.04 | hold |
| Private Advisor Group, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Omega Fund Management, LLC | 1,788,160 | 1,788,160 | 0 | 1.84 | 1.16 | -0.68 | hold |
| Parallel Advisors, LLC | 2 | 2 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LEVEL FOUR ADVISORY SERVICES, LLC | 11,167 | 11,167 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BFSG, LLC | 3,000 | 3,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Soleus Capital Management, L.P. | 7,293,007 | 7,293,007 | 0 | 1.00 | 0.55 | -0.45 | hold |
| Balboa Wealth Partners | 12,000 | 12,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PFG Investments, LLC | 10,500 | 10,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 27,521 | 27,521 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALDWELL SUTTER CAPITAL, INC. | 5 | 5 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 250 | 250 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EARNED WEALTH ADVISORS, LLC | 21 | 0 | -21 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 231,585 | 231,218 | -367 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 174,961 | 165,761 | -9,200 | 0.00 | 0.00 | -0.00 | sell |
| CANTOR FITZGERALD, L. P. | 13,000 | 0 | -13,000 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 28,957 | 15,684 | -13,273 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 16,600 | 0 | -16,600 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 41,062 | 23,312 | -17,750 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 30,359 | 12,128 | -18,231 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 19,884 | 0 | -19,884 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 51,718 | 10,718 | -41,000 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 466,287 | 417,883 | -48,404 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 96,548 | 0 | -96,548 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 262,875 | 157,204 | -105,671 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 108,187 | 1,433 | -106,754 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 118,652 | 0 | -118,652 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 240,057 | 0 | -240,057 | 0.00 | 0.00 | -0.00 | sell |
| Avidity Partners Management LP | 8,266,000 | 7,966,400 | -299,600 | 0.70 | 0.79 | +0.10 | sell |
| VANGUARD GROUP INC | 4,700,016 | 3,923,763 | -776,253 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 5,099,278 | 2,689,082 | -2,410,196 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,594,406 | 1,398,600 | -4,195,806 | 0.02 | 0.00 | -0.01 | sell |