| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Nantahala Capital Management, LLC | 0 | 4,378,406 | +4,378,406 | 0.00 | 0.14 | +0.14 | buy |
| MILLENNIUM MANAGEMENT LLC | 530,470 | 3,419,299 | +2,888,829 | 0.00 | 0.00 | +0.00 | buy |
| Laurion Capital Management LP | 1,882,162 | 3,882,162 | +2,000,000 | 0.23 | 0.14 | -0.09 | buy |
| VANGUARD GROUP INC | 4,345,105 | 5,020,337 | +675,232 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 533,515 | 1,019,983 | +486,468 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 192,923 | 527,455 | +334,532 | 0.01 | 0.02 | +0.01 | buy |
| Connective Capital Management, LLC | 0 | 301,296 | +301,296 | 0.00 | 0.09 | +0.09 | buy |
| XTX Topco Ltd | 0 | 225,271 | +225,271 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,033,772 | 1,176,285 | +142,513 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 271,574 | 352,875 | +81,301 | 0.00 | 0.00 | -0.00 | buy |
| Focus Partners Wealth | 2,581,587 | 2,622,462 | +40,875 | 0.00 | 0.00 | -0.00 | buy |
| StoneX Group Inc. | 0 | 20,540 | +20,540 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 58,681 | 76,186 | +17,505 | 0.00 | 0.00 | -0.00 | buy |
| Marex Group plc | 22,500 | 32,700 | +10,200 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 211,347 | 220,727 | +9,380 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 3,841 | +3,841 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 380 | 406 | +26 | 0.00 | 0.00 | -0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 21 | +21 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 3,596 | 3,605 | +9 | 0.00 | 0.00 | -0.00 | buy |
| BVF INC/IL | 7,652,972 | 7,652,972 | 0 | 0.27 | 0.14 | -0.14 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 1,500 | 1,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,398,600 | 1,398,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 26 | 26 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bank of New York Mellon Corp | 30,456 | 30,456 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Retirement Planning Group, LLC | 10,417 | 10,417 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 8,642 | 8,642 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Creative Planning | 35,000 | 35,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allworth Financial LP | 842 | 842 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Private Advisor Group, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Dynamic Advisor Solutions LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Parallel Advisors, LLC | 2 | 2 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LEVEL FOUR ADVISORY SERVICES, LLC | 10,780 | 10,780 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Crescent Grove Advisors, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aberdeen Group plc | 8,243,941 | 8,243,941 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Rockefeller Capital Management L.P. | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avidity Partners Management LP | 4,699,411 | 4,699,411 | 0 | 0.94 | 0.72 | -0.22 | hold |
| Addison Advisors LLC | 5,200 | 5,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HB Wealth Management, LLC | 91,450 | 91,450 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Balboa Wealth Partners | 12,000 | 12,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PFG Investments, LLC | 10,500 | 10,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Strategies Wealth Advisors, LLC | 100,000 | 100,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| CALDWELL SUTTER CAPITAL, INC. | 3 | 3 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 331,945 | 331,945 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bell Investment Advisors, Inc | 649 | 0 | -649 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 4,383 | 0 | -4,383 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 725,743 | 717,470 | -8,273 | 0.00 | 0.00 | -0.00 | sell |
| Ring Mountain Capital, LLC | 18,039 | 0 | -18,039 | 0.01 | 0.00 | -0.01 | sell |
| Qube Research & Technologies Ltd | 32,669 | 0 | -32,669 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 115,000 | 40,000 | -75,000 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 240,873 | 130,585 | -110,288 | 0.01 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 112,287 | 0 | -112,287 | 0.01 | 0.00 | -0.01 | sell |
| Exome Asset Management LLC | 173,900 | 0 | -173,900 | 0.10 | 0.00 | -0.10 | sell |
| Ikarian Capital, LLC | 914,170 | 674,662 | -239,508 | 0.16 | 0.05 | -0.12 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 391,653 | 0 | -391,653 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 535,083 | 0 | -535,083 | 0.00 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 1,580,007 | 0 | -1,580,007 | 0.07 | 0.00 | -0.07 | sell |
| MORGAN STANLEY | 3,103,122 | 0 | -3,103,122 | 0.00 | 0.00 | -0.00 | sell |