| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 17,687,772 | 17,687,772 | 0 | 8.28 | 7.03 | -1.25 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 8,197,546 | 9,156,099 | +958,553 | 0.05 | 0.04 | -0.00 | buy |
| VANGUARD GROUP INC | 5,447,565 | 5,370,885 | -76,680 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 3,231,411 | 4,193,077 | +961,666 | 0.00 | 0.01 | +0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 3,941,859 | 3,984,030 | +42,171 | 0.69 | 0.56 | -0.13 | buy |
| MAVERICK CAPITAL LTD | 4,034,068 | 3,888,312 | -145,756 | 2.49 | 2.03 | -0.46 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,629,074 | 2,943,160 | +314,086 | 0.01 | 0.01 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 949,905 | 2,606,016 | +1,656,111 | 0.02 | 0.04 | +0.02 | buy |
| CITADEL ADVISORS LLC | 2,457,561 | 2,469,813 | +12,252 | 0.07 | 0.06 | -0.01 | buy |
| FRANKLIN RESOURCES INC | 1,072,910 | 1,867,329 | +794,419 | 0.02 | 0.02 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,707,398 | 1,801,068 | +93,670 | 1.14 | 0.86 | -0.29 | buy |
| Frazier Life Sciences Management, L.P. | 1,523,013 | 1,561,230 | +38,217 | 2.44 | 1.77 | -0.67 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,457,250 | 1,502,587 | +45,337 | 0.00 | 0.00 | -0.00 | buy |
| Pictet Asset Management Holding SA | 1,347,163 | 1,323,447 | -23,716 | 0.04 | 0.04 | -0.01 | sell |
| Logos Global Management LP | 1,275,000 | 1,300,000 | +25,000 | 4.25 | 3.69 | -0.56 | buy |
| Avoro Capital Advisors LLC | 1,260,900 | 1,260,900 | 0 | 0.52 | 0.40 | -0.13 | hold |
| Novo Holdings A/S | 1,050,000 | 1,050,000 | 0 | 1.94 | 1.95 | +0.01 | hold |
| DIMENSIONAL FUND ADVISORS LP | 1,047,941 | 1,029,788 | -18,153 | 0.01 | 0.01 | -0.00 | sell |
| Avidity Partners Management LP | 1,719,103 | 1,025,000 | -694,103 | 1.97 | 0.98 | -0.99 | sell |
| BANK OF AMERICA CORP /DE/ | 793,738 | 1,018,488 | +224,750 | 0.00 | 0.00 | +0.00 | buy |
| BAMCO INC /NY/ | 1,052,501 | 990,544 | -61,957 | 0.08 | 0.07 | -0.01 | sell |
| Altium Capital Management LLC | 0 | 731,561 | +731,561 | 0.00 | 0.10 | +0.10 | buy |
| Walleye Capital LLC | 720,920 | 720,905 | -15 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 611,973 | 688,813 | +76,840 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 748,340 | 682,524 | -65,816 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 648,946 | 675,769 | +26,823 | 0.03 | 0.03 | -0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 250,000 | 660,000 | +410,000 | 0.69 | 1.85 | +1.16 | buy |
| NORTHERN TRUST CORP | 628,705 | 610,037 | -18,668 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 529,496 | 576,667 | +47,171 | 0.00 | 0.00 | -0.00 | buy |
| COMERICA BANK | 558,025 | 534,525 | -23,500 | 0.08 | 0.06 | -0.01 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 525,452 | 532,563 | +7,111 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 42,804 | 508,954 | +466,150 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 490,732 | 490,732 | 0 | 0.24 | 0.21 | -0.03 | hold |
| GOLDMAN SACHS GROUP INC | 594,665 | 430,875 | -163,790 | 0.00 | 0.00 | -0.00 | sell |
| Sio Capital Management, LLC | 400,000 | 400,000 | 0 | 0.04 | 0.04 | -0.01 | hold |
| M28 Capital Management LP | 523,280 | 385,680 | -137,600 | 12.99 | 7.68 | -5.31 | sell |
| RTW INVESTMENTS, LP | 350,000 | 350,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rafferty Asset Management, LLC | 208,505 | 329,043 | +120,538 | 0.03 | 0.03 | +0.01 | buy |
| Fort Baker Capital Management LP | 328,698 | 328,698 | 0 | 0.02 | 0.01 | -0.01 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 366,015 | 326,787 | -39,228 | 6.18 | 5.72 | -0.46 | sell |
| Mirae Asset Global Investments Co., Ltd. | 172,474 | 301,832 | +129,358 | 0.01 | 0.01 | +0.00 | buy |
| Cormorant Asset Management, LP | 450,000 | 300,000 | -150,000 | 0.65 | 0.36 | -0.29 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 296,013 | 297,658 | +1,645 | 0.03 | 0.02 | -0.01 | buy |
| Ikarian Capital, LLC | 239,726 | 297,096 | +57,370 | 1.97 | 2.18 | +0.21 | buy |
| CITIGROUP INC | 90,254 | 285,143 | +194,889 | 0.00 | 0.01 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 156,000 | 275,720 | +119,720 | 0.01 | 0.01 | +0.00 | buy |
| First Turn Management, LLC | 0 | 250,870 | +250,870 | 0.00 | 1.01 | +1.01 | buy |
| Privium Fund Management B.V. | 233,050 | 235,050 | +2,000 | 1.92 | 1.69 | -0.22 | buy |
| Hennion & Walsh Asset Management, Inc. | 193,350 | 231,287 | +37,937 | 0.33 | 0.33 | +0.00 | buy |
| GMT CAPITAL CORP | 306,500 | 230,000 | -76,500 | 0.35 | 0.24 | -0.10 | sell |
| Bank of New York Mellon Corp | 232,490 | 217,356 | -15,134 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 190,783 | 183,722 | -7,061 | 1.06 | 0.80 | -0.26 | sell |
| Qube Research & Technologies Ltd | 0 | 177,524 | +177,524 | 0.00 | 0.01 | +0.01 | buy |
| Candriam S.C.A. | 110,000 | 165,000 | +55,000 | 0.02 | 0.03 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 45,657 | 161,630 | +115,973 | 0.00 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 76,510 | 155,244 | +78,734 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 154,864 | 155,164 | +300 | 0.00 | 0.00 | -0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 152,861 | 154,070 | +1,209 | 0.01 | 0.00 | -0.00 | buy |
| EFG Asset Management (North America) Corp. | 155,205 | 151,002 | -4,203 | 0.88 | 0.70 | -0.18 | sell |
| TWO SIGMA INVESTMENTS, LP | 254,916 | 150,008 | -104,908 | 0.02 | 0.01 | -0.01 | sell |
| BLAIR WILLIAM & CO/IL | 146,879 | 147,280 | +401 | 0.01 | 0.01 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 140,000 | 130,000 | -10,000 | 0.01 | 0.01 | -0.00 | sell |
| Swiss National Bank | 133,000 | 124,600 | -8,400 | 0.00 | 0.00 | -0.00 | sell |
| Nicholas Investment Partners, LP | 0 | 119,137 | +119,137 | 0.00 | 0.33 | +0.33 | buy |
| New Leaf Venture Partners, L.L.C. | 118,242 | 118,242 | 0 | 2.85 | 2.79 | -0.07 | hold |
| Neuberger Berman Group LLC | 0 | 114,617 | +114,617 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 100,936 | 113,057 | +12,121 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 177,535 | 105,505 | -72,030 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 104,828 | 104,828 | 0 | 0.02 | 0.01 | -0.01 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 382,672 | 101,002 | -281,670 | 3.54 | 0.76 | -2.77 | sell |
| RHUMBLINE ADVISERS | 92,013 | 96,176 | +4,163 | 0.00 | 0.00 | -0.00 | buy |
| DekaBank Deutsche Girozentrale | 89,700 | 89,700 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Rockefeller Capital Management L.P. | 85,464 | 85,462 | -2 | 0.01 | 0.01 | -0.00 | sell |
| SYNOVUS FINANCIAL CORP | 84,970 | 83,411 | -1,559 | 0.04 | 0.03 | -0.01 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 54,355 | 81,426 | +27,071 | 0.31 | 0.29 | -0.03 | buy |
| Assenagon Asset Management S.A. | 702,625 | 80,726 | -621,899 | 0.06 | 0.01 | -0.06 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 78,387 | 78,387 | 0 | 0.01 | 0.00 | -0.00 | hold |
| TWO SIGMA ADVISERS, LP | 110,576 | 77,576 | -33,000 | 0.01 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 75,000 | 75,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| RICE HALL JAMES & ASSOCIATES, LLC | 72,428 | 72,528 | +100 | 0.13 | 0.11 | -0.01 | buy |
| Legal & General Group Plc | 66,440 | 66,197 | -243 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 71,011 | 65,790 | -5,221 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 48,281 | 65,172 | +16,891 | 0.05 | 0.05 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 70,429 | 63,062 | -7,367 | 0.00 | 0.00 | -0.00 | sell |
| TORRAY INVESTMENT PARTNERS LLC | 60,856 | 60,933 | +77 | 0.30 | 0.25 | -0.05 | buy |
| NORGES BANK | 243,351 | 60,851 | -182,500 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 60,771 | 60,771 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MACQUARIE GROUP LTD | 58,000 | 58,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEOS Investment Management LLC | 19,520 | 57,600 | +38,080 | 0.06 | 0.10 | +0.04 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 49,657 | 57,404 | +7,747 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 38,666 | 52,746 | +14,080 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 34,471 | 51,148 | +16,677 | 0.04 | 0.05 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 45,508 | 48,018 | +2,510 | 0.00 | 0.00 | -0.00 | buy |
| Erste Asset Management GmbH | 16,700 | 44,700 | +28,000 | 0.01 | 0.02 | +0.01 | buy |
| PURA VIDA INVESTMENTS, LLC | 42,960 | 42,960 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Vontobel Holding Ltd. | 43,540 | 42,700 | -840 | 0.01 | 0.01 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 86,587 | 42,538 | -44,049 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 42,079 | 42,434 | +355 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 96,843 | 41,190 | -55,653 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 27,173 | 41,011 | +13,838 | 0.00 | 0.00 | +0.00 | buy |