| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 949,905 | 2,606,016 | +1,656,111 | 0.02 | 0.04 | +0.02 | buy |
| STATE STREET CORP | 3,231,411 | 4,193,077 | +961,666 | 0.00 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 8,197,546 | 9,156,099 | +958,553 | 0.05 | 0.04 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 1,072,910 | 1,867,329 | +794,419 | 0.02 | 0.02 | +0.00 | buy |
| Altium Capital Management LLC | 0 | 731,561 | +731,561 | 0.00 | 0.10 | +0.10 | buy |
| UBS Group AG | 42,804 | 508,954 | +466,150 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 250,000 | 660,000 | +410,000 | 0.69 | 1.85 | +1.16 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,629,074 | 2,943,160 | +314,086 | 0.01 | 0.01 | -0.00 | buy |
| First Turn Management, LLC | 0 | 250,870 | +250,870 | 0.00 | 1.01 | +1.01 | buy |
| BANK OF AMERICA CORP /DE/ | 793,738 | 1,018,488 | +224,750 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 90,254 | 285,143 | +194,889 | 0.00 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 177,524 | +177,524 | 0.00 | 0.01 | +0.01 | buy |
| Mirae Asset Global Investments Co., Ltd. | 172,474 | 301,832 | +129,358 | 0.01 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 208,505 | 329,043 | +120,538 | 0.03 | 0.03 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 156,000 | 275,720 | +119,720 | 0.01 | 0.01 | +0.00 | buy |
| Nicholas Investment Partners, LP | 0 | 119,137 | +119,137 | 0.00 | 0.33 | +0.33 | buy |
| PRUDENTIAL FINANCIAL INC | 45,657 | 161,630 | +115,973 | 0.00 | 0.01 | +0.00 | buy |
| Neuberger Berman Group LLC | 0 | 114,617 | +114,617 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,707,398 | 1,801,068 | +93,670 | 1.14 | 0.86 | -0.29 | buy |
| ALLIANCEBERNSTEIN L.P. | 76,510 | 155,244 | +78,734 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 611,973 | 688,813 | +76,840 | 0.00 | 0.00 | -0.00 | buy |
| Ikarian Capital, LLC | 239,726 | 297,096 | +57,370 | 1.97 | 2.18 | +0.21 | buy |
| Candriam S.C.A. | 110,000 | 165,000 | +55,000 | 0.02 | 0.03 | +0.01 | buy |
| FMR LLC | 529,496 | 576,667 | +47,171 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,457,250 | 1,502,587 | +45,337 | 0.00 | 0.00 | -0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 3,941,859 | 3,984,030 | +42,171 | 0.69 | 0.56 | -0.13 | buy |
| Frazier Life Sciences Management, L.P. | 1,523,013 | 1,561,230 | +38,217 | 2.44 | 1.77 | -0.67 | buy |
| NEOS Investment Management LLC | 19,520 | 57,600 | +38,080 | 0.06 | 0.10 | +0.04 | buy |
| Hennion & Walsh Asset Management, Inc. | 193,350 | 231,287 | +37,937 | 0.33 | 0.33 | +0.00 | buy |
| Erste Asset Management GmbH | 16,700 | 44,700 | +28,000 | 0.01 | 0.02 | +0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 54,355 | 81,426 | +27,071 | 0.31 | 0.29 | -0.03 | buy |
| Russell Investments Group, Ltd. | 648,946 | 675,769 | +26,823 | 0.03 | 0.03 | -0.01 | buy |
| Logos Global Management LP | 1,275,000 | 1,300,000 | +25,000 | 4.25 | 3.69 | -0.56 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 48,281 | 65,172 | +16,891 | 0.05 | 0.05 | -0.00 | buy |
| PROFUND ADVISORS LLC | 34,471 | 51,148 | +16,677 | 0.04 | 0.05 | +0.01 | buy |
| TWINBEECH CAPITAL LP | 0 | 14,122 | +14,122 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 38,666 | 52,746 | +14,080 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 27,173 | 41,011 | +13,838 | 0.00 | 0.00 | +0.00 | buy |
| Sigma Planning Corp | 11,870 | 25,480 | +13,610 | 0.03 | 0.02 | -0.01 | buy |
| Aquatic Capital Management LLC | 0 | 13,100 | +13,100 | 0.00 | 0.01 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 17,963 | 30,774 | +12,811 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 0 | 12,746 | +12,746 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 2,457,561 | 2,469,813 | +12,252 | 0.07 | 0.06 | -0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 100,936 | 113,057 | +12,121 | 0.00 | 0.00 | +0.00 | buy |
| Harbour Capital Advisors, LLC | 9,825 | 21,155 | +11,330 | 0.08 | 0.13 | +0.06 | buy |
| XTX Topco Ltd | 0 | 9,507 | +9,507 | 0.00 | 0.03 | +0.03 | buy |
| Scientech Research LLC | 7,081 | 15,858 | +8,777 | 0.21 | 0.23 | +0.02 | buy |
| HSBC HOLDINGS PLC | 0 | 8,048 | +8,048 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 49,657 | 57,404 | +7,747 | 0.00 | 0.00 | -0.00 | buy |
| Pearl River Capital, LLC | 0 | 7,712 | +7,712 | 0.00 | 0.03 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 525,452 | 532,563 | +7,111 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 10,424 | 17,365 | +6,941 | 0.06 | 0.06 | -0.00 | buy |
| AlphaQuest LLC | 0 | 6,180 | +6,180 | 0.00 | 0.03 | +0.03 | buy |
| E Fund Management Co., Ltd. | 11,197 | 15,549 | +4,352 | 0.02 | 0.03 | +0.00 | buy |
| RHUMBLINE ADVISERS | 92,013 | 96,176 | +4,163 | 0.00 | 0.00 | -0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 12,280 | 14,810 | +2,530 | 0.16 | 0.16 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 45,508 | 48,018 | +2,510 | 0.00 | 0.00 | -0.00 | buy |
| Steward Partners Investment Advisory, LLC | 5,000 | 7,500 | +2,500 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 0 | 2,109 | +2,109 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 8,058 | 10,118 | +2,060 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 233,050 | 235,050 | +2,000 | 1.92 | 1.69 | -0.22 | buy |
| STRS OHIO | 0 | 1,700 | +1,700 | 0.00 | 0.00 | +0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 296,013 | 297,658 | +1,645 | 0.03 | 0.02 | -0.01 | buy |
| GUGGENHEIM CAPITAL LLC | 8,380 | 9,985 | +1,605 | 0.00 | 0.00 | -0.00 | buy |
| Pacer Advisors, Inc. | 0 | 1,528 | +1,528 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 16,146 | 17,614 | +1,468 | 0.00 | 0.00 | -0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 152,861 | 154,070 | +1,209 | 0.01 | 0.00 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 25,880 | 26,783 | +903 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 26,460 | 27,229 | +769 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 12,374 | 13,097 | +723 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 19,337 | 20,046 | +709 | 0.00 | 0.00 | -0.00 | buy |
| BLAIR WILLIAM & CO/IL | 146,879 | 147,280 | +401 | 0.01 | 0.01 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 42,079 | 42,434 | +355 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 154,864 | 155,164 | +300 | 0.00 | 0.00 | -0.00 | buy |
| Clearstead Advisors, LLC | 1,840 | 2,120 | +280 | 0.00 | 0.00 | -0.00 | buy |
| PITCAIRN CO | 9,110 | 9,364 | +254 | 0.02 | 0.02 | -0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 16,300 | 16,490 | +190 | 0.00 | 0.00 | -0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 72,428 | 72,528 | +100 | 0.13 | 0.11 | -0.01 | buy |
| TORRAY INVESTMENT PARTNERS LLC | 60,856 | 60,933 | +77 | 0.30 | 0.25 | -0.05 | buy |
| NISA INVESTMENT ADVISORS, LLC | 2,340 | 2,396 | +56 | 0.00 | 0.00 | -0.00 | buy |
| EVERMAY WEALTH MANAGEMENT LLC | 0 | 25 | +25 | 0.00 | 0.00 | +0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 0 | 25 | +25 | 0.00 | 0.00 | +0.00 | buy |
| HUNTINGTON NATIONAL BANK | 458 | 477 | +19 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 23 | 38 | +15 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 828 | 836 | +8 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| COBBLESTONE CAPITAL ADVISORS LLC /NY/ | 9,000 | 9,000 | 0 | 0.02 | 0.02 | -0.00 | hold |
| CANADA LIFE ASSURANCE Co | 6,276 | 6,276 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SANDERS MORRIS HARRIS LLC | 27,709 | 27,709 | 0 | 0.40 | 0.14 | -0.26 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Ameritas Investment Partners, Inc. | 6,494 | 6,494 | 0 | 0.01 | 0.01 | -0.00 | hold |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 24,518 | 24,518 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Amundi | 3,839 | 3,839 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rathbones Group PLC | 30,000 | 30,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Novo Holdings A/S | 1,050,000 | 1,050,000 | 0 | 1.94 | 1.95 | +0.01 | hold |
| Walleye Trading LLC | 34,829 | 34,829 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Handelsbanken Fonder AB | 17,600 | 17,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MACQUARIE GROUP LTD | 58,000 | 58,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 490,732 | 490,732 | 0 | 0.24 | 0.21 | -0.03 | hold |
| DekaBank Deutsche Girozentrale | 89,700 | 89,700 | 0 | 0.01 | 0.00 | -0.00 | hold |