| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 949,905 | 2,606,016 | +1,656,111 | 0.02 | 0.04 | 0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 250,000 | 660,000 | +410,000 | 0.69 | 1.85 | +1.16 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,629,074 | 2,943,160 | +314,086 | 0.01 | 0.01 | -0.00 | buy |
| Rafferty Asset Management, LLC | 208,505 | 329,043 | +120,538 | 0.03 | 0.03 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 156,000 | 275,720 | +119,720 | 0.01 | 0.01 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,707,398 | 1,801,068 | +93,670 | 1.14 | 0.85 | -0.29 | buy |
| Ikarian Capital, LLC | 239,726 | 297,096 | +57,370 | 1.97 | 2.18 | +0.21 | buy |
| Candriam S.C.A. | 110,000 | 165,000 | +55,000 | 0.02 | 0.03 | +0.01 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 3,941,859 | 3,984,030 | +42,171 | 0.69 | 0.56 | -0.13 | buy |
| Frazier Life Sciences Management, L.P. | 1,523,013 | 1,561,230 | +38,217 | 2.44 | 1.77 | -0.67 | buy |
| NEOS Investment Management LLC | 19,520 | 57,600 | +38,080 | 0.06 | 0.10 | +0.04 | buy |
| Hennion & Walsh Asset Management, Inc. | 193,350 | 231,287 | +37,937 | 0.33 | 0.33 | +0.00 | buy |
| Erste Asset Management GmbH | 16,700 | 44,700 | +28,000 | 0.01 | 0.02 | +0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 54,355 | 81,426 | +27,071 | 0.31 | 0.29 | -0.03 | buy |
| Logos Global Management LP | 1,275,000 | 1,300,000 | +25,000 | 4.25 | 3.69 | -0.56 | buy |
| PROFUND ADVISORS LLC | 34,471 | 51,148 | +16,677 | 0.04 | 0.05 | 0.00 | buy |
| CITADEL ADVISORS LLC | 2,457,561 | 2,469,813 | +12,252 | 0.11 | 0.09 | -0.01 | buy |
| Harbour Capital Advisors, LLC | 9,825 | 21,155 | +11,330 | 0.08 | 0.13 | +0.06 | buy |
| Scientech Research LLC | 7,081 | 15,858 | +8,777 | 0.21 | 0.23 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 10,424 | 17,365 | +6,941 | 0.06 | 0.06 | -0.00 | buy |
| E Fund Management Co., Ltd. | 11,197 | 15,549 | +4,352 | 0.02 | 0.03 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 12,280 | 14,810 | +2,530 | 0.16 | 0.16 | -0.00 | buy |
| Privium Fund Management B.V. | 233,050 | 235,050 | +2,000 | 1.92 | 1.69 | -0.22 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 296,013 | 297,658 | +1,645 | 0.03 | 0.02 | -0.01 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 152,861 | 154,070 | +1,209 | 0.01 | 0.00 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 25,880 | 26,783 | +903 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 154,864 | 155,164 | +300 | 0.00 | 0.00 | -0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 72,428 | 72,528 | +100 | 0.13 | 0.11 | -0.01 | buy |
| TORRAY INVESTMENT PARTNERS LLC | 60,856 | 60,933 | +77 | 0.30 | 0.25 | -0.05 | buy |
| Rockefeller Capital Management L.P. | 85,464 | 85,462 | +2 | 0.01 | 0.01 | 0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 19,379 | 19,270 | -109 | 0.01 | 0.01 | -0.00 | sell |
| Dana Investment Advisors, Inc. | 13,417 | 13,261 | -156 | 0.02 | 0.01 | -0.01 | sell |
| VIRTUS ADVISERS, LLC | 3,274 | 3,063 | -211 | 0.06 | 0.04 | -0.02 | sell |
| Bellevue Group AG | 21,000 | 19,700 | -1,300 | 0.01 | 0.01 | -0.00 | sell |
| SYNOVUS FINANCIAL CORP | 84,970 | 83,411 | -1,559 | 0.04 | 0.03 | -0.01 | sell |
| Entropy Technologies, LP | 17,344 | 13,544 | -3,800 | 0.10 | 0.04 | -0.06 | sell |
| EFG Asset Management (North America) Corp. | 155,205 | 151,002 | -4,203 | 0.88 | 0.70 | -0.18 | sell |
| EFG Asset Management (Americas) Corp. | 11,972 | 7,500 | -4,472 | 0.08 | 0.06 | -0.02 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 190,783 | 183,722 | -7,061 | 0.92 | 0.70 | -0.22 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 140,000 | 130,000 | -10,000 | 0.01 | 0.01 | -0.00 | sell |
| Atom Investors LP | 30,971 | 11,472 | -19,499 | 0.16 | 0.04 | -0.13 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 366,015 | 326,787 | -39,228 | 6.17 | 5.72 | -0.46 | sell |
| BAMCO INC /NY/ | 1,052,501 | 990,544 | -61,957 | 0.08 | 0.07 | -0.01 | sell |
| GMT CAPITAL CORP | 306,500 | 230,000 | -76,500 | 0.35 | 0.24 | -0.10 | sell |
| M28 Capital Management LP | 523,280 | 385,680 | -137,600 | 12.99 | 7.68 | -5.31 | sell |
| MAVERICK CAPITAL LTD | 4,034,068 | 3,888,312 | -145,756 | 2.49 | 2.03 | -0.46 | sell |
| Cormorant Asset Management, LP | 450,000 | 300,000 | -150,000 | 0.64 | 0.35 | -0.29 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 382,672 | 101,002 | -281,670 | 3.54 | 0.76 | -2.77 | sell |
| Avidity Partners Management LP | 1,719,103 | 1,025,000 | -694,103 | 1.97 | 0.98 | -0.99 | sell |