| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 97,079 | 1,097,079 | +1,000,000 | 0.01 | 0.08 | +0.07 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,566,951 | 3,502,000 | +935,049 | 1.10 | 0.87 | -0.23 | buy |
| JANUS HENDERSON GROUP PLC | 4,004,039 | 3,290,843 | +713,196 | 0.03 | 0.01 | 0.00 | sell |
| MPM BioImpact LLC | 1,020,559 | 1,618,265 | +597,706 | 1.82 | 1.86 | +0.03 | buy |
| Prosight Management, LP | 1,088,706 | 1,480,000 | +391,294 | 3.78 | 3.24 | -0.54 | buy |
| Sovran Advisors, LLC | 150,767 | 323,091 | +172,324 | 0.22 | 0.27 | +0.04 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 127,270 | 254,405 | +127,135 | 0.00 | 0.00 | +0.00 | buy |
| Mirador Capital Partners LP | 84,529 | 203,829 | +119,300 | 0.19 | 0.24 | +0.05 | buy |
| SYNOVUS FINANCIAL CORP | 163,893 | 278,450 | +114,557 | 0.03 | 0.02 | -0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 4,714,610 | 4,820,701 | +106,091 | 0.26 | 0.16 | -0.10 | buy |
| TANG CAPITAL MANAGEMENT LLC | 750,000 | 850,000 | +100,000 | 0.62 | 0.31 | -0.31 | buy |
| AlphaQuest LLC | 21,686 | 96,391 | +74,705 | 0.04 | 0.08 | 0.00 | buy |
| EntryPoint Capital, LLC | 24,903 | 76,419 | +51,516 | 0.13 | 0.23 | +0.10 | buy |
| Main Management ETF Advisors, LLC | 29,904 | 74,972 | +45,068 | 0.02 | 0.02 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 70,304 | 114,580 | +44,276 | 0.00 | 0.00 | -0.00 | buy |
| Privium Fund Management B.V. | 397,650 | 432,760 | +35,110 | 1.13 | 0.75 | -0.38 | buy |
| THOMPSON SIEGEL & WALMSLEY LLC | 12,747 | 46,747 | +34,000 | 0.00 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 211,400 | 241,800 | +30,400 | 0.55 | 0.31 | -0.24 | buy |
| Campbell & CO Investment Adviser LLC | 59,969 | 90,084 | +30,115 | 0.06 | 0.05 | -0.01 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 37,500 | 56,820 | +19,320 | 0.09 | 0.07 | -0.02 | buy |
| ALGERT GLOBAL LLC | 40,060 | 55,510 | +15,450 | 0.01 | 0.01 | 0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 165,127 | 178,236 | +13,109 | 0.09 | 0.05 | 0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 237,499 | 249,526 | +12,027 | 0.14 | 0.07 | -0.06 | buy |
| ExodusPoint Capital Management, LP | 189,879 | 200,684 | +10,805 | 0.03 | 0.02 | 0.00 | buy |
| Voss Capital, LP | 421,700 | 432,240 | +10,540 | 0.39 | 0.22 | -0.17 | buy |
| Marex Group plc | 17,500 | 22,500 | +5,000 | 0.00 | 0.00 | -0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 40,183 | 44,383 | +4,200 | 0.34 | 0.23 | -0.11 | buy |
| E Fund Management Co., Ltd. | 11,054 | 14,567 | +3,513 | 0.01 | 0.00 | -0.00 | buy |
| Cornerstone Select Advisors, LLC | 19,045 | 22,265 | +3,220 | 0.23 | 0.14 | -0.09 | buy |
| PROFUND ADVISORS LLC | 30,161 | 32,285 | +2,124 | 0.01 | 0.01 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 19,329 | 21,388 | +2,059 | 0.02 | 0.01 | -0.01 | buy |
| Riverview Trust Co | 40 | 2,051 | +2,011 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 652,421 | 652,865 | +444 | 0.06 | 0.03 | -0.03 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,914 | 2,333 | +419 | 0.00 | 0.00 | -0.00 | buy |
| MAVERICK CAPITAL LTD | 5,198,900 | 5,199,218 | +318 | 1.18 | 0.62 | -0.55 | buy |
| Dana Investment Advisors, Inc. | 17,608 | 17,638 | +30 | 0.01 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 156,260 | 155,875 | -385 | 0.01 | 0.00 | -0.00 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 90,834 | 87,519 | -3,315 | 0.06 | 0.03 | -0.03 | sell |
| TORRAY INVESTMENT PARTNERS LLC | 122,095 | 117,301 | -4,794 | 0.22 | 0.12 | -0.10 | sell |
| Siren, L.L.C. | 600,000 | 591,263 | -8,737 | 0.33 | 0.22 | -0.11 | sell |
| Bayesian Capital Management, LP | 29,536 | 20,536 | -9,000 | 0.05 | 0.02 | -0.02 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 38,208 | 14,725 | -23,483 | 0.01 | 0.00 | -0.01 | sell |
| EFG Asset Management (North America) Corp. | 145,629 | 110,961 | -34,668 | 0.25 | 0.12 | -0.13 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 134,500 | 83,350 | -51,150 | 1.70 | 0.64 | -1.06 | sell |
| NEOS Investment Management LLC | 90,985 | 36,863 | -54,122 | 0.03 | 0.00 | -0.02 | sell |
| TEMA ETFS LLC | 90,985 | 36,863 | -54,122 | 0.47 | 0.07 | -0.40 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,148,520 | 3,043,682 | -104,838 | 0.00 | 0.00 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 378,584 | 140,726 | -237,858 | 0.13 | 0.03 | -0.10 | sell |
| Frazier Life Sciences Management, L.P. | 1,479,025 | 1,079,025 | -400,000 | 0.77 | 0.33 | -0.44 | sell |