| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Woodline Partners LP | 0 | 561,966 | +561,966 | 0.00 | 0.12 | +0.12 | buy |
| EcoR1 Capital, LLC | 0 | 508,393 | +508,393 | 0.00 | 0.33 | +0.33 | buy |
| VANGUARD GROUP INC | 5,370,885 | 5,808,550 | +437,665 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 2,469,813 | 2,818,069 | +348,256 | 0.06 | 0.06 | -0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 3,984,030 | 4,327,922 | +343,892 | 0.56 | 0.46 | -0.11 | buy |
| JANUS HENDERSON GROUP PLC | 2,606,016 | 2,919,078 | +313,062 | 0.04 | 0.03 | -0.00 | buy |
| Invesco Ltd. | 41,190 | 352,026 | +310,836 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 250,870 | 560,989 | +310,119 | 1.01 | 1.96 | +0.95 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 490,732 | 770,691 | +279,959 | 0.21 | 0.28 | +0.08 | buy |
| GOLDMAN SACHS GROUP INC | 430,875 | 695,908 | +265,033 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,943,160 | 3,169,448 | +226,288 | 0.01 | 0.01 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,018,488 | 1,238,044 | +219,556 | 0.00 | 0.00 | -0.00 | buy |
| COMERICA BANK | 534,525 | 686,654 | +152,129 | 0.06 | 0.06 | -0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 130,538 | +130,538 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 275,720 | 386,996 | +111,276 | 0.01 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 155,244 | 261,347 | +106,103 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 105,325 | +105,325 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,502,587 | 1,603,610 | +101,023 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 99,574 | +99,574 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 660,000 | 750,000 | +90,000 | 1.85 | 1.64 | -0.21 | buy |
| SYNOVUS FINANCIAL CORP | 83,411 | 168,090 | +84,679 | 0.03 | 0.05 | +0.02 | buy |
| Avidity Partners Management LP | 1,025,000 | 1,100,000 | +75,000 | 0.98 | 1.01 | +0.02 | buy |
| EFG Asset Management (North America) Corp. | 151,002 | 222,046 | +71,044 | 0.70 | 0.83 | +0.13 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 130,000 | 200,000 | +70,000 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 65,790 | 118,072 | +52,282 | 0.00 | 0.00 | +0.00 | buy |
| Novo Holdings A/S | 1,050,000 | 1,100,000 | +50,000 | 1.95 | 1.28 | -0.67 | buy |
| NEOS Investment Management LLC | 57,600 | 102,847 | +45,247 | 0.10 | 0.09 | -0.00 | buy |
| MAVERICK CAPITAL LTD | 3,888,312 | 3,928,312 | +40,000 | 2.03 | 1.60 | -0.43 | buy |
| Neuberger Berman Group LLC | 114,617 | 150,578 | +35,961 | 0.00 | 0.00 | +0.00 | buy |
| New Leaf Venture Partners, L.L.C. | 118,242 | 150,706 | +32,464 | 2.79 | 3.95 | +1.16 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 113,057 | 139,613 | +26,556 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 105,505 | 130,797 | +25,292 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 183,722 | 206,933 | +23,211 | 0.80 | 0.73 | -0.08 | buy |
| TD ASSET MANAGEMENT INC | 155,164 | 178,164 | +23,000 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 217,356 | 239,877 | +22,521 | 0.00 | 0.00 | -0.00 | buy |
| Strategic Financial Concepts, LLC | 0 | 21,981 | +21,981 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 19,583 | +19,583 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 17,992 | +17,992 | 0.00 | 0.03 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 532,563 | 549,492 | +16,929 | 0.00 | 0.00 | -0.00 | buy |
| Privium Fund Management B.V. | 235,050 | 250,980 | +15,930 | 1.69 | 1.27 | -0.42 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 81,426 | 97,134 | +15,708 | 0.29 | 0.16 | -0.13 | buy |
| Harbour Capital Advisors, LLC | 21,155 | 36,180 | +15,025 | 0.13 | 0.18 | +0.04 | buy |
| Tower Research Capital LLC (TRC) | 1,014 | 14,605 | +13,591 | 0.00 | 0.01 | +0.00 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 18,000 | 30,900 | +12,900 | 0.12 | 0.15 | +0.03 | buy |
| FRANKLIN RESOURCES INC | 1,867,329 | 1,873,689 | +6,360 | 0.02 | 0.01 | -0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 6,331 | +6,331 | 0.00 | 0.00 | +0.00 | buy |
| TORRAY INVESTMENT PARTNERS LLC | 60,933 | 67,216 | +6,283 | 0.25 | 0.22 | -0.03 | buy |
| SIMPLEX TRADING, LLC | 0 | 5,825 | +5,825 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 4,208 | 9,229 | +5,021 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 96,176 | 101,134 | +4,958 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 33,003 | 37,501 | +4,498 | 0.01 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 13,097 | 17,092 | +3,995 | 0.00 | 0.00 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 26,783 | 30,578 | +3,795 | 0.00 | 0.00 | -0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 72,528 | 75,423 | +2,895 | 0.11 | 0.10 | -0.01 | buy |
| FMR LLC | 576,667 | 579,279 | +2,612 | 0.00 | 0.00 | -0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 10,901 | 13,118 | +2,217 | 0.00 | 0.00 | -0.00 | buy |
| Cetera Investment Advisers | 12,746 | 14,885 | +2,139 | 0.00 | 0.00 | -0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 2,100 | +2,100 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 675,769 | 677,744 | +1,975 | 0.03 | 0.02 | -0.01 | buy |
| WELLS FARGO & COMPANY/MN | 22,840 | 24,747 | +1,907 | 0.00 | 0.00 | -0.00 | buy |
| Rockefeller Capital Management L.P. | 85,462 | 86,973 | +1,511 | 0.01 | 0.01 | -0.00 | buy |
| LPL Financial LLC | 9,182 | 10,479 | +1,297 | 0.00 | 0.00 | -0.00 | buy |
| Avior Wealth Management, LLC | 14,767 | 16,026 | +1,259 | 0.02 | 0.01 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 28,569 | 29,791 | +1,222 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 20,656 | 21,847 | +1,191 | 0.00 | 0.00 | -0.00 | buy |
| STRS OHIO | 1,700 | 2,600 | +900 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 3,063 | 3,960 | +897 | 0.04 | 0.04 | -0.00 | buy |
| Legal & General Group Plc | 66,197 | 67,057 | +860 | 0.00 | 0.00 | -0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 14,336 | 15,130 | +794 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 2,396 | 3,160 | +764 | 0.00 | 0.00 | +0.00 | buy |
| PITCAIRN CO | 9,364 | 10,089 | +725 | 0.02 | 0.01 | -0.00 | buy |
| Handelsbanken Fonder AB | 17,600 | 18,200 | +600 | 0.00 | 0.00 | -0.00 | buy |
| Dana Investment Advisors, Inc. | 13,261 | 13,847 | +586 | 0.01 | 0.01 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 20,046 | 20,583 | +537 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 17,344 | 17,735 | +391 | 0.00 | 0.00 | -0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 383 | +383 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 220 | +220 | 0.00 | 0.00 | +0.00 | buy |
| BFSG, LLC | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 0 | 178 | +178 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 24,212 | 24,377 | +165 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 2,120 | 2,180 | +60 | 0.00 | 0.00 | -0.00 | buy |
| INNEALTA CAPITAL, LLC | 0 | 49 | +49 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 35 | +35 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 836 | 856 | +20 | 0.00 | 0.00 | -0.00 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 5 | 20 | +15 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 1,218 | 1,232 | +14 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 38 | 52 | +14 | 0.00 | 0.00 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 6,276 | 6,276 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SANDERS MORRIS HARRIS LLC | 27,709 | 27,709 | 0 | 0.14 | 0.10 | -0.04 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Ameritas Investment Partners, Inc. | 6,494 | 6,494 | 0 | 0.01 | 0.00 | -0.00 | hold |
| EVERMAY WEALTH MANAGEMENT LLC | 25 | 25 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 24,518 | 24,518 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Amundi | 3,839 | 3,839 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rathbones Group PLC | 30,000 | 30,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Walleye Trading LLC | 34,829 | 34,829 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KBC Group NV | 2,109 | 2,109 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MACQUARIE GROUP LTD | 58,000 | 58,000 | 0 | 0.00 | 0.00 | -0.00 | hold |