| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WESTFIELD CAPITAL MANAGEMENT CO LP | 3,984,030 | 4,327,922 | +343,892 | 0.56 | 0.46 | -0.11 | buy |
| JANUS HENDERSON GROUP PLC | 2,606,016 | 2,919,078 | +313,062 | 0.04 | 0.03 | 0.00 | buy |
| First Turn Management, LLC | 250,870 | 560,989 | +310,119 | 1.01 | 1.96 | +0.95 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 490,732 | 770,691 | +279,959 | 0.21 | 0.28 | +0.08 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,943,160 | 3,169,448 | +226,288 | 0.01 | 0.01 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 275,720 | 386,996 | +111,276 | 0.01 | 0.01 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 660,000 | 750,000 | +90,000 | 1.85 | 1.64 | -0.21 | buy |
| SYNOVUS FINANCIAL CORP | 83,411 | 168,090 | +84,679 | 0.03 | 0.05 | +0.02 | buy |
| Avidity Partners Management LP | 1,025,000 | 1,100,000 | +75,000 | 0.98 | 1.01 | +0.02 | buy |
| EFG Asset Management (North America) Corp. | 151,002 | 222,046 | +71,044 | 0.70 | 0.83 | +0.13 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 130,000 | 200,000 | +70,000 | 0.01 | 0.01 | +0.00 | buy |
| Novo Holdings A/S | 1,050,000 | 1,100,000 | +50,000 | 1.95 | 1.28 | -0.67 | buy |
| NEOS Investment Management LLC | 57,600 | 102,847 | +45,247 | 0.10 | 0.09 | -0.00 | buy |
| MAVERICK CAPITAL LTD | 3,888,312 | 3,928,312 | +40,000 | 2.03 | 1.60 | -0.43 | buy |
| New Leaf Venture Partners, L.L.C. | 118,242 | 150,706 | +32,464 | 2.79 | 3.95 | +1.16 | buy |
| PROFUND ADVISORS LLC | 51,148 | 22,201 | +28,947 | 0.05 | 0.02 | 0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 183,722 | 206,933 | +23,211 | 0.70 | 0.61 | -0.09 | buy |
| TD ASSET MANAGEMENT INC | 155,164 | 178,164 | +23,000 | 0.00 | 0.00 | -0.00 | buy |
| Privium Fund Management B.V. | 235,050 | 250,980 | +15,930 | 1.69 | 1.27 | -0.42 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 81,426 | 97,134 | +15,708 | 0.29 | 0.16 | -0.13 | buy |
| Harbour Capital Advisors, LLC | 21,155 | 36,180 | +15,025 | 0.13 | 0.18 | +0.04 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 18,000 | 30,900 | +12,900 | 0.12 | 0.15 | +0.03 | buy |
| TORRAY INVESTMENT PARTNERS LLC | 60,933 | 67,216 | +6,283 | 0.25 | 0.22 | -0.03 | buy |
| JENNISON ASSOCIATES LLC | 26,783 | 30,578 | +3,795 | 0.00 | 0.00 | -0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 72,528 | 75,423 | +2,895 | 0.11 | 0.10 | -0.01 | buy |
| Rockefeller Capital Management L.P. | 85,462 | 86,973 | +1,511 | 0.01 | 0.01 | 0.00 | buy |
| VIRTUS ADVISERS, LLC | 3,063 | 3,960 | +897 | 0.04 | 0.04 | -0.00 | buy |
| PITCAIRN CO | 9,364 | 10,089 | +725 | 0.02 | 0.01 | -0.00 | buy |
| Dana Investment Advisors, Inc. | 13,261 | 13,847 | +586 | 0.01 | 0.01 | -0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 14,810 | 12,530 | -2,280 | 0.16 | 0.11 | -0.05 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 297,658 | 292,901 | -4,757 | 0.02 | 0.01 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 17,365 | 10,666 | -6,699 | 0.06 | 0.03 | -0.03 | sell |
| BAMCO INC /NY/ | 990,544 | 979,331 | -11,213 | 0.07 | 0.06 | -0.01 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 154,070 | 132,486 | -21,584 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 231,287 | 204,110 | -27,177 | 0.33 | 0.23 | -0.11 | sell |
| GMT CAPITAL CORP | 230,000 | 188,100 | -41,900 | 0.24 | 0.15 | -0.09 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 326,787 | 250,370 | -76,417 | 5.72 | 4.54 | -1.18 | sell |
| Ikarian Capital, LLC | 297,096 | 197,096 | -100,000 | 2.18 | 1.32 | -0.85 | sell |
| Rafferty Asset Management, LLC | 329,043 | 117,645 | -211,398 | 0.03 | 0.01 | -0.02 | sell |
| PERCEPTIVE ADVISORS LLC | 1,801,068 | 1,246,597 | -554,471 | 0.85 | 0.65 | -0.20 | sell |
| Logos Global Management LP | 1,300,000 | 350,000 | -950,000 | 3.69 | 0.87 | -2.82 | sell |