| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 17,687,772 | 17,687,772 | 0 | 7.03 | 5.90 | -1.14 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 9,156,099 | 9,155,720 | -379 | 0.04 | 0.04 | -0.01 | sell |
| VANGUARD GROUP INC | 5,370,885 | 5,808,550 | +437,665 | 0.00 | 0.00 | -0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 3,984,030 | 4,327,922 | +343,892 | 0.56 | 0.46 | -0.11 | buy |
| MAVERICK CAPITAL LTD | 3,888,312 | 3,928,312 | +40,000 | 2.03 | 1.60 | -0.43 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,943,160 | 3,169,448 | +226,288 | 0.01 | 0.01 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 2,606,016 | 2,919,078 | +313,062 | 0.04 | 0.03 | -0.00 | buy |
| CITADEL ADVISORS LLC | 2,469,813 | 2,818,069 | +348,256 | 0.06 | 0.06 | -0.00 | buy |
| STATE STREET CORP | 4,193,077 | 2,779,866 | -1,413,211 | 0.01 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 1,867,329 | 1,873,689 | +6,360 | 0.02 | 0.01 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,502,587 | 1,603,610 | +101,023 | 0.00 | 0.00 | -0.00 | buy |
| Frazier Life Sciences Management, L.P. | 1,561,230 | 1,561,230 | 0 | 1.77 | 1.57 | -0.20 | hold |
| PERCEPTIVE ADVISORS LLC | 1,801,068 | 1,246,597 | -554,471 | 0.86 | 0.65 | -0.21 | sell |
| BANK OF AMERICA CORP /DE/ | 1,018,488 | 1,238,044 | +219,556 | 0.00 | 0.00 | -0.00 | buy |
| Pictet Asset Management Holding SA | 1,323,447 | 1,226,387 | -97,060 | 0.04 | 0.03 | -0.01 | sell |
| Novo Holdings A/S | 1,050,000 | 1,100,000 | +50,000 | 1.95 | 1.28 | -0.67 | buy |
| Avidity Partners Management LP | 1,025,000 | 1,100,000 | +75,000 | 0.98 | 1.01 | +0.02 | buy |
| BAMCO INC /NY/ | 990,544 | 979,331 | -11,213 | 0.07 | 0.06 | -0.01 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,029,788 | 946,175 | -83,613 | 0.01 | 0.01 | -0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 490,732 | 770,691 | +279,959 | 0.21 | 0.28 | +0.08 | buy |
| TANG CAPITAL MANAGEMENT LLC | 660,000 | 750,000 | +90,000 | 1.85 | 1.64 | -0.21 | buy |
| Altium Capital Management LLC | 731,561 | 731,561 | 0 | 0.10 | 0.02 | -0.08 | hold |
| Walleye Capital LLC | 720,905 | 720,905 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GOLDMAN SACHS GROUP INC | 430,875 | 695,908 | +265,033 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 534,525 | 686,654 | +152,129 | 0.06 | 0.06 | -0.00 | buy |
| Russell Investments Group, Ltd. | 675,769 | 677,744 | +1,975 | 0.03 | 0.02 | -0.01 | buy |
| NORTHERN TRUST CORP | 610,037 | 588,597 | -21,440 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 682,524 | 579,738 | -102,786 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 576,667 | 579,279 | +2,612 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 0 | 561,966 | +561,966 | 0.00 | 0.12 | +0.12 | buy |
| First Turn Management, LLC | 250,870 | 560,989 | +310,119 | 1.01 | 1.96 | +0.95 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 532,563 | 549,492 | +16,929 | 0.00 | 0.00 | -0.00 | buy |
| EcoR1 Capital, LLC | 0 | 508,393 | +508,393 | 0.00 | 0.33 | +0.33 | buy |
| MORGAN STANLEY | 688,813 | 475,988 | -212,825 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 508,954 | 405,782 | -103,172 | 0.00 | 0.00 | -0.00 | sell |
| Sio Capital Management, LLC | 400,000 | 400,000 | 0 | 0.04 | 0.01 | -0.03 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 275,720 | 386,996 | +111,276 | 0.01 | 0.01 | +0.00 | buy |
| M28 Capital Management LP | 385,680 | 385,680 | 0 | 7.68 | 10.76 | +3.09 | hold |
| Invesco Ltd. | 41,190 | 352,026 | +310,836 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 350,000 | 350,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Logos Global Management LP | 1,300,000 | 350,000 | -950,000 | 3.69 | 0.87 | -2.82 | sell |
| Fort Baker Capital Management LP | 328,698 | 328,698 | 0 | 0.01 | 0.00 | -0.01 | hold |
| WCM INVESTMENT MANAGEMENT, LLC | 297,658 | 292,901 | -4,757 | 0.02 | 0.01 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 155,244 | 261,347 | +106,103 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 235,050 | 250,980 | +15,930 | 1.69 | 1.27 | -0.42 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 326,787 | 250,370 | -76,417 | 5.72 | 4.54 | -1.18 | sell |
| Bank of New York Mellon Corp | 217,356 | 239,877 | +22,521 | 0.00 | 0.00 | -0.00 | buy |
| EFG Asset Management (North America) Corp. | 151,002 | 222,046 | +71,044 | 0.70 | 0.83 | +0.13 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 183,722 | 206,933 | +23,211 | 0.80 | 0.73 | -0.08 | buy |
| Hennion & Walsh Asset Management, Inc. | 231,287 | 204,110 | -27,177 | 0.33 | 0.23 | -0.11 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 130,000 | 200,000 | +70,000 | 0.01 | 0.01 | +0.00 | buy |
| Ikarian Capital, LLC | 297,096 | 197,096 | -100,000 | 2.18 | 1.32 | -0.85 | sell |
| GMT CAPITAL CORP | 230,000 | 188,100 | -41,900 | 0.24 | 0.15 | -0.09 | sell |
| TD ASSET MANAGEMENT INC | 155,164 | 178,164 | +23,000 | 0.00 | 0.00 | -0.00 | buy |
| SYNOVUS FINANCIAL CORP | 83,411 | 168,090 | +84,679 | 0.03 | 0.05 | +0.02 | buy |
| New Leaf Venture Partners, L.L.C. | 118,242 | 150,706 | +32,464 | 2.79 | 3.95 | +1.16 | buy |
| Neuberger Berman Group LLC | 114,617 | 150,578 | +35,961 | 0.00 | 0.00 | +0.00 | buy |
| BLAIR WILLIAM & CO/IL | 147,280 | 142,714 | -4,566 | 0.01 | 0.01 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 113,057 | 139,613 | +26,556 | 0.00 | 0.00 | -0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 154,070 | 132,486 | -21,584 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 105,505 | 130,797 | +25,292 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 130,538 | +130,538 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 124,600 | 124,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 65,790 | 118,072 | +52,282 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 329,043 | 117,645 | -211,398 | 0.03 | 0.01 | -0.02 | sell |
| MILLENNIUM MANAGEMENT LLC | 0 | 105,325 | +105,325 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 104,828 | 104,828 | 0 | 0.01 | 0.00 | -0.01 | hold |
| NEOS Investment Management LLC | 57,600 | 102,847 | +45,247 | 0.10 | 0.09 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 161,630 | 102,705 | -58,925 | 0.01 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 96,176 | 101,134 | +4,958 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 99,574 | +99,574 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 81,426 | 97,134 | +15,708 | 0.29 | 0.16 | -0.13 | buy |
| DekaBank Deutsche Girozentrale | 89,700 | 89,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rockefeller Capital Management L.P. | 85,462 | 86,973 | +1,511 | 0.01 | 0.01 | -0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 72,528 | 75,423 | +2,895 | 0.11 | 0.10 | -0.01 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 78,387 | 75,177 | -3,210 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 75,000 | 75,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TORRAY INVESTMENT PARTNERS LLC | 60,933 | 67,216 | +6,283 | 0.25 | 0.22 | -0.03 | buy |
| Legal & General Group Plc | 66,197 | 67,057 | +860 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 63,062 | 62,120 | -942 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 60,771 | 60,771 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MACQUARIE GROUP LTD | 58,000 | 58,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 52,746 | 50,497 | -2,249 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 57,404 | 44,745 | -12,659 | 0.00 | 0.00 | -0.00 | sell |
| Erste Asset Management GmbH | 44,700 | 44,700 | 0 | 0.02 | 0.01 | -0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 65,172 | 43,236 | -21,936 | 0.05 | 0.03 | -0.02 | sell |
| DEUTSCHE BANK AG\ | 42,434 | 39,671 | -2,763 | 0.00 | 0.00 | -0.00 | sell |
| Vontobel Holding Ltd. | 42,700 | 38,544 | -4,156 | 0.01 | 0.00 | -0.01 | sell |
| MetLife Investment Management, LLC | 33,003 | 37,501 | +4,498 | 0.01 | 0.00 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 36,912 | 36,912 | 0 | 0.03 | 0.02 | -0.00 | hold |
| Harbour Capital Advisors, LLC | 21,155 | 36,180 | +15,025 | 0.13 | 0.18 | +0.04 | buy |
| Walleye Trading LLC | 34,829 | 34,829 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORGES BANK | 60,851 | 34,752 | -26,099 | 0.00 | 0.00 | -0.00 | sell |
| B. Metzler seel. Sohn & Co. AG | 34,418 | 34,418 | 0 | 0.01 | 0.01 | -0.00 | hold |
| CITIGROUP INC | 285,143 | 34,090 | -251,053 | 0.01 | 0.00 | -0.01 | sell |
| PIER 88 INVESTMENT PARTNERS LLC | 18,000 | 30,900 | +12,900 | 0.12 | 0.15 | +0.03 | buy |
| JENNISON ASSOCIATES LLC | 26,783 | 30,578 | +3,795 | 0.00 | 0.00 | -0.00 | buy |
| Rathbones Group PLC | 30,000 | 30,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Assenagon Asset Management S.A. | 80,726 | 29,986 | -50,740 | 0.01 | 0.00 | -0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 28,569 | 29,791 | +1,222 | 0.00 | 0.00 | -0.00 | buy |