| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 17,687,772 | 17,687,772 | 0 | 1.80 | 0.62 | -1.19 | hold |
| MAVERICK CAPITAL LTD | 5,199,218 | 8,363,813 | +3,164,595 | 0.62 | 0.31 | -0.31 | buy |
| BlackRock, Inc. | 7,274,234 | 7,428,676 | +154,442 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 6,617,784 | 6,122,461 | -495,323 | 0.00 | 0.00 | -0.00 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,502,000 | 4,143,333 | +641,333 | 0.95 | 0.38 | -0.56 | buy |
| MPM BioImpact LLC | 1,618,265 | 3,903,081 | +2,284,816 | 1.86 | 1.66 | -0.20 | buy |
| MORGAN STANLEY | 2,641,892 | 3,169,036 | +527,144 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 747,147 | 2,348,837 | +1,601,690 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,994,044 | 2,030,891 | +36,847 | 0.00 | 0.00 | -0.00 | buy |
| Newtyn Management, LLC | 0 | 2,000,000 | +2,000,000 | 0.00 | 0.74 | +0.74 | buy |
| STATE STREET CORP | 3,705,461 | 1,943,690 | -1,761,771 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 0 | 1,725,360 | +1,725,360 | 0.00 | 0.01 | +0.01 | buy |
| Prosight Management, LP | 1,480,000 | 1,580,588 | +100,588 | 3.24 | 0.94 | -2.30 | buy |
| GOLDMAN SACHS GROUP INC | 995,690 | 1,575,468 | +579,778 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 195,793 | 1,548,262 | +1,352,469 | 0.00 | 0.01 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 1,490,251 | +1,490,251 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 610,089 | 1,207,802 | +597,713 | 0.00 | 0.00 | -0.00 | buy |
| TORONTO DOMINION BANK | 1,100,000 | 1,100,000 | 0 | 0.02 | 0.01 | -0.01 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,043,682 | 1,099,829 | -1,943,853 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 0 | 992,825 | +992,825 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 850,000 | 850,000 | 0 | 0.31 | 0.11 | -0.21 | hold |
| UBS Group AG | 647,830 | 836,508 | +188,678 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 163,622 | 777,668 | +614,046 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 718,781 | +718,781 | 0.00 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 700,301 | 701,337 | +1,036 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 652,865 | 652,865 | 0 | 0.03 | 0.01 | -0.02 | hold |
| Walleye Capital LLC | 665,969 | 642,847 | -23,122 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 178,293 | 638,515 | +460,222 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 414,497 | 624,303 | +209,806 | 0.01 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 675,481 | 614,761 | -60,720 | 0.00 | 0.00 | -0.00 | sell |
| Siren, L.L.C. | 591,263 | 591,263 | 0 | 0.22 | 0.07 | -0.15 | hold |
| Walleye Capital LLC | 287,088 | 576,051 | +288,963 | 0.02 | 0.01 | -0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 577,488 | 559,950 | -17,538 | 0.00 | 0.00 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 1,097,079 | 552,079 | -545,000 | 0.08 | 0.01 | -0.07 | sell |
| Voss Capital, LP | 432,240 | 500,000 | +67,760 | 0.22 | 0.08 | -0.14 | buy |
| BANK OF AMERICA CORP /DE/ | 421,487 | 467,105 | +45,618 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 338,474 | 461,374 | +122,900 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 133,894 | 454,640 | +320,746 | 0.00 | 0.00 | +0.00 | buy |
| Monaco Asset Management SAM | 0 | 452,767 | +452,767 | 0.00 | 0.42 | +0.42 | buy |
| Jump Financial, LLC | 253,723 | 437,295 | +183,572 | 0.03 | 0.01 | -0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 32,096 | 434,409 | +402,313 | 0.09 | 0.02 | -0.07 | buy |
| Privium Fund Management B.V. | 432,760 | 432,760 | 0 | 0.75 | 0.24 | -0.51 | hold |
| Sio Capital Management, LLC | 400,000 | 400,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| M28 Capital Management LP | 385,680 | 385,680 | 0 | 3.53 | 1.61 | -1.91 | hold |
| ROYAL BANK OF CANADA | 15,856 | 377,796 | +361,940 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 350,000 | 350,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALGERT GLOBAL LLC | 55,510 | 341,760 | +286,250 | 0.01 | 0.02 | +0.01 | buy |
| EntryPoint Capital, LLC | 76,419 | 301,053 | +224,634 | 0.23 | 0.37 | +0.14 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 297,905 | +297,905 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 184,692 | 286,312 | +101,620 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 241,800 | 275,800 | +34,000 | 0.31 | 0.11 | -0.20 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 274,875 | +274,875 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 249,526 | 274,259 | +24,733 | 0.07 | 0.03 | -0.05 | buy |
| FMR LLC | 45,555 | 266,049 | +220,494 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 0 | 265,982 | +265,982 | 0.00 | 0.04 | +0.04 | buy |
| Engineers Gate Manager LP | 21,027 | 264,203 | +243,176 | 0.00 | 0.01 | +0.01 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 254,405 | 263,746 | +9,341 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 11,150 | 238,250 | +227,100 | 0.00 | 0.02 | +0.02 | buy |
| Bank of New York Mellon Corp | 209,967 | 231,986 | +22,019 | 0.00 | 0.00 | -0.00 | buy |
| Amitell Capital Pte Ltd | 0 | 227,000 | +227,000 | 0.00 | 0.31 | +0.31 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 214,412 | +214,412 | 0.00 | 0.65 | +0.65 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 205,378 | 205,378 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Sovran Advisors, LLC | 323,091 | 196,028 | -127,063 | 0.27 | 0.06 | -0.20 | sell |
| Squarepoint Ops LLC | 53,476 | 192,018 | +138,542 | 0.00 | 0.00 | +0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 184,658 | +184,658 | 0.00 | 0.05 | +0.05 | buy |
| ALLIANCEBERNSTEIN L.P. | 119,465 | 180,140 | +60,675 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 154,687 | 175,703 | +21,016 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 162,710 | 174,910 | +12,200 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 166,882 | 174,438 | +7,556 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 200,684 | 165,037 | -35,647 | 0.02 | 0.00 | -0.01 | sell |
| CITADEL ADVISORS LLC | 1,509,004 | 156,050 | -1,352,954 | 0.01 | 0.00 | -0.01 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 13,019 | 153,814 | +140,795 | 0.00 | 0.02 | +0.01 | buy |
| Swiss National Bank | 153,700 | 153,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 128,471 | 152,238 | +23,767 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 234,178 | 148,029 | -86,149 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 34,407 | 134,445 | +100,038 | 0.01 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 352,957 | 131,806 | -221,151 | 0.01 | 0.00 | -0.01 | sell |
| RAYMOND JAMES FINANCIAL INC | 31,577 | 122,670 | +91,093 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 107,638 | 120,282 | +12,644 | 0.00 | 0.00 | -0.00 | buy |
| Brooklyn Investment Group | 0 | 114,692 | +114,692 | 0.00 | 0.04 | +0.04 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 178,114 | 112,382 | -65,732 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 400,969 | 111,004 | -289,965 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 104,828 | 104,828 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BLAIR WILLIAM & CO/IL | 111,475 | 104,211 | -7,264 | 0.00 | 0.00 | -0.00 | sell |
| Nebula Research & Development LLC | 0 | 100,780 | +100,780 | 0.00 | 0.02 | +0.02 | buy |
| MYDA Advisors LLC | 460,381 | 100,000 | -360,381 | 1.09 | 0.07 | -1.02 | sell |
| Quinn Opportunity Partners LLC | 0 | 100,000 | +100,000 | 0.00 | 0.02 | +0.02 | buy |
| Rockefeller Capital Management L.P. | 90,402 | 96,982 | +6,580 | 0.00 | 0.00 | -0.00 | buy |
| Quadrature Capital Ltd | 0 | 92,592 | +92,592 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 87,519 | 92,398 | +4,879 | 0.03 | 0.01 | -0.02 | buy |
| DekaBank Deutsche Girozentrale | 89,700 | 89,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Main Management ETF Advisors, LLC | 74,972 | 76,208 | +1,236 | 0.02 | 0.01 | -0.02 | buy |
| LMR Partners LLP | 75,731 | 75,731 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Affinity Asset Advisors, LLC | 75,000 | 75,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 74,917 | +74,917 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 73,800 | +73,800 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 122,627 | 71,466 | -51,161 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 71,470 | 70,248 | -1,222 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 1,084 | 65,498 | +64,414 | 0.00 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 63,637 | 63,637 | 0 | 0.00 | 0.00 | -0.00 | hold |