| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Logos Global Management LP | 250,000 | 1,975,000 | +1,725,000 | 0.69 | 5.77 | +5.09 | buy |
| MAVERICK CAPITAL LTD | 4,379,970 | 5,629,970 | +1,250,000 | 1.86 | 2.70 | +0.84 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 3,655,787 | 4,193,996 | +538,209 | 0.46 | 0.59 | +0.12 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,118,806 | 2,637,951 | +519,145 | 0.01 | 0.01 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,168,363 | 1,517,467 | +349,104 | 0.67 | 1.05 | +0.37 | buy |
| Avidity Partners Management LP | 1,326,000 | 1,587,429 | +261,429 | 0.92 | 1.31 | +0.39 | buy |
| BAMCO INC /NY/ | 882,786 | 1,108,017 | +225,231 | 0.05 | 0.07 | +0.02 | buy |
| Privium Fund Management B.V. | 59,350 | 143,350 | +84,000 | 0.34 | 0.87 | +0.53 | buy |
| Novo Holdings A/S | 920,000 | 1,001,000 | +81,000 | 1.41 | 1.52 | +0.10 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 306,194 | 362,000 | +55,806 | 4.12 | 5.39 | +1.27 | buy |
| SECTORAL ASSET MANAGEMENT INC | 190,790 | 227,030 | +36,240 | 0.63 | 0.91 | +0.27 | buy |
| Hennion & Walsh Asset Management, Inc. | 125,229 | 151,074 | +25,845 | 0.15 | 0.20 | +0.05 | buy |
| EFG Asset Management (North America) Corp. | 140,023 | 151,068 | +11,045 | 0.60 | 0.73 | +0.14 | buy |
| Rockefeller Capital Management L.P. | 82,114 | 91,864 | +9,750 | 0.01 | 0.01 | 0.00 | buy |
| Rafferty Asset Management, LLC | 233,084 | 241,642 | +8,558 | 0.03 | 0.03 | +0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 282,934 | 288,801 | +5,867 | 0.02 | 0.02 | +0.00 | buy |
| TORRAY INVESTMENT PARTNERS LLC | 54,569 | 60,177 | +5,608 | 0.19 | 0.22 | +0.03 | buy |
| SYNOVUS FINANCIAL CORP | 80,982 | 84,681 | +3,699 | 0.02 | 0.02 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 55,282 | 57,317 | +2,035 | 0.22 | 0.25 | +0.03 | buy |
| EFG Asset Management (Americas) Corp. | 11,711 | 12,840 | +1,129 | 0.05 | 0.06 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 1,054 | 2,068 | +1,014 | 0.01 | 0.01 | +0.01 | buy |
| NATIXIS | 660 | 649 | -11 | 0.00 | 0.00 | -0.00 | sell |
| E Fund Management Co., Ltd. | 12,532 | 12,412 | -120 | 0.02 | 0.02 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 4,792 | 4,356 | -436 | 0.06 | 0.05 | -0.00 | sell |
| Dana Investment Advisors, Inc. | 16,724 | 15,409 | -1,315 | 0.02 | 0.02 | -0.00 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 78,986 | 77,389 | -1,597 | 0.09 | 0.10 | +0.01 | sell |
| PROFUND ADVISORS LLC | 42,502 | 40,861 | -1,641 | 0.05 | 0.05 | +0.00 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 162,772 | 158,571 | -4,201 | 0.00 | 0.00 | -0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 23,388 | 18,904 | -4,484 | 0.01 | 0.01 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 33,679 | 27,636 | -6,043 | 0.00 | 0.00 | -0.00 | sell |
| GMT CAPITAL CORP | 432,100 | 411,200 | -20,900 | 0.32 | 0.32 | -0.01 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 41,000 | 17,500 | -23,500 | 0.00 | 0.00 | -0.00 | sell |
| B. Metzler seel. Sohn & Co. AG | 56,924 | 30,559 | -26,365 | 0.02 | 0.01 | -0.01 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 236,000 | 209,040 | -26,960 | 1.01 | 1.03 | +0.02 | sell |
| M28 Capital Management LP | 630,380 | 523,280 | -107,100 | 16.55 | 12.30 | -4.26 | sell |
| Cormorant Asset Management, LP | 868,550 | 450,000 | -418,550 | 0.98 | 0.54 | -0.45 | sell |