| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 17,687,772 | 17,687,772 | 0 | 5.90 | 4.73 | -1.17 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 9,155,720 | 11,242,144 | +2,086,424 | 0.04 | 0.04 | +0.00 | buy |
| VANGUARD GROUP INC | 5,808,550 | 5,536,940 | -271,610 | 0.00 | 0.00 | -0.00 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 4,327,922 | 4,493,833 | +165,911 | 0.46 | 0.37 | -0.08 | buy |
| MAVERICK CAPITAL LTD | 3,928,312 | 4,118,672 | +190,360 | 1.60 | 1.48 | -0.12 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,169,448 | 3,207,781 | +38,333 | 0.01 | 0.01 | -0.00 | buy |
| STATE STREET CORP | 2,779,866 | 3,102,022 | +322,156 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 2,818,069 | 2,148,093 | -669,976 | 0.06 | 0.04 | -0.02 | sell |
| JANUS HENDERSON GROUP PLC | 2,919,078 | 1,897,340 | -1,021,738 | 0.03 | 0.02 | -0.02 | sell |
| FRANKLIN RESOURCES INC | 1,873,689 | 1,730,344 | -143,345 | 0.01 | 0.01 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,603,610 | 1,617,866 | +14,256 | 0.00 | 0.00 | -0.00 | buy |
| Frazier Life Sciences Management, L.P. | 1,561,230 | 1,485,630 | -75,600 | 1.57 | 1.10 | -0.47 | sell |
| Pictet Asset Management Holding SA | 1,226,387 | 1,386,705 | +160,318 | 0.03 | 0.03 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 105,325 | 1,202,495 | +1,097,170 | 0.00 | 0.02 | +0.02 | buy |
| Novo Holdings A/S | 1,100,000 | 1,100,000 | 0 | 1.28 | 1.01 | -0.27 | hold |
| MPM BioImpact LLC | 0 | 1,066,373 | +1,066,373 | 0.00 | 2.95 | +2.95 | buy |
| PERCEPTIVE ADVISORS LLC | 1,246,597 | 931,851 | -314,746 | 0.65 | 0.37 | -0.28 | sell |
| DIMENSIONAL FUND ADVISORS LP | 946,175 | 912,605 | -33,570 | 0.01 | 0.00 | -0.00 | sell |
| BAMCO INC /NY/ | 979,331 | 884,341 | -94,990 | 0.06 | 0.04 | -0.02 | sell |
| Russell Investments Group, Ltd. | 677,744 | 812,310 | +134,566 | 0.02 | 0.02 | -0.00 | buy |
| COMERICA BANK | 686,654 | 785,526 | +98,872 | 0.06 | 0.06 | -0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 770,691 | 770,691 | 0 | 0.28 | 0.25 | -0.04 | hold |
| TANG CAPITAL MANAGEMENT LLC | 750,000 | 750,000 | 0 | 1.64 | 0.99 | -0.65 | hold |
| Avidity Partners Management LP | 1,100,000 | 749,000 | -351,000 | 1.01 | 0.71 | -0.30 | sell |
| Altium Capital Management LLC | 731,561 | 731,561 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Walleye Capital LLC | 720,905 | 720,905 | 0 | 0.00 | 0.00 | +0.00 | hold |
| First Turn Management, LLC | 560,989 | 621,306 | +60,317 | 1.96 | 1.82 | -0.15 | buy |
| MORGAN STANLEY | 475,988 | 615,528 | +139,540 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 561,966 | 601,063 | +39,097 | 0.12 | 0.09 | -0.02 | buy |
| NORTHERN TRUST CORP | 588,597 | 580,836 | -7,761 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 549,492 | 569,814 | +20,322 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 579,738 | 556,552 | -23,186 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 579,279 | 465,456 | -113,823 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 695,908 | 424,073 | -271,835 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 1,238,044 | 406,159 | -831,885 | 0.00 | 0.00 | -0.00 | sell |
| Sio Capital Management, LLC | 400,000 | 400,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| M28 Capital Management LP | 385,680 | 385,680 | 0 | 10.76 | 7.83 | -2.94 | hold |
| Invesco Ltd. | 352,026 | 352,622 | +596 | 0.00 | 0.00 | -0.00 | buy |
| RTW INVESTMENTS, LP | 350,000 | 350,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GREAT LAKES ADVISORS, LLC | 0 | 347,625 | +347,625 | 0.00 | 0.05 | +0.05 | buy |
| UBS Group AG | 405,782 | 338,134 | -67,648 | 0.00 | 0.00 | -0.00 | sell |
| Fort Baker Capital Management LP | 328,698 | 328,698 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Logos Global Management LP | 350,000 | 325,000 | -25,000 | 0.87 | 0.67 | -0.20 | sell |
| Privium Fund Management B.V. | 250,980 | 294,800 | +43,820 | 1.27 | 1.35 | +0.09 | buy |
| ALLIANCEBERNSTEIN L.P. | 261,347 | 291,106 | +29,759 | 0.00 | 0.00 | -0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 292,901 | 285,665 | -7,236 | 0.01 | 0.01 | -0.00 | sell |
| EFG Asset Management (North America) Corp. | 222,046 | 244,420 | +22,374 | 0.83 | 0.76 | -0.07 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 386,996 | 235,004 | -151,992 | 0.01 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 206,933 | 231,792 | +24,859 | 0.73 | 0.70 | -0.03 | buy |
| Hennion & Walsh Asset Management, Inc. | 204,110 | 221,046 | +16,936 | 0.23 | 0.19 | -0.04 | buy |
| Ikarian Capital, LLC | 197,096 | 197,096 | 0 | 1.32 | 1.13 | -0.19 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 250,370 | 190,000 | -60,370 | 4.54 | 2.84 | -1.70 | sell |
| Bank of New York Mellon Corp | 239,877 | 184,233 | -55,644 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 130,538 | 177,672 | +47,134 | 0.00 | 0.01 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 178,164 | 177,610 | -554 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 198,771 | 173,563 | -25,208 | 0.01 | 0.01 | -0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 97,134 | 168,506 | +71,372 | 0.16 | 0.14 | -0.02 | buy |
| Prosight Management, LP | 0 | 159,369 | +159,369 | 0.00 | 0.75 | +0.75 | buy |
| NORGES BANK | 34,752 | 159,094 | +124,342 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 130,797 | 154,974 | +24,177 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 139,613 | 152,293 | +12,680 | 0.00 | 0.00 | -0.00 | buy |
| New Leaf Venture Partners, L.L.C. | 150,706 | 150,706 | 0 | 3.95 | 2.86 | -1.08 | hold |
| Walleye Capital LLC | 0 | 138,403 | +138,403 | 0.00 | 0.03 | +0.03 | buy |
| BLAIR WILLIAM & CO/IL | 142,714 | 134,969 | -7,745 | 0.01 | 0.01 | -0.00 | sell |
| Rafferty Asset Management, LLC | 117,645 | 128,726 | +11,081 | 0.01 | 0.01 | -0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 132,486 | 126,769 | -5,717 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 124,600 | 124,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 118,072 | 119,633 | +1,561 | 0.00 | 0.00 | -0.00 | buy |
| NEOS Investment Management LLC | 102,847 | 111,454 | +8,607 | 0.09 | 0.06 | -0.03 | buy |
| Rockefeller Capital Management L.P. | 86,973 | 107,912 | +20,939 | 0.01 | 0.01 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 104,828 | 104,828 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 101,134 | 98,097 | -3,037 | 0.00 | 0.00 | -0.00 | sell |
| SYNOVUS FINANCIAL CORP | 168,090 | 95,504 | -72,586 | 0.05 | 0.02 | -0.03 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 75,423 | 92,142 | +16,719 | 0.10 | 0.09 | -0.01 | buy |
| DekaBank Deutsche Girozentrale | 89,700 | 89,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| THRIVENT FINANCIAL FOR LUTHERANS | 75,177 | 75,177 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Affinity Asset Advisors, LLC | 75,000 | 75,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TORRAY INVESTMENT PARTNERS LLC | 67,216 | 73,424 | +6,208 | 0.22 | 0.19 | -0.03 | buy |
| Legal & General Group Plc | 67,057 | 67,187 | +130 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 65,618 | +65,618 | 0.00 | 0.01 | +0.01 | buy |
| Hudson Bay Capital Management LP | 0 | 65,000 | +65,000 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 62,120 | 60,293 | -1,827 | 0.00 | 0.00 | -0.00 | sell |
| MACQUARIE GROUP LTD | 58,000 | 58,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Harbour Capital Advisors, LLC | 36,180 | 53,690 | +17,510 | 0.18 | 0.21 | +0.03 | buy |
| Squarepoint Ops LLC | 0 | 53,039 | +53,039 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 34,090 | 51,496 | +17,406 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 48,096 | +48,096 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 50,497 | 48,035 | -2,462 | 0.00 | 0.00 | -0.00 | sell |
| Erste Asset Management GmbH | 44,700 | 44,700 | 0 | 0.01 | 0.01 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 39,671 | 44,468 | +4,797 | 0.00 | 0.00 | -0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 12,530 | 43,383 | +30,853 | 0.11 | 0.47 | +0.36 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 43,236 | 43,236 | 0 | 0.03 | 0.02 | -0.00 | hold |
| JENNISON ASSOCIATES LLC | 30,578 | 40,740 | +10,162 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 11,043 | 38,957 | +27,914 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 37,501 | 37,501 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vontobel Holding Ltd. | 38,544 | 37,398 | -1,146 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 44,745 | 37,010 | -7,735 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 36,912 | 36,912 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Corebridge Financial, Inc. | 35,400 | 35,182 | -218 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Trading LLC | 34,829 | 34,829 | 0 | 0.00 | 0.00 | +0.00 | hold |