| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 17,687,772 | 17,687,772 | 0 | 0.62 | 0.71 | +0.09 | hold |
| MAVERICK CAPITAL LTD | 8,363,813 | 8,468,344 | +104,531 | 0.31 | 0.37 | +0.05 | buy |
| BlackRock, Inc. | 7,428,676 | 7,114,371 | -314,305 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 6,122,461 | 6,892,204 | +769,743 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 3,903,081 | 3,903,381 | +300 | 1.66 | 2.08 | +0.43 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,143,333 | 3,843,333 | -300,000 | 0.38 | 0.38 | -0.00 | sell |
| MORGAN STANLEY | 3,169,036 | 3,647,039 | +478,003 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,348,837 | 3,570,391 | +1,221,554 | 0.01 | 0.01 | +0.00 | buy |
| Monaco Asset Management SAM | 452,767 | 2,892,261 | +2,439,494 | 0.42 | 3.51 | +3.09 | buy |
| Newtyn Management, LLC | 2,000,000 | 2,502,863 | +502,863 | 0.74 | 1.00 | +0.26 | buy |
| D. E. Shaw & Co., Inc. | 992,825 | 2,189,750 | +1,196,925 | 0.00 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 1,207,802 | 2,097,033 | +889,231 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,030,891 | 1,914,554 | -116,337 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 1,490,251 | 1,795,751 | +305,500 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 1,943,690 | 1,745,310 | -198,380 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 156,050 | 1,670,927 | +1,514,877 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,725,360 | 1,609,682 | -115,678 | 0.01 | 0.01 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 131,806 | 1,313,737 | +1,181,931 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,575,468 | 1,271,093 | -304,375 | 0.00 | 0.00 | -0.00 | sell |
| Prosight Management, LP | 1,580,588 | 1,267,965 | -312,623 | 0.94 | 0.99 | +0.05 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,099,829 | 1,061,295 | -38,534 | 0.00 | 0.00 | +0.00 | sell |
| Qube Research & Technologies Ltd | 1,548,262 | 1,014,358 | -533,904 | 0.01 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 777,668 | 873,247 | +95,579 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 850,000 | 850,000 | 0 | 0.11 | 0.11 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 614,761 | 744,074 | +129,313 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 701,337 | 657,013 | -44,324 | 0.00 | 0.00 | +0.00 | sell |
| FEDERATED HERMES, INC. | 624,303 | 627,567 | +3,264 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 576,051 | 625,533 | +49,482 | 0.01 | 0.02 | +0.00 | buy |
| Walleye Capital LLC | 642,847 | 593,631 | -49,216 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 275,800 | 575,800 | +300,000 | 0.11 | 0.19 | +0.08 | buy |
| DIMENSIONAL FUND ADVISORS LP | 559,950 | 555,823 | -4,127 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 836,508 | 532,992 | -303,516 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 467,105 | 514,921 | +47,816 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 44,268 | 484,481 | +440,213 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 192,018 | 438,379 | +246,361 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 434,409 | 434,409 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Privium Fund Management B.V. | 432,760 | 432,760 | 0 | 0.24 | 0.25 | +0.01 | hold |
| Sio Capital Management, LLC | 400,000 | 400,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| M28 Capital Management LP | 385,680 | 385,680 | 0 | 1.61 | 1.85 | +0.24 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 454,640 | 377,584 | -77,056 | 0.00 | 0.00 | +0.00 | sell |
| RTW INVESTMENTS, LP | 350,000 | 350,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FMR LLC | 266,049 | 311,701 | +45,652 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 274,259 | 305,438 | +31,179 | 0.03 | 0.04 | +0.01 | buy |
| Voss Capital, LP | 500,000 | 300,000 | -200,000 | 0.08 | 0.06 | -0.03 | sell |
| ROYAL BANK OF CANADA | 377,796 | 280,709 | -97,087 | 0.00 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 265,982 | 265,982 | 0 | 0.04 | 0.05 | +0.02 | hold |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 74,917 | 264,431 | +189,514 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 231,986 | 245,313 | +13,327 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 165,037 | 242,184 | +77,147 | 0.00 | 0.01 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 37,239 | 224,276 | +187,037 | 0.01 | 0.06 | +0.05 | buy |
| Invesco Ltd. | 111,004 | 222,453 | +111,449 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 437,295 | 222,038 | -215,257 | 0.01 | 0.01 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 297,905 | 209,846 | -88,059 | 0.00 | 0.00 | -0.00 | sell |
| Amitell Capital Pte Ltd | 227,000 | 178,769 | -48,231 | 0.31 | 0.43 | +0.12 | sell |
| Nuveen, LLC | 638,515 | 158,012 | -480,503 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 180,140 | 157,290 | -22,850 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 175,703 | 156,638 | -19,065 | 0.00 | 0.00 | +0.00 | sell |
| Creative Planning | 43,471 | 154,985 | +111,514 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 153,814 | 153,814 | 0 | 0.02 | 0.01 | -0.00 | hold |
| BARCLAYS PLC | 174,438 | 149,393 | -25,045 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 134,445 | 147,501 | +13,056 | 0.01 | 0.02 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 461,374 | 137,177 | -324,197 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 238,250 | 133,512 | -104,738 | 0.02 | 0.02 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 122,670 | 129,858 | +7,188 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 301,053 | 125,590 | -175,463 | 0.37 | 0.16 | -0.21 | sell |
| RHUMBLINE ADVISERS | 120,282 | 120,771 | +489 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 205,378 | 119,613 | -85,765 | 0.01 | 0.02 | +0.00 | sell |
| Rockefeller Capital Management L.P. | 96,982 | 106,982 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 112,382 | 104,919 | -7,463 | 0.00 | 0.00 | +0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 104,828 | 104,828 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD ASSET MANAGEMENT INC | 174,910 | 102,538 | -72,372 | 0.00 | 0.00 | -0.00 | sell |
| MYDA Advisors LLC | 100,000 | 100,000 | 0 | 0.07 | 0.10 | +0.03 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 98,741 | +98,741 | 0.00 | 0.01 | +0.01 | buy |
| Brooklyn Investment Group | 114,692 | 93,094 | -21,598 | 0.04 | 0.03 | -0.01 | sell |
| DekaBank Deutsche Girozentrale | 89,700 | 89,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ballentine Partners, LLC | 0 | 88,570 | +88,570 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 152,238 | 87,338 | -64,900 | 0.00 | 0.00 | -0.00 | sell |
| Lion Point Capital, LP | 0 | 86,000 | +86,000 | 0.00 | 1.59 | +1.59 | buy |
| Quadrature Capital Ltd | 92,592 | 85,513 | -7,079 | 0.00 | 0.00 | -0.00 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 92,398 | 83,007 | -9,391 | 0.01 | 0.01 | +0.00 | sell |
| IEQ CAPITAL, LLC | 39,052 | 81,177 | +42,125 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 70,248 | 80,735 | +10,487 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 73,800 | 76,521 | +2,721 | 0.00 | 0.00 | +0.00 | buy |
| Concurrent Investment Advisors, LLC | 56,606 | 76,096 | +19,490 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 75,731 | 75,731 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Affinity Asset Advisors, LLC | 75,000 | 75,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Engineers Gate Manager LP | 264,203 | 71,406 | -192,797 | 0.01 | 0.00 | -0.01 | sell |
| Voleon Capital Management LP | 40,027 | 68,037 | +28,010 | 0.01 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 55,749 | 67,533 | +11,784 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 62,576 | +62,576 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 58,000 | 58,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Atom Investors LP | 0 | 53,334 | +53,334 | 0.00 | 0.01 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 50,173 | 50,107 | -66 | 0.00 | 0.00 | +0.00 | sell |
| SG Americas Securities, LLC | 63,553 | 48,729 | -14,824 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 45,859 | 46,305 | +446 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 44,700 | 44,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AXQ CAPITAL, LP | 0 | 41,994 | +41,994 | 0.00 | 0.05 | +0.05 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 49,990 | 40,727 | -9,263 | 0.00 | 0.00 | +0.00 | sell |
| STIFEL FINANCIAL CORP | 16,350 | 39,200 | +22,850 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 30,630 | 37,064 | +6,434 | 0.03 | 0.03 | +0.01 | buy |