| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 1,517,467 | 1,707,398 | +189,931 | 1.04 | 1.14 | +0.11 | buy |
| TWO SIGMA INVESTMENTS, LP | 396,339 | 254,916 | +141,423 | 0.02 | 0.02 | 0.00 | sell |
| Avidity Partners Management LP | 1,587,429 | 1,719,103 | +131,674 | 1.31 | 1.97 | +0.66 | buy |
| Frazier Life Sciences Management, L.P. | 1,403,013 | 1,523,013 | +120,000 | 1.91 | 2.44 | +0.53 | buy |
| TANG CAPITAL MANAGEMENT LLC | 150,000 | 250,000 | +100,000 | 0.43 | 0.69 | +0.26 | buy |
| Privium Fund Management B.V. | 143,350 | 233,050 | +89,700 | 0.87 | 1.92 | +1.04 | buy |
| Candriam S.C.A. | 50,000 | 110,000 | +60,000 | 0.01 | 0.02 | +0.02 | buy |
| Novo Holdings A/S | 1,001,000 | 1,050,000 | +49,000 | 1.52 | 1.94 | +0.43 | buy |
| JANUS HENDERSON GROUP PLC | 902,095 | 949,905 | +47,810 | 0.01 | 0.02 | 0.00 | buy |
| TD ASSET MANAGEMENT INC | 112,030 | 154,864 | +42,834 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 151,074 | 193,350 | +42,276 | 0.20 | 0.33 | +0.13 | buy |
| Avoro Capital Advisors LLC | 1,250,000 | 1,260,900 | +10,900 | 0.40 | 0.52 | +0.12 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 13,980 | 24,518 | +10,538 | 0.00 | 0.00 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 2,068 | 10,424 | +8,356 | 0.01 | 0.06 | +0.05 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 288,801 | 296,013 | +7,212 | 0.02 | 0.03 | +0.01 | buy |
| Rockefeller Capital Management L.P. | 91,864 | 85,464 | +6,400 | 0.01 | 0.01 | 0.00 | sell |
| PROFUND ADVISORS LLC | 40,861 | 34,471 | +6,390 | 0.05 | 0.04 | 0.00 | sell |
| VELA Investment Management, LLC | 16,079 | 20,773 | +4,694 | 0.14 | 0.25 | +0.11 | buy |
| EFG Asset Management (North America) Corp. | 151,068 | 155,205 | +4,137 | 0.73 | 0.88 | +0.15 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 362,000 | 366,015 | +4,015 | 4.97 | 6.17 | +1.20 | buy |
| B. Metzler seel. Sohn & Co. AG | 30,559 | 34,418 | +3,859 | 0.01 | 0.01 | +0.00 | buy |
| TORRAY INVESTMENT PARTNERS LLC | 60,177 | 60,856 | +679 | 0.22 | 0.30 | +0.08 | buy |
| GILDER GAGNON HOWE & CO LLC | 18,904 | 19,379 | +475 | 0.01 | 0.01 | +0.00 | buy |
| SYNOVUS FINANCIAL CORP | 84,681 | 84,970 | +289 | 0.02 | 0.04 | +0.02 | buy |
| EFG Asset Management (Americas) Corp. | 12,840 | 11,972 | -868 | 0.06 | 0.08 | +0.01 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 17,500 | 16,500 | -1,000 | 0.00 | 0.00 | +0.00 | sell |
| VIRTUS ADVISERS, LLC | 4,356 | 3,274 | -1,082 | 0.05 | 0.06 | +0.01 | sell |
| E Fund Management Co., Ltd. | 12,412 | 11,197 | -1,215 | 0.02 | 0.02 | +0.00 | sell |
| JENNISON ASSOCIATES LLC | 27,636 | 25,880 | -1,756 | 0.00 | 0.00 | +0.00 | sell |
| Dana Investment Advisors, Inc. | 15,409 | 13,417 | -1,992 | 0.02 | 0.02 | +0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 57,317 | 54,355 | -2,962 | 0.25 | 0.31 | +0.06 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 77,389 | 72,428 | -4,961 | 0.10 | 0.13 | +0.02 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 158,571 | 152,861 | -5,710 | 0.00 | 0.01 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,637,951 | 2,629,074 | -8,877 | 0.01 | 0.01 | +0.00 | sell |
| Sigma Planning Corp | 25,780 | 11,870 | -13,910 | 0.02 | 0.03 | +0.01 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 209,040 | 190,783 | -18,257 | 0.78 | 0.92 | +0.14 | sell |
| MOODY ALDRICH PARTNERS LLC | 58,027 | 36,311 | -21,716 | 0.23 | 0.20 | -0.03 | sell |
| Rafferty Asset Management, LLC | 241,642 | 208,505 | -33,137 | 0.03 | 0.03 | -0.00 | sell |
| Fort Baker Capital Management LP | 377,439 | 328,698 | -48,741 | 0.01 | 0.02 | +0.01 | sell |
| BAMCO INC /NY/ | 1,108,017 | 1,052,501 | -55,516 | 0.07 | 0.08 | +0.02 | sell |
| GMT CAPITAL CORP | 411,200 | 306,500 | -104,700 | 0.32 | 0.35 | +0.03 | sell |
| SECTORAL ASSET MANAGEMENT INC | 227,030 | 12,280 | -214,750 | 0.91 | 0.16 | -0.75 | sell |
| CITADEL ADVISORS LLC | 2,678,501 | 2,457,561 | -220,940 | 0.08 | 0.11 | +0.02 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 4,193,996 | 3,941,859 | -252,137 | 0.59 | 0.69 | +0.10 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 898,000 | 490,732 | -407,268 | 0.33 | 0.24 | -0.09 | sell |
| Ikarian Capital, LLC | 654,726 | 239,726 | -415,000 | 4.98 | 1.97 | -3.02 | sell |
| Logos Global Management LP | 1,975,000 | 1,275,000 | -700,000 | 5.77 | 4.25 | -1.52 | sell |
| MAVERICK CAPITAL LTD | 5,629,970 | 4,034,068 | -1,595,902 | 2.70 | 2.49 | -0.20 | sell |