| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Pictet Asset Management Holding SA | 0 | 1,347,163 | +1,347,163 | 0.00 | 0.04 | +0.04 | buy |
| VANGUARD GROUP INC | 4,604,013 | 5,447,565 | +843,552 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 332,892 | 793,738 | +460,846 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 667,055 | 1,072,910 | +405,855 | 0.01 | 0.02 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 382,672 | +382,672 | 0.00 | 3.54 | +3.54 | buy |
| CITADEL ADVISORS LLC | 0 | 300,300 | +300,300 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,240,160 | 1,457,250 | +217,090 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,517,467 | 1,707,398 | +189,931 | 1.05 | 1.14 | +0.10 | buy |
| FMR LLC | 342,699 | 529,496 | +186,797 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 8,022,830 | 8,197,546 | +174,716 | 0.03 | 0.05 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 156,000 | +156,000 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 140,000 | +140,000 | 0.00 | 0.01 | +0.01 | buy |
| Avidity Partners Management LP | 1,587,429 | 1,719,103 | +131,674 | 1.31 | 1.97 | +0.66 | buy |
| Frazier Life Sciences Management, L.P. | 1,403,013 | 1,523,013 | +120,000 | 1.91 | 2.44 | +0.53 | buy |
| COMERICA BANK | 440,076 | 558,025 | +117,949 | 0.05 | 0.08 | +0.03 | buy |
| TANG CAPITAL MANAGEMENT LLC | 150,000 | 250,000 | +100,000 | 0.43 | 0.69 | +0.26 | buy |
| STATE STREET CORP | 3,139,505 | 3,231,411 | +91,906 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 143,350 | 233,050 | +89,700 | 0.87 | 1.92 | +1.04 | buy |
| GOLDMAN SACHS GROUP INC | 529,719 | 594,665 | +64,946 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 50,000 | 110,000 | +60,000 | 0.01 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 468,206 | 525,452 | +57,246 | 0.00 | 0.00 | +0.00 | buy |
| Novo Holdings A/S | 1,001,000 | 1,050,000 | +49,000 | 1.52 | 1.94 | +0.43 | buy |
| JANUS HENDERSON GROUP PLC | 902,095 | 949,905 | +47,810 | 0.01 | 0.02 | +0.00 | buy |
| NORTHERN TRUST CORP | 582,895 | 628,705 | +45,810 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 45,657 | +45,657 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 0 | 43,540 | +43,540 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 53,928 | 96,843 | +42,915 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 112,030 | 154,864 | +42,834 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 151,074 | 193,350 | +42,276 | 0.20 | 0.33 | +0.13 | buy |
| Atom Investors LP | 0 | 30,971 | +30,971 | 0.00 | 0.16 | +0.16 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 61,506 | 86,587 | +25,081 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 24,710 | +24,710 | 0.00 | 0.03 | +0.03 | buy |
| BARCLAYS PLC | 154,409 | 177,535 | +23,126 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 0 | 21,000 | +21,000 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 50,170 | 71,011 | +20,841 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 20,400 | +20,400 | 0.00 | 0.05 | +0.05 | buy |
| NEOS Investment Management LLC | 0 | 19,520 | +19,520 | 0.00 | 0.06 | +0.06 | buy |
| Bayesian Capital Management, LP | 0 | 17,009 | +17,009 | 0.00 | 0.05 | +0.05 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,073 | 38,666 | +12,593 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 35,695 | 48,048 | +12,353 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 11,072 | +11,072 | 0.00 | 0.03 | +0.03 | buy |
| Avoro Capital Advisors LLC | 1,250,000 | 1,260,900 | +10,900 | 0.40 | 0.52 | +0.12 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 13,980 | 24,518 | +10,538 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 10,813 | 20,639 | +9,826 | 0.00 | 0.00 | +0.00 | buy |
| Harbour Capital Advisors, LLC | 0 | 9,825 | +9,825 | 0.00 | 0.08 | +0.08 | buy |
| Legal & General Group Plc | 57,157 | 66,440 | +9,283 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 123,800 | 133,000 | +9,200 | 0.00 | 0.00 | +0.00 | buy |
| PITCAIRN CO | 0 | 9,110 | +9,110 | 0.00 | 0.02 | +0.02 | buy |
| COBBLESTONE CAPITAL ADVISORS LLC /NY/ | 0 | 9,000 | +9,000 | 0.00 | 0.02 | +0.02 | buy |
| GUGGENHEIM CAPITAL LLC | 0 | 8,380 | +8,380 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 8,370 | +8,370 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 2,068 | 10,424 | +8,356 | 0.01 | 0.06 | +0.05 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 62,154 | 70,429 | +8,275 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 8,058 | +8,058 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 7,353 | +7,353 | 0.00 | 0.06 | +0.06 | buy |
| Cubist Systematic Strategies, LLC | 0 | 7,319 | +7,319 | 0.00 | 0.00 | +0.00 | buy |
| Edgestream Partners, L.P. | 0 | 7,317 | +7,317 | 0.00 | 0.02 | +0.02 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 7,257 | +7,257 | 0.00 | 0.00 | +0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 288,801 | 296,013 | +7,212 | 0.02 | 0.03 | +0.01 | buy |
| Old Well Partners, LLC | 0 | 6,688 | +6,688 | 0.00 | 0.19 | +0.19 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 39,210 | 45,508 | +6,298 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 24,759 | 30,751 | +5,992 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 36,196 | 42,079 | +5,883 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 12,300 | 17,600 | +5,300 | 0.00 | 0.00 | +0.00 | buy |
| VELA Investment Management, LLC | 16,079 | 20,773 | +4,694 | 0.14 | 0.25 | +0.11 | buy |
| RHUMBLINE ADVISERS | 87,527 | 92,013 | +4,486 | 0.00 | 0.00 | +0.00 | buy |
| EFG Asset Management (North America) Corp. | 151,068 | 155,205 | +4,137 | 0.73 | 0.88 | +0.15 | buy |
| MetLife Investment Management, LLC | 28,906 | 33,003 | +4,097 | 0.00 | 0.01 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 362,000 | 366,015 | +4,015 | 5.39 | 6.18 | +0.78 | buy |
| B. Metzler seel. Sohn & Co. AG | 30,559 | 34,418 | +3,859 | 0.01 | 0.01 | +0.00 | buy |
| ProShare Advisors LLC | 12,553 | 16,146 | +3,593 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 28,000 | 31,184 | +3,184 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 24,124 | 27,173 | +3,049 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 16,036 | 18,864 | +2,828 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 22,447 | 24,484 | +2,037 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,728 | 3,557 | +1,829 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 4,987 | 6,276 | +1,289 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,574 | 6,494 | +920 | 0.00 | 0.01 | +0.00 | buy |
| TORRAY INVESTMENT PARTNERS LLC | 60,177 | 60,856 | +679 | 0.22 | 0.30 | +0.08 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 17,302 | 17,963 | +661 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 18,904 | 19,379 | +475 | 0.01 | 0.01 | +0.00 | buy |
| AMALGAMATED BANK | 8,213 | 8,653 | +440 | 0.00 | 0.00 | +0.00 | buy |
| UMB Bank, n.a. | 0 | 408 | +408 | 0.00 | 0.00 | +0.00 | buy |
| SYNOVUS FINANCIAL CORP | 84,681 | 84,970 | +289 | 0.02 | 0.04 | +0.02 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 16,090 | 16,300 | +210 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 5 | 105 | +100 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 80 | +80 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 1,722 | 1,794 | +72 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 5 | 7 | +2 | 0.00 | 0.00 | 0.00 | buy |
| HUNTINGTON NATIONAL BANK | 456 | 458 | +2 | 0.00 | 0.00 | +0.00 | buy |
| SANDERS MORRIS HARRIS LLC | 27,709 | 27,709 | 0 | 0.11 | 0.40 | +0.29 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NATIXIS | 649 | 649 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rathbones Group PLC | 30,000 | 30,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| NORGES BANK | 243,351 | 243,351 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Walleye Trading LLC | 34,829 | 34,829 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MACQUARIE GROUP LTD | 58,000 | 58,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 89,700 | 89,700 | 0 | 0.00 | 0.01 | +0.00 | hold |