| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 17,687,772 | 17,687,772 | 0 | 4.73 | 3.36 | -1.36 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 11,242,144 | 13,995,177 | +2,753,033 | 0.04 | 0.03 | -0.00 | buy |
| BlackRock, Inc. | 6,370,721 | 7,097,287 | +726,566 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 5,536,940 | 6,577,595 | +1,040,655 | 0.00 | 0.00 | -0.00 | buy |
| MAVERICK CAPITAL LTD | 4,118,672 | 5,198,900 | +1,080,228 | 1.48 | 1.18 | -0.31 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 4,493,833 | 4,714,610 | +220,777 | 0.37 | 0.26 | -0.12 | buy |
| CITADEL ADVISORS LLC | 2,148,093 | 4,122,824 | +1,974,731 | 0.04 | 0.05 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 1,897,340 | 4,004,039 | +2,106,699 | 0.02 | 0.03 | +0.01 | buy |
| STATE STREET CORP | 3,102,022 | 3,458,079 | +356,057 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,207,781 | 3,148,520 | -59,261 | 0.01 | 0.00 | -0.00 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 2,566,951 | +2,566,951 | 0.00 | 1.20 | +1.20 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,617,866 | 1,752,975 | +135,109 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 48,096 | 1,569,823 | +1,521,727 | 0.00 | 0.05 | +0.05 | buy |
| Frazier Life Sciences Management, L.P. | 1,485,630 | 1,479,025 | -6,605 | 1.10 | 0.77 | -0.33 | sell |
| Pictet Asset Management Holding SA | 1,386,705 | 1,317,969 | -68,736 | 0.03 | 0.02 | -0.01 | sell |
| Avoro Capital Advisors LLC | 0 | 1,200,000 | +1,200,000 | 0.00 | 0.21 | +0.21 | buy |
| MORGAN STANLEY | 615,528 | 1,184,709 | +569,181 | 0.00 | 0.00 | +0.00 | buy |
| Novo Holdings A/S | 1,100,000 | 1,100,000 | 0 | 1.01 | 0.84 | -0.17 | hold |
| TORONTO DOMINION BANK | 0 | 1,100,000 | +1,100,000 | 0.00 | 0.03 | +0.03 | buy |
| Prosight Management, LP | 159,369 | 1,088,706 | +929,337 | 0.75 | 3.83 | +3.09 | buy |
| Avidity Partners Management LP | 749,000 | 1,053,300 | +304,300 | 0.71 | 1.32 | +0.61 | buy |
| MPM BioImpact LLC | 1,066,373 | 1,020,559 | -45,814 | 2.95 | 1.82 | -1.13 | sell |
| GOLDMAN SACHS GROUP INC | 424,073 | 802,785 | +378,712 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 812,310 | 791,877 | -20,433 | 0.02 | 0.01 | -0.01 | sell |
| COMERICA BANK | 785,526 | 780,380 | -5,146 | 0.06 | 0.04 | -0.02 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 770,691 | 770,691 | 0 | 0.25 | 0.18 | -0.07 | hold |
| DIMENSIONAL FUND ADVISORS LP | 912,605 | 760,941 | -151,664 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 750,000 | 750,000 | 0 | 0.99 | 0.62 | -0.37 | hold |
| Walleye Capital LLC | 720,905 | 671,743 | -49,162 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 580,836 | 663,152 | +82,316 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 569,814 | 656,090 | +86,276 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 1,730,344 | 653,559 | -1,076,785 | 0.01 | 0.00 | -0.01 | sell |
| Woodline Partners LP | 601,063 | 652,421 | +51,358 | 0.09 | 0.06 | -0.04 | buy |
| Siren, L.L.C. | 0 | 600,000 | +600,000 | 0.00 | 0.33 | +0.33 | buy |
| UBS Group AG | 338,134 | 569,963 | +231,829 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 556,552 | 515,528 | -41,024 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 10,100 | 456,762 | +446,662 | 0.00 | 0.01 | +0.01 | buy |
| Voss Capital, LP | 0 | 421,700 | +421,700 | 0.00 | 0.39 | +0.39 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 235,004 | 413,550 | +178,546 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 400,000 | 400,000 | 0 | 0.01 | 0.00 | -0.01 | hold |
| Privium Fund Management B.V. | 294,800 | 397,650 | +102,850 | 1.35 | 1.13 | -0.22 | buy |
| M28 Capital Management LP | 385,680 | 385,680 | 0 | 7.83 | 4.76 | -3.07 | hold |
| PERCEPTIVE ADVISORS LLC | 931,851 | 378,584 | -553,267 | 0.37 | 0.13 | -0.24 | sell |
| Invesco Ltd. | 352,622 | 357,840 | +5,218 | 0.00 | 0.00 | -0.00 | buy |
| RTW INVESTMENTS, LP | 350,000 | 350,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MILLENNIUM MANAGEMENT LLC | 1,202,495 | 336,909 | -865,586 | 0.02 | 0.00 | -0.02 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 231,792 | 271,792 | +40,000 | 0.70 | 0.63 | -0.07 | buy |
| Soleus Capital Management, L.P. | 0 | 271,659 | +271,659 | 0.00 | 0.26 | +0.26 | buy |
| STEMPOINT CAPITAL LP | 0 | 270,983 | +270,983 | 0.00 | 0.85 | +0.85 | buy |
| Hennion & Walsh Asset Management, Inc. | 221,046 | 237,499 | +16,453 | 0.19 | 0.14 | -0.06 | buy |
| BARCLAYS PLC | 154,974 | 233,952 | +78,978 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 406,159 | 224,311 | -181,848 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 197,096 | 221,911 | +24,815 | 1.13 | 0.80 | -0.33 | buy |
| Walleye Capital LLC | 138,403 | 220,142 | +81,739 | 0.03 | 0.03 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 218,519 | +218,519 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 4,300 | 211,400 | +207,100 | 0.01 | 0.55 | +0.53 | buy |
| Ovata Capital Management Ltd | 0 | 200,000 | +200,000 | 0.00 | 0.96 | +0.96 | buy |
| Bank of New York Mellon Corp | 184,233 | 194,182 | +9,949 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 65,618 | 189,879 | +124,261 | 0.01 | 0.02 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 177,610 | 178,454 | +844 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 173,563 | 177,548 | +3,985 | 0.01 | 0.00 | -0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 168,506 | 165,127 | -3,379 | 0.14 | 0.09 | -0.04 | sell |
| SYNOVUS FINANCIAL CORP | 95,504 | 163,893 | +68,389 | 0.02 | 0.03 | +0.01 | buy |
| Exome Asset Management LLC | 0 | 159,552 | +159,552 | 0.00 | 1.51 | +1.51 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 38,957 | 158,439 | +119,482 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 128,726 | 156,260 | +27,534 | 0.01 | 0.01 | -0.00 | buy |
| Swiss National Bank | 124,600 | 153,700 | +29,100 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 152,293 | 152,489 | +196 | 0.00 | 0.00 | -0.00 | buy |
| New Leaf Venture Partners, L.L.C. | 150,706 | 150,706 | 0 | 2.86 | 2.53 | -0.33 | hold |
| EFG Asset Management (North America) Corp. | 244,420 | 145,629 | -98,791 | 0.76 | 0.25 | -0.51 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 119,633 | 139,572 | +19,939 | 0.00 | 0.00 | -0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 190,000 | 134,500 | -55,500 | 2.84 | 1.70 | -1.14 | sell |
| FMR LLC | 465,456 | 129,534 | -335,922 | 0.00 | 0.00 | -0.00 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 126,769 | 127,270 | +501 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 51,496 | 123,415 | +71,919 | 0.00 | 0.00 | +0.00 | buy |
| TORRAY INVESTMENT PARTNERS LLC | 73,424 | 122,095 | +48,671 | 0.19 | 0.22 | +0.03 | buy |
| BLAIR WILLIAM & CO/IL | 134,969 | 116,038 | -18,931 | 0.01 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 65,000 | 113,500 | +48,500 | 0.01 | 0.01 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 104,828 | 104,828 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 98,097 | 99,339 | +1,242 | 0.00 | 0.00 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 0 | 97,079 | +97,079 | 0.00 | 0.01 | +0.01 | buy |
| NEOS Investment Management LLC | 111,454 | 90,985 | -20,469 | 0.06 | 0.03 | -0.04 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 92,142 | 90,834 | -1,308 | 0.09 | 0.06 | -0.03 | sell |
| DekaBank Deutsche Girozentrale | 89,700 | 89,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Creative Planning | 0 | 88,844 | +88,844 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 107,912 | 88,565 | -19,347 | 0.01 | 0.00 | -0.00 | sell |
| Mirador Capital Partners LP | 16,774 | 84,529 | +67,755 | 0.06 | 0.19 | +0.14 | buy |
| Walleye Trading LLC | 34,829 | 83,991 | +49,162 | 0.00 | 0.00 | -0.00 | buy |
| LMR Partners LLP | 0 | 75,731 | +75,731 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 67,187 | 75,454 | +8,267 | 0.00 | 0.00 | -0.00 | buy |
| BAMCO INC /NY/ | 884,341 | 75,000 | -809,341 | 0.04 | 0.00 | -0.04 | sell |
| LMR Partners LLP | 0 | 75,000 | +75,000 | 0.00 | 0.02 | +0.02 | buy |
| Affinity Asset Advisors, LLC | 75,000 | 75,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 291,106 | 73,760 | -217,346 | 0.00 | 0.00 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 40,740 | 70,304 | +29,564 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 18,908 | 65,864 | +46,956 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 44,468 | 63,778 | +19,310 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 60,293 | 63,637 | +3,344 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 15,503 | 63,634 | +48,131 | 0.02 | 0.07 | +0.05 | buy |
| Campbell & CO Investment Adviser LLC | 26,251 | 59,969 | +33,718 | 0.04 | 0.06 | +0.02 | buy |