| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 1,897,340 | 4,004,039 | +2,106,699 | 0.02 | 0.03 | 0.00 | buy |
| MAVERICK CAPITAL LTD | 4,118,672 | 5,198,900 | +1,080,228 | 1.48 | 1.18 | -0.31 | buy |
| Prosight Management, LP | 159,369 | 1,088,706 | +929,337 | 0.72 | 3.78 | +3.06 | buy |
| Avidity Partners Management LP | 749,000 | 1,053,300 | +304,300 | 0.71 | 1.32 | +0.61 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 4,493,833 | 4,714,610 | +220,777 | 0.37 | 0.26 | -0.12 | buy |
| ADAR1 Capital Management, LLC | 4,300 | 211,400 | +207,100 | 0.01 | 0.55 | +0.53 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 235,004 | 413,550 | +178,546 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 65,618 | 189,879 | +124,261 | 0.01 | 0.03 | 0.00 | buy |
| Privium Fund Management B.V. | 294,800 | 397,650 | +102,850 | 1.35 | 1.13 | -0.22 | buy |
| SYNOVUS FINANCIAL CORP | 95,504 | 163,893 | +68,389 | 0.02 | 0.03 | +0.01 | buy |
| Mirador Capital Partners LP | 16,774 | 84,529 | +67,755 | 0.06 | 0.19 | +0.14 | buy |
| Woodline Partners LP | 601,063 | 652,421 | +51,358 | 0.09 | 0.06 | -0.04 | buy |
| TORRAY INVESTMENT PARTNERS LLC | 73,424 | 122,095 | +48,671 | 0.19 | 0.22 | +0.03 | buy |
| Hudson Bay Capital Management LP | 65,000 | 113,500 | +48,500 | 0.00 | 0.01 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 231,792 | 271,792 | +40,000 | 0.68 | 0.62 | -0.06 | buy |
| JENNISON ASSOCIATES LLC | 40,740 | 70,304 | +29,564 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 128,726 | 156,260 | +27,534 | 0.01 | 0.01 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 11,843 | 38,208 | +26,365 | 0.00 | 0.01 | +0.01 | buy |
| Ikarian Capital, LLC | 197,096 | 221,911 | +24,815 | 1.13 | 0.80 | -0.33 | buy |
| Hennion & Walsh Asset Management, Inc. | 221,046 | 237,499 | +16,453 | 0.19 | 0.14 | -0.06 | buy |
| Brevan Howard Capital Management LP | 16,720 | 25,147 | +8,427 | 0.00 | 0.00 | -0.00 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 32,490 | 37,500 | +5,010 | 0.13 | 0.09 | -0.04 | buy |
| PROFUND ADVISORS LLC | 25,725 | 30,161 | +4,436 | 0.02 | 0.01 | 0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 168,506 | 165,127 | +3,379 | 0.14 | 0.09 | 0.00 | sell |
| Dana Investment Advisors, Inc. | 14,981 | 17,608 | +2,627 | 0.01 | 0.01 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 17,505 | 19,329 | +1,824 | 0.04 | 0.02 | -0.01 | buy |
| VIRTUS ADVISERS, LLC | 4,028 | 5,656 | +1,628 | 0.03 | 0.03 | -0.01 | buy |
| BFSG, LLC | 500 | 1,900 | +1,400 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 177,610 | 178,454 | +844 | 0.00 | 0.00 | -0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 126,769 | 127,270 | +501 | 0.00 | 0.00 | -0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 92,142 | 90,834 | -1,308 | 0.09 | 0.06 | -0.03 | sell |
| Main Management ETF Advisors, LLC | 32,592 | 29,904 | -2,688 | 0.03 | 0.02 | -0.01 | sell |
| SECTORAL ASSET MANAGEMENT INC | 43,383 | 40,183 | -3,200 | 0.47 | 0.34 | -0.14 | sell |
| Frazier Life Sciences Management, L.P. | 1,485,630 | 1,479,025 | -6,605 | 1.10 | 0.77 | -0.33 | sell |
| NEOS Investment Management LLC | 111,454 | 90,985 | -20,469 | 0.06 | 0.03 | -0.04 | sell |
| MPM BioImpact LLC | 1,066,373 | 1,020,559 | -45,814 | 2.95 | 1.82 | -1.13 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 190,000 | 134,500 | -55,500 | 2.84 | 1.70 | -1.14 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,207,781 | 3,148,520 | -59,261 | 0.01 | 0.00 | -0.00 | sell |
| EFG Asset Management (North America) Corp. | 244,420 | 145,629 | -98,791 | 0.76 | 0.25 | -0.51 | sell |
| PERCEPTIVE ADVISORS LLC | 931,851 | 378,584 | -553,267 | 0.36 | 0.13 | -0.23 | sell |
| BAMCO INC /NY/ | 884,341 | 75,000 | -809,341 | 0.04 | 0.00 | -0.04 | sell |