| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 17,687,772 | 17,687,772 | 0 | 0.71 | 0.62 | -0.09 | hold |
| VANGUARD GROUP INC | 6,892,204 | 8,544,423 | +1,652,219 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 7,114,371 | 7,906,071 | +791,700 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 10,425 | 5,246,349 | +5,235,924 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 3,647,039 | 3,941,377 | +294,338 | 0.00 | 0.00 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,843,333 | 2,992,735 | -850,598 | 0.38 | 0.26 | -0.12 | sell |
| Monaco Asset Management SAM | 2,892,261 | 2,987,296 | +95,035 | 3.51 | 3.11 | -0.40 | buy |
| Newtyn Management, LLC | 2,502,863 | 2,650,000 | +147,137 | 1.00 | 0.98 | -0.01 | buy |
| D. E. Shaw & Co., Inc. | 2,189,750 | 2,640,518 | +450,768 | 0.01 | 0.01 | +0.00 | buy |
| MAVERICK CAPITAL LTD | 8,468,344 | 2,513,110 | -5,955,234 | 0.37 | 0.09 | -0.27 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,609,682 | 2,131,929 | +522,247 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,914,554 | 2,120,269 | +205,715 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 1,795,751 | 1,864,651 | +68,900 | 0.01 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 3,570,391 | 1,784,921 | -1,785,470 | 0.01 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 1,745,310 | 1,700,631 | -44,679 | 0.00 | 0.00 | +0.00 | sell |
| MPM BioImpact LLC | 3,903,381 | 1,586,076 | -2,317,305 | 2.08 | 0.64 | -1.45 | sell |
| JPMORGAN CHASE & CO | 2,097,033 | 1,475,624 | -621,409 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 1,670,927 | 1,299,991 | -370,936 | 0.00 | 0.00 | -0.00 | sell |
| Opaleye Management Inc. | 0 | 955,000 | +955,000 | 0.00 | 0.44 | +0.44 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,061,295 | 944,873 | -116,422 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,271,093 | 936,594 | -334,499 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 627,567 | 881,249 | +253,682 | 0.00 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 744,074 | 744,286 | +212 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 1,267,965 | 743,942 | -524,023 | 0.99 | 0.54 | -0.45 | sell |
| AQR CAPITAL MANAGEMENT LLC | 873,247 | 703,528 | -169,719 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 657,013 | 618,654 | -38,359 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 484,481 | 602,580 | +118,099 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 514,921 | 579,507 | +64,586 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 507,909 | +507,909 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 625,533 | 499,331 | -126,202 | 0.02 | 0.01 | -0.01 | sell |
| ADAR1 Capital Management, LLC | 575,800 | 475,800 | -100,000 | 0.19 | 0.12 | -0.06 | sell |
| DEUTSCHE BANK AG\ | 80,735 | 474,866 | +394,131 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 434,409 | 434,409 | 0 | 0.02 | 0.02 | +0.00 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 137,177 | 421,174 | +283,997 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,313,737 | 400,706 | -913,031 | 0.01 | 0.00 | -0.01 | sell |
| Sio Capital Management, LLC | 400,000 | 400,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FMR LLC | 311,701 | 395,275 | +83,574 | 0.00 | 0.00 | +0.00 | buy |
| M28 Capital Management LP | 385,680 | 385,680 | 0 | 1.85 | 0.98 | -0.86 | hold |
| RTW INVESTMENTS, LP | 350,000 | 350,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PANAGORA ASSET MANAGEMENT INC | 0 | 348,803 | +348,803 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 555,823 | 338,830 | -216,993 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 305,438 | 309,247 | +3,809 | 0.04 | 0.04 | +0.00 | buy |
| Invesco Ltd. | 222,453 | 304,437 | +81,984 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 593,631 | 284,345 | -309,286 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 245,313 | 250,962 | +5,649 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 209,846 | 242,169 | +32,323 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 265,982 | 220,884 | -45,098 | 0.05 | 0.05 | -0.00 | sell |
| Qube Research & Technologies Ltd | 1,014,358 | 219,973 | -794,385 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 87,338 | 193,430 | +106,092 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 264,431 | 187,401 | -77,030 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 242,184 | 178,926 | -63,258 | 0.01 | 0.01 | -0.00 | sell |
| Amitell Capital Pte Ltd | 178,769 | 178,769 | 0 | 0.43 | 0.70 | +0.27 | hold |
| Privium Fund Management B.V. | 432,760 | 170,146 | -262,614 | 0.25 | 0.11 | -0.14 | sell |
| Creative Planning | 154,985 | 167,039 | +12,054 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 158,012 | 158,012 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 157,290 | 157,290 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 156,638 | 153,121 | -3,517 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 149,393 | 153,049 | +3,656 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 532,992 | 151,432 | -381,560 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 0 | 149,413 | +149,413 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 147,501 | 146,400 | -1,101 | 0.02 | 0.01 | -0.01 | sell |
| MONIMUS CAPITAL MANAGEMENT, LP | 0 | 138,012 | +138,012 | 0.00 | 0.32 | +0.32 | buy |
| RAYMOND JAMES FINANCIAL INC | 129,858 | 118,746 | -11,112 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 222,038 | 118,200 | -103,838 | 0.01 | 0.01 | -0.01 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 377,584 | 115,165 | -262,419 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 120,771 | 113,420 | -7,351 | 0.00 | 0.00 | +0.00 | sell |
| HRT FINANCIAL LP | 0 | 109,797 | +109,797 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 104,828 | 104,828 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WELLS FARGO & COMPANY/MN | 67,533 | 103,906 | +36,373 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 102,538 | 102,538 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 850,000 | 100,000 | -750,000 | 0.11 | 0.02 | -0.09 | sell |
| Ballentine Partners, LLC | 88,570 | 97,625 | +9,055 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 125,590 | 96,354 | -29,236 | 0.16 | 0.13 | -0.03 | sell |
| Engineers Gate Manager LP | 71,406 | 96,009 | +24,603 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 95,100 | +95,100 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 0 | 94,256 | +94,256 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 104,919 | 92,795 | -12,124 | 0.00 | 0.00 | -0.00 | sell |
| Jain Global LLC | 0 | 92,058 | +92,058 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 98,741 | 91,642 | -7,099 | 0.01 | 0.01 | +0.00 | sell |
| DekaBank Deutsche Girozentrale | 89,700 | 89,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Brevan Howard Capital Management LP | 0 | 89,130 | +89,130 | 0.00 | 0.01 | +0.01 | buy |
| Lion Point Capital, LP | 86,000 | 86,000 | 0 | 1.59 | 1.56 | -0.03 | hold |
| RICE HALL JAMES & ASSOCIATES, LLC | 83,007 | 84,987 | +1,980 | 0.01 | 0.02 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 37,064 | 78,474 | +41,410 | 0.03 | 0.07 | +0.04 | buy |
| LMR Partners LLP | 75,731 | 75,731 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BANK OF MONTREAL /CAN/ | 76,521 | 75,310 | -1,211 | 0.00 | 0.00 | +0.00 | sell |
| Affinity Asset Advisors, LLC | 75,000 | 75,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Graham Capital Management, L.P. | 133,512 | 73,743 | -59,769 | 0.02 | 0.01 | -0.01 | sell |
| Squarepoint Ops LLC | 438,379 | 68,317 | -370,062 | 0.00 | 0.00 | -0.00 | sell |
| Concurrent Investment Advisors, LLC | 76,096 | 68,096 | -8,000 | 0.00 | 0.00 | -0.00 | sell |
| Voleon Capital Management LP | 68,037 | 67,981 | -56 | 0.01 | 0.01 | -0.00 | sell |
| Quadrature Capital Ltd | 85,513 | 65,376 | -20,137 | 0.00 | 0.00 | -0.00 | sell |
| Rockefeller Capital Management L.P. | 106,982 | 64,222 | -42,760 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 48,729 | 63,748 | +15,019 | 0.00 | 0.00 | -0.00 | buy |
| Marex Group plc | 28,500 | 57,500 | +29,000 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 119,613 | 50,970 | -68,643 | 0.02 | 0.01 | -0.01 | sell |
| PIER 88 INVESTMENT PARTNERS LLC | 11,380 | 47,880 | +36,500 | 0.01 | 0.04 | +0.03 | buy |
| SIMPLEX TRADING, LLC | 0 | 42,495 | +42,495 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 50,107 | 42,411 | -7,696 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 40,727 | 40,727 | 0 | 0.00 | 0.00 | +0.00 | hold |