| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| CADIAN CAPITAL MANAGEMENT, LP | 5,644,898 | 6,560,484 | +915,586 | 1.06 | 0.98 | -0.08 | buy |
| MILLENNIUM MANAGEMENT LLC | 5,012,283 | 6,171,046 | +1,158,763 | 0.02 | 0.02 | -0.00 | buy |
| VANGUARD GROUP INC | 5,282,108 | 5,347,112 | +65,004 | 0.00 | 0.00 | -0.00 | buy |
| Vitruvian Partners LLP | 5,043,356 | 5,043,356 | 0 | 6.02 | 6.70 | +0.68 | hold |
| MORGAN STANLEY | 3,481,010 | 3,519,116 | +38,106 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 2,833,715 | 3,448,651 | +614,936 | 0.00 | 0.00 | -0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 2,537,114 | 2,525,124 | -11,990 | 0.00 | 0.00 | -0.00 | sell |
| Mudita Advisors LLP | 1,881,349 | 2,275,381 | +394,032 | 6.14 | 5.68 | -0.46 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,096,497 | 2,128,314 | +31,817 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 1,943,997 | 1,985,524 | +41,527 | 0.00 | 0.00 | -0.00 | buy |
| Portolan Capital Management, LLC | 2,757,249 | 1,721,777 | -1,035,472 | 1.13 | 0.55 | -0.58 | sell |
| Swedbank AB | 1,600,000 | 1,600,000 | 0 | 0.01 | 0.06 | +0.05 | hold |
| Chevy Chase Trust Holdings, LLC | 56,795 | 1,296,397 | +1,239,602 | 0.00 | 0.02 | +0.02 | buy |
| ArrowMark Colorado Holdings LLC | 1,373,777 | 1,258,200 | -115,577 | 0.07 | 0.06 | -0.01 | sell |
| AMERIPRISE FINANCIAL INC | 1,448,907 | 1,143,537 | -305,370 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 694,961 | 889,202 | +194,241 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 795,086 | 786,739 | -8,347 | 0.00 | 0.00 | -0.00 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 668,880 | 699,089 | +30,209 | 0.02 | 0.02 | -0.00 | buy |
| Blue Water Life Science Advisors, LP | 1,885,000 | 603,937 | -1,281,063 | 7.76 | 2.38 | -5.38 | sell |
| Willis Investment Counsel | 550,000 | 525,000 | -25,000 | 0.18 | 0.15 | -0.03 | sell |
| Roubaix Capital, LLC | 386,201 | 497,353 | +111,152 | 1.27 | 1.32 | +0.05 | buy |
| LAZARD ASSET MANAGEMENT LLC | 367,132 | 467,687 | +100,555 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 407,096 | 399,162 | -7,934 | 0.01 | 0.01 | -0.00 | sell |
| Bank of New York Mellon Corp | 381,833 | 340,184 | -41,649 | 0.00 | 0.00 | -0.00 | sell |
| Apollo Management Holdings, L.P. | 307,987 | 307,987 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Allspring Global Investments Holdings, LLC | 290,552 | 285,146 | -5,406 | 0.00 | 0.00 | -0.00 | sell |
| Rathbones Group PLC | 300,988 | 282,876 | -18,112 | 0.01 | 0.01 | -0.00 | sell |
| BLAIR WILLIAM & CO/IL | 254,563 | 273,064 | +18,501 | 0.00 | 0.00 | -0.00 | buy |
| Grandeur Peak Global Advisors, LLC | 656,916 | 250,743 | -406,173 | 0.22 | 0.08 | -0.13 | sell |
| Bleichroeder LP | 250,000 | 250,000 | 0 | 0.25 | 0.27 | +0.02 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 243,743 | 242,892 | -851 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 240,679 | 241,572 | +893 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 209,015 | +209,015 | 0.00 | 0.03 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 197,428 | 184,859 | -12,569 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 173,500 | 173,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Squarepoint Ops LLC | 111,375 | 169,142 | +57,767 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 189,100 | 162,600 | -26,500 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 147,958 | 147,958 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 132,851 | 136,752 | +3,901 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 145,249 | 132,752 | -12,497 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 84,136 | 130,206 | +46,070 | 0.00 | 0.00 | +0.00 | buy |
| AWM Investment Company, Inc. | 450,000 | 121,724 | -328,276 | 0.28 | 0.07 | -0.21 | sell |
| Valmark Advisers, Inc. | 83,927 | 116,080 | +32,153 | 0.01 | 0.01 | +0.00 | buy |
| Alberta Investment Management Corp | 136,135 | 109,545 | -26,590 | 0.01 | 0.00 | -0.00 | sell |
| STRS OHIO | 114,900 | 108,000 | -6,900 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 95,574 | 96,432 | +858 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 9,043 | 95,852 | +86,809 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 92,693 | 88,219 | -4,474 | 0.00 | 0.00 | -0.00 | sell |
| M&T BANK CORP | 87,872 | 88,054 | +182 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 152,360 | 86,350 | -66,010 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 80,822 | 84,632 | +3,810 | 0.00 | 0.00 | -0.00 | buy |
| ROYCE & ASSOCIATES LP | 327,338 | 81,428 | -245,910 | 0.01 | 0.00 | -0.01 | sell |
| BARCLAYS PLC | 137,831 | 79,232 | -58,599 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 70,228 | 71,845 | +1,617 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 73,460 | 70,706 | -2,754 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 63,090 | 63,090 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ensign Peak Advisors, Inc | 61,990 | 59,013 | -2,977 | 0.00 | 0.00 | -0.00 | sell |
| SALEM INVESTMENT COUNSELORS INC | 27,634 | 56,375 | +28,741 | 0.00 | 0.01 | +0.00 | buy |
| GAGNON SECURITIES LLC | 56,701 | 56,342 | -359 | 0.06 | 0.06 | -0.01 | sell |
| JANE STREET GROUP, LLC | 68,662 | 56,084 | -12,578 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 135,055 | 55,899 | -79,156 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 47,668 | 47,668 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Invesco Ltd. | 66,585 | 47,239 | -19,346 | 0.00 | 0.00 | -0.00 | sell |
| APIS CAPITAL ADVISORS, LLC | 0 | 45,800 | +45,800 | 0.00 | 0.15 | +0.15 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 43,440 | 43,071 | -369 | 0.00 | 0.00 | -0.00 | sell |
| SHERBROOKE PARK ADVISERS LLC | 32,378 | 42,895 | +10,517 | 0.07 | 0.03 | -0.04 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 42,472 | +42,472 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 57,521 | 39,312 | -18,209 | 0.00 | 0.00 | -0.00 | sell |
| BOSUN ASSET MANAGEMENT, LLC | 0 | 37,250 | +37,250 | 0.00 | 0.09 | +0.09 | buy |
| DEUTSCHE BANK AG\ | 35,670 | 36,634 | +964 | 0.00 | 0.00 | -0.00 | buy |
| Centiva Capital, LP | 0 | 36,591 | +36,591 | 0.00 | 0.01 | +0.01 | buy |
| HSBC HOLDINGS PLC | 27,535 | 35,616 | +8,081 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 34,550 | 33,835 | -715 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 37,352 | 31,976 | -5,376 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 48,550 | 31,778 | -16,772 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 26,753 | 30,686 | +3,933 | 0.00 | 0.00 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 30,554 | 30,559 | +5 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 22,500 | 27,400 | +4,900 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 23,205 | 26,808 | +3,603 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 28,440 | 26,384 | -2,056 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 20,879 | 25,199 | +4,320 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 24,605 | 24,285 | -320 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 23,664 | 23,633 | -31 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 21,084 | 22,962 | +1,878 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,986 | 19,884 | +7,898 | 0.01 | 0.01 | -0.00 | buy |
| Qube Research & Technologies Ltd | 5,845 | 17,535 | +11,690 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 15,121 | 16,538 | +1,417 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 29,314 | 15,395 | -13,919 | 0.00 | 0.00 | -0.00 | sell |
| Pictet Asset Management Holding SA | 14,535 | 14,535 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Moors & Cabot, Inc. | 0 | 12,532 | +12,532 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 12,316 | 11,995 | -321 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 11,800 | 11,947 | +147 | 0.00 | 0.00 | -0.00 | buy |
| State of Wyoming | 0 | 8,991 | +8,991 | 0.00 | 0.01 | +0.01 | buy |
| Ameritas Investment Partners, Inc. | 7,417 | 7,417 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EntryPoint Capital, LLC | 30,854 | 6,883 | -23,971 | 0.14 | 0.03 | -0.11 | sell |
| FEDERATED HERMES, INC. | 0 | 6,740 | +6,740 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 6,700 | +6,700 | 0.00 | 0.00 | +0.00 | buy |
| BROWN BROTHERS HARRIMAN & CO | 6,255 | 6,255 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PNC FINANCIAL SERVICES GROUP, INC. | 6,255 | 6,255 | 0 | 0.00 | 0.00 | -0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 5,026 | 5,026 | 0 | 0.00 | 0.00 | -0.00 | hold |