| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ARK Investment Management LLC | 34,504,273 | 33,290,137 | -1,214,136 | 2.00 | 0.86 | -1.14 | sell |
| VANGUARD GROUP INC | 26,789,552 | 26,606,485 | -183,067 | 0.01 | 0.00 | -0.00 | sell |
| Madrone Advisors, LLC | 17,591,915 | 17,591,915 | 0 | 21.50 | 9.04 | -12.46 | hold |
| Sumitomo Mitsui Trust Group, Inc. | 13,200,375 | 12,824,385 | -375,990 | 0.10 | 0.03 | -0.06 | sell |
| Nikko Asset Management Americas, Inc. | 13,200,375 | 12,824,385 | -375,990 | 1.25 | 0.48 | -0.77 | sell |
| Bank of New York Mellon Corp | 4,892,438 | 11,375,399 | +6,482,961 | 0.01 | 0.01 | -0.00 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 995,500 | 10,507,287 | +9,511,787 | 0.17 | 0.66 | +0.48 | buy |
| T. Rowe Price Investment Management, Inc. | 7,753,781 | 8,397,820 | +644,039 | 0.05 | 0.02 | -0.03 | buy |
| Jackson Square Partners, LLC | 9,704,766 | 7,184,313 | -2,520,453 | 3.09 | 1.12 | -1.97 | sell |
| Deep Track Capital, LP | 7,000,000 | 7,000,000 | 0 | 2.41 | 0.75 | -1.65 | hold |
| MACQUARIE GROUP LTD | 4,971,504 | 6,638,910 | +1,667,406 | 0.06 | 0.03 | -0.03 | buy |
| STATE STREET CORP | 5,624,329 | 5,768,887 | +144,558 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 5,516,386 | 5,642,779 | +126,393 | 0.01 | 0.00 | -0.00 | buy |
| Bellevue Group AG | 7,317,128 | 4,592,251 | -2,724,877 | 1.10 | 0.26 | -0.84 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 6,191,370 | 3,772,452 | -2,418,918 | 0.38 | 0.08 | -0.30 | sell |
| DIMENSIONAL FUND ADVISORS LP | 3,057,262 | 3,434,468 | +377,206 | 0.01 | 0.00 | -0.01 | buy |
| Capital World Investors | 3,390,000 | 3,390,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Capital International Investors | 3,113,749 | 3,113,749 | 0 | 0.01 | 0.00 | -0.00 | hold |
| VK Services, LLC | 2,632,784 | 2,632,784 | 0 | 3.92 | 1.80 | -2.12 | hold |
| NORTHERN TRUST CORP | 2,697,693 | 2,542,897 | -154,796 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 0 | 2,414,121 | +2,414,121 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,591,107 | 2,206,006 | +614,899 | 0.00 | 0.00 | -0.00 | buy |
| Eagle Health Investments LP | 1,522,721 | 2,167,021 | +644,300 | 3.04 | 1.55 | -1.49 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,966,837 | 1,987,519 | +20,682 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,599,275 | 1,955,382 | -1,643,893 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 11,109,582 | 1,902,851 | -9,206,731 | 0.01 | 0.00 | -0.01 | sell |
| Qube Research & Technologies Ltd | 0 | 1,789,237 | +1,789,237 | 0.00 | 0.01 | +0.01 | buy |
| SOROS FUND MANAGEMENT LLC | 0 | 1,633,000 | +1,633,000 | 0.00 | 0.14 | +0.14 | buy |
| BANK OF AMERICA CORP /DE/ | 823,045 | 1,599,143 | +776,098 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 1,840,073 | 1,557,714 | -282,359 | 0.03 | 0.01 | -0.02 | sell |
| NORGES BANK | 1,374,715 | 1,552,577 | +177,862 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 1,854,107 | 1,537,433 | -316,674 | 0.20 | 0.05 | -0.15 | sell |
| CITADEL ADVISORS LLC | 544,504 | 1,482,315 | +937,811 | 0.01 | 0.01 | -0.00 | buy |
| ORACLE INVESTMENT MANAGEMENT INC | 1,376,795 | 1,356,026 | -20,769 | 14.75 | 4.09 | -10.66 | sell |
| Mirae Asset Global Investments Co., Ltd. | 926,988 | 1,335,862 | +408,874 | 0.02 | 0.03 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 582,974 | 1,167,708 | +584,734 | 0.01 | 0.01 | -0.01 | buy |
| Casdin Capital, LLC | 1,035,859 | 1,035,859 | 0 | 1.00 | 0.29 | -0.71 | hold |
| Vestmark Advisory Solutions, Inc. | 494,790 | 935,289 | +440,499 | 0.25 | 0.15 | -0.10 | buy |
| HHLR ADVISORS, LTD. | 918,892 | 918,892 | 0 | 0.18 | 0.07 | -0.11 | hold |
| JPMORGAN CHASE & CO | 1,283,272 | 861,393 | -421,879 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 3,725,054 | 852,907 | -2,872,147 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 10,855 | 809,260 | +798,405 | 0.00 | 0.00 | +0.00 | buy |
| Senvest Management, LLC | 0 | 694,554 | +694,554 | 0.00 | 0.10 | +0.10 | buy |
| UBS Group AG | 33,894 | 677,253 | +643,359 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 0 | 675,000 | +675,000 | 0.00 | 0.09 | +0.09 | buy |
| BARCLAYS PLC | 465,850 | 665,077 | +199,227 | 0.00 | 0.00 | -0.00 | buy |
| BOURNE LENT ASSET MANAGEMENT INC | 592,215 | 654,415 | +62,200 | 2.36 | 0.99 | -1.37 | buy |
| TD ASSET MANAGEMENT INC | 661,300 | 533,500 | -127,800 | 0.01 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 766,165 | 529,616 | -236,549 | 0.01 | 0.00 | -0.01 | sell |
| JANE STREET GROUP, LLC | 487,185 | 520,811 | +33,626 | 0.01 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 144,088 | 493,334 | +349,246 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 469,046 | 475,246 | +6,200 | 0.00 | 0.00 | -0.00 | buy |
| ArrowMark Colorado Holdings LLC | 233,186 | 468,382 | +235,196 | 0.03 | 0.02 | -0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 471,464 | 459,830 | -11,634 | 0.01 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 383,318 | 385,141 | +1,823 | 0.00 | 0.00 | -0.00 | buy |
| Mirador Capital Partners LP | 52,538 | 318,373 | +265,835 | 0.11 | 0.23 | +0.12 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 326,477 | 314,248 | -12,229 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 20,800 | 297,871 | +277,071 | 0.01 | 0.03 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 296,771 | 296,771 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TUDOR INVESTMENT CORP ET AL | 0 | 291,569 | +291,569 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 288,612 | +288,612 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 274,488 | 274,488 | 0 | 1.68 | 0.95 | -0.72 | hold |
| ALLIANCEBERNSTEIN L.P. | 270,730 | 270,730 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Schonfeld Strategic Advisors LLC | 151,376 | 268,245 | +116,869 | 0.01 | 0.01 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 140,434 | 247,209 | +106,775 | 0.02 | 0.01 | -0.01 | buy |
| Invesco Ltd. | 201,992 | 242,733 | +40,741 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 253,494 | 241,821 | -11,673 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 236,272 | 235,610 | -662 | 0.00 | 0.00 | -0.00 | sell |
| GUGGENHEIM CAPITAL LLC | 195,377 | 227,526 | +32,149 | 0.01 | 0.01 | -0.01 | buy |
| Daiwa Securities Group Inc. | 909 | 225,792 | +224,883 | 0.00 | 0.00 | +0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 142,757 | 214,155 | +71,398 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 403,987 | 193,915 | -210,072 | 0.12 | 0.03 | -0.10 | sell |
| Dynamic Technology Lab Private Ltd | 153,122 | 193,609 | +40,487 | 0.16 | 0.08 | -0.08 | buy |
| TWO SIGMA INVESTMENTS, LP | 73,573 | 188,692 | +115,119 | 0.00 | 0.00 | -0.00 | buy |
| LPL Financial LLC | 180,175 | 180,652 | +477 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 29,360 | 180,000 | +150,640 | 0.01 | 0.03 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 196,021 | 173,543 | -22,478 | 0.01 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 158,747 | 168,012 | +9,265 | 0.00 | 0.00 | -0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 155,769 | +155,769 | 0.00 | 0.11 | +0.11 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 148,046 | +148,046 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 151,800 | 144,400 | -7,400 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 100,538 | 141,959 | +41,421 | 0.00 | 0.00 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 129,029 | 125,507 | -3,522 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 125,298 | 124,232 | -1,066 | 0.01 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 131,795 | 121,301 | -10,494 | 0.01 | 0.00 | -0.01 | sell |
| Koa Wealth Management, LLC | 120,000 | 120,000 | 0 | 1.16 | 0.41 | -0.76 | hold |
| ROYAL BANK OF CANADA | 211,775 | 119,158 | -92,617 | 0.00 | 0.00 | -0.00 | sell |
| IMC-Chicago, LLC | 0 | 115,620 | +115,620 | 0.00 | 0.02 | +0.02 | buy |
| Clear Harbor Asset Management, LLC | 64,050 | 114,936 | +50,886 | 0.06 | 0.04 | -0.02 | buy |
| Amundi | 112,869 | 112,869 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Capital Impact Advisors, LLC | 145,574 | 112,567 | -33,007 | 1.88 | 0.55 | -1.33 | sell |
| JANUS HENDERSON GROUP PLC | 111,276 | 111,324 | +48 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 104,143 | 108,586 | +4,443 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 72,090 | 108,364 | +36,274 | 0.00 | 0.00 | -0.00 | buy |
| Quarry LP | 0 | 106,985 | +106,985 | 0.00 | 0.16 | +0.16 | buy |
| Nebula Research & Development LLC | 0 | 106,434 | +106,434 | 0.00 | 0.09 | +0.09 | buy |
| GABELLI FUNDS LLC | 100,000 | 100,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| NJ State Employees Deferred Compensation Plan | 100,000 | 100,000 | 0 | 0.13 | 0.05 | -0.09 | hold |
| Abacus Planning Group, Inc. | 100,000 | 100,000 | 0 | 0.21 | 0.07 | -0.13 | hold |
| Ensign Peak Advisors, Inc | 93,450 | 98,112 | +4,662 | 0.00 | 0.00 | -0.00 | buy |