| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Octagon Capital Advisors LP | 0 | 1,093,503 | +1,093,503 | 0.00 | 2.75 | +2.75 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 938,591 | +938,591 | 0.00 | 0.25 | +0.25 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,128,638 | 2,046,438 | +917,800 | 0.02 | 0.04 | +0.01 | buy |
| Cormorant Asset Management, LP | 6,038,235 | 6,893,235 | +855,000 | 6.68 | 6.28 | -0.40 | buy |
| Fiera Capital Corp | 0 | 671,118 | +671,118 | 0.00 | 0.04 | +0.04 | buy |
| Finepoint Capital LP | 0 | 656,600 | +656,600 | 0.00 | 3.48 | +3.48 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 579,594 | +579,594 | 0.00 | 0.21 | +0.21 | buy |
| STATE STREET CORP | 550,609 | 1,032,572 | +481,963 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 388,955 | +388,955 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 2,034,060 | 2,396,228 | +362,168 | 0.00 | 0.00 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,466,420 | 4,756,299 | +289,879 | 0.21 | 0.19 | -0.03 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 282,814 | +282,814 | 0.00 | 0.03 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 567,986 | 839,478 | +271,492 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 317,010 | 585,447 | +268,437 | 1.05 | 1.81 | +0.76 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 247,968 | +247,968 | 0.00 | 1.44 | +1.44 | buy |
| Candriam S.C.A. | 140,000 | 383,000 | +243,000 | 0.02 | 0.05 | +0.03 | buy |
| Walleye Capital LLC | 0 | 186,958 | +186,958 | 0.00 | 0.04 | +0.04 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 21,511 | 198,760 | +177,249 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 682,417 | 832,637 | +150,220 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 1,227,278 | 1,375,517 | +148,239 | 0.03 | 0.03 | -0.00 | buy |
| JANE STREET GROUP, LLC | 69,895 | 214,694 | +144,799 | 0.00 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 138,659 | +138,659 | 0.00 | 0.01 | +0.01 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 130,000 | +130,000 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 180,000 | 306,206 | +126,206 | 0.01 | 0.01 | +0.00 | buy |
| MYDA Advisors LLC | 0 | 115,000 | +115,000 | 0.00 | 0.83 | +0.83 | buy |
| BANK OF AMERICA CORP /DE/ | 78,444 | 175,404 | +96,960 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 86,700 | +86,700 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 4,672 | 89,962 | +85,290 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 84,359 | +84,359 | 0.00 | 0.05 | +0.05 | buy |
| Trexquant Investment LP | 48,760 | 132,493 | +83,733 | 0.03 | 0.05 | +0.03 | buy |
| NORTHERN TRUST CORP | 239,621 | 322,225 | +82,604 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 400,000 | 479,682 | +79,682 | 0.10 | 0.09 | -0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 71,900 | +71,900 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 770,503 | 835,722 | +65,219 | 0.01 | 0.01 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 9,029 | 70,972 | +61,943 | 0.00 | 0.00 | +0.00 | buy |
| ORACLE INVESTMENT MANAGEMENT INC | 401,557 | 461,857 | +60,300 | 10.13 | 7.69 | -2.45 | buy |
| Corient Private Wealth LLC | 0 | 52,898 | +52,898 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 50,954 | +50,954 | 0.00 | 0.13 | +0.13 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 48,331 | +48,331 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 53,236 | 99,765 | +46,529 | 0.14 | 0.21 | +0.07 | buy |
| T. Rowe Price Investment Management, Inc. | 1,558,675 | 1,604,763 | +46,088 | 0.02 | 0.02 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 123,764 | 165,112 | +41,348 | 0.01 | 0.01 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 40,400 | +40,400 | 0.00 | 0.03 | +0.03 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,397 | 43,275 | +38,878 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 21,600 | 57,384 | +35,784 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 24,268 | 59,076 | +34,808 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 2,628 | 36,915 | +34,287 | 0.00 | 0.00 | +0.00 | buy |
| Legacy Capital Group California, Inc. | 0 | 33,832 | +33,832 | 0.00 | 0.26 | +0.26 | buy |
| Engineers Gate Manager LP | 0 | 33,036 | +33,036 | 0.00 | 0.02 | +0.02 | buy |
| AlphaQuest LLC | 0 | 26,887 | +26,887 | 0.00 | 0.10 | +0.10 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 26,856 | +26,856 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 121,095 | 147,265 | +26,170 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 129,610 | 154,504 | +24,894 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,318,897 | 1,342,115 | +23,218 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 10,937 | 33,887 | +22,950 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 22,044 | +22,044 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 78,410 | 99,850 | +21,440 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 7,876 | 28,779 | +20,903 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 20,760 | +20,760 | 0.00 | 0.02 | +0.02 | buy |
| Gotham Asset Management, LLC | 13,159 | 32,052 | +18,893 | 0.01 | 0.01 | +0.00 | buy |
| Orion Porfolio Solutions, LLC | 0 | 17,502 | +17,502 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 15,342 | +15,342 | 0.00 | 0.01 | +0.01 | buy |
| ASSETMARK, INC | 0 | 14,920 | +14,920 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 14,709 | +14,709 | 0.00 | 0.03 | +0.03 | buy |
| Entropy Technologies, LP | 0 | 13,512 | +13,512 | 0.00 | 0.03 | +0.03 | buy |
| STIFEL FINANCIAL CORP | 0 | 13,343 | +13,343 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 12,102 | +12,102 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 0 | 12,080 | +12,080 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 46,140 | 57,936 | +11,796 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 11,639 | +11,639 | 0.00 | 0.02 | +0.02 | buy |
| SECTORAL ASSET MANAGEMENT INC | 81,160 | 92,340 | +11,180 | 0.81 | 0.75 | -0.06 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 11,130 | +11,130 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 10,121 | +10,121 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 10,100 | +10,100 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 9,784 | +9,784 | 0.00 | 0.00 | +0.00 | buy |
| WOODSTOCK CORP | 22,253 | 30,778 | +8,525 | 0.06 | 0.07 | +0.01 | buy |
| BARCLAYS PLC | 159,642 | 165,687 | +6,045 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 5,949 | +5,949 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 4,085 | 9,393 | +5,308 | 0.02 | 0.02 | +0.01 | buy |
| MetLife Investment Management, LLC | 13,973 | 19,179 | +5,206 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 13,277 | 18,378 | +5,101 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 22,600 | 27,600 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| Janney Montgomery Scott LLC | 14,260 | 18,040 | +3,780 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 24,665 | 27,621 | +2,956 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 2,935 | +2,935 | 0.00 | 0.00 | +0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 147,541 | 149,819 | +2,278 | 0.67 | 0.61 | -0.06 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 74,421 | 76,539 | +2,118 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 2,068 | +2,068 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 50,000 | 51,500 | +1,500 | 0.46 | 0.26 | -0.20 | buy |
| Parallel Advisors, LLC | 0 | 1,395 | +1,395 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,583 | 3,719 | +1,136 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 0 | 1,127 | +1,127 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 467 | 1,171 | +704 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 30,007 | 30,690 | +683 | 0.00 | 0.00 | -0.00 | buy |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,446 | 1,974 | +528 | 0.00 | 0.00 | +0.00 | buy |
| First Horizon Advisors, Inc. | 0 | 368 | +368 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 316 | +316 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 11,511 | 11,779 | +268 | 0.08 | 0.09 | +0.00 | buy |
| WHITTIER TRUST CO OF NEVADA INC | 0 | 41 | +41 | 0.00 | 0.00 | +0.00 | buy |