| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 6,038,235 | 6,893,235 | +855,000 | 6.66 | 6.25 | -0.41 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,466,420 | 4,756,299 | +289,879 | 0.21 | 0.19 | -0.03 | buy |
| First Turn Management, LLC | 317,010 | 585,447 | +268,437 | 1.05 | 1.81 | +0.76 | buy |
| Candriam S.C.A. | 140,000 | 383,000 | +243,000 | 0.02 | 0.05 | +0.03 | buy |
| Woodline Partners LP | 400,000 | 479,682 | +79,682 | 0.10 | 0.09 | -0.01 | buy |
| ORACLE INVESTMENT MANAGEMENT INC | 401,557 | 461,857 | +60,300 | 5.64 | 6.34 | +0.70 | buy |
| Nicholas Investment Partners, LP | 53,236 | 99,765 | +46,529 | 0.14 | 0.21 | +0.07 | buy |
| T. Rowe Price Investment Management, Inc. | 1,558,675 | 1,604,763 | +46,088 | 0.02 | 0.02 | -0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 81,160 | 92,340 | +11,180 | 0.81 | 0.75 | -0.06 | buy |
| WOODSTOCK CORP | 22,253 | 30,778 | +8,525 | 0.06 | 0.07 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 4,085 | 9,393 | +5,308 | 0.02 | 0.02 | +0.01 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 147,541 | 149,819 | +2,278 | 0.67 | 0.61 | -0.06 | buy |
| Artia Global Partners LP | 50,000 | 51,500 | +1,500 | 0.46 | 0.26 | -0.20 | buy |
| Corton Capital Inc. | 11,511 | 11,779 | +268 | 0.08 | 0.09 | +0.00 | buy |
| BELLEVUE ASSET MANAGEMENT, LLC | 126 | 100 | -26 | 0.00 | 0.00 | -0.00 | sell |
| Washington Trust Advisors, Inc. | 332 | 264 | -68 | 0.00 | 0.00 | -0.00 | sell |
| Laurion Capital Management LP | 633,409 | 629,396 | -4,013 | 0.12 | 0.11 | -0.01 | sell |
| Alyeska Investment Group, L.P. | 186,840 | 147,837 | -39,003 | 0.03 | 0.02 | -0.01 | sell |
| Monashee Investment Management LLC | 175,000 | 100,000 | -75,000 | 0.71 | 0.24 | -0.47 | sell |
| LORD, ABBETT & CO. LLC | 370,987 | 242,580 | -128,407 | 0.03 | 0.02 | -0.01 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,056,847 | 3,763,888 | -292,959 | 4.24 | 2.89 | -1.35 | sell |
| Ikarian Capital, LLC | 368,130 | 1,047 | -367,083 | 2.33 | 0.01 | -2.32 | sell |
| Essex Woodlands Management, Inc. | 2,337,786 | 1,551,521 | -786,265 | 13.37 | 9.30 | -4.07 | sell |