| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 7,827,685 | 8,296,375 | +468,690 | 3.57 | 2.90 | -0.67 | buy |
| Cormorant Asset Management, LP | 8,265,000 | 8,265,000 | 0 | 8.56 | 5.37 | -3.19 | hold |
| BlackRock, Inc. | 6,787,872 | 7,177,337 | +389,465 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 6,017,433 | 5,669,589 | -347,844 | 0.18 | 0.12 | -0.06 | sell |
| FRANKLIN RESOURCES INC | 4,976,915 | 5,048,598 | +71,683 | 0.02 | 0.02 | -0.01 | buy |
| JANUS HENDERSON GROUP PLC | 2,937,729 | 3,601,168 | +663,439 | 0.02 | 0.02 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,700,000 | 3,300,000 | -1,400,000 | 0.13 | 0.07 | -0.06 | sell |
| Paradigm Biocapital Advisors LP | 3,691,475 | 3,142,437 | -549,038 | 1.81 | 0.83 | -0.98 | sell |
| Commodore Capital LP | 0 | 2,825,000 | +2,825,000 | 0.00 | 2.11 | +2.11 | buy |
| STATE STREET CORP | 1,834,850 | 2,097,202 | +262,352 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,899,367 | 1,983,665 | +84,298 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 1,905,875 | +1,905,875 | 0.00 | 0.02 | +0.02 | buy |
| Aberdeen Group plc | 1,605,984 | 1,738,378 | +132,394 | 0.05 | 0.04 | -0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 595,392 | 1,438,737 | +843,345 | 0.02 | 0.04 | +0.02 | buy |
| Parkman Healthcare Partners LLC | 1,088,033 | 1,354,800 | +266,767 | 1.89 | 1.81 | -0.08 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 1,245,583 | +1,245,583 | 0.00 | 0.27 | +0.27 | buy |
| MORGAN STANLEY | 223,699 | 1,096,109 | +872,410 | 0.00 | 0.00 | +0.00 | buy |
| Essex Woodlands Management, Inc. | 1,084,857 | 1,084,857 | 0 | 6.23 | 5.58 | -0.65 | hold |
| ORBIMED ADVISORS LLC | 2,468,314 | 1,069,147 | -1,399,167 | 0.92 | 0.30 | -0.62 | sell |
| 5AM Venture Management, LLC | 1,050,000 | 1,050,000 | 0 | 6.03 | 3.76 | -2.27 | hold |
| Rosalind Advisors, Inc. | 690,000 | 1,036,737 | +346,737 | 4.59 | 5.48 | +0.88 | buy |
| Blue Owl Capital Holdings LP | 392,594 | 912,594 | +520,000 | 2.21 | 3.16 | +0.95 | buy |
| HSBC HOLDINGS PLC | 0 | 833,455 | +833,455 | 0.00 | 0.01 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 353,849 | 810,764 | +456,915 | 1.11 | 2.01 | +0.90 | buy |
| Patient Square Capital LP | 780,000 | 795,000 | +15,000 | 3.05 | 1.82 | -1.23 | buy |
| Artia Global Partners LP | 767,098 | 767,098 | 0 | 2.25 | 2.23 | -0.02 | hold |
| Sio Capital Management, LLC | 0 | 721,785 | +721,785 | 0.00 | 1.34 | +1.34 | buy |
| GOLDMAN SACHS GROUP INC | 1,249,757 | 699,706 | -550,051 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 577,586 | 676,812 | +99,226 | 0.00 | 0.00 | -0.00 | buy |
| Candriam S.C.A. | 674,395 | 674,395 | 0 | 0.06 | 0.05 | -0.02 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 648,565 | 640,123 | -8,442 | 0.00 | 0.00 | -0.00 | sell |
| Principia Wealth Advisory, LLC | 530,725 | 633,764 | +103,039 | 6.06 | 4.62 | -1.44 | buy |
| Alyeska Investment Group, L.P. | 784,403 | 509,403 | -275,000 | 0.04 | 0.02 | -0.02 | sell |
| MILLENNIUM MANAGEMENT LLC | 556,469 | 475,190 | -81,279 | 0.01 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 544,077 | 458,102 | -85,975 | 0.11 | 0.06 | -0.05 | sell |
| TWO SIGMA INVESTMENTS, LP | 138,461 | 430,315 | +291,854 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 213,301 | 423,262 | +209,961 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 402,063 | 401,121 | -942 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 416,100 | 383,443 | -32,657 | 0.00 | 0.00 | -0.00 | sell |
| MYDA Advisors LLC | 300,000 | 330,000 | +30,000 | 1.54 | 1.00 | -0.54 | buy |
| Simplify Asset Management Inc. | 375,264 | 326,142 | -49,122 | 0.11 | 0.06 | -0.05 | sell |
| Bleichroeder LP | 316,515 | 316,515 | 0 | 1.02 | 0.71 | -0.31 | hold |
| Walleye Capital LLC | 0 | 300,184 | +300,184 | 0.00 | 0.02 | +0.02 | buy |
| Granahan Investment Management, LLC | 366,675 | 297,108 | -69,567 | 0.29 | 0.19 | -0.10 | sell |
| Nuveen, LLC | 181,256 | 260,276 | +79,020 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 188,199 | 258,942 | +70,743 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 258,739 | 258,739 | 0 | 0.24 | 0.20 | -0.05 | hold |
| Bank of New York Mellon Corp | 256,743 | 255,381 | -1,362 | 0.00 | 0.00 | -0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 246,279 | 245,359 | -920 | 0.01 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 226,770 | 239,062 | +12,292 | 0.00 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 168,382 | 218,550 | +50,168 | 0.00 | 0.00 | -0.00 | buy |
| Propel Bio Management, LLC | 0 | 215,825 | +215,825 | 0.00 | 1.76 | +1.76 | buy |
| Schonfeld Strategic Advisors LLC | 661,452 | 207,120 | -454,332 | 0.06 | 0.02 | -0.04 | sell |
| Jump Financial, LLC | 0 | 198,400 | +198,400 | 0.00 | 0.04 | +0.04 | buy |
| HighVista Strategies LLC | 0 | 183,037 | +183,037 | 0.00 | 0.65 | +0.65 | buy |
| DIADEMA PARTNERS LP | 0 | 178,545 | +178,545 | 0.00 | 0.95 | +0.95 | buy |
| MARSHALL WACE, LLP | 0 | 161,784 | +161,784 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,175 | 149,861 | +148,686 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 147,400 | +147,400 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 74,944 | 139,375 | +64,431 | 0.02 | 0.03 | +0.01 | buy |
| PANAGORA ASSET MANAGEMENT INC | 132,214 | 132,214 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Invesco Ltd. | 339,004 | 131,941 | -207,063 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 188,651 | 129,455 | -59,196 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 19,168 | 129,438 | +110,270 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 127,489 | 127,502 | +13 | 0.00 | 0.00 | -0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 124,956 | 127,213 | +2,257 | 0.35 | 0.26 | -0.09 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 60,317 | 126,705 | +66,388 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 61,600 | 117,300 | +55,700 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 116,477 | +116,477 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 92,570 | 106,138 | +13,568 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,654 | 105,101 | +100,447 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 100,463 | 100,463 | 0 | 0.01 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 89,045 | 96,677 | +7,632 | 0.00 | 0.00 | -0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 94,500 | +94,500 | 0.00 | 0.04 | +0.04 | buy |
| Squarepoint Ops LLC | 0 | 80,119 | +80,119 | 0.00 | 0.00 | +0.00 | buy |
| Waverly Advisors, LLC | 78,063 | 77,914 | -149 | 0.01 | 0.01 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 75,090 | 75,336 | +246 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 5,968 | 71,631 | +65,663 | 0.00 | 0.00 | +0.00 | buy |
| WOODSTOCK CORP | 68,465 | 68,465 | 0 | 0.11 | 0.08 | -0.03 | hold |
| XTX Topco Ltd | 0 | 66,646 | +66,646 | 0.00 | 0.01 | +0.01 | buy |
| Persistent Asset Partners Ltd | 5,387 | 58,995 | +53,608 | 0.05 | 0.30 | +0.25 | buy |
| Marex Group plc | 47,777 | 56,313 | +8,536 | 0.01 | 0.01 | -0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 56,300 | +56,300 | 0.00 | 0.08 | +0.08 | buy |
| Legal & General Group Plc | 6,739 | 53,117 | +46,378 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 28,820 | 50,506 | +21,686 | 0.00 | 0.00 | +0.00 | buy |
| SILVERBACK ASSET MANAGEMENT LLC | 0 | 50,000 | +50,000 | 0.00 | 0.13 | +0.13 | buy |
| Erste Asset Management GmbH | 50,000 | 50,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 47,941 | 47,771 | -170 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 42,655 | 44,472 | +1,817 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 41,799 | 43,469 | +1,670 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 43,086 | 42,523 | -563 | 0.00 | 0.00 | -0.00 | sell |
| SCOTIA CAPITAL INC. | 31,589 | 41,751 | +10,162 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 37,189 | 40,112 | +2,923 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 0 | 40,000 | +40,000 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 29,490 | 39,691 | +10,201 | 0.04 | 0.04 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 137,555 | 37,681 | -99,874 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 36,929 | +36,929 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 35,106 | 36,326 | +1,220 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 22,775 | 36,072 | +13,297 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 31,218 | 33,080 | +1,862 | 0.00 | 0.00 | -0.00 | buy |