| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 6,893,235 | 8,325,000 | +1,431,765 | 6.25 | 4.18 | -2.07 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,763,888 | 5,175,823 | +1,411,935 | 2.89 | 1.65 | -1.24 | buy |
| T. Rowe Price Investment Management, Inc. | 1,604,763 | 2,071,563 | +466,800 | 0.02 | 0.01 | -0.01 | buy |
| Laurion Capital Management LP | 629,396 | 1,072,577 | +443,181 | 0.11 | 0.11 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 579,594 | 877,790 | +298,196 | 0.21 | 0.13 | -0.08 | buy |
| PFM Health Sciences, LP | 170,871 | 292,926 | +122,055 | 0.17 | 0.13 | -0.04 | buy |
| Alyeska Investment Group, L.P. | 147,837 | 251,348 | +103,511 | 0.02 | 0.01 | -0.01 | buy |
| Finepoint Capital LP | 656,600 | 707,404 | +50,804 | 3.48 | 1.75 | -1.73 | buy |
| PERCEPTIVE ADVISORS LLC | 589,646 | 640,274 | +50,628 | 0.21 | 0.13 | -0.08 | buy |
| Artia Global Partners LP | 51,500 | 101,500 | +50,000 | 0.26 | 0.23 | -0.03 | buy |
| Dynamic Technology Lab Private Ltd | 14,709 | 53,188 | +38,479 | 0.03 | 0.05 | +0.02 | buy |
| Corton Capital Inc. | 11,779 | 49,905 | +38,126 | 0.09 | 0.23 | +0.14 | buy |
| WOODSTOCK CORP | 30,778 | 55,387 | +24,609 | 0.07 | 0.05 | -0.02 | buy |
| Fiera Capital Corp | 671,118 | 677,038 | +5,920 | 0.04 | 0.02 | -0.02 | buy |
| Entropy Technologies, LP | 13,512 | 17,560 | +4,048 | 0.03 | 0.02 | -0.01 | buy |
| China Universal Asset Management Co., Ltd. | 9,393 | 6,121 | -3,272 | 0.02 | 0.01 | -0.02 | sell |
| MYDA Advisors LLC | 115,000 | 100,000 | -15,000 | 0.68 | 0.19 | -0.49 | sell |
| Atom Investors LP | 50,954 | 25,499 | -25,455 | 0.13 | 0.02 | -0.11 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 149,819 | 42,538 | -107,281 | 0.61 | 0.07 | -0.54 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 247,968 | 100,000 | -147,968 | 1.44 | 0.21 | -1.22 | sell |
| ORACLE INVESTMENT MANAGEMENT INC | 461,857 | 231,857 | -230,000 | 6.34 | 1.88 | -4.46 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,756,299 | 3,591,420 | -1,164,879 | 0.19 | 0.06 | -0.13 | sell |