| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 6,893,235 | 8,325,000 | +1,431,765 | 6.28 | 4.21 | -2.07 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,763,888 | 5,175,823 | +1,411,935 | 3.28 | 1.84 | -1.44 | buy |
| TCG Crossover Management, LLC | 0 | 922,335 | +922,335 | 0.00 | 0.84 | +0.84 | buy |
| MORGAN STANLEY | 1,342,115 | 2,252,797 | +910,682 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 630,769 | +630,769 | 0.00 | 0.02 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 104,890 | 600,402 | +495,512 | 0.01 | 0.01 | +0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 1,604,763 | 2,071,563 | +466,800 | 0.02 | 0.01 | -0.01 | buy |
| Laurion Capital Management LP | 629,396 | 1,072,577 | +443,181 | 0.36 | 0.30 | -0.06 | buy |
| Cubist Systematic Strategies, LLC | 50,533 | 476,250 | +425,717 | 0.01 | 0.07 | +0.06 | buy |
| VANGUARD GROUP INC | 2,396,228 | 2,774,454 | +378,226 | 0.00 | 0.00 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 579,594 | 877,790 | +298,196 | 0.21 | 0.13 | -0.08 | buy |
| FRANKLIN RESOURCES INC | 3,389,237 | 3,649,649 | +260,412 | 0.02 | 0.01 | -0.01 | buy |
| AMERIPRISE FINANCIAL INC | 673,348 | 921,919 | +248,571 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 49,077 | 269,885 | +220,808 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 0 | 201,332 | +201,332 | 0.00 | 0.07 | +0.07 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 832,637 | 1,032,357 | +199,720 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 1,032,572 | 1,219,729 | +187,157 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 186,958 | 373,974 | +187,016 | 0.04 | 0.03 | -0.01 | buy |
| TWO SIGMA ADVISERS, LP | 11,400 | 176,300 | +164,900 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 170,871 | 292,926 | +122,055 | 0.18 | 0.14 | -0.04 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 116,195 | +116,195 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 175,404 | 288,035 | +112,631 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 5,949 | 115,037 | +109,088 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 107,756 | +107,756 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 147,837 | 251,348 | +103,511 | 0.02 | 0.01 | -0.01 | buy |
| Jump Financial, LLC | 0 | 102,422 | +102,422 | 0.00 | 0.02 | +0.02 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 101,772 | +101,772 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 57,384 | 139,526 | +82,142 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 39,520 | 120,721 | +81,201 | 0.00 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 71,900 | 152,800 | +80,900 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 0 | 76,288 | +76,288 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 52,898 | 127,579 | +74,681 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 10,100 | 79,246 | +69,146 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 58,291 | +58,291 | 0.00 | 0.24 | +0.24 | buy |
| Finepoint Capital LP | 656,600 | 707,404 | +50,804 | 3.48 | 1.75 | -1.73 | buy |
| PERCEPTIVE ADVISORS LLC | 589,646 | 640,274 | +50,628 | 0.21 | 0.13 | -0.08 | buy |
| Bank of New York Mellon Corp | 154,504 | 204,892 | +50,388 | 0.00 | 0.00 | -0.00 | buy |
| 5AM Venture Management, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.10 | +0.10 | buy |
| Artia Global Partners LP | 51,500 | 101,500 | +50,000 | 0.26 | 0.23 | -0.03 | buy |
| D. E. Shaw & Co., Inc. | 0 | 48,959 | +48,959 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 14,709 | 53,188 | +38,479 | 0.03 | 0.05 | +0.02 | buy |
| Corton Capital Inc. | 11,779 | 49,905 | +38,126 | 0.09 | 0.23 | +0.14 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 37,838 | +37,838 | 0.00 | 0.41 | +0.41 | buy |
| Trexquant Investment LP | 132,493 | 169,305 | +36,812 | 0.05 | 0.02 | -0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,465,815 | 2,502,371 | +36,556 | 0.01 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 99,850 | 134,796 | +34,946 | 0.00 | 0.00 | -0.00 | buy |
| WOODSTOCK CORP | 30,778 | 55,387 | +24,609 | 0.07 | 0.05 | -0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 27,600 | 51,760 | +24,160 | 0.00 | 0.00 | -0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 19,800 | +19,800 | 0.00 | 0.03 | +0.03 | buy |
| LMR Partners LLP | 0 | 19,785 | +19,785 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 57,936 | 76,833 | +18,897 | 0.00 | 0.00 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 14,363 | +14,363 | 0.00 | 0.01 | +0.01 | buy |
| Brevan Howard Capital Management LP | 0 | 13,561 | +13,561 | 0.00 | 0.01 | +0.01 | buy |
| Alpine Global Management, LLC | 0 | 13,471 | +13,471 | 0.00 | 0.02 | +0.02 | buy |
| SCOTIA CAPITAL INC. | 0 | 12,421 | +12,421 | 0.00 | 0.00 | +0.00 | buy |
| Greenwich Wealth Management LLC | 0 | 10,800 | +10,800 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 19,179 | 29,285 | +10,106 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,935 | 10,888 | +7,953 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 14,920 | 22,038 | +7,118 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 28,779 | 35,502 | +6,723 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 86,700 | 93,100 | +6,400 | 0.00 | 0.00 | -0.00 | buy |
| Fiera Capital Corp | 671,118 | 677,038 | +5,920 | 0.04 | 0.02 | -0.02 | buy |
| WELLS FARGO & COMPANY/MN | 70,972 | 75,303 | +4,331 | 0.00 | 0.00 | -0.00 | buy |
| Entropy Technologies, LP | 13,512 | 17,560 | +4,048 | 0.03 | 0.02 | -0.01 | buy |
| Legal & General Group Plc | 36,915 | 40,279 | +3,364 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 43,275 | 46,374 | +3,099 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 33,887 | 36,527 | +2,640 | 0.00 | 0.00 | -0.00 | buy |
| HighTower Advisors, LLC | 30,690 | 32,690 | +2,000 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,826 | 4,564 | +1,738 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 1,555 | +1,555 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,719 | 4,898 | +1,179 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 12,080 | 13,251 | +1,171 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 3,559 | 4,608 | +1,049 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 20 | 1,067 | +1,047 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 48,331 | 49,301 | +970 | 0.00 | 0.00 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 9,784 | 10,386 | +602 | 0.00 | 0.00 | -0.00 | buy |
| Clearstead Advisors, LLC | 0 | 235 | +235 | 0.00 | 0.00 | +0.00 | buy |
| Ashton Thomas Private Wealth, LLC | 0 | 151 | +151 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 263,335 | 263,483 | +148 | 0.02 | 0.01 | -0.01 | buy |
| Quarry LP | 0 | 139 | +139 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 7,980 | 8,109 | +129 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 13,343 | 13,388 | +45 | 0.00 | 0.00 | -0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 65 | 107 | +42 | 0.00 | 0.00 | -0.00 | buy |
| INNEALTA CAPITAL, LLC | 0 | 36 | +36 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 5 | 20 | +15 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WHITTIER TRUST CO OF NEVADA INC | 41 | 41 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 35,000 | 35,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 144 | 144 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Skandinaviska Enskilda Banken AB (publ) | 282,814 | 282,814 | 0 | 0.03 | 0.01 | -0.02 | hold |
| Candriam S.C.A. | 383,000 | 383,000 | 0 | 0.05 | 0.02 | -0.03 | hold |
| Essex Woodlands Management, Inc. | 1,551,521 | 1,551,521 | 0 | 9.30 | 4.40 | -4.90 | hold |
| First Horizon Advisors, Inc. | 368 | 368 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 2,068 | 2,068 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Parallel Advisors, LLC | 1,395 | 1,395 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cedar Mountain Advisors, LLC | 1,000 | 1,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Octagon Capital Advisors LP | 1,093,503 | 1,093,503 | 0 | 2.75 | 1.57 | -1.18 | hold |
| Continuum Advisory, LLC | 16 | 16 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Washington Trust Advisors, Inc. | 264 | 264 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Covestor Ltd | 4 | 4 | 0 | 0.00 | 0.00 | 0.00 | hold |