| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 8,325,000 | 8,325,000 | 0 | 3.42 | 5.84 | +2.42 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 6,804,091 | 6,804,091 | 0 | 1.49 | 2.41 | +0.92 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 6,200,000 | 6,800,000 | +600,000 | 0.06 | 0.11 | +0.05 | buy |
| BlackRock, Inc. | 5,722,045 | 5,360,214 | -361,831 | 0.00 | 0.00 | +0.00 | sell |
| FEDERATED HERMES, INC. | 4,085,580 | 4,599,450 | +513,870 | 0.05 | 0.08 | +0.03 | buy |
| FRANKLIN RESOURCES INC | 4,149,861 | 4,301,123 | +151,262 | 0.01 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 3,834,368 | 3,802,646 | -31,722 | 0.00 | 0.00 | +0.00 | sell |
| TCG Crossover Management, LLC | 3,572,335 | 3,572,335 | 0 | 2.64 | 3.84 | +1.20 | hold |
| CITADEL ADVISORS LLC | 2,286,089 | 2,344,210 | +58,121 | 0.01 | 0.02 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,593,030 | 1,592,048 | -982 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 1,593,211 | 1,515,549 | -77,662 | 0.00 | 0.00 | +0.00 | sell |
| Patient Square Capital LP | 1,481,977 | 1,352,837 | -129,140 | 3.32 | 4.59 | +1.27 | sell |
| GOLDMAN SACHS GROUP INC | 1,531,556 | 1,280,692 | -250,864 | 0.00 | 0.00 | +0.00 | sell |
| Essex Woodlands Management, Inc. | 1,169,857 | 1,169,857 | 0 | 1.83 | 3.94 | +2.11 | hold |
| 5AM Venture Management, LLC | 1,050,000 | 1,050,000 | 0 | 2.15 | 3.80 | +1.65 | hold |
| Aberdeen Group plc | 230,745 | 1,031,201 | +800,456 | 0.00 | 0.02 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 750,212 | 814,153 | +63,941 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 864,111 | 782,642 | -81,469 | 0.00 | 0.00 | +0.00 | sell |
| HSBC HOLDINGS PLC | 625,140 | 631,074 | +5,934 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 593,091 | 593,091 | 0 | 0.27 | 0.39 | +0.13 | hold |
| Blue Owl Capital Holdings LP | 797,594 | 562,594 | -235,000 | 1.39 | 1.71 | +0.31 | sell |
| Principia Wealth Advisory, LLC | 533,778 | 533,778 | 0 | 2.35 | 4.27 | +1.91 | hold |
| NORTHERN TRUST CORP | 629,879 | 515,613 | -114,266 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 357,442 | 512,113 | +154,671 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 500,335 | 500,335 | 0 | 0.02 | 0.02 | +0.01 | hold |
| FMR LLC | 442,992 | 446,305 | +3,313 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 323,860 | 376,776 | +52,916 | 0.00 | 0.01 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 351,348 | 351,348 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Granahan Investment Management, LLC | 0 | 340,984 | +340,984 | 0.00 | 0.13 | +0.13 | buy |
| STEMPOINT CAPITAL LP | 0 | 329,254 | +329,254 | 0.00 | 1.00 | +1.00 | buy |
| Artia Global Partners LP | 316,700 | 316,700 | 0 | 0.50 | 0.77 | +0.26 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 257,985 | 313,979 | +55,994 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 148,049 | 281,115 | +133,066 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 233,231 | 265,109 | +31,878 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 262,809 | 263,233 | +424 | 0.00 | 0.01 | +0.00 | buy |
| Bleichroeder LP | 0 | 256,515 | +256,515 | 0.00 | 0.59 | +0.59 | buy |
| MYDA Advisors LLC | 180,000 | 250,000 | +70,000 | 0.35 | 0.66 | +0.31 | buy |
| JPMORGAN CHASE & CO | 395,345 | 247,412 | -147,933 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 0 | 225,964 | +225,964 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 202,954 | 207,702 | +4,748 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 33,206 | 199,449 | +166,243 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 191,144 | 189,878 | -1,266 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 88,780 | 172,446 | +83,666 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 43,740 | 137,950 | +94,210 | 0.01 | 0.05 | +0.04 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 206,605 | 132,764 | -73,841 | 0.02 | 0.03 | +0.01 | sell |
| Invesco Ltd. | 42,948 | 128,772 | +85,824 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 271,611 | 128,538 | -143,073 | 0.00 | 0.00 | -0.00 | sell |
| Corient Private Wealth LLC | 0 | 127,489 | +127,489 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 387,079 | 126,160 | -260,919 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 73,097 | 125,623 | +52,526 | 0.00 | 0.00 | +0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 124,583 | 123,691 | -892 | 0.14 | 0.21 | +0.07 | sell |
| BARCLAYS PLC | 99,025 | 123,307 | +24,282 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 119,566 | +119,566 | 0.00 | 0.10 | +0.10 | buy |
| PANAGORA ASSET MANAGEMENT INC | 116,099 | 116,099 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nuveen, LLC | 194,897 | 113,730 | -81,167 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 0 | 99,764 | +99,764 | 0.00 | 0.07 | +0.07 | buy |
| RHUMBLINE ADVISERS | 86,732 | 96,280 | +9,548 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 95,613 | +95,613 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 94,250 | 94,075 | -175 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,354,014 | 83,709 | -1,270,305 | 0.00 | 0.00 | -0.00 | sell |
| Simplify Asset Management Inc. | 88,155 | 79,472 | -8,683 | 0.02 | 0.05 | +0.02 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 21,923 | 78,647 | +56,724 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 14,509 | 72,682 | +58,173 | 0.00 | 0.00 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 71,515 | 71,515 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 22,717 | 69,962 | +47,245 | 0.00 | 0.00 | +0.00 | buy |
| WOODSTOCK CORP | 71,480 | 68,465 | -3,015 | 0.04 | 0.06 | +0.02 | sell |
| AMERICAN CENTURY COMPANIES INC | 42,860 | 67,612 | +24,752 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 60,400 | 65,568 | +5,168 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 61,194 | +61,194 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 50,890 | 58,590 | +7,700 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 50,000 | 50,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Squarepoint Ops LLC | 19,072 | 48,422 | +29,350 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 34,324 | 45,225 | +10,901 | 0.09 | 0.21 | +0.13 | buy |
| MetLife Investment Management, LLC | 39,718 | 39,718 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MILLENNIUM MANAGEMENT LLC | 30,800 | 38,149 | +7,349 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 117,300 | 37,000 | -80,300 | 0.00 | 0.00 | -0.00 | sell |
| Waverly Advisors, LLC | 36,632 | 36,704 | +72 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 36,353 | 36,353 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 35,000 | 35,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 38,660 | 33,962 | -4,698 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 30,100 | 33,200 | +3,100 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 32,567 | 32,567 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SCOTIA CAPITAL INC. | 31,589 | 31,589 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 22,928 | 22,575 | -353 | 0.00 | 0.00 | +0.00 | sell |
| LEVIN CAPITAL STRATEGIES, L.P. | 43,000 | 19,000 | -24,000 | 0.02 | 0.02 | -0.01 | sell |
| Creative Planning | 20,895 | 18,554 | -2,341 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 15,720 | +15,720 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 15,404 | 15,404 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ProShare Advisors LLC | 17,229 | 15,282 | -1,947 | 0.00 | 0.00 | +0.00 | sell |
| Cyndeo Wealth Partners, LLC | 25,250 | 14,250 | -11,000 | 0.01 | 0.01 | -0.00 | sell |
| INCEPTIONR LLC | 0 | 13,873 | +13,873 | 0.00 | 0.03 | +0.03 | buy |
| China Universal Asset Management Co., Ltd. | 13,690 | 13,821 | +131 | 0.01 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 0 | 13,340 | +13,340 | 0.00 | 0.00 | +0.00 | buy |
| Janney Montgomery Scott LLC | 0 | 12,094 | +12,094 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 17,031 | 11,946 | -5,085 | 0.31 | 0.13 | -0.17 | sell |
| RAYMOND JAMES FINANCIAL INC | 10,723 | 11,900 | +1,177 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 11,450 | 11,450 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Brooklyn Investment Group | 0 | 11,084 | +11,084 | 0.00 | 0.01 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 20,674 | 10,613 | -10,061 | 0.03 | 0.03 | +0.00 | sell |
| R Squared Ltd | 0 | 10,611 | +10,611 | 0.00 | 0.06 | +0.06 | buy |