| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 8,296,375 | 8,296,375 | 0 | 2.90 | 2.49 | -0.41 | hold |
| BlackRock, Inc. | 7,177,337 | 7,463,197 | +285,860 | 0.00 | 0.00 | -0.00 | buy |
| Cormorant Asset Management, LP | 8,265,000 | 7,000,000 | -1,265,000 | 5.37 | 5.13 | -0.24 | sell |
| FEDERATED HERMES, INC. | 5,669,589 | 5,681,052 | +11,463 | 0.12 | 0.12 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,300,000 | 4,827,792 | +1,527,792 | 0.07 | 0.10 | +0.03 | buy |
| FRANKLIN RESOURCES INC | 5,048,598 | 4,807,078 | -241,520 | 0.02 | 0.01 | -0.00 | sell |
| Commodore Capital LP | 2,825,000 | 4,600,000 | +1,775,000 | 2.11 | 3.92 | +1.81 | buy |
| Paradigm Biocapital Advisors LP | 3,142,437 | 2,890,397 | -252,040 | 0.83 | 0.77 | -0.05 | sell |
| STATE STREET CORP | 2,097,202 | 2,357,545 | +260,343 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,983,665 | 2,062,390 | +78,725 | 0.00 | 0.00 | -0.00 | buy |
| Aberdeen Group plc | 1,738,378 | 2,008,802 | +270,424 | 0.04 | 0.04 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,905,875 | 1,977,610 | +71,735 | 0.02 | 0.02 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,438,737 | 1,812,358 | +373,621 | 0.04 | 0.05 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 1,354,800 | 1,288,163 | -66,637 | 1.81 | 1.89 | +0.08 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,245,583 | 1,245,583 | 0 | 0.27 | 0.24 | -0.03 | hold |
| TWO SIGMA INVESTMENTS, LP | 430,315 | 1,181,143 | +750,828 | 0.00 | 0.01 | +0.01 | buy |
| Essex Woodlands Management, Inc. | 1,084,857 | 1,084,857 | 0 | 5.58 | 6.10 | +0.52 | hold |
| ORBIMED ADVISORS LLC | 1,069,147 | 1,069,147 | 0 | 0.30 | 0.29 | -0.01 | hold |
| 5AM Venture Management, LLC | 1,050,000 | 1,050,000 | 0 | 3.76 | 5.22 | +1.46 | hold |
| Rosalind Advisors, Inc. | 1,036,737 | 988,230 | -48,507 | 5.48 | 5.31 | -0.17 | sell |
| AMERIPRISE FINANCIAL INC | 423,262 | 848,410 | +425,148 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 401,121 | 841,746 | +440,625 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 833,455 | 833,455 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Candriam S.C.A. | 674,395 | 787,769 | +113,374 | 0.05 | 0.05 | +0.01 | buy |
| Artia Global Partners LP | 767,098 | 767,098 | 0 | 2.23 | 2.09 | -0.14 | hold |
| Blue Owl Capital Holdings LP | 912,594 | 762,594 | -150,000 | 3.16 | 1.66 | -1.50 | sell |
| NORTHERN TRUST CORP | 676,812 | 720,917 | +44,105 | 0.00 | 0.00 | +0.00 | buy |
| Patient Square Capital LP | 795,000 | 720,000 | -75,000 | 1.82 | 1.59 | -0.22 | sell |
| Principia Wealth Advisory, LLC | 633,764 | 649,944 | +16,180 | 4.62 | 4.65 | +0.02 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 647,613 | +647,613 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 640,123 | 647,613 | +7,490 | 0.00 | 0.00 | -0.00 | buy |
| Sio Capital Management, LLC | 721,785 | 623,130 | -98,655 | 1.34 | 1.53 | +0.19 | sell |
| Alyeska Investment Group, L.P. | 509,403 | 509,403 | 0 | 0.02 | 0.02 | +0.00 | hold |
| MILLENNIUM MANAGEMENT LLC | 475,190 | 500,093 | +24,903 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 699,706 | 465,087 | -234,619 | 0.00 | 0.00 | -0.00 | sell |
| Simplify Asset Management Inc. | 326,142 | 400,044 | +73,902 | 0.06 | 0.08 | +0.02 | buy |
| Ghisallo Capital Management LLC | 0 | 350,000 | +350,000 | 0.00 | 0.10 | +0.10 | buy |
| STEMPOINT CAPITAL LP | 810,764 | 338,471 | -472,293 | 2.01 | 0.84 | -1.17 | sell |
| MORGAN STANLEY | 1,096,109 | 336,730 | -759,379 | 0.00 | 0.00 | -0.00 | sell |
| E Fund Management Co., Ltd. | 94,500 | 330,774 | +236,274 | 0.04 | 0.11 | +0.07 | buy |
| Jump Financial, LLC | 198,400 | 320,757 | +122,357 | 0.04 | 0.04 | +0.00 | buy |
| Bleichroeder LP | 316,515 | 316,515 | 0 | 0.71 | 0.81 | +0.10 | hold |
| Woodline Partners LP | 100,463 | 300,463 | +200,000 | 0.00 | 0.01 | +0.01 | buy |
| Eversept Partners, LP | 0 | 297,735 | +297,735 | 0.00 | 0.23 | +0.23 | buy |
| Rock Springs Capital Management LP | 258,739 | 268,519 | +9,780 | 0.20 | 0.19 | -0.01 | buy |
| CITIGROUP INC | 28,882 | 266,910 | +238,028 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 255,381 | 250,783 | -4,598 | 0.00 | 0.00 | -0.00 | sell |
| MYDA Advisors LLC | 330,000 | 250,000 | -80,000 | 1.00 | 0.87 | -0.13 | sell |
| UBS Group AG | 129,455 | 241,363 | +111,908 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 245,359 | 234,809 | -10,550 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 207,120 | 229,780 | +22,660 | 0.02 | 0.02 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 258,942 | 228,559 | -30,383 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 260,276 | 193,480 | -66,796 | 0.00 | 0.00 | -0.00 | sell |
| Propel Bio Management, LLC | 215,825 | 191,745 | -24,080 | 1.76 | 1.43 | -0.32 | sell |
| Qube Research & Technologies Ltd | 116,477 | 189,102 | +72,625 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 300,184 | 188,221 | -111,963 | 0.02 | 0.01 | -0.01 | sell |
| Susquehanna Portfolio Strategies, LLC | 139,375 | 187,801 | +48,426 | 0.03 | 0.04 | +0.02 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 218,550 | 169,334 | -49,216 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 183,037 | 155,704 | -27,333 | 0.65 | 0.51 | -0.14 | sell |
| DEUTSCHE BANK AG\ | 239,062 | 152,799 | -86,263 | 0.00 | 0.00 | -0.00 | sell |
| Granahan Investment Management, LLC | 297,108 | 149,387 | -147,721 | 0.19 | 0.08 | -0.11 | sell |
| Swiss National Bank | 147,400 | 142,300 | -5,100 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 126,705 | 139,770 | +13,065 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 149,861 | 135,340 | -14,521 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 132,214 | 132,214 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Corient Private Wealth LLC | 127,502 | 127,199 | -303 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 106,138 | 124,989 | +18,851 | 0.00 | 0.00 | +0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 127,213 | 121,684 | -5,529 | 0.26 | 0.23 | -0.03 | sell |
| Invesco Ltd. | 131,941 | 116,204 | -15,737 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 71,631 | 110,017 | +38,386 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 105,101 | 102,640 | -2,461 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 80,119 | 98,002 | +17,883 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 96,677 | 97,437 | +760 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 0 | 88,802 | +88,802 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 78,990 | +78,990 | 0.00 | 0.01 | +0.01 | buy |
| Waverly Advisors, LLC | 77,914 | 77,914 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 75,336 | 75,336 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cinctive Capital Management LP | 27,861 | 72,582 | +44,721 | 0.02 | 0.04 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 29,292 | 70,739 | +41,447 | 0.00 | 0.00 | +0.00 | buy |
| WOODSTOCK CORP | 68,465 | 68,465 | 0 | 0.08 | 0.08 | +0.00 | hold |
| BANK OF AMERICA CORP /DE/ | 383,443 | 65,048 | -318,395 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 36,929 | 62,939 | +26,010 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 21,648 | 60,539 | +38,891 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 53,117 | 59,220 | +6,103 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 58,528 | +58,528 | 0.00 | 0.14 | +0.14 | buy |
| HRT FINANCIAL LP | 0 | 57,212 | +57,212 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 51,190 | +51,190 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 47,771 | 50,089 | +2,318 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 40,112 | 50,053 | +9,941 | 0.00 | 0.00 | +0.00 | buy |
| SILVERBACK ASSET MANAGEMENT LLC | 50,000 | 50,000 | 0 | 0.13 | 0.09 | -0.04 | hold |
| Erste Asset Management GmbH | 50,000 | 50,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Point72 Asset Management, L.P. | 0 | 48,574 | +48,574 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 26,159 | 43,948 | +17,789 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 43,469 | 43,469 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SCOTIA CAPITAL INC. | 41,751 | 41,751 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Marex Group plc | 56,313 | 41,300 | -15,013 | 0.01 | 0.00 | -0.00 | sell |
| Magnetar Financial LLC | 0 | 39,737 | +39,737 | 0.00 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 39,691 | 38,343 | -1,348 | 0.04 | 0.03 | -0.01 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 36,326 | 35,635 | -691 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 36,072 | 35,134 | -938 | 0.00 | 0.00 | -0.00 | sell |