| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FEDERATED HERMES, INC. | 290,212 | 1,923,680 | +1,633,468 | 0.01 | 0.03 | +0.03 | buy |
| Patient Square Capital LP | 0 | 1,361,979 | +1,361,979 | 0.00 | 4.04 | +4.04 | buy |
| 5AM Venture Management, LLC | 50,000 | 1,050,000 | +1,000,000 | 0.10 | 1.73 | +1.64 | buy |
| GOLDMAN SACHS GROUP INC | 791,508 | 1,215,328 | +423,820 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 400,000 | +400,000 | 0.00 | 0.03 | +0.03 | buy |
| PERCEPTIVE ADVISORS LLC | 640,274 | 1,037,274 | +397,000 | 0.13 | 0.18 | +0.04 | buy |
| JPMORGAN CHASE & CO | 0 | 371,758 | +371,758 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 3,649,649 | 4,012,048 | +362,399 | 0.01 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 2,774,454 | 3,048,182 | +273,728 | 0.00 | 0.00 | -0.00 | buy |
| Granahan Investment Management, LLC | 201,332 | 458,411 | +257,079 | 0.07 | 0.14 | +0.07 | buy |
| HSBC HOLDINGS PLC | 0 | 253,986 | +253,986 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 288,035 | 502,965 | +214,930 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 189,903 | 401,159 | +211,256 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,591,420 | 3,791,420 | +200,000 | 0.06 | 0.05 | -0.00 | buy |
| BARCLAYS PLC | 48,012 | 245,045 | +197,033 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,032,357 | 1,199,056 | +166,699 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 319,998 | 471,783 | +151,785 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 125,890 | +125,890 | 0.00 | 0.11 | +0.11 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 42,538 | 142,144 | +99,606 | 0.07 | 0.20 | +0.13 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 107,756 | 171,764 | +64,008 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 101,500 | 156,300 | +54,800 | 0.23 | 0.35 | +0.13 | buy |
| CITADEL ADVISORS LLC | 1,354,532 | 1,407,353 | +52,821 | 0.01 | 0.01 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 48,959 | 96,796 | +47,837 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 152,800 | 187,437 | +34,637 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 20,646 | 46,509 | +25,863 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 14,363 | 32,979 | +18,616 | 0.01 | 0.02 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 16,968 | +16,968 | 0.00 | 0.00 | +0.00 | buy |
| WOODSTOCK CORP | 55,387 | 71,480 | +16,093 | 0.05 | 0.05 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 633,519 | 647,848 | +14,329 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 0 | 12,698 | +12,698 | 0.00 | 0.00 | +0.00 | buy |
| Cyndeo Wealth Partners, LLC | 0 | 12,540 | +12,540 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 0 | 11,468 | +11,468 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 11,209 | +11,209 | 0.00 | 0.00 | +0.00 | buy |
| LEVIN CAPITAL STRATEGIES, L.P. | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 15,600 | 24,000 | +8,400 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 134,796 | 142,763 | +7,967 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 19,524 | 27,429 | +7,905 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 4,564 | 9,822 | +5,258 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 0 | 4,214 | +4,214 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 6,121 | 10,293 | +4,172 | 0.01 | 0.01 | +0.00 | buy |
| Swiss National Bank | 93,100 | 96,600 | +3,500 | 0.00 | 0.00 | -0.00 | buy |
| Corient Private Wealth LLC | 127,579 | 130,662 | +3,083 | 0.00 | 0.00 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 10,386 | 12,410 | +2,024 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 1,864 | +1,864 | 0.00 | 0.00 | +0.00 | buy |
| TOTH FINANCIAL ADVISORY CORP | 0 | 1,001 | +1,001 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 13,251 | 14,247 | +996 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 10,514 | 11,445 | +931 | 0.00 | 0.00 | -0.00 | buy |
| Greenwich Wealth Management LLC | 10,800 | 11,700 | +900 | 0.01 | 0.01 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 46,374 | 46,817 | +443 | 0.00 | 0.00 | -0.00 | buy |
| HighTower Advisors, LLC | 32,690 | 33,104 | +414 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,555 | 1,936 | +381 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 76,833 | 77,117 | +284 | 0.00 | 0.00 | -0.00 | buy |
| Truvestments Capital LLC | 0 | 258 | +258 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 25 | 159 | +134 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 12,793 | 12,909 | +116 | 0.00 | 0.00 | -0.00 | buy |
| BESSEMER GROUP INC | 0 | 90 | +90 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 263,483 | 263,558 | +75 | 0.01 | 0.01 | -0.00 | buy |
| GAMMA Investing LLC | 35 | 106 | +71 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 33 | +33 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 20 | 45 | +25 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 4 | 10 | +6 | 0.00 | 0.00 | 0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,898 | 4,898 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 48,000 | 48,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JANUS HENDERSON GROUP PLC | 26,700 | 26,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SCOTIA CAPITAL INC. | 12,421 | 12,421 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alyeska Investment Group, L.P. | 251,348 | 251,348 | 0 | 0.01 | 0.01 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 35,000 | 35,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 144 | 144 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 29,285 | 29,285 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Essex Woodlands Management, Inc. | 1,551,521 | 1,551,521 | 0 | 4.40 | 3.54 | -0.86 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 5,175,823 | 5,175,823 | 0 | 1.84 | 1.48 | -0.35 | hold |
| Cormorant Asset Management, LP | 8,325,000 | 8,325,000 | 0 | 4.21 | 3.53 | -0.69 | hold |
| MYDA Advisors LLC | 100,000 | 100,000 | 0 | 0.27 | 0.23 | -0.04 | hold |
| Finepoint Capital LP | 707,404 | 707,404 | 0 | 1.75 | 0.69 | -1.06 | hold |
| Cedar Mountain Advisors, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 100,000 | 100,000 | 0 | 0.21 | 0.18 | -0.03 | hold |
| Octagon Capital Advisors LP | 1,093,503 | 1,093,503 | 0 | 1.57 | 1.40 | -0.17 | hold |
| TCG Crossover Management, LLC | 922,335 | 922,335 | 0 | 0.84 | 0.62 | -0.21 | hold |
| Washington Trust Advisors, Inc. | 264 | 264 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 40,279 | 40,279 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 1,259 | 1,259 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 1 | 0 | -1 | 0.00 | 0.00 | 0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 10,888 | 10,874 | -14 | 0.00 | 0.00 | -0.00 | sell |
| Continuum Advisory, LLC | 16 | 0 | -16 | 0.00 | 0.00 | -0.00 | sell |
| Park Place Capital Corp | 23 | 0 | -23 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL SECURITIES, INC. | 24 | 0 | -24 | 0.00 | 0.00 | -0.00 | sell |
| INNEALTA CAPITAL, LLC | 36 | 0 | -36 | 0.00 | 0.00 | -0.00 | sell |
| WHITTIER TRUST CO OF NEVADA INC | 41 | 0 | -41 | 0.00 | 0.00 | -0.00 | sell |
| MassMutual Private Wealth & Trust, FSB | 107 | 65 | -42 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 1,870 | 1,797 | -73 | 0.00 | 0.00 | -0.00 | sell |
| Quarry LP | 139 | 0 | -139 | 0.00 | 0.00 | -0.00 | sell |
| Ashton Thomas Private Wealth, LLC | 151 | 0 | -151 | 0.00 | 0.00 | -0.00 | sell |
| IFP Advisors, Inc | 2,068 | 1,915 | -153 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 26,899 | 26,734 | -165 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 13,697 | 13,480 | -217 | 0.00 | 0.00 | -0.00 | sell |
| Clearstead Advisors, LLC | 235 | 0 | -235 | 0.00 | 0.00 | -0.00 | sell |
| First Horizon Advisors, Inc. | 368 | 0 | -368 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 68,043 | 67,581 | -462 | 0.00 | 0.00 | -0.00 | sell |