| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 8,325,000 | 8,325,000 | 0 | 5.84 | 8.18 | +2.34 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 6,804,091 | 6,192,715 | -611,376 | 2.41 | 2.67 | +0.26 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 6,800,000 | 5,559,782 | -1,240,218 | 0.11 | 0.13 | +0.02 | sell |
| BlackRock, Inc. | 5,360,214 | 4,964,526 | -395,688 | 0.00 | 0.00 | +0.00 | sell |
| FEDERATED HERMES, INC. | 4,599,450 | 4,416,332 | -183,118 | 0.08 | 0.11 | +0.03 | sell |
| FRANKLIN RESOURCES INC | 4,301,123 | 4,171,884 | -129,239 | 0.01 | 0.01 | +0.00 | sell |
| VANGUARD GROUP INC | 3,802,646 | 3,794,516 | -8,130 | 0.00 | 0.00 | +0.00 | sell |
| TCG Crossover Management, LLC | 3,572,335 | 3,572,335 | 0 | 3.84 | 2.50 | -1.34 | hold |
| CITADEL ADVISORS LLC | 2,344,210 | 2,135,389 | -208,821 | 0.02 | 0.02 | +0.01 | sell |
| Paradigm Biocapital Advisors LP | 0 | 2,005,365 | +2,005,365 | 0.00 | 0.84 | +0.84 | buy |
| ORBIMED ADVISORS LLC | 0 | 1,796,000 | +1,796,000 | 0.00 | 0.61 | +0.61 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,592,048 | 1,524,526 | -67,522 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,280,692 | 1,514,606 | +233,914 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,515,549 | 1,473,199 | -42,350 | 0.00 | 0.00 | +0.00 | sell |
| Essex Woodlands Management, Inc. | 1,169,857 | 1,084,857 | -85,000 | 3.94 | 5.03 | +1.09 | sell |
| 5AM Venture Management, LLC | 1,050,000 | 1,050,000 | 0 | 3.80 | 5.48 | +1.68 | hold |
| Patient Square Capital LP | 1,352,837 | 1,011,839 | -340,998 | 4.59 | 3.85 | -0.74 | sell |
| BANK OF AMERICA CORP /DE/ | 814,153 | 1,010,331 | +196,178 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 782,642 | 978,129 | +195,487 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 1,031,201 | 796,802 | -234,399 | 0.02 | 0.02 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 756,087 | +756,087 | 0.00 | 0.02 | +0.02 | buy |
| HSBC HOLDINGS PLC | 631,074 | 716,453 | +85,379 | 0.00 | 0.01 | +0.00 | buy |
| Rosalind Advisors, Inc. | 0 | 650,000 | +650,000 | 0.00 | 3.27 | +3.27 | buy |
| Artia Global Partners LP | 316,700 | 628,367 | +311,667 | 0.77 | 1.57 | +0.81 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 189,878 | 531,723 | +341,845 | 0.00 | 0.00 | +0.00 | buy |
| Principia Wealth Advisory, LLC | 533,778 | 530,725 | -3,053 | 4.27 | 5.39 | +1.13 | sell |
| NORTHERN TRUST CORP | 515,613 | 504,053 | -11,560 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 38,149 | 483,054 | +444,905 | 0.00 | 0.01 | +0.01 | buy |
| Blue Owl Capital Holdings LP | 562,594 | 367,594 | -195,000 | 1.71 | 1.62 | -0.08 | sell |
| DEUTSCHE BANK AG\ | 512,113 | 355,810 | -156,303 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 126,160 | 350,164 | +224,004 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 340,984 | 347,892 | +6,908 | 0.13 | 0.20 | +0.07 | buy |
| MYDA Advisors LLC | 250,000 | 300,000 | +50,000 | 0.66 | 1.28 | +0.62 | buy |
| Invesco Ltd. | 128,772 | 290,818 | +162,046 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 225,964 | 258,783 | +32,819 | 0.00 | 0.00 | +0.00 | buy |
| Bleichroeder LP | 256,515 | 256,515 | 0 | 0.59 | 0.71 | +0.12 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 313,979 | 247,754 | -66,225 | 0.00 | 0.00 | +0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 230,837 | +230,837 | 0.00 | 0.48 | +0.48 | buy |
| DIMENSIONAL FUND ADVISORS LP | 69,962 | 229,087 | +159,125 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 265,109 | 215,450 | -49,659 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 207,702 | 211,897 | +4,195 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 351,348 | 201,348 | -150,000 | 0.01 | 0.01 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 376,776 | 179,436 | -197,340 | 0.01 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 172,446 | 171,668 | -778 | 0.00 | 0.00 | +0.00 | sell |
| Jefferies Financial Group Inc. | 0 | 140,000 | +140,000 | 0.00 | 0.02 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 128,538 | 133,747 | +5,209 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 132,764 | 132,764 | 0 | 0.03 | 0.07 | +0.04 | hold |
| JANE STREET GROUP, LLC | 15,720 | 131,764 | +116,044 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 94,075 | 130,124 | +36,049 | 0.00 | 0.00 | +0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 123,691 | 127,789 | +4,098 | 0.21 | 0.28 | +0.07 | buy |
| Corient Private Wealth LLC | 127,489 | 127,489 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERICAN CENTURY COMPANIES INC | 67,612 | 121,901 | +54,289 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 125,623 | 119,166 | -6,457 | 0.00 | 0.00 | +0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 116,099 | 114,283 | -1,816 | 0.00 | 0.01 | +0.00 | sell |
| Nuveen, LLC | 113,730 | 104,699 | -9,031 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 123,307 | 103,703 | -19,604 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 500,335 | 100,263 | -400,072 | 0.02 | 0.01 | -0.02 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 281,115 | 90,655 | -190,460 | 0.00 | 0.00 | -0.00 | sell |
| Simplify Asset Management Inc. | 79,472 | 90,440 | +10,968 | 0.05 | 0.03 | -0.02 | buy |
| RHUMBLINE ADVISERS | 96,280 | 90,393 | -5,887 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 83,709 | 81,912 | -1,797 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 78,647 | 77,547 | -1,100 | 0.00 | 0.00 | +0.00 | sell |
| WOODSTOCK CORP | 68,465 | 68,465 | 0 | 0.06 | 0.08 | +0.03 | hold |
| Legal & General Group Plc | 5,763 | 67,293 | +61,530 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 61,194 | 61,194 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Brevan Howard Capital Management LP | 0 | 60,641 | +60,641 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 58,590 | 58,590 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Erste Asset Management GmbH | 50,000 | 50,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| MetLife Investment Management, LLC | 39,718 | 39,718 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 35,000 | 35,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Waverly Advisors, LLC | 36,704 | 33,096 | -3,608 | 0.00 | 0.00 | +0.00 | sell |
| HighTower Advisors, LLC | 32,567 | 32,567 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 2,900 | 32,500 | +29,600 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 0 | 31,655 | +31,655 | 0.00 | 0.03 | +0.03 | buy |
| SCOTIA CAPITAL INC. | 31,589 | 31,589 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JPMORGAN CHASE & CO | 247,412 | 30,262 | -217,150 | 0.00 | 0.00 | -0.00 | sell |
| LEVIN CAPITAL STRATEGIES, L.P. | 19,000 | 29,000 | +10,000 | 0.02 | 0.04 | +0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 33,962 | 27,002 | -6,960 | 0.00 | 0.00 | -0.00 | sell |
| Allianz Asset Management GmbH | 0 | 26,400 | +26,400 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 95,613 | 24,364 | -71,249 | 0.00 | 0.00 | -0.00 | sell |
| Cyndeo Wealth Partners, LLC | 14,250 | 22,230 | +7,980 | 0.01 | 0.02 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 36,353 | 22,105 | -14,248 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 13,821 | 22,082 | +8,261 | 0.01 | 0.03 | +0.01 | buy |
| Creative Planning | 18,554 | 22,059 | +3,505 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 0 | 21,735 | +21,735 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 22,575 | 20,064 | -2,511 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 446,305 | 17,872 | -428,433 | 0.00 | 0.00 | -0.00 | sell |
| Baird Financial Group, Inc. | 0 | 17,518 | +17,518 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 119,566 | 17,000 | -102,566 | 0.10 | 0.01 | -0.09 | sell |
| SIMPLEX TRADING, LLC | 2,144 | 16,741 | +14,597 | 0.00 | 0.01 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 15,404 | 16,614 | +1,210 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 16,484 | +16,484 | 0.00 | 0.00 | +0.00 | buy |
| RWC Asset Management LLP | 0 | 16,195 | +16,195 | 0.00 | 0.01 | +0.01 | buy |
| RAYMOND JAMES FINANCIAL INC | 11,900 | 15,200 | +3,300 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 65,568 | 14,800 | -50,768 | 0.00 | 0.00 | -0.00 | sell |
| Janney Montgomery Scott LLC | 12,094 | 14,094 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| MCF Advisors LLC | 0 | 13,772 | +13,772 | 0.00 | 0.01 | +0.01 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 12,967 | +12,967 | 0.00 | 0.03 | +0.03 | buy |
| Virtus Investment Advisers, LLC | 10,613 | 12,843 | +2,230 | 0.03 | 0.05 | +0.02 | buy |
| ProShare Advisors LLC | 15,282 | 12,490 | -2,792 | 0.00 | 0.00 | +0.00 | sell |