| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 3,200,000 | 6,038,235 | +2,838,235 | 1.49 | 6.66 | +5.17 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,736,503 | 4,466,420 | +2,729,917 | 0.03 | 0.21 | +0.18 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,492,147 | 4,056,847 | +564,700 | 1.51 | 4.24 | +2.73 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 300,128 | 425,128 | +125,000 | 1.61 | 5.53 | +3.92 | buy |
| TOTH FINANCIAL ADVISORY CORP | 3,500 | 5,000 | +1,500 | 0.00 | 0.02 | +0.01 | buy |
| BARD ASSOCIATES INC | 19,100 | 14,600 | -4,500 | 0.06 | 0.13 | +0.06 | sell |
| Corton Capital Inc. | 22,682 | 11,511 | -11,171 | 0.09 | 0.08 | -0.01 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 207,160 | 147,541 | -59,619 | 0.27 | 0.67 | +0.40 | sell |
| SCOTIA CAPITAL INC. | 90,963 | 8,963 | -82,000 | 0.01 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 176,080 | 81,160 | -94,920 | 0.27 | 0.81 | +0.53 | sell |
| Essex Woodlands Management, Inc. | 3,490,921 | 2,337,786 | -1,153,135 | 24.59 | 13.37 | -11.22 | sell |