| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 3,200,000 | 6,038,235 | +2,838,235 | 1.49 | 6.68 | +5.19 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,736,503 | 4,466,420 | +2,729,917 | 0.03 | 0.21 | +0.18 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 1,558,675 | +1,558,675 | 0.00 | 0.02 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 10,349 | 1,536,125 | +1,525,776 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 136,821 | 1,318,897 | +1,182,076 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,374,346 | 2,522,704 | +1,148,358 | 0.00 | 0.01 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 0 | 1,066,240 | +1,066,240 | 0.00 | 0.02 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 21,764 | 770,503 | +748,739 | 0.00 | 0.01 | +0.01 | buy |
| Laurion Capital Management LP | 0 | 633,409 | +633,409 | 0.00 | 0.52 | +0.52 | buy |
| VANGUARD GROUP INC | 1,440,724 | 2,034,060 | +593,336 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 589,646 | +589,646 | 0.00 | 0.30 | +0.30 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,492,147 | 4,056,847 | +564,700 | 1.51 | 4.29 | +2.78 | buy |
| MILLENNIUM MANAGEMENT LLC | 580,629 | 1,128,638 | +548,009 | 0.00 | 0.02 | +0.02 | buy |
| FRANKLIN RESOURCES INC | 4,152,445 | 4,640,651 | +488,206 | 0.02 | 0.05 | +0.03 | buy |
| FEDERATED HERMES, INC. | 229,535 | 674,824 | +445,289 | 0.00 | 0.04 | +0.03 | buy |
| ORACLE INVESTMENT MANAGEMENT INC | 0 | 401,557 | +401,557 | 0.00 | 10.13 | +10.13 | buy |
| Woodline Partners LP | 0 | 400,000 | +400,000 | 0.00 | 0.10 | +0.10 | buy |
| LORD, ABBETT & CO. LLC | 0 | 370,987 | +370,987 | 0.00 | 0.03 | +0.03 | buy |
| Ikarian Capital, LLC | 0 | 368,130 | +368,130 | 0.00 | 2.33 | +2.33 | buy |
| Invesco Ltd. | 0 | 288,353 | +288,353 | 0.00 | 0.00 | +0.00 | buy |
| VR Adviser, LLC | 0 | 250,000 | +250,000 | 0.00 | 0.40 | +0.40 | buy |
| Alyeska Investment Group, L.P. | 0 | 186,840 | +186,840 | 0.00 | 0.03 | +0.03 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 180,000 | +180,000 | 0.00 | 0.01 | +0.01 | buy |
| Monashee Investment Management LLC | 0 | 175,000 | +175,000 | 0.00 | 0.71 | +0.71 | buy |
| PFM Health Sciences, LP | 0 | 170,871 | +170,871 | 0.00 | 0.24 | +0.24 | buy |
| CITADEL ADVISORS LLC | 1,059,047 | 1,227,278 | +168,231 | 0.01 | 0.03 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 535,575 | 682,417 | +146,842 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 140,705 | +140,705 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 125,680 | 266,031 | +140,351 | 0.00 | 0.01 | +0.01 | buy |
| Candriam S.C.A. | 0 | 140,000 | +140,000 | 0.00 | 0.02 | +0.02 | buy |
| Informed Momentum Co LLC | 0 | 138,310 | +138,310 | 0.00 | 0.57 | +0.57 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 137,000 | +137,000 | 0.00 | 0.01 | +0.01 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 300,128 | 425,128 | +125,000 | 1.74 | 5.53 | +3.79 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 123,764 | +123,764 | 0.00 | 0.01 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 121,095 | +121,095 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 45,659 | 159,642 | +113,983 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 109,900 | +109,900 | 0.00 | 0.51 | +0.51 | buy |
| Ghisallo Capital Management LLC | 0 | 108,634 | +108,634 | 0.00 | 0.26 | +0.26 | buy |
| D. E. Shaw & Co., Inc. | 0 | 100,960 | +100,960 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 88,443 | +88,443 | 0.00 | 0.07 | +0.07 | buy |
| TWO SIGMA INVESTMENTS, LP | 69,630 | 149,782 | +80,152 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 78,444 | +78,444 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 71,800 | 142,894 | +71,094 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 0 | 53,236 | +53,236 | 0.00 | 0.14 | +0.14 | buy |
| Artia Global Partners LP | 0 | 50,000 | +50,000 | 0.00 | 0.46 | +0.46 | buy |
| UBS Group AG | 526,848 | 574,169 | +47,321 | 0.00 | 0.01 | +0.00 | buy |
| Ratan Capital Management LP | 0 | 45,000 | +45,000 | 0.00 | 0.68 | +0.68 | buy |
| JANE STREET GROUP, LLC | 30,223 | 69,895 | +39,672 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 0 | 35,000 | +35,000 | 0.00 | 0.00 | +0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 32,176 | +32,176 | 0.00 | 0.10 | +0.10 | buy |
| FMR LLC | 2,397 | 32,485 | +30,088 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 28,530 | +28,530 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 211,715 | 239,621 | +27,906 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 25,400 | +25,400 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 24,450 | +24,450 | 0.00 | 0.02 | +0.02 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 24,103 | +24,103 | 0.00 | 0.05 | +0.05 | buy |
| Belvedere Trading LLC | 0 | 24,054 | +24,054 | 0.00 | 0.05 | +0.05 | buy |
| WOODSTOCK CORP | 0 | 22,253 | +22,253 | 0.00 | 0.06 | +0.06 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 52,939 | 74,421 | +21,482 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 20,000 | +20,000 | 0.00 | 0.03 | +0.03 | buy |
| SEI INVESTMENTS CO | 0 | 19,238 | +19,238 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 533,055 | 550,609 | +17,554 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 115,690 | 129,610 | +13,920 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,776 | 21,511 | +13,735 | 0.00 | 0.00 | +0.00 | buy |
| Gotham Asset Management, LLC | 0 | 13,159 | +13,159 | 0.00 | 0.01 | +0.01 | buy |
| Maven Securities LTD | 0 | 10,000 | +10,000 | 0.00 | 0.03 | +0.03 | buy |
| AQR CAPITAL MANAGEMENT LLC | 15,328 | 24,268 | +8,940 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 8,300 | +8,300 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 71,548 | 78,410 | +6,862 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 75,239 | 80,780 | +5,541 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 12 | 4,672 | +4,660 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 41,752 | 46,140 | +4,388 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 4,085 | +4,085 | 0.00 | 0.02 | +0.02 | buy |
| US BANCORP \DE\ | 0 | 3,697 | +3,697 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 19,820 | 22,600 | +2,780 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS | 0 | 2,500 | +2,500 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 0 | 1,860 | +1,860 | 0.00 | 0.03 | +0.03 | buy |
| TOTH FINANCIAL ADVISORY CORP | 3,500 | 5,000 | +1,500 | 0.00 | 0.02 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 3,474 | 4,724 | +1,250 | 0.00 | 0.00 | +0.00 | buy |
| FNY Investment Advisers, LLC | 0 | 1,210 | +1,210 | 0.00 | 0.03 | +0.03 | buy |
| Quantbot Technologies LP | 0 | 1,100 | +1,100 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 14,702 | 15,584 | +882 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 8,290 | 9,029 | +739 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 13,071 | 13,277 | +206 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 10,742 | 10,937 | +195 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 144 | +144 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,583 | 2,583 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MassMutual Private Wealth & Trust, FSB | 108 | 108 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 13,973 | 13,973 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Truvestments Capital LLC | 258 | 258 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Geneos Wealth Management Inc. | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cedar Mountain Advisors, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| BELLEVUE ASSET MANAGEMENT, LLC | 126 | 126 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Washington Trust Advisors, Inc. | 332 | 332 | 0 | 0.00 | 0.00 | +0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,446 | 1,446 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 43,761 | 43,761 | 0 | 0.00 | 0.01 | +0.00 | hold |
| COMERICA BANK | 467 | 467 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 25 | 25 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 2,733 | 2,628 | -105 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 3,358 | 3,086 | -272 | 0.00 | 0.00 | +0.00 | sell |