| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 3,181,818 | +3,181,818 | 0.00 | 0.32 | +0.32 | buy |
| TCG Crossover Management, LLC | 922,335 | 3,572,335 | +2,650,000 | 0.62 | 2.60 | +1.98 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,791,420 | 5,750,000 | +1,958,580 | 0.05 | 0.07 | +0.02 | buy |
| FEDERATED HERMES, INC. | 1,923,680 | 3,707,445 | +1,783,765 | 0.03 | 0.06 | +0.03 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 5,175,823 | 6,783,091 | +1,607,268 | 1.48 | 1.87 | +0.39 | buy |
| BlackRock, Inc. | 4,155,158 | 5,281,375 | +1,126,217 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,407,353 | 2,466,866 | +1,059,513 | 0.01 | 0.02 | +0.01 | buy |
| VANGUARD GROUP INC | 3,048,182 | 3,803,227 | +755,045 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 0 | 667,594 | +667,594 | 0.00 | 1.15 | +1.15 | buy |
| Nantahala Capital Management, LLC | 0 | 600,000 | +600,000 | 0.00 | 0.31 | +0.31 | buy |
| STEMPOINT CAPITAL LP | 0 | 579,500 | +579,500 | 0.00 | 1.08 | +1.08 | buy |
| PERCEPTIVE ADVISORS LLC | 1,037,274 | 1,537,274 | +500,000 | 0.18 | 0.32 | +0.14 | buy |
| GOLDMAN SACHS GROUP INC | 1,215,328 | 1,662,421 | +447,093 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 446,199 | +446,199 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 451,318 | 857,853 | +406,535 | 0.01 | 0.02 | +0.00 | buy |
| Finepoint Capital LP | 707,404 | 1,111,104 | +403,700 | 0.69 | 0.95 | +0.27 | buy |
| Ally Bridge Group (NY) LLC | 0 | 348,000 | +348,000 | 0.00 | 2.22 | +2.22 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,199,056 | 1,538,902 | +339,846 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,215,881 | 1,491,667 | +275,786 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 0 | 230,745 | +230,745 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 471,783 | 643,157 | +171,374 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 401,159 | 570,026 | +168,867 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 67,073 | 223,641 | +156,568 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 123,933 | 270,336 | +146,403 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 502,965 | 648,030 | +145,065 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 4,012,048 | 4,137,567 | +125,519 | 0.01 | 0.01 | -0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 123,769 | +123,769 | 0.00 | 0.02 | +0.02 | buy |
| Woodline Partners LP | 400,000 | 501,724 | +101,724 | 0.03 | 0.03 | -0.00 | buy |
| Alyeska Investment Group, L.P. | 251,348 | 351,348 | +100,000 | 0.01 | 0.01 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 86,809 | +86,809 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 31,971 | 99,498 | +67,527 | 0.00 | 0.01 | +0.01 | buy |
| Artia Global Partners LP | 156,300 | 216,700 | +60,400 | 0.35 | 0.65 | +0.30 | buy |
| MYDA Advisors LLC | 100,000 | 160,000 | +60,000 | 0.23 | 0.34 | +0.11 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 16,709 | 73,914 | +57,205 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 0 | 50,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 49,375 | +49,375 | 0.00 | 0.32 | +0.32 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 142,763 | 191,165 | +48,402 | 0.00 | 0.00 | +0.00 | buy |
| Patient Square Capital LP | 1,361,979 | 1,410,331 | +48,352 | 4.04 | 3.93 | -0.11 | buy |
| Verition Fund Management LLC | 0 | 44,220 | +44,220 | 0.00 | 0.00 | +0.00 | buy |
| LEVIN CAPITAL STRATEGIES, L.P. | 10,000 | 54,000 | +44,000 | 0.01 | 0.04 | +0.03 | buy |
| FMR LLC | 1,797 | 42,274 | +40,477 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 56,338 | 95,149 | +38,811 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 167,206 | 204,260 | +37,054 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 24,887 | 52,038 | +27,151 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 24,000 | 50,700 | +26,700 | 0.00 | 0.00 | +0.00 | buy |
| One68 Global Capital, LLC | 0 | 25,800 | +25,800 | 0.00 | 0.10 | +0.10 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 25,705 | +25,705 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 371,758 | 395,444 | +23,686 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 68,630 | 90,349 | +21,719 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 100,000 | 121,274 | +21,274 | 0.18 | 0.20 | +0.02 | buy |
| DELTEC ASSET MANAGEMENT LLC | 0 | 20,300 | +20,300 | 0.00 | 0.03 | +0.03 | buy |
| Dynamic Technology Lab Private Ltd | 12,049 | 32,178 | +20,129 | 0.01 | 0.04 | +0.03 | buy |
| CITIGROUP INC | 46,509 | 65,651 | +19,142 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 22,098 | 40,514 | +18,416 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 19,502 | 34,792 | +15,290 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 77,117 | 89,560 | +12,443 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 12,200 | +12,200 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 29,285 | 40,502 | +11,217 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 73 | 9,743 | +9,670 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 27,429 | 37,022 | +9,593 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 9,353 | +9,353 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 12,698 | 21,679 | +8,981 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 8,953 | +8,953 | 0.00 | 0.03 | +0.03 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 16,968 | 23,105 | +6,137 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 40,279 | 46,263 | +5,984 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 26,734 | 32,499 | +5,765 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 171,764 | 177,316 | +5,552 | 0.00 | 0.00 | +0.00 | buy |
| Cyndeo Wealth Partners, LLC | 12,540 | 16,990 | +4,450 | 0.01 | 0.01 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 10,293 | 14,472 | +4,179 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 67,581 | 71,238 | +3,657 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 253,986 | 257,615 | +3,629 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 96,600 | 100,000 | +3,400 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 10,874 | 13,895 | +3,021 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 12,410 | 15,192 | +2,782 | 0.00 | 0.00 | -0.00 | buy |
| Brooklyn Investment Group | 0 | 2,578 | +2,578 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 13,480 | 15,657 | +2,177 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 4,836 | 6,899 | +2,063 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,898 | 6,838 | +1,940 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 46,817 | 48,614 | +1,797 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 110 | 1,142 | +1,032 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 12,909 | 13,746 | +837 | 0.00 | 0.00 | -0.00 | buy |
| Versant Capital Management, Inc | 0 | 492 | +492 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 14,247 | 14,723 | +476 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,936 | 2,274 | +338 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 106 | 313 | +207 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 187 | +187 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 45 | 100 | +55 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 159 | 208 | +49 | 0.00 | 0.00 | -0.00 | buy |
| WOODSTOCK CORP | 71,480 | 71,480 | 0 | 0.05 | 0.05 | -0.00 | hold |
| ORACLE INVESTMENT MANAGEMENT INC | 32,500 | 32,500 | 0 | 0.21 | 0.16 | -0.04 | hold |
| BESSEMER GROUP INC | 90 | 90 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MassMutual Private Wealth & Trust, FSB | 65 | 65 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 43,790 | 43,790 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JANUS HENDERSON GROUP PLC | 26,700 | 26,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SCOTIA CAPITAL INC. | 12,421 | 12,421 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 35,000 | 35,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 144 | 144 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Skandinaviska Enskilda Banken AB (publ) | 71,515 | 71,515 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cormorant Asset Management, LP | 8,325,000 | 8,325,000 | 0 | 3.53 | 3.41 | -0.12 | hold |