| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 8,325,000 | 8,265,000 | -60,000 | 8.18 | 8.56 | +0.38 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 6,192,715 | 7,827,685 | +1,634,970 | 2.67 | 3.57 | +0.89 | buy |
| BlackRock, Inc. | 4,964,526 | 6,787,872 | +1,823,346 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 4,416,332 | 6,017,433 | +1,601,101 | 0.11 | 0.18 | +0.07 | buy |
| FRANKLIN RESOURCES INC | 4,171,884 | 4,976,915 | +805,031 | 0.01 | 0.02 | +0.01 | buy |
| VANGUARD GROUP INC | 3,794,516 | 4,822,139 | +1,027,623 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,559,782 | 4,700,000 | -859,782 | 0.13 | 0.13 | +0.00 | sell |
| Paradigm Biocapital Advisors LP | 2,005,365 | 3,691,475 | +1,686,110 | 0.84 | 1.81 | +0.96 | buy |
| TCG Crossover Management, LLC | 3,572,335 | 3,572,335 | 0 | 2.50 | 2.16 | -0.34 | hold |
| JANUS HENDERSON GROUP PLC | 0 | 2,937,729 | +2,937,729 | 0.00 | 0.02 | +0.02 | buy |
| ORBIMED ADVISORS LLC | 1,796,000 | 2,468,314 | +672,314 | 0.61 | 0.92 | +0.31 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,524,526 | 1,899,367 | +374,841 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,473,199 | 1,834,850 | +361,651 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 796,802 | 1,605,984 | +809,182 | 0.02 | 0.05 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 1,514,606 | 1,249,757 | -264,849 | 0.00 | 0.00 | +0.00 | sell |
| Parkman Healthcare Partners LLC | 0 | 1,088,033 | +1,088,033 | 0.00 | 1.89 | +1.89 | buy |
| Essex Woodlands Management, Inc. | 1,084,857 | 1,084,857 | 0 | 5.03 | 6.23 | +1.20 | hold |
| 5AM Venture Management, LLC | 1,050,000 | 1,050,000 | 0 | 5.48 | 6.03 | +0.55 | hold |
| Alyeska Investment Group, L.P. | 201,348 | 784,403 | +583,055 | 0.01 | 0.04 | +0.03 | buy |
| Patient Square Capital LP | 1,011,839 | 780,000 | -231,839 | 3.85 | 3.05 | -0.80 | sell |
| Artia Global Partners LP | 628,367 | 767,098 | +138,731 | 1.57 | 2.25 | +0.68 | buy |
| Rosalind Advisors, Inc. | 650,000 | 690,000 | +40,000 | 3.27 | 4.59 | +1.32 | buy |
| Candriam S.C.A. | 0 | 674,395 | +674,395 | 0.00 | 0.06 | +0.06 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 661,452 | +661,452 | 0.00 | 0.06 | +0.06 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 531,723 | 648,565 | +116,842 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 756,087 | 595,392 | -160,695 | 0.02 | 0.02 | -0.00 | sell |
| NORTHERN TRUST CORP | 504,053 | 577,586 | +73,533 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 483,054 | 556,469 | +73,415 | 0.01 | 0.01 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 544,077 | +544,077 | 0.00 | 0.11 | +0.11 | buy |
| Principia Wealth Advisory, LLC | 530,725 | 530,725 | 0 | 5.39 | 6.06 | +0.67 | hold |
| BANK OF AMERICA CORP /DE/ | 1,010,331 | 416,100 | -594,231 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 229,087 | 402,063 | +172,976 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 367,594 | 392,594 | +25,000 | 1.62 | 2.21 | +0.59 | buy |
| Simplify Asset Management Inc. | 90,440 | 375,264 | +284,824 | 0.03 | 0.11 | +0.09 | buy |
| Granahan Investment Management, LLC | 347,892 | 366,675 | +18,783 | 0.20 | 0.29 | +0.08 | buy |
| STEMPOINT CAPITAL LP | 0 | 353,849 | +353,849 | 0.00 | 1.11 | +1.11 | buy |
| Invesco Ltd. | 290,818 | 339,004 | +48,186 | 0.00 | 0.00 | +0.00 | buy |
| Bleichroeder LP | 256,515 | 316,515 | +60,000 | 0.71 | 1.02 | +0.31 | buy |
| MYDA Advisors LLC | 300,000 | 300,000 | 0 | 1.28 | 1.54 | +0.26 | hold |
| Rock Springs Capital Management LP | 31,655 | 258,739 | +227,084 | 0.03 | 0.24 | +0.22 | buy |
| Bank of New York Mellon Corp | 211,897 | 256,743 | +44,846 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 246,279 | +246,279 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 355,810 | 226,770 | -129,040 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 978,129 | 223,699 | -754,430 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 130,124 | 213,301 | +83,177 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.19 | +0.19 | buy |
| UBS Group AG | 350,164 | 188,651 | -161,513 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 215,450 | 188,199 | -27,251 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 104,699 | 181,256 | +76,557 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 247,754 | 168,382 | -79,372 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 103,703 | 140,726 | +37,023 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 179,436 | 138,461 | -40,975 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 90,655 | 137,555 | +46,900 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 114,283 | 132,214 | +17,931 | 0.01 | 0.01 | +0.00 | buy |
| Corient Private Wealth LLC | 127,489 | 127,489 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 127,789 | 124,956 | -2,833 | 0.28 | 0.35 | +0.07 | sell |
| Burkehill Global Management, LP | 0 | 115,000 | +115,000 | 0.00 | 0.14 | +0.14 | buy |
| Woodline Partners LP | 100,263 | 100,463 | +200 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 81,912 | 92,570 | +10,658 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 90,393 | 89,045 | -1,348 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 133,747 | 88,286 | -45,461 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 132,764 | 87,245 | -45,519 | 0.07 | 0.05 | -0.02 | sell |
| Waverly Advisors, LLC | 33,096 | 78,063 | +44,967 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 58,590 | 75,090 | +16,500 | 0.00 | 0.00 | +0.00 | buy |
| Centiva Capital, LP | 0 | 75,000 | +75,000 | 0.00 | 0.08 | +0.08 | buy |
| Susquehanna Portfolio Strategies, LLC | 61,194 | 74,944 | +13,750 | 0.01 | 0.02 | +0.01 | buy |
| WOODSTOCK CORP | 68,465 | 68,465 | 0 | 0.08 | 0.11 | +0.02 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 61,600 | +61,600 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 77,547 | 60,317 | -17,230 | 0.00 | 0.00 | -0.00 | sell |
| Erste Asset Management GmbH | 50,000 | 50,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 119,166 | 47,941 | -71,225 | 0.00 | 0.00 | -0.00 | sell |
| Marex Group plc | 0 | 47,777 | +47,777 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 14,800 | 45,480 | +30,680 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 171,668 | 43,086 | -128,582 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 32,500 | 42,655 | +10,155 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 39,718 | 41,799 | +2,081 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 30,262 | 37,189 | +6,927 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 27,002 | 35,106 | +8,104 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 35,000 | 35,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIMPLEX TRADING, LLC | 16,741 | 34,525 | +17,784 | 0.01 | 0.02 | +0.01 | buy |
| HighTower Advisors, LLC | 32,567 | 32,562 | -5 | 0.00 | 0.00 | +0.00 | sell |
| Brevan Howard Capital Management LP | 60,641 | 32,333 | -28,308 | 0.01 | 0.01 | -0.00 | sell |
| SCOTIA CAPITAL INC. | 31,589 | 31,589 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Creative Planning | 22,059 | 31,218 | +9,159 | 0.00 | 0.00 | +0.00 | buy |
| Longaeva Partners L.P. | 0 | 30,000 | +30,000 | 0.00 | 0.07 | +0.07 | buy |
| China Universal Asset Management Co., Ltd. | 22,082 | 29,490 | +7,408 | 0.03 | 0.04 | +0.02 | buy |
| SEI INVESTMENTS CO | 0 | 28,820 | +28,820 | 0.00 | 0.00 | +0.00 | buy |
| Janney Montgomery Scott LLC | 14,094 | 26,415 | +12,321 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 25,913 | +25,913 | 0.00 | 0.00 | +0.00 | buy |
| Cyndeo Wealth Partners, LLC | 22,230 | 22,990 | +760 | 0.02 | 0.02 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 20,064 | 22,775 | +2,711 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 22,105 | 22,201 | +96 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 6,831 | 20,678 | +13,847 | 0.01 | 0.02 | +0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 16,614 | 20,073 | +3,459 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 17,872 | 19,168 | +1,296 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 258,783 | 19,047 | -239,736 | 0.00 | 0.00 | -0.00 | sell |
| LEVIN CAPITAL STRATEGIES, L.P. | 29,000 | 19,000 | -10,000 | 0.04 | 0.03 | -0.01 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,214 | 18,714 | +6,500 | 0.00 | 0.00 | +0.00 | buy |
| Baird Financial Group, Inc. | 17,518 | 17,518 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ProShare Advisors LLC | 12,490 | 17,443 | +4,953 | 0.00 | 0.00 | +0.00 | buy |