| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Darwin Global Management, Ltd. | 0 | 1,109,650 | +1,109,650 | 0.00 | 3.27 | +3.27 | buy |
| STATE STREET CORP | 3,326,856 | 4,235,443 | +908,587 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 825,400 | +825,400 | 0.00 | 0.05 | +0.05 | buy |
| Logos Global Management LP | 0 | 650,000 | +650,000 | 0.00 | 1.51 | +1.51 | buy |
| MILLENNIUM MANAGEMENT LLC | 350,214 | 822,976 | +472,762 | 0.01 | 0.02 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 119,372 | 493,315 | +373,943 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,483,775 | 3,819,656 | +335,881 | 0.01 | 0.01 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 245,431 | 545,431 | +300,000 | 0.06 | 0.15 | +0.09 | buy |
| TWO SIGMA ADVISERS, LP | 319,200 | 601,900 | +282,700 | 0.02 | 0.03 | +0.01 | buy |
| VANGUARD GROUP INC | 6,767,249 | 7,011,042 | +243,793 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 0 | 210,805 | +210,805 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 208,227 | +208,227 | 0.00 | 0.02 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 395,727 | 599,513 | +203,786 | 0.02 | 0.03 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 0 | 196,452 | +196,452 | 0.00 | 0.00 | +0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 8,901,607 | 9,090,707 | +189,100 | 0.15 | 0.15 | +0.00 | buy |
| CITADEL ADVISORS LLC | 169,476 | 318,100 | +148,624 | 0.00 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 82,157 | 229,111 | +146,954 | 0.00 | 0.01 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 113,722 | +113,722 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 119,818 | 229,371 | +109,553 | 0.01 | 0.02 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 104,404 | +104,404 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,279,077 | 1,371,448 | +92,371 | 0.01 | 0.01 | +0.00 | buy |
| MACQUARIE GROUP LTD | 129,191 | 200,000 | +70,809 | 0.00 | 0.01 | +0.00 | buy |
| Russell Investments Group, Ltd. | 156,618 | 224,140 | +67,522 | 0.01 | 0.01 | +0.00 | buy |
| Man Group plc | 0 | 66,657 | +66,657 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 10,240 | 69,863 | +59,623 | 0.01 | 0.06 | +0.05 | buy |
| MORGAN STANLEY | 745,047 | 802,689 | +57,642 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 137,089 | 193,344 | +56,255 | 0.04 | 0.05 | +0.01 | buy |
| EcoR1 Capital, LLC | 5,282,516 | 5,330,416 | +47,900 | 2.91 | 3.00 | +0.08 | buy |
| Advantage Alpha Capital Partners LP | 0 | 47,375 | +47,375 | 0.00 | 0.20 | +0.20 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,314,943 | 1,349,786 | +34,843 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 520,698 | 552,922 | +32,224 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 166,111 | 193,972 | +27,861 | 0.03 | 0.03 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 26,315 | +26,315 | 0.00 | 0.04 | +0.04 | buy |
| Entropy Technologies, LP | 0 | 25,886 | +25,886 | 0.00 | 0.06 | +0.06 | buy |
| Trexquant Investment LP | 93,759 | 117,230 | +23,471 | 0.04 | 0.05 | +0.01 | buy |
| UniSuper Management Pty Ltd | 0 | 22,543 | +22,543 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 23,099 | 44,598 | +21,499 | 0.04 | 0.07 | +0.03 | buy |
| Pathstone Holdings, LLC | 0 | 21,375 | +21,375 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS | 0 | 21,300 | +21,300 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 62,290 | 83,292 | +21,002 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 123,250 | 143,450 | +20,200 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 18,968 | +18,968 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 170,021 | 188,383 | +18,362 | 0.00 | 0.00 | +0.00 | buy |
| Teza Capital Management LLC | 0 | 17,246 | +17,246 | 0.00 | 0.05 | +0.05 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 0 | 17,139 | +17,139 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 22,729 | 38,071 | +15,342 | 0.02 | 0.03 | +0.01 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 15,118 | +15,118 | 0.00 | 0.07 | +0.07 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 83,591 | 97,881 | +14,290 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 14,215 | 28,430 | +14,215 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 13,016 | +13,016 | 0.00 | 0.00 | +0.00 | buy |
| Cannell & Spears LLC | 0 | 12,600 | +12,600 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 89,805 | 101,505 | +11,700 | 0.05 | 0.06 | +0.00 | buy |
| NATIXIS ADVISORS, LLC | 0 | 11,222 | +11,222 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 10,839 | +10,839 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 38,582 | 49,164 | +10,582 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 10,347 | +10,347 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 9,374 | +9,374 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 29,730 | 38,783 | +9,053 | 0.00 | 0.00 | +0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 137,941 | 144,235 | +6,294 | 0.02 | 0.02 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 6,776 | 12,934 | +6,158 | 0.00 | 0.01 | +0.00 | buy |
| AlphaQuest LLC | 2,862 | 8,425 | +5,563 | 0.01 | 0.03 | +0.02 | buy |
| TUDOR INVESTMENT CORP ET AL | 28,674 | 33,867 | +5,193 | 0.01 | 0.01 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 16,579 | 21,569 | +4,990 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,041 | 11,755 | +4,714 | 0.03 | 0.03 | +0.00 | buy |
| Creative Planning | 14,168 | 18,711 | +4,543 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 12,431 | 16,562 | +4,131 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 30,443 | 34,419 | +3,976 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 75,215 | 78,425 | +3,210 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 30,798 | 33,942 | +3,144 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 40,224 | 43,106 | +2,882 | 0.01 | 0.01 | +0.00 | buy |
| Amundi | 7,852 | 10,673 | +2,821 | 0.00 | 0.00 | +0.00 | buy |
| nVerses Capital, LLC | 0 | 2,200 | +2,200 | 0.00 | 0.12 | +0.12 | buy |
| WELLS FARGO & COMPANY/MN | 17,633 | 19,575 | +1,942 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 4,757 | 6,278 | +1,521 | 0.01 | 0.01 | +0.00 | buy |
| US BANCORP \DE\ | 934 | 2,297 | +1,363 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 856 | 2,172 | +1,316 | 0.00 | 0.01 | +0.01 | buy |
| Linden Thomas Advisory Services, LLC | 41,653 | 42,944 | +1,291 | 0.17 | 0.15 | -0.01 | buy |
| ProShare Advisors LLC | 14,833 | 16,036 | +1,203 | 0.00 | 0.00 | -0.00 | buy |
| Corton Capital Inc. | 33,210 | 34,336 | +1,126 | 0.22 | 0.28 | +0.06 | buy |
| Pacer Advisors, Inc. | 0 | 1,064 | +1,064 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 15,125 | 16,060 | +935 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 41,390 | 42,316 | +926 | 0.00 | 0.00 | +0.00 | buy |
| TEXAS PERMANENT SCHOOL FUND CORP | 52,587 | 53,277 | +690 | 0.01 | 0.01 | -0.00 | buy |
| Diversified Trust Co | 12,496 | 13,059 | +563 | 0.01 | 0.01 | -0.00 | buy |
| Parallel Advisors, LLC | 1,349 | 1,789 | +440 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 269,342 | 269,693 | +351 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 1,377 | 1,526 | +149 | 0.00 | 0.00 | +0.00 | buy |
| FIFTH THIRD BANCORP | 98 | 190 | +92 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 30 | 116 | +86 | 0.00 | 0.00 | +0.00 | buy |
| HUNTINGTON NATIONAL BANK | 111 | 179 | +68 | 0.00 | 0.00 | +0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 341 | 384 | +43 | 0.00 | 0.00 | +0.00 | buy |
| Private Wealth Management Group, LLC | 88 | 119 | +31 | 0.00 | 0.00 | +0.00 | buy |
| UMB Bank, n.a. | 0 | 22 | +22 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 18 | 31 | +13 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 13,136 | 13,146 | +10 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 24,290 | 24,293 | +3 | 0.00 | 0.00 | -0.00 | buy |
| JFS WEALTH ADVISORS, LLC | 3 | 4 | +1 | 0.00 | 0.00 | +0.00 | buy |