| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRIMECAP MANAGEMENT CO/CA/ | 8,901,607 | 9,090,707 | +189,100 | 0.15 | 0.15 | +0.00 | buy |
| VANGUARD GROUP INC | 6,767,249 | 7,011,042 | +243,793 | 0.00 | 0.00 | -0.00 | buy |
| EcoR1 Capital, LLC | 5,282,516 | 5,330,416 | +47,900 | 2.91 | 3.00 | +0.08 | buy |
| STATE STREET CORP | 3,326,856 | 4,235,443 | +908,587 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,483,775 | 3,819,656 | +335,881 | 0.01 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,279,077 | 1,371,448 | +92,371 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,314,943 | 1,349,786 | +34,843 | 0.00 | 0.00 | -0.00 | buy |
| Darwin Global Management, Ltd. | 0 | 1,109,650 | +1,109,650 | 0.00 | 3.27 | +3.27 | buy |
| ARMISTICE CAPITAL, LLC | 1,500,000 | 1,000,000 | -500,000 | 0.85 | 0.59 | -0.26 | sell |
| LOOMIS SAYLES & CO L P | 988,244 | 957,811 | -30,433 | 0.03 | 0.03 | -0.00 | sell |
| Point72 Asset Management, L.P. | 0 | 825,400 | +825,400 | 0.00 | 0.05 | +0.05 | buy |
| MILLENNIUM MANAGEMENT LLC | 350,214 | 822,976 | +472,762 | 0.01 | 0.02 | +0.01 | buy |
| MORGAN STANLEY | 745,047 | 802,689 | +57,642 | 0.00 | 0.00 | +0.00 | buy |
| JOHNSON & JOHNSON | 748,062 | 748,062 | 0 | 0.36 | 0.38 | +0.01 | hold |
| NORTHERN TRUST CORP | 718,919 | 684,284 | -34,635 | 0.00 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 707,984 | 651,317 | -56,667 | 0.10 | 0.09 | -0.01 | sell |
| Logos Global Management LP | 0 | 650,000 | +650,000 | 0.00 | 1.51 | +1.51 | buy |
| TWO SIGMA ADVISERS, LP | 319,200 | 601,900 | +282,700 | 0.02 | 0.03 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 395,727 | 599,513 | +203,786 | 0.02 | 0.03 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 520,698 | 552,922 | +32,224 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 245,431 | 545,431 | +300,000 | 0.06 | 0.15 | +0.09 | buy |
| BANK OF AMERICA CORP /DE/ | 119,372 | 493,315 | +373,943 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 508,851 | 484,734 | -24,117 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 437,900 | 338,508 | -99,392 | 0.00 | 0.00 | -0.00 | sell |
| Erste Asset Management GmbH | 334,200 | 334,200 | 0 | 0.10 | 0.10 | -0.00 | hold |
| NORGES BANK | 325,439 | 325,439 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRINCIPAL FINANCIAL GROUP INC | 342,010 | 323,665 | -18,345 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 169,476 | 318,100 | +148,624 | 0.00 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 269,342 | 269,693 | +351 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 254,350 | 229,876 | -24,474 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 119,818 | 229,371 | +109,553 | 0.01 | 0.02 | +0.01 | buy |
| CITIGROUP INC | 82,157 | 229,111 | +146,954 | 0.00 | 0.01 | +0.00 | buy |
| Russell Investments Group, Ltd. | 156,618 | 224,140 | +67,522 | 0.01 | 0.01 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 225,000 | 218,750 | -6,250 | 0.48 | 0.46 | -0.02 | sell |
| PANAGORA ASSET MANAGEMENT INC | 218,288 | 212,332 | -5,956 | 0.03 | 0.02 | -0.00 | sell |
| UBS Group AG | 0 | 210,805 | +210,805 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 245,000 | 209,800 | -35,200 | 0.05 | 0.04 | -0.00 | sell |
| DCF Advisers, LLC | 237,107 | 208,979 | -28,128 | 3.41 | 2.79 | -0.62 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 208,227 | +208,227 | 0.00 | 0.02 | +0.02 | buy |
| Invesco Ltd. | 227,451 | 202,955 | -24,496 | 0.00 | 0.00 | -0.00 | sell |
| MACQUARIE GROUP LTD | 129,191 | 200,000 | +70,809 | 0.00 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 196,452 | +196,452 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 166,111 | 193,972 | +27,861 | 0.03 | 0.03 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 137,089 | 193,344 | +56,255 | 0.04 | 0.05 | +0.01 | buy |
| Legal & General Group Plc | 170,021 | 188,383 | +18,362 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 175,520 | 175,520 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ExodusPoint Capital Management, LP | 280,813 | 173,969 | -106,844 | 0.07 | 0.05 | -0.03 | sell |
| RHUMBLINE ADVISERS | 184,831 | 150,308 | -34,523 | 0.00 | 0.00 | -0.00 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 137,941 | 144,235 | +6,294 | 0.02 | 0.02 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 123,250 | 143,450 | +20,200 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 501,167 | 129,211 | -371,956 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 126,331 | 124,781 | -1,550 | 0.02 | 0.02 | -0.00 | sell |
| Qube Research & Technologies Ltd | 145,846 | 123,414 | -22,432 | 0.01 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 93,759 | 117,230 | +23,471 | 0.04 | 0.05 | +0.01 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 113,722 | +113,722 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 133,752 | 107,774 | -25,978 | 0.01 | 0.01 | -0.00 | sell |
| Swiss National Bank | 107,500 | 107,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 104,404 | +104,404 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 89,805 | 101,505 | +11,700 | 0.05 | 0.06 | +0.00 | buy |
| BARCLAYS PLC | 268,499 | 98,165 | -170,334 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 83,591 | 97,881 | +14,290 | 0.00 | 0.00 | +0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 99,335 | 92,506 | -6,829 | 0.02 | 0.02 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 62,290 | 83,292 | +21,002 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 75,215 | 78,425 | +3,210 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 77,700 | 75,250 | -2,450 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 10,240 | 69,863 | +59,623 | 0.01 | 0.06 | +0.05 | buy |
| PRUDENTIAL FINANCIAL INC | 69,955 | 68,695 | -1,260 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 0 | 66,657 | +66,657 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 58,526 | 58,526 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NFJ INVESTMENT GROUP, LLC | 55,538 | 55,384 | -154 | 0.03 | 0.03 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 58,086 | 55,102 | -2,984 | 0.00 | 0.00 | -0.00 | sell |
| TEXAS PERMANENT SCHOOL FUND CORP | 52,587 | 53,277 | +690 | 0.01 | 0.01 | -0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 54,244 | 52,810 | -1,434 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 38,582 | 49,164 | +10,582 | 0.00 | 0.00 | +0.00 | buy |
| Advantage Alpha Capital Partners LP | 0 | 47,375 | +47,375 | 0.00 | 0.20 | +0.20 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 82,488 | 45,795 | -36,693 | 0.00 | 0.00 | -0.00 | sell |
| WINTON GROUP Ltd | 23,099 | 44,598 | +21,499 | 0.04 | 0.07 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 180,300 | 43,600 | -136,700 | 0.01 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 40,224 | 43,106 | +2,882 | 0.01 | 0.01 | +0.00 | buy |
| Linden Thomas Advisory Services, LLC | 41,653 | 42,944 | +1,291 | 0.17 | 0.15 | -0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 41,390 | 42,316 | +926 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 46,887 | 41,681 | -5,206 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 29,730 | 38,783 | +9,053 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 22,729 | 38,071 | +15,342 | 0.02 | 0.03 | +0.01 | buy |
| State of Alaska, Department of Revenue | 37,451 | 37,085 | -366 | 0.01 | 0.01 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 38,370 | 36,527 | -1,843 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 30,443 | 34,419 | +3,976 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 33,210 | 34,336 | +1,126 | 0.22 | 0.28 | +0.06 | buy |
| Mirae Asset Global Investments Co., Ltd. | 30,798 | 33,942 | +3,144 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 28,674 | 33,867 | +5,193 | 0.01 | 0.01 | +0.00 | buy |
| Jump Financial, LLC | 84,689 | 32,237 | -52,452 | 0.06 | 0.02 | -0.04 | sell |
| DekaBank Deutsche Girozentrale | 31,800 | 31,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERICAN INTERNATIONAL GROUP, INC. | 31,688 | 31,408 | -280 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 32,499 | 30,989 | -1,510 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 30,664 | 30,664 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Louisiana State Employees Retirement System | 30,500 | 30,100 | -400 | 0.01 | 0.01 | -0.00 | sell |
| State of Tennessee, Department of Treasury | 34,035 | 29,965 | -4,070 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 14,215 | 28,430 | +14,215 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 26,315 | +26,315 | 0.00 | 0.04 | +0.04 | buy |
| Entropy Technologies, LP | 0 | 25,886 | +25,886 | 0.00 | 0.06 | +0.06 | buy |