| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,483,775 | 3,819,656 | +335,881 | 0.01 | 0.01 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 245,431 | 545,431 | +300,000 | 0.06 | 0.15 | +0.09 | buy |
| TWO SIGMA INVESTMENTS, LP | 395,727 | 599,513 | +203,786 | 0.02 | 0.03 | 0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 8,901,607 | 9,090,707 | +189,100 | 0.15 | 0.15 | +0.00 | buy |
| Rafferty Asset Management, LLC | 119,818 | 229,371 | +109,553 | 0.01 | 0.02 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 280,813 | 173,969 | +106,844 | 0.08 | 0.05 | 0.00 | sell |
| EcoR1 Capital, LLC | 5,282,516 | 5,330,416 | +47,900 | 2.91 | 2.98 | +0.07 | buy |
| WINTON GROUP Ltd | 23,099 | 44,598 | +21,499 | 0.04 | 0.07 | +0.03 | buy |
| TD ASSET MANAGEMENT INC | 123,250 | 143,450 | +20,200 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 22,729 | 38,071 | +15,342 | 0.02 | 0.03 | 0.00 | buy |
| Dynamic Technology Lab Private Ltd | 26,906 | 13,729 | +13,177 | 0.06 | 0.03 | -0.03 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 137,941 | 144,235 | +6,294 | 0.02 | 0.02 | -0.00 | buy |
| AlphaQuest LLC | 2,862 | 8,425 | +5,563 | 0.01 | 0.03 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,041 | 11,755 | +4,714 | 0.03 | 0.03 | +0.00 | buy |
| ALPS ADVISORS INC | 40,224 | 43,106 | +2,882 | 0.01 | 0.01 | +0.00 | buy |
| Linden Thomas Advisory Services, LLC | 41,653 | 42,944 | +1,291 | 0.17 | 0.15 | -0.01 | buy |
| Corton Capital Inc. | 33,210 | 34,336 | +1,126 | 0.22 | 0.28 | +0.06 | buy |
| Diversified Trust Co | 12,496 | 13,059 | +563 | 0.01 | 0.01 | -0.00 | buy |
| NFJ INVESTMENT GROUP, LLC | 55,538 | 55,384 | -154 | 0.03 | 0.03 | +0.00 | sell |
| VIRTUS ADVISERS, LLC | 4,363 | 4,087 | -276 | 0.06 | 0.05 | -0.01 | sell |
| Inspire Investing, LLC | 18,412 | 16,080 | -2,332 | 0.04 | 0.04 | -0.01 | sell |
| Rhenman & Partners Asset Management AB | 225,000 | 218,750 | -6,250 | 0.48 | 0.46 | -0.02 | sell |
| BAILLIE GIFFORD & CO | 31,005 | 22,786 | -8,219 | 0.00 | 0.00 | -0.00 | sell |
| DCF Advisers, LLC | 237,107 | 208,979 | -28,128 | 3.41 | 2.79 | -0.62 | sell |
| LOOMIS SAYLES & CO L P | 988,244 | 957,811 | -30,433 | 0.03 | 0.03 | -0.00 | sell |
| Hudson Bay Capital Management LP | 245,000 | 209,800 | -35,200 | 0.03 | 0.03 | -0.01 | sell |
| Candriam S.C.A. | 707,984 | 651,317 | -56,667 | 0.10 | 0.09 | -0.01 | sell |
| ARMISTICE CAPITAL, LLC | 1,500,000 | 1,000,000 | -500,000 | 0.43 | 0.29 | -0.14 | sell |