| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 615,531 | 1,655,690 | +1,040,159 | 0.42 | 0.62 | +0.20 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 8,984,432 | 9,761,012 | +776,580 | 0.16 | 0.09 | -0.07 | buy |
| BVF INC/IL | 2,288,760 | 2,740,141 | +451,381 | 1.78 | 1.19 | -0.59 | buy |
| Aberdeen Group plc | 175,520 | 377,112 | +201,592 | 0.01 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 234,607 | 398,152 | +163,545 | 1.11 | 0.82 | -0.30 | buy |
| Deep Track Capital, LP | 500,000 | 549,439 | +49,439 | 0.43 | 0.19 | -0.24 | buy |
| Rafferty Asset Management, LLC | 51,976 | 86,741 | +34,765 | 0.00 | 0.00 | -0.00 | buy |
| WINTON GROUP Ltd | 53,705 | 85,970 | +32,265 | 0.08 | 0.06 | -0.03 | buy |
| Erste Asset Management GmbH | 352,200 | 380,200 | +28,000 | 0.10 | 0.05 | -0.05 | buy |
| Inspire Investing, LLC | 17,489 | 32,402 | +14,913 | 0.04 | 0.04 | -0.00 | buy |
| Advantage Alpha Capital Partners LP | 13,548 | 21,760 | +8,212 | 0.07 | 0.06 | -0.01 | buy |
| PROFUND ADVISORS LLC | 13,416 | 20,294 | +6,878 | 0.01 | 0.01 | -0.00 | buy |
| Capula Management Ltd | 13,120 | 19,856 | +6,736 | 0.00 | 0.00 | -0.00 | buy |
| Linden Thomas Advisory Services, LLC | 42,877 | 43,227 | +350 | 0.12 | 0.06 | -0.07 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,469 | 1,791 | +322 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 14,839 | 14,133 | -706 | 0.03 | 0.01 | -0.02 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 143,743 | 142,917 | -826 | 0.02 | 0.01 | -0.01 | sell |
| DCF Advisers, LLC | 203,167 | 202,167 | -1,000 | 2.36 | 1.16 | -1.20 | sell |
| Woodline Partners LP | 845,916 | 843,296 | -2,620 | 0.13 | 0.06 | -0.07 | sell |
| Essex LLC | 113,661 | 109,661 | -4,000 | 0.55 | 0.25 | -0.30 | sell |
| ALPS ADVISORS INC | 56,585 | 51,459 | -5,126 | 0.01 | 0.00 | -0.01 | sell |
| Finepoint Capital LP | 660,000 | 642,200 | -17,800 | 0.93 | 0.52 | -0.41 | sell |
| LOOMIS SAYLES & CO L P | 1,092,346 | 1,069,762 | -22,584 | 0.03 | 0.02 | -0.02 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,036,412 | 3,930,647 | -105,765 | 0.01 | 0.01 | -0.01 | sell |