| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 4,897,237 | +4,897,237 | 0.00 | 0.63 | +0.63 | buy |
| BlackRock, Inc. | 11,927,218 | 13,035,918 | +1,108,700 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 268,737 | 805,421 | +536,684 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 638,021 | 1,082,419 | +444,398 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 0 | 250,000 | +250,000 | 0.00 | 1.89 | +1.89 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 10,218,322 | 10,338,022 | +119,700 | 0.12 | 0.10 | -0.02 | buy |
| Nantahala Capital Management, LLC | 164,639 | 264,639 | +100,000 | 0.15 | 0.20 | +0.05 | buy |
| GSA CAPITAL PARTNERS LLP | 14,099 | 106,699 | +92,600 | 0.02 | 0.08 | +0.06 | buy |
| Man Group plc | 19,096 | 93,694 | +74,598 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 674,657 | 744,519 | +69,862 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,752,918 | 1,815,577 | +62,659 | 0.00 | 0.00 | -0.00 | buy |
| Hudson Bay Capital Management LP | 425,000 | 487,320 | +62,320 | 0.04 | 0.04 | -0.00 | buy |
| XTX Topco Ltd | 32,009 | 92,098 | +60,089 | 0.01 | 0.02 | +0.01 | buy |
| HRT FINANCIAL LP | 0 | 59,707 | +59,707 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 321,808 | 377,699 | +55,891 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 0 | 53,045 | +53,045 | 0.00 | 0.18 | +0.18 | buy |
| AQR CAPITAL MANAGEMENT LLC | 112,271 | 162,415 | +50,144 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 1,508,727 | 1,558,290 | +49,563 | 0.00 | 0.00 | -0.00 | buy |
| DRW Securities, LLC | 0 | 48,442 | +48,442 | 0.00 | 0.03 | +0.03 | buy |
| ExodusPoint Capital Management, LP | 0 | 48,073 | +48,073 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,249,288 | 1,294,887 | +45,599 | 0.00 | 0.00 | -0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 43,526 | +43,526 | 0.00 | 0.03 | +0.03 | buy |
| HSBC HOLDINGS PLC | 20,969 | 58,579 | +37,610 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 56,165 | 93,665 | +37,500 | 0.06 | 0.07 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 583,778 | 620,756 | +36,978 | 0.03 | 0.03 | -0.00 | buy |
| Russell Investments Group, Ltd. | 47,189 | 82,534 | +35,345 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 259,319 | 293,080 | +33,761 | 0.02 | 0.01 | -0.00 | buy |
| EntryPoint Capital, LLC | 0 | 25,292 | +25,292 | 0.00 | 0.09 | +0.09 | buy |
| Qube Research & Technologies Ltd | 0 | 20,995 | +20,995 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 23,051 | 42,684 | +19,633 | 0.01 | 0.01 | -0.00 | buy |
| FMR LLC | 92,883 | 111,891 | +19,008 | 0.00 | 0.00 | -0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 17,084 | +17,084 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 88,038 | 104,713 | +16,675 | 0.05 | 0.04 | -0.00 | buy |
| FIFTH THIRD BANCORP | 449 | 17,018 | +16,569 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 594,435 | 609,788 | +15,353 | 0.01 | 0.01 | -0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 87,717 | 102,987 | +15,270 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 5,277 | 18,459 | +13,182 | 0.00 | 0.00 | +0.00 | buy |
| Inspire Investing, LLC | 30,676 | 42,529 | +11,853 | 0.04 | 0.05 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 753,258 | 763,793 | +10,535 | 0.00 | 0.00 | -0.00 | buy |
| Quantinno Capital Management LP | 47,134 | 57,077 | +9,943 | 0.00 | 0.00 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 34,794 | 43,818 | +9,024 | 0.00 | 0.00 | -0.00 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 247,242 | 255,472 | +8,230 | 0.01 | 0.01 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 216,568 | 223,669 | +7,101 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 340,326 | 347,078 | +6,752 | 0.00 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 67,570 | 74,190 | +6,620 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 20,480 | 26,145 | +5,665 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 165,797 | 170,461 | +4,664 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,075 | 6,608 | +4,533 | 0.00 | 0.00 | +0.00 | buy |
| Diversified Trust Co | 18,442 | 21,528 | +3,086 | 0.01 | 0.00 | -0.00 | buy |
| Rockefeller Capital Management L.P. | 15,545 | 18,435 | +2,890 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 7,376 | 10,013 | +2,637 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 119,789 | 121,342 | +1,553 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,636 | 13,015 | +1,379 | 0.01 | 0.01 | -0.00 | buy |
| Linden Thomas Advisory Services, LLC | 40,963 | 42,084 | +1,121 | 0.06 | 0.05 | -0.01 | buy |
| ALPS ADVISORS INC | 58,639 | 59,702 | +1,063 | 0.01 | 0.00 | -0.00 | buy |
| BESSEMER GROUP INC | 417 | 1,237 | +820 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 134,051 | 134,778 | +727 | 0.00 | 0.00 | -0.00 | buy |
| Quantbot Technologies LP | 0 | 701 | +701 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 174,603 | 175,177 | +574 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 6,500 | 7,053 | +553 | 0.00 | 0.00 | -0.00 | buy |
| Salomon & Ludwin, LLC | 587 | 1,130 | +543 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 1,548 | 2,059 | +511 | 0.00 | 0.00 | +0.00 | buy |
| EP Wealth Advisors, LLC | 13,188 | 13,623 | +435 | 0.00 | 0.00 | -0.00 | buy |
| Smartleaf Asset Management LLC | 41 | 458 | +417 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 16,103 | 16,506 | +403 | 0.07 | 0.05 | -0.01 | buy |
| NorthCrest Asset Manangement, LLC | 10,464 | 10,821 | +357 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,470 | 3,825 | +355 | 0.00 | 0.00 | -0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 690 | 974 | +284 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 3,425 | 3,656 | +231 | 0.01 | 0.00 | -0.00 | buy |
| Allworth Financial LP | 2,576 | 2,790 | +214 | 0.00 | 0.00 | -0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 5,573 | 5,770 | +197 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 3,650 | 3,843 | +193 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,402 | 1,593 | +191 | 0.00 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 10,658 | 10,831 | +173 | 0.00 | 0.00 | -0.00 | buy |
| TWIN PEAKS WEALTH ADVISORS, LLC | 0 | 98 | +98 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 155 | 249 | +94 | 0.00 | 0.00 | +0.00 | buy |
| Pinnacle Wealth Planning Services, Inc. | 4,238 | 4,316 | +78 | 0.01 | 0.01 | -0.00 | buy |
| True Wealth Design, LLC | 14 | 74 | +60 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 85 | 123 | +38 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 0 | 29 | +29 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 21 | +21 | 0.00 | 0.00 | +0.00 | buy |
| Wealth Preservation Advisors, LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 6 | 21 | +15 | 0.00 | 0.00 | +0.00 | buy |
| Parkside Financial Bank & Trust | 57 | 64 | +7 | 0.00 | 0.00 | -0.00 | buy |
| Freestone Grove Partners LP | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Hughes Financial Services, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 57,164 | 57,164 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 5,885 | 5,885 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 7,133,720 | 7,133,720 | 0 | 3.68 | 2.74 | -0.94 | hold |
| MassMutual Private Wealth & Trust, FSB | 319 | 319 | 0 | 0.00 | 0.00 | -0.00 | hold |
| OREGON PUBLIC EMPLOYEES RETIREMENT FUND | 16,312 | 16,312 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 72,090 | 72,090 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FARMERS & MERCHANTS INVESTMENTS INC | 46 | 46 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 1,102,106 | 1,102,106 | 0 | 0.10 | 0.08 | -0.02 | hold |
| JANUS HENDERSON GROUP PLC | 23,986 | 23,986 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ASSETMARK, INC | 20 | 20 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GHP Investment Advisors, Inc. | 468 | 468 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ensign Peak Advisors, Inc | 5,577 | 5,577 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIGNATUREFD, LLC | 55 | 55 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RTW INVESTMENTS, LP | 6,777,461 | 6,777,461 | 0 | 1.04 | 0.81 | -0.23 | hold |