| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 11,927,218 | 13,035,918 | +1,108,700 | 0.00 | 0.00 | -0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 10,218,322 | 10,338,022 | +119,700 | 0.12 | 0.10 | -0.02 | buy |
| BVF INC/IL | 7,133,720 | 7,133,720 | 0 | 3.68 | 2.74 | -0.94 | hold |
| RTW INVESTMENTS, LP | 6,777,461 | 6,777,461 | 0 | 1.04 | 0.81 | -0.23 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 4,897,237 | +4,897,237 | 0.00 | 0.63 | +0.63 | buy |
| STATE STREET CORP | 4,507,254 | 4,352,036 | -155,218 | 0.00 | 0.00 | -0.00 | sell |
| TCG Crossover Management, LLC | 2,452,138 | 2,452,138 | 0 | 1.24 | 0.85 | -0.40 | hold |
| EcoR1 Capital, LLC | 3,251,112 | 2,183,000 | -1,068,112 | 2.27 | 1.13 | -1.15 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,752,918 | 1,815,577 | +62,659 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,601,762 | 1,560,420 | -41,342 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 1,508,727 | 1,558,290 | +49,563 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,249,288 | 1,294,887 | +45,599 | 0.00 | 0.00 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 1,102,106 | 1,102,106 | 0 | 0.10 | 0.08 | -0.02 | hold |
| UBS Group AG | 638,021 | 1,082,419 | +444,398 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 1,308,088 | 1,066,780 | -241,308 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 268,737 | 805,421 | +536,684 | 0.01 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 753,258 | 763,793 | +10,535 | 0.00 | 0.00 | -0.00 | buy |
| JOHNSON & JOHNSON | 748,062 | 748,062 | 0 | 2.06 | 1.38 | -0.68 | hold |
| NORTHERN TRUST CORP | 674,657 | 744,519 | +69,862 | 0.00 | 0.00 | -0.00 | buy |
| Jefferies Financial Group Inc. | 720,440 | 720,440 | 0 | 0.09 | 0.11 | +0.02 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 700,435 | 696,854 | -3,581 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 583,778 | 620,756 | +36,978 | 0.03 | 0.03 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 594,435 | 609,788 | +15,353 | 0.01 | 0.01 | -0.00 | buy |
| Lynx1 Capital Management LP | 705,558 | 536,398 | -169,160 | 2.19 | 1.02 | -1.16 | sell |
| TORONTO DOMINION BANK | 491,000 | 491,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Hudson Bay Capital Management LP | 425,000 | 487,320 | +62,320 | 0.04 | 0.04 | -0.00 | buy |
| Erste Asset Management GmbH | 480,200 | 430,200 | -50,000 | 0.06 | 0.05 | -0.02 | sell |
| Bank of New York Mellon Corp | 410,650 | 395,941 | -14,709 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 321,808 | 377,699 | +55,891 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 629,408 | 366,093 | -263,315 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 340,326 | 347,078 | +6,752 | 0.00 | 0.00 | -0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 259,319 | 293,080 | +33,761 | 0.02 | 0.01 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 411,725 | 291,624 | -120,101 | 0.01 | 0.00 | -0.01 | sell |
| Nantahala Capital Management, LLC | 164,639 | 264,639 | +100,000 | 0.15 | 0.20 | +0.05 | buy |
| Invesco Ltd. | 265,820 | 263,844 | -1,976 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 247,242 | 255,472 | +8,230 | 0.01 | 0.01 | -0.00 | buy |
| Velan Capital Investment Management LP | 0 | 250,000 | +250,000 | 0.00 | 1.89 | +1.89 | buy |
| DEUTSCHE BANK AG\ | 216,568 | 223,669 | +7,101 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 359,235 | 218,354 | -140,881 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 303,979 | 201,890 | -102,089 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 174,603 | 175,177 | +574 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 165,797 | 170,461 | +4,664 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 112,271 | 162,415 | +50,144 | 0.00 | 0.00 | -0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 191,463 | 138,124 | -53,339 | 0.05 | 0.02 | -0.02 | sell |
| Nuveen, LLC | 134,051 | 134,778 | +727 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 135,806 | 128,558 | -7,248 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 119,789 | 121,342 | +1,553 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 92,883 | 111,891 | +19,008 | 0.00 | 0.00 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 14,099 | 106,699 | +92,600 | 0.02 | 0.08 | +0.06 | buy |
| WINTON GROUP Ltd | 88,038 | 104,713 | +16,675 | 0.05 | 0.04 | -0.00 | buy |
| CITIGROUP INC | 112,275 | 104,299 | -7,976 | 0.00 | 0.00 | -0.00 | sell |
| DCF Advisers, LLC | 154,736 | 103,736 | -51,000 | 0.78 | 0.47 | -0.31 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 87,717 | 102,987 | +15,270 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 119,600 | 98,800 | -20,800 | 0.00 | 0.00 | -0.00 | sell |
| Essex LLC | 98,661 | 98,661 | 0 | 0.27 | 0.21 | -0.06 | hold |
| Man Group plc | 19,096 | 93,694 | +74,598 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 56,165 | 93,665 | +37,500 | 0.06 | 0.07 | +0.00 | buy |
| XTX Topco Ltd | 32,009 | 92,098 | +60,089 | 0.01 | 0.02 | +0.01 | buy |
| Russell Investments Group, Ltd. | 47,189 | 82,534 | +35,345 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 82,942 | 80,899 | -2,043 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 124,400 | 80,490 | -43,910 | 0.03 | 0.01 | -0.02 | sell |
| Rafferty Asset Management, LLC | 97,749 | 75,580 | -22,169 | 0.01 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 67,570 | 74,190 | +6,620 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 72,090 | 72,090 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 70,526 | 68,187 | -2,339 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 128,345 | 67,566 | -60,779 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 77,802 | 62,174 | -15,628 | 0.00 | 0.00 | -0.00 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 82,828 | 61,273 | -21,555 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 0 | 59,707 | +59,707 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 58,639 | 59,702 | +1,063 | 0.01 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 70,612 | 58,767 | -11,845 | 0.01 | 0.01 | -0.00 | sell |
| HSBC HOLDINGS PLC | 20,969 | 58,579 | +37,610 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 57,164 | 57,164 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Quantinno Capital Management LP | 47,134 | 57,077 | +9,943 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 0 | 53,045 | +53,045 | 0.00 | 0.18 | +0.18 | buy |
| DRW Securities, LLC | 0 | 48,442 | +48,442 | 0.00 | 0.03 | +0.03 | buy |
| ExodusPoint Capital Management, LP | 0 | 48,073 | +48,073 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 175,152 | 44,491 | -130,661 | 0.02 | 0.00 | -0.02 | sell |
| TUDOR INVESTMENT CORP ET AL | 34,794 | 43,818 | +9,024 | 0.00 | 0.00 | -0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 43,526 | +43,526 | 0.00 | 0.03 | +0.03 | buy |
| Brevan Howard Capital Management LP | 23,051 | 42,684 | +19,633 | 0.01 | 0.01 | -0.00 | buy |
| Inspire Investing, LLC | 30,676 | 42,529 | +11,853 | 0.04 | 0.05 | +0.01 | buy |
| Linden Thomas Advisory Services, LLC | 40,963 | 42,084 | +1,121 | 0.06 | 0.05 | -0.01 | buy |
| FRANKLIN RESOURCES INC | 41,225 | 41,184 | -41 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 58,530 | 41,070 | -17,460 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 40,212 | 39,715 | -497 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 38,448 | 38,284 | -164 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 38,825 | 37,236 | -1,589 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 43,960 | 36,855 | -7,105 | 0.02 | 0.02 | -0.00 | sell |
| State of Alaska, Department of Revenue | 36,407 | 35,250 | -1,157 | 0.01 | 0.00 | -0.00 | sell |
| Louisiana State Employees Retirement System | 32,700 | 31,700 | -1,000 | 0.01 | 0.01 | -0.00 | sell |
| Cerity Partners LLC | 31,302 | 30,512 | -790 | 0.00 | 0.00 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 34,097 | 30,263 | -3,834 | 0.00 | 0.00 | -0.00 | sell |
| Quinn Opportunity Partners LLC | 30,000 | 30,000 | 0 | 0.02 | 0.02 | -0.00 | hold |
| State of Tennessee, Department of Treasury | 28,276 | 27,951 | -325 | 0.00 | 0.00 | +0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 38,037 | 27,880 | -10,157 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 79,667 | 27,233 | -52,434 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 20,480 | 26,145 | +5,665 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 25,292 | +25,292 | 0.00 | 0.09 | +0.09 | buy |
| JANUS HENDERSON GROUP PLC | 23,986 | 23,986 | 0 | 0.00 | 0.00 | -0.00 | hold |