| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRIMECAP MANAGEMENT CO/CA/ | 9,090,707 | 9,116,202 | +25,495 | 0.15 | 0.12 | -0.03 | buy |
| VANGUARD GROUP INC | 7,011,042 | 6,996,994 | -14,048 | 0.00 | 0.00 | -0.00 | sell |
| EcoR1 Capital, LLC | 5,330,416 | 5,330,416 | 0 | 3.00 | 3.09 | +0.09 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,819,656 | 3,962,403 | +142,747 | 0.01 | 0.01 | -0.00 | buy |
| STATE STREET CORP | 4,235,443 | 3,352,376 | -883,067 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 650,000 | 1,500,000 | +850,000 | 1.51 | 3.27 | +1.76 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,371,448 | 1,459,427 | +87,979 | 0.01 | 0.01 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,349,786 | 1,437,692 | +87,906 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 825,400 | 1,261,789 | +436,389 | 0.05 | 0.08 | +0.02 | buy |
| LOOMIS SAYLES & CO L P | 957,811 | 921,184 | -36,627 | 0.03 | 0.02 | -0.01 | sell |
| ARMISTICE CAPITAL, LLC | 1,000,000 | 864,000 | -136,000 | 0.59 | 0.43 | -0.16 | sell |
| MILLENNIUM MANAGEMENT LLC | 822,976 | 820,871 | -2,105 | 0.02 | 0.01 | -0.00 | sell |
| JOHNSON & JOHNSON | 748,062 | 748,062 | 0 | 0.38 | 3.53 | +3.16 | hold |
| NORTHERN TRUST CORP | 684,284 | 664,109 | -20,175 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 802,689 | 621,263 | -181,426 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 552,922 | 586,200 | +33,278 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 601,900 | 580,500 | -21,400 | 0.03 | 0.02 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 493,315 | 569,017 | +75,702 | 0.00 | 0.00 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 545,431 | 545,431 | 0 | 0.15 | 0.13 | -0.02 | hold |
| TWO SIGMA INVESTMENTS, LP | 599,513 | 501,614 | -97,899 | 0.03 | 0.02 | -0.01 | sell |
| Bank of New York Mellon Corp | 484,734 | 500,708 | +15,974 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 202,955 | 491,264 | +288,309 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 338,508 | 464,812 | +126,304 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 269,693 | 339,856 | +70,163 | 0.00 | 0.00 | -0.00 | buy |
| Erste Asset Management GmbH | 334,200 | 334,200 | 0 | 0.10 | 0.08 | -0.02 | hold |
| Candriam S.C.A. | 651,317 | 310,019 | -341,298 | 0.09 | 0.04 | -0.06 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 323,665 | 307,167 | -16,498 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 208,227 | 305,673 | +97,446 | 0.02 | 0.02 | +0.00 | buy |
| Hudson Bay Capital Management LP | 209,800 | 300,000 | +90,200 | 0.04 | 0.04 | +0.00 | buy |
| CITADEL ADVISORS LLC | 318,100 | 268,577 | -49,523 | 0.01 | 0.01 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 212,332 | 232,375 | +20,043 | 0.02 | 0.02 | -0.00 | buy |
| NORGES BANK | 325,439 | 219,893 | -105,546 | 0.00 | 0.00 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 218,750 | 218,750 | 0 | 0.46 | 0.40 | -0.06 | hold |
| ExodusPoint Capital Management, LP | 173,969 | 216,173 | +42,204 | 0.05 | 0.04 | -0.00 | buy |
| Russell Investments Group, Ltd. | 224,140 | 212,559 | -11,581 | 0.01 | 0.01 | -0.00 | sell |
| DCF Advisers, LLC | 208,979 | 208,979 | 0 | 2.79 | 2.07 | -0.72 | hold |
| FRANKLIN RESOURCES INC | 196,452 | 203,023 | +6,571 | 0.00 | 0.00 | -0.00 | buy |
| MACQUARIE GROUP LTD | 200,000 | 200,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| AMERIPRISE FINANCIAL INC | 229,876 | 192,041 | -37,835 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 49,164 | 189,023 | +139,859 | 0.00 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 188,383 | 184,075 | -4,308 | 0.00 | 0.00 | -0.00 | sell |
| Aberdeen Group plc | 175,520 | 175,520 | 0 | 0.01 | 0.01 | -0.00 | hold |
| RHUMBLINE ADVISERS | 150,308 | 154,573 | +4,265 | 0.00 | 0.00 | -0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 144,235 | 146,113 | +1,878 | 0.02 | 0.02 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 143,450 | 145,650 | +2,200 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 15,107 | 141,958 | +126,851 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 124,781 | 135,657 | +10,876 | 0.02 | 0.02 | -0.00 | buy |
| Qube Research & Technologies Ltd | 123,414 | 135,047 | +11,633 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 193,972 | 134,165 | -59,807 | 0.03 | 0.02 | -0.01 | sell |
| JPMORGAN CHASE & CO | 129,211 | 126,719 | -2,492 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 97,881 | 119,988 | +22,107 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 107,500 | 107,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cubist Systematic Strategies, LLC | 193,344 | 101,653 | -91,691 | 0.05 | 0.03 | -0.02 | sell |
| Rafferty Asset Management, LLC | 229,371 | 95,515 | -133,856 | 0.02 | 0.01 | -0.01 | sell |
| AMERICAN CENTURY COMPANIES INC | 83,292 | 95,375 | +12,083 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 117,230 | 86,264 | -30,966 | 0.05 | 0.02 | -0.03 | sell |
| UBS Group AG | 210,805 | 83,195 | -127,610 | 0.00 | 0.00 | -0.00 | sell |
| CANADA LIFE ASSURANCE Co | 78,425 | 80,876 | +2,451 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 98,165 | 77,502 | -20,663 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 101,505 | 76,672 | -24,833 | 0.06 | 0.03 | -0.03 | sell |
| ALLIANCEBERNSTEIN L.P. | 75,250 | 75,250 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Man Group plc | 66,657 | 74,100 | +7,443 | 0.00 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 68,695 | 65,905 | -2,790 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 43,600 | 65,323 | +21,723 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 58,526 | 58,526 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Y-Intercept (Hong Kong) Ltd | 26,315 | 58,449 | +32,134 | 0.04 | 0.06 | +0.02 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 55,102 | 54,192 | -910 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 229,111 | 52,718 | -176,393 | 0.01 | 0.00 | -0.00 | sell |
| NFJ INVESTMENT GROUP, LLC | 55,384 | 52,641 | -2,743 | 0.03 | 0.03 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 34,419 | 51,453 | +17,034 | 0.00 | 0.00 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 52,810 | 51,189 | -1,621 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 32,237 | 50,706 | +18,469 | 0.02 | 0.02 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 42,316 | 48,870 | +6,554 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 43,106 | 48,097 | +4,991 | 0.01 | 0.01 | -0.00 | buy |
| WINTON GROUP Ltd | 44,598 | 46,481 | +1,883 | 0.07 | 0.06 | -0.01 | buy |
| TEXAS PERMANENT SCHOOL FUND CORP | 53,277 | 45,562 | -7,715 | 0.01 | 0.01 | -0.00 | sell |
| Linden Thomas Advisory Services, LLC | 42,944 | 43,643 | +699 | 0.15 | 0.13 | -0.03 | buy |
| Advantage Alpha Capital Partners LP | 47,375 | 42,871 | -4,504 | 0.20 | 0.18 | -0.02 | sell |
| AQR CAPITAL MANAGEMENT LLC | 0 | 39,791 | +39,791 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 41,681 | 39,737 | -1,944 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 38,059 | +38,059 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 36,527 | 36,527 | 0 | 0.00 | 0.00 | -0.00 | hold |
| State of Alaska, Department of Revenue | 37,085 | 36,204 | -881 | 0.01 | 0.01 | -0.00 | sell |
| MetLife Investment Management, LLC | 30,664 | 34,852 | +4,188 | 0.00 | 0.00 | -0.00 | buy |
| STRS OHIO | 1,200 | 33,500 | +32,300 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 31,800 | 31,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Louisiana State Employees Retirement System | 30,100 | 31,000 | +900 | 0.01 | 0.01 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 33,867 | 30,774 | -3,093 | 0.01 | 0.01 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 30,989 | 29,753 | -1,236 | 0.00 | 0.00 | -0.00 | sell |
| State of Tennessee, Department of Treasury | 29,965 | 29,684 | -281 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 38,783 | 28,698 | -10,085 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 19,575 | 24,066 | +4,491 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 24,293 | 23,986 | -307 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 23,300 | 23,789 | +489 | 0.00 | 0.00 | -0.00 | buy |
| BAILLIE GIFFORD & CO | 22,786 | 23,530 | +744 | 0.00 | 0.00 | -0.00 | buy |
| PDT Partners, LLC | 0 | 22,965 | +22,965 | 0.00 | 0.04 | +0.04 | buy |
| UniSuper Management Pty Ltd | 22,543 | 22,543 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Maryland State Retirement & Pension System | 21,936 | 21,499 | -437 | 0.01 | 0.01 | -0.00 | sell |
| GUGGENHEIM CAPITAL LLC | 0 | 20,571 | +20,571 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 20,499 | +20,499 | 0.00 | 0.03 | +0.03 | buy |