| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 11,947,614 | 11,855,254 | -92,360 | 0.00 | 0.00 | -0.00 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 9,761,012 | 10,527,322 | +766,310 | 0.09 | 0.07 | -0.02 | buy |
| VANGUARD GROUP INC | 7,898,466 | 8,624,374 | +725,908 | 0.00 | 0.00 | -0.00 | buy |
| EcoR1 Capital, LLC | 6,144,767 | 6,144,767 | 0 | 3.88 | 2.86 | -1.02 | hold |
| STATE STREET CORP | 3,683,715 | 3,817,610 | +133,895 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,930,647 | 3,760,184 | -170,463 | 0.01 | 0.00 | -0.00 | sell |
| BVF INC/IL | 2,740,141 | 2,740,141 | 0 | 1.19 | 0.77 | -0.42 | hold |
| TCG Crossover Management, LLC | 2,452,138 | 2,452,138 | 0 | 3.56 | 2.20 | -1.36 | hold |
| RTW INVESTMENTS, LP | 2,402,883 | 2,402,883 | 0 | 0.39 | 0.27 | -0.12 | hold |
| DIMENSIONAL FUND ADVISORS LP | 1,737,388 | 1,780,570 | +43,182 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,674,348 | 1,703,664 | +29,316 | 0.00 | 0.00 | -0.00 | buy |
| BRAIDWELL LP | 1,655,690 | 1,655,690 | 0 | 0.62 | 0.45 | -0.17 | hold |
| ROYAL BANK OF CANADA | 10,098 | 1,319,034 | +1,308,936 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 0 | 1,250,000 | +1,250,000 | 0.00 | 1.31 | +1.31 | buy |
| MORGAN STANLEY | 854,723 | 1,025,398 | +170,675 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 482,691 | 938,993 | +456,302 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 843,296 | 843,296 | 0 | 0.06 | 0.04 | -0.02 | hold |
| Nantahala Capital Management, LLC | 456,741 | 820,103 | +363,362 | 0.40 | 0.46 | +0.05 | buy |
| UBS Group AG | 941,842 | 776,196 | -165,646 | 0.00 | 0.00 | -0.00 | sell |
| JOHNSON & JOHNSON | 748,062 | 748,062 | 0 | 2.33 | 1.82 | -0.51 | hold |
| GOLDMAN SACHS GROUP INC | 726,734 | 716,392 | -10,342 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 706,632 | 715,867 | +9,235 | 0.00 | 0.00 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 670,431 | 670,431 | 0 | 0.08 | 0.05 | -0.03 | hold |
| BARCLAYS PLC | 178,260 | 654,397 | +476,137 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 636,656 | 599,039 | -37,617 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 398,300 | 579,300 | +181,000 | 0.01 | 0.01 | -0.00 | buy |
| Aberdeen Group plc | 377,112 | 558,810 | +181,698 | 0.01 | 0.01 | -0.00 | buy |
| Deep Track Capital, LP | 549,439 | 549,439 | 0 | 0.19 | 0.14 | -0.05 | hold |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 904,485 | 521,667 | -382,818 | 0.04 | 0.02 | -0.02 | sell |
| PANAGORA ASSET MANAGEMENT INC | 290,328 | 488,892 | +198,564 | 0.02 | 0.02 | +0.00 | buy |
| Hudson Bay Capital Management LP | 460,890 | 485,000 | +24,110 | 0.03 | 0.03 | -0.01 | buy |
| Bank of New York Mellon Corp | 429,150 | 478,678 | +49,528 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 305,131 | 439,843 | +134,712 | 0.01 | 0.01 | -0.00 | buy |
| Erste Asset Management GmbH | 380,200 | 380,200 | 0 | 0.05 | 0.03 | -0.03 | hold |
| Squarepoint Ops LLC | 11,174 | 363,153 | +351,979 | 0.00 | 0.01 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 348,726 | 352,839 | +4,113 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 59,383 | 346,934 | +287,551 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 155,580 | 335,493 | +179,913 | 0.02 | 0.03 | +0.01 | buy |
| JPMORGAN CHASE & CO | 121,825 | 330,007 | +208,182 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 308,958 | 314,853 | +5,895 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 166,689 | 294,798 | +128,109 | 0.02 | 0.03 | +0.00 | buy |
| Walleye Capital LLC | 0 | 248,706 | +248,706 | 0.00 | 0.02 | +0.02 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 221,971 | 242,652 | +20,681 | 0.01 | 0.01 | -0.00 | buy |
| CITADEL ADVISORS LLC | 58,484 | 220,268 | +161,784 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 656,201 | 216,901 | -439,300 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 180,100 | 209,375 | +29,275 | 0.00 | 0.00 | -0.00 | buy |
| MACQUARIE GROUP LTD | 200,000 | 200,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 183,627 | 180,905 | -2,722 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 163,857 | 176,404 | +12,547 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 133,360 | 171,420 | +38,060 | 0.02 | 0.02 | -0.00 | buy |
| Rhenman & Partners Asset Management AB | 195,750 | 165,750 | -30,000 | 0.24 | 0.16 | -0.07 | sell |
| AMERICAN CENTURY COMPANIES INC | 139,242 | 155,973 | +16,731 | 0.00 | 0.00 | -0.00 | buy |
| DCF Advisers, LLC | 202,167 | 140,000 | -62,167 | 1.16 | 0.53 | -0.63 | sell |
| Nuveen, LLC | 161,149 | 134,051 | -27,098 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 0 | 132,045 | +132,045 | 0.00 | 0.02 | +0.02 | buy |
| Verition Fund Management LLC | 28,032 | 128,949 | +100,917 | 0.00 | 0.01 | +0.00 | buy |
| Jump Financial, LLC | 50,473 | 126,972 | +76,499 | 0.01 | 0.01 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 120,207 | 121,137 | +930 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 37,330 | 118,970 | +81,640 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 115,300 | 115,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Essex LLC | 109,661 | 105,961 | -3,700 | 0.25 | 0.16 | -0.09 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 101,407 | 104,650 | +3,243 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 101,722 | 101,722 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 165,179 | 99,184 | -65,995 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 41,127 | 96,301 | +55,174 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 12,704 | 95,847 | +83,143 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 49,605 | 95,745 | +46,140 | 0.04 | 0.02 | -0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 99,578 | 93,130 | -6,448 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 92,614 | +92,614 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 85,970 | 91,241 | +5,271 | 0.06 | 0.04 | -0.02 | buy |
| Rafferty Asset Management, LLC | 86,741 | 90,599 | +3,858 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 398,152 | 85,826 | -312,326 | 0.82 | 0.11 | -0.71 | sell |
| ALLIANCEBERNSTEIN L.P. | 72,090 | 72,090 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 68,275 | 71,990 | +3,715 | 0.00 | 0.00 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 67,759 | 70,015 | +2,256 | 0.00 | 0.00 | -0.00 | buy |
| Birchview Capital, LP | 26,000 | 70,000 | +44,000 | 0.24 | 0.55 | +0.31 | buy |
| FMR LLC | 76,652 | 68,327 | -8,325 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 37,029 | 65,566 | +28,537 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 101,392 | 64,184 | -37,208 | 0.02 | 0.01 | -0.00 | sell |
| Man Group plc | 0 | 61,752 | +61,752 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 64,681 | 61,376 | -3,305 | 0.01 | 0.00 | -0.00 | sell |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 59,326 | 59,426 | +100 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 152,400 | 55,600 | -96,800 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 59,130 | 54,193 | -4,937 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 51,832 | 51,832 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Engineers Gate Manager LP | 0 | 50,562 | +50,562 | 0.00 | 0.00 | +0.00 | buy |
| Inspire Investing, LLC | 32,402 | 49,111 | +16,709 | 0.04 | 0.04 | +0.00 | buy |
| Centiva Capital, LP | 0 | 48,958 | +48,958 | 0.00 | 0.03 | +0.03 | buy |
| WELLS FARGO & COMPANY/MN | 39,460 | 46,133 | +6,673 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 42,376 | 44,683 | +2,307 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 44,047 | 43,265 | -782 | 0.00 | 0.00 | -0.00 | sell |
| Linden Thomas Advisory Services, LLC | 43,227 | 42,505 | -722 | 0.06 | 0.04 | -0.02 | sell |
| State of Alaska, Department of Revenue | 38,777 | 42,351 | +3,574 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 40,353 | 40,353 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 52,432 | 39,485 | -12,947 | 0.00 | 0.00 | -0.00 | sell |
| Jain Global LLC | 0 | 38,981 | +38,981 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 51,459 | 38,399 | -13,060 | 0.00 | 0.00 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 36,527 | 36,527 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 34,708 | 34,437 | -271 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 31,942 | 33,304 | +1,362 | 0.13 | 0.10 | -0.03 | buy |