| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 13,035,918 | 13,651,261 | +615,343 | 0.00 | 0.00 | +0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 10,338,022 | 10,181,322 | -156,700 | 0.10 | 0.10 | -0.00 | sell |
| BVF INC/IL | 7,133,720 | 7,133,720 | 0 | 2.74 | 2.94 | +0.20 | hold |
| RTW INVESTMENTS, LP | 6,777,461 | 6,777,461 | 0 | 0.81 | 0.93 | +0.12 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 4,897,237 | 5,274,274 | +377,037 | 0.63 | 0.74 | +0.11 | buy |
| STATE STREET CORP | 4,352,036 | 4,954,016 | +601,980 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 2,452,138 | 2,452,138 | 0 | 0.85 | 0.95 | +0.10 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,560,420 | 2,356,409 | +795,989 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,815,577 | 1,920,859 | +105,282 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,558,290 | 1,752,556 | +194,266 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 1,082,419 | 1,306,174 | +223,755 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 1,102,106 | 1,102,106 | 0 | 0.08 | 0.09 | +0.01 | hold |
| Legal & General Group Plc | 1,066,780 | 1,091,177 | +24,397 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,294,887 | 1,011,119 | -283,768 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 763,793 | 968,778 | +204,985 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 609,788 | 853,677 | +243,889 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 805,421 | 819,515 | +14,094 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 744,519 | 794,279 | +49,760 | 0.00 | 0.00 | +0.00 | buy |
| JOHNSON & JOHNSON | 748,062 | 748,062 | 0 | 1.38 | 1.51 | +0.13 | hold |
| Jefferies Financial Group Inc. | 720,440 | 720,440 | 0 | 0.11 | 0.11 | +0.00 | hold |
| Sixth Street Partners Management Company, L.P. | 0 | 707,242 | +707,242 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 696,854 | 707,242 | +10,388 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 620,756 | 680,182 | +59,426 | 0.03 | 0.03 | +0.01 | buy |
| Deep Track Capital, LP | 0 | 593,551 | +593,551 | 0.00 | 0.14 | +0.14 | buy |
| TORONTO DOMINION BANK | 491,000 | 491,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| AQR CAPITAL MANAGEMENT LLC | 162,415 | 483,834 | +321,419 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 395,941 | 410,769 | +14,828 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 121,342 | 382,094 | +260,752 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 366,093 | 360,396 | -5,697 | 0.00 | 0.00 | +0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 347,078 | 358,229 | +11,151 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 263,844 | 260,612 | -3,232 | 0.00 | 0.00 | -0.00 | sell |
| Velan Capital Investment Management LP | 250,000 | 255,000 | +5,000 | 1.89 | 2.52 | +0.63 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 255,472 | 254,741 | -731 | 0.01 | 0.01 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 93,665 | 232,560 | +138,895 | 0.07 | 0.18 | +0.11 | buy |
| Hudson Bay Capital Management LP | 487,320 | 210,000 | -277,320 | 0.04 | 0.02 | -0.02 | sell |
| BARCLAYS PLC | 218,354 | 203,619 | -14,735 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 377,699 | 190,826 | -186,873 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 170,461 | 181,617 | +11,156 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 175,177 | 180,205 | +5,028 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 104,299 | 167,189 | +62,890 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 201,890 | 167,089 | -34,801 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 138,124 | 159,584 | +21,460 | 0.02 | 0.04 | +0.02 | buy |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 0 | 151,410 | +151,410 | 0.00 | 0.05 | +0.05 | buy |
| Trexquant Investment LP | 44,491 | 144,555 | +100,064 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 134,778 | 139,370 | +4,592 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 10,531 | 131,000 | +120,469 | 0.00 | 0.02 | +0.02 | buy |
| HSBC HOLDINGS PLC | 58,579 | 125,482 | +66,903 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 128,558 | 124,368 | -4,190 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 223,669 | 119,822 | -103,847 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 111,891 | 119,745 | +7,854 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 92,098 | 107,377 | +15,279 | 0.02 | 0.02 | +0.00 | buy |
| WINTON GROUP Ltd | 104,713 | 106,247 | +1,534 | 0.04 | 0.06 | +0.01 | buy |
| DCF Advisers, LLC | 103,736 | 103,736 | 0 | 0.47 | 0.44 | -0.03 | hold |
| Essex LLC | 98,661 | 98,661 | 0 | 0.21 | 0.24 | +0.03 | hold |
| ALLIANCEBERNSTEIN L.P. | 72,090 | 97,790 | +25,700 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 430,200 | 92,200 | -338,000 | 0.05 | 0.01 | -0.03 | sell |
| Swiss National Bank | 98,800 | 92,000 | -6,800 | 0.00 | 0.00 | +0.00 | sell |
| Quinn Opportunity Partners LLC | 30,000 | 90,000 | +60,000 | 0.02 | 0.07 | +0.05 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 102,987 | 80,736 | -22,251 | 0.00 | 0.01 | +0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 27,880 | 75,105 | +47,225 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 74,190 | 74,870 | +680 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 59,702 | 74,646 | +14,944 | 0.00 | 0.01 | +0.00 | buy |
| HRT FINANCIAL LP | 59,707 | 74,615 | +14,908 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 43,818 | 72,917 | +29,099 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 71,572 | +71,572 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 68,187 | 70,526 | +2,339 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 21,788 | 70,241 | +48,453 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 67,566 | 68,168 | +602 | 0.00 | 0.00 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 291,624 | 67,854 | -223,770 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 62,174 | 62,174 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLS FARGO & COMPANY/MN | 27,233 | 60,837 | +33,604 | 0.00 | 0.00 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 61,273 | 59,716 | -1,557 | 0.00 | 0.00 | +0.00 | sell |
| Man Group plc | 93,694 | 58,380 | -35,314 | 0.00 | 0.00 | -0.00 | sell |
| CANADA LIFE ASSURANCE Co | 57,164 | 57,164 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rafferty Asset Management, LLC | 75,580 | 53,920 | -21,660 | 0.00 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 57,077 | 53,494 | -3,583 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 0 | 50,475 | +50,475 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 80,899 | 49,696 | -31,203 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 41,070 | 46,328 | +5,258 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 82,534 | 45,146 | -37,388 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 44,403 | +44,403 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 41,184 | 43,841 | +2,657 | 0.00 | 0.00 | +0.00 | buy |
| Inspire Investing, LLC | 42,529 | 41,642 | -887 | 0.05 | 0.03 | -0.02 | sell |
| MetLife Investment Management, LLC | 39,715 | 40,614 | +899 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 30,512 | 39,929 | +9,417 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 38,284 | 38,193 | -91 | 0.00 | 0.00 | +0.00 | sell |
| Palumbo Wealth Management LLC | 17,806 | 37,540 | +19,734 | 0.05 | 0.13 | +0.07 | buy |
| GSA CAPITAL PARTNERS LLP | 106,699 | 34,520 | -72,179 | 0.08 | 0.04 | -0.04 | sell |
| EntryPoint Capital, LLC | 25,292 | 32,752 | +7,460 | 0.09 | 0.13 | +0.04 | buy |
| Louisiana State Employees Retirement System | 31,700 | 32,500 | +800 | 0.01 | 0.01 | +0.00 | buy |
| LPL Financial LLC | 0 | 30,839 | +30,839 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 36,855 | 29,616 | -7,239 | 0.02 | 0.01 | -0.00 | sell |
| State of Tennessee, Department of Treasury | 27,951 | 29,363 | +1,412 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 28,507 | +28,507 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 18,459 | 28,147 | +9,688 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 26,145 | 27,077 | +932 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 53,045 | 26,822 | -26,223 | 0.18 | 0.10 | -0.08 | sell |
| Virtus Investment Advisers, LLC | 16,506 | 26,537 | +10,031 | 0.05 | 0.10 | +0.04 | buy |
| Creative Planning | 16,322 | 25,867 | +9,545 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 18,989 | 25,789 | +6,800 | 0.00 | 0.00 | +0.00 | buy |