| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRIMECAP MANAGEMENT CO/CA/ | 9,116,202 | 9,137,195 | +20,993 | 0.12 | 0.14 | +0.01 | buy |
| VANGUARD GROUP INC | 6,996,994 | 7,599,326 | +602,332 | 0.00 | 0.00 | +0.00 | buy |
| EcoR1 Capital, LLC | 5,330,416 | 5,330,416 | 0 | 3.09 | 3.67 | +0.58 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,962,403 | 3,929,062 | -33,341 | 0.01 | 0.01 | +0.00 | sell |
| Point72 Asset Management, L.P. | 1,261,789 | 3,120,229 | +1,858,440 | 0.08 | 0.22 | +0.14 | buy |
| STATE STREET CORP | 3,352,376 | 3,119,290 | -233,086 | 0.00 | 0.00 | -0.00 | sell |
| TCG Crossover Management, LLC | 0 | 2,427,138 | +2,427,138 | 0.00 | 4.14 | +4.14 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,437,692 | 1,455,350 | +17,658 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 820,871 | 1,414,296 | +593,425 | 0.01 | 0.02 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,459,427 | 1,399,235 | -60,192 | 0.01 | 0.01 | -0.00 | sell |
| LOOMIS SAYLES & CO L P | 921,184 | 900,266 | -20,918 | 0.02 | 0.02 | -0.00 | sell |
| BVF INC/IL | 0 | 850,000 | +850,000 | 0.00 | 0.50 | +0.50 | buy |
| Woodline Partners LP | 0 | 843,325 | +843,325 | 0.00 | 0.14 | +0.14 | buy |
| Deep Track Capital, LP | 0 | 800,000 | +800,000 | 0.00 | 0.51 | +0.51 | buy |
| JOHNSON & JOHNSON | 748,062 | 748,062 | 0 | 3.53 | 3.52 | -0.01 | hold |
| BAKER BROS. ADVISORS LP | 545,431 | 670,431 | +125,000 | 0.13 | 0.14 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 586,200 | 626,988 | +40,788 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 664,109 | 626,497 | -37,612 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 569,017 | 619,437 | +50,420 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 621,263 | 616,207 | -5,056 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 491,264 | 610,875 | +119,611 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 575,000 | +575,000 | 0.00 | 0.13 | +0.13 | buy |
| RTW INVESTMENTS, LP | 0 | 575,000 | +575,000 | 0.00 | 0.17 | +0.17 | buy |
| TWO SIGMA ADVISERS, LP | 580,500 | 572,900 | -7,600 | 0.02 | 0.03 | +0.00 | sell |
| CITADEL ADVISORS LLC | 268,577 | 555,987 | +287,410 | 0.01 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 527,671 | +527,671 | 0.00 | 0.23 | +0.23 | buy |
| ARMISTICE CAPITAL, LLC | 864,000 | 478,000 | -386,000 | 0.43 | 0.25 | -0.18 | sell |
| TWO SIGMA INVESTMENTS, LP | 501,614 | 469,837 | -31,777 | 0.02 | 0.02 | -0.00 | sell |
| BRAIDWELL LP | 0 | 466,448 | +466,448 | 0.00 | 0.27 | +0.27 | buy |
| Bank of New York Mellon Corp | 500,708 | 418,566 | -82,142 | 0.00 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 0 | 401,013 | +401,013 | 0.00 | 0.26 | +0.26 | buy |
| GOLDMAN SACHS GROUP INC | 464,812 | 367,137 | -97,675 | 0.00 | 0.00 | -0.00 | sell |
| Erste Asset Management GmbH | 334,200 | 352,200 | +18,000 | 0.08 | 0.08 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 342,262 | +342,262 | 0.00 | 1.15 | +1.15 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 339,856 | 332,876 | -6,980 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 307,167 | 291,916 | -15,251 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 212,559 | 233,025 | +20,466 | 0.01 | 0.01 | +0.00 | buy |
| NORGES BANK | 219,893 | 216,859 | -3,034 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 300,000 | 210,000 | -90,000 | 0.04 | 0.03 | -0.01 | sell |
| DCF Advisers, LLC | 208,979 | 209,479 | +500 | 2.07 | 2.17 | +0.10 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 305,673 | 207,622 | -98,051 | 0.02 | 0.02 | -0.01 | sell |
| Trexquant Investment LP | 86,264 | 206,022 | +119,758 | 0.02 | 0.05 | +0.03 | buy |
| Rhenman & Partners Asset Management AB | 218,750 | 203,750 | -15,000 | 0.40 | 0.33 | -0.07 | sell |
| MACQUARIE GROUP LTD | 200,000 | 200,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FRANKLIN RESOURCES INC | 203,023 | 188,480 | -14,543 | 0.00 | 0.00 | -0.00 | sell |
| Aberdeen Group plc | 175,520 | 175,520 | 0 | 0.01 | 0.01 | +0.00 | hold |
| AMERIPRISE FINANCIAL INC | 192,041 | 169,706 | -22,335 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 141,958 | 168,431 | +26,473 | 0.00 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 184,075 | 166,936 | -17,139 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 189,023 | 158,314 | -30,709 | 0.01 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 216,173 | 156,908 | -59,265 | 0.04 | 0.03 | -0.01 | sell |
| BARCLAYS PLC | 77,502 | 155,568 | +78,066 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 154,573 | 152,257 | -2,316 | 0.00 | 0.00 | +0.00 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 146,113 | 145,162 | -951 | 0.02 | 0.02 | +0.00 | sell |
| Essex LLC | 0 | 132,661 | +132,661 | 0.00 | 0.55 | +0.55 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 135,657 | 131,157 | -4,500 | 0.02 | 0.01 | -0.00 | sell |
| JPMORGAN CHASE & CO | 126,719 | 130,354 | +3,635 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 145,650 | 125,250 | -20,400 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 107,500 | 120,000 | +12,500 | 0.00 | 0.00 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 51,189 | 116,369 | +65,180 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 119,988 | 109,716 | -10,272 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 95,375 | 102,835 | +7,460 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 96,100 | +96,100 | 0.00 | 0.10 | +0.10 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 38,059 | 90,288 | +52,229 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 83,195 | 89,457 | +6,262 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 52,718 | 80,059 | +27,341 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 80,000 | +80,000 | 0.00 | 0.17 | +0.17 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 75,507 | +75,507 | 0.00 | 0.34 | +0.34 | buy |
| ALLIANCEBERNSTEIN L.P. | 75,250 | 75,250 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CANADA LIFE ASSURANCE Co | 80,876 | 75,245 | -5,631 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 101,653 | 68,029 | -33,624 | 0.03 | 0.02 | -0.01 | sell |
| Rafferty Asset Management, LLC | 95,515 | 64,273 | -31,242 | 0.01 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 65,905 | 63,905 | -2,000 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 0 | 62,190 | +62,190 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 58,526 | 58,226 | -300 | 0.00 | 0.00 | +0.00 | sell |
| WINTON GROUP Ltd | 46,481 | 55,747 | +9,266 | 0.06 | 0.08 | +0.02 | buy |
| Jump Financial, LLC | 50,706 | 54,123 | +3,417 | 0.02 | 0.02 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 54,192 | 52,754 | -1,438 | 0.00 | 0.00 | -0.00 | sell |
| NFJ INVESTMENT GROUP, LLC | 52,641 | 50,311 | -2,330 | 0.03 | 0.03 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 134,165 | 50,284 | -83,881 | 0.02 | 0.01 | -0.01 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 51,453 | 50,213 | -1,240 | 0.00 | 0.00 | +0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 232,375 | 49,459 | -182,916 | 0.02 | 0.00 | -0.02 | sell |
| ALPS ADVISORS INC | 48,097 | 48,083 | -14 | 0.01 | 0.01 | +0.00 | sell |
| Polar Asset Management Partners Inc. | 0 | 46,700 | +46,700 | 0.00 | 0.02 | +0.02 | buy |
| Engineers Gate Manager LP | 76,672 | 46,671 | -30,001 | 0.03 | 0.02 | -0.01 | sell |
| Linden Thomas Advisory Services, LLC | 43,643 | 43,428 | -215 | 0.13 | 0.12 | -0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 39,737 | 39,737 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 29,753 | 37,913 | +8,160 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 36,527 | 36,527 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STRS OHIO | 33,500 | 35,300 | +1,800 | 0.00 | 0.00 | +0.00 | buy |
| State of Alaska, Department of Revenue | 36,204 | 35,286 | -918 | 0.01 | 0.01 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 30,774 | 34,894 | +4,120 | 0.01 | 0.01 | +0.00 | buy |
| MetLife Investment Management, LLC | 34,852 | 34,852 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Corebridge Financial, Inc. | 34,563 | 34,203 | -360 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32,882 | 32,705 | -177 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 12,805 | 32,196 | +19,391 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 32,000 | +32,000 | 0.00 | 0.02 | +0.02 | buy |
| SG Americas Securities, LLC | 8,130 | 31,887 | +23,757 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 31,800 | 31,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Louisiana State Employees Retirement System | 31,000 | 29,900 | -1,100 | 0.01 | 0.01 | -0.00 | sell |