| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 0 | 2,427,138 | +2,427,138 | 0.00 | 4.14 | +4.14 | buy |
| Point72 Asset Management, L.P. | 1,261,789 | 3,120,229 | +1,858,440 | 0.08 | 0.22 | +0.14 | buy |
| BVF INC/IL | 0 | 850,000 | +850,000 | 0.00 | 0.50 | +0.50 | buy |
| Woodline Partners LP | 0 | 843,325 | +843,325 | 0.00 | 0.14 | +0.14 | buy |
| Deep Track Capital, LP | 0 | 800,000 | +800,000 | 0.00 | 0.51 | +0.51 | buy |
| VANGUARD GROUP INC | 6,996,994 | 7,599,326 | +602,332 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 820,871 | 1,414,296 | +593,425 | 0.01 | 0.02 | +0.01 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 575,000 | +575,000 | 0.00 | 0.13 | +0.13 | buy |
| RTW INVESTMENTS, LP | 0 | 575,000 | +575,000 | 0.00 | 0.17 | +0.17 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 527,671 | +527,671 | 0.00 | 0.23 | +0.23 | buy |
| BRAIDWELL LP | 0 | 466,448 | +466,448 | 0.00 | 0.27 | +0.27 | buy |
| Rock Springs Capital Management LP | 0 | 401,013 | +401,013 | 0.00 | 0.26 | +0.26 | buy |
| ADAR1 Capital Management, LLC | 0 | 342,262 | +342,262 | 0.00 | 1.15 | +1.15 | buy |
| CITADEL ADVISORS LLC | 268,577 | 555,987 | +287,410 | 0.01 | 0.01 | +0.01 | buy |
| Essex LLC | 0 | 132,661 | +132,661 | 0.00 | 0.55 | +0.55 | buy |
| BAKER BROS. ADVISORS LP | 545,431 | 670,431 | +125,000 | 0.13 | 0.14 | +0.01 | buy |
| Trexquant Investment LP | 86,264 | 206,022 | +119,758 | 0.02 | 0.05 | +0.03 | buy |
| Invesco Ltd. | 491,264 | 610,875 | +119,611 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 96,100 | +96,100 | 0.00 | 0.10 | +0.10 | buy |
| Monashee Investment Management LLC | 0 | 80,000 | +80,000 | 0.00 | 0.17 | +0.17 | buy |
| BARCLAYS PLC | 77,502 | 155,568 | +78,066 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 75,507 | +75,507 | 0.00 | 0.34 | +0.34 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 51,189 | 116,369 | +65,180 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 62,190 | +62,190 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 38,059 | 90,288 | +52,229 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 569,017 | 619,437 | +50,420 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 46,700 | +46,700 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 586,200 | 626,988 | +40,788 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 32,000 | +32,000 | 0.00 | 0.02 | +0.02 | buy |
| CITIGROUP INC | 52,718 | 80,059 | +27,341 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 141,958 | 168,431 | +26,473 | 0.00 | 0.01 | +0.00 | buy |
| Illinois Municipal Retirement Fund | 0 | 26,396 | +26,396 | 0.00 | 0.01 | +0.01 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 24,363 | +24,363 | 0.00 | 0.04 | +0.04 | buy |
| SG Americas Securities, LLC | 8,130 | 31,887 | +23,757 | 0.00 | 0.00 | +0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 9,116,202 | 9,137,195 | +20,993 | 0.12 | 0.14 | +0.01 | buy |
| Russell Investments Group, Ltd. | 212,559 | 233,025 | +20,466 | 0.01 | 0.01 | +0.00 | buy |
| Nebula Research & Development LLC | 0 | 20,383 | +20,383 | 0.00 | 0.05 | +0.05 | buy |
| ProShare Advisors LLC | 12,805 | 32,196 | +19,391 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 18,287 | +18,287 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 334,200 | 352,200 | +18,000 | 0.08 | 0.08 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 17,998 | +17,998 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,437,692 | 1,455,350 | +17,658 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 4,035 | 16,764 | +12,729 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 107,500 | 120,000 | +12,500 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 10,355 | 22,080 | +11,725 | 0.02 | 0.03 | +0.02 | buy |
| Bayesian Capital Management, LP | 0 | 10,816 | +10,816 | 0.00 | 0.03 | +0.03 | buy |
| Rockefeller Capital Management L.P. | 0 | 10,211 | +10,211 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 46,481 | 55,747 | +9,266 | 0.06 | 0.08 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 29,753 | 37,913 | +8,160 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 95,375 | 102,835 | +7,460 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 17,230 | 24,495 | +7,265 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 83,195 | 89,457 | +6,262 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,243 | 11,893 | +4,650 | 0.02 | 0.03 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 30,774 | 34,894 | +4,120 | 0.01 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 126,719 | 130,354 | +3,635 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 50,706 | 54,123 | +3,417 | 0.02 | 0.02 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 12,078 | 15,395 | +3,317 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 20,300 | 23,300 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 2,521 | +2,521 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 1,892 | 4,000 | +2,108 | 0.01 | 0.02 | +0.01 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 2,000 | +2,000 | 0.00 | 0.01 | +0.01 | buy |
| HSBC HOLDINGS PLC | 10,750 | 12,659 | +1,909 | 0.00 | 0.00 | +0.00 | buy |
| Inspire Investing, LLC | 18,643 | 20,530 | +1,887 | 0.04 | 0.04 | +0.00 | buy |
| STRS OHIO | 33,500 | 35,300 | +1,800 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 9,098 | 10,886 | +1,788 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 12,178 | 13,511 | +1,333 | 0.02 | 0.02 | +0.00 | buy |
| KBC Group NV | 1,910 | 3,123 | +1,213 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 16,395 | 17,567 | +1,172 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 6,379 | 7,513 | +1,134 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 11,207 | 12,156 | +949 | 0.04 | 0.05 | +0.00 | buy |
| Arizona State Retirement System | 15,399 | 16,058 | +659 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 21 | 585 | +564 | 0.00 | 0.00 | +0.00 | buy |
| DCF Advisers, LLC | 208,979 | 209,479 | +500 | 2.07 | 2.17 | +0.10 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,841 | 2,236 | +395 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 269 | +269 | 0.00 | 0.00 | +0.00 | buy |
| Atria Investments, Inc | 14,611 | 14,835 | +224 | 0.00 | 0.00 | +0.00 | buy |
| LGT Financial Advisors LLC | 0 | 222 | +222 | 0.00 | 0.01 | +0.01 | buy |
| C M BIDWELL & ASSOCIATES LTD | 0 | 193 | +193 | 0.00 | 0.00 | +0.00 | buy |
| FIFTH THIRD BANCORP | 248 | 382 | +134 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 130 | +130 | 0.00 | 0.00 | +0.00 | buy |
| BROWN BROTHERS HARRIMAN & CO | 0 | 122 | +122 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 831 | 927 | +96 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 80 | +80 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,248 | 4,323 | +75 | 0.04 | 0.04 | +0.00 | buy |
| UMB Bank, n.a. | 64 | 129 | +65 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 25 | 65 | +40 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 4 | 35 | +31 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 516 | 534 | +18 | 0.00 | 0.00 | -0.00 | buy |
| Parkside Financial Bank & Trust | 13 | 18 | +5 | 0.00 | 0.00 | +0.00 | buy |
| Mendota Financial Group, LLC | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,763 | 5,763 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 75,250 | 75,250 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FARMERS & MERCHANTS INVESTMENTS INC | 46 | 46 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JANUS HENDERSON GROUP PLC | 23,986 | 23,986 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CIBC Private Wealth Group LLC | 17,563 | 17,563 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 14,215 | 14,215 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MACQUARIE GROUP LTD | 200,000 | 200,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cannell & Spears LLC | 12,600 | 12,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ensign Peak Advisors, Inc | 36,527 | 36,527 | 0 | 0.00 | 0.00 | +0.00 | hold |