| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 2,402,883 | 6,221,054 | +3,818,171 | 0.27 | 0.90 | +0.63 | buy |
| Legal & General Group Plc | 180,905 | 1,273,000 | +1,092,095 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 92,614 | 532,202 | +439,588 | 0.00 | 0.01 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 670,431 | 1,102,106 | +431,675 | 0.05 | 0.09 | +0.04 | buy |
| UBS Group AG | 776,196 | 1,175,267 | +399,071 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 346,934 | 702,574 | +355,640 | 0.00 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 716,392 | 1,017,453 | +301,061 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 820,103 | 1,100,000 | +279,897 | 0.46 | 0.80 | +0.34 | buy |
| CITADEL ADVISORS LLC | 220,268 | 481,168 | +260,900 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 579,300 | 810,200 | +230,900 | 0.01 | 0.02 | +0.01 | buy |
| ALGERT GLOBAL LLC | 132,045 | 360,462 | +228,417 | 0.02 | 0.07 | +0.05 | buy |
| MACQUARIE GROUP LTD | 200,000 | 400,000 | +200,000 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 439,843 | 629,376 | +189,533 | 0.01 | 0.01 | +0.01 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 10,527,322 | 10,675,022 | +147,700 | 0.07 | 0.10 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 55,600 | 190,389 | +134,789 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 488,892 | 621,029 | +132,137 | 0.02 | 0.03 | +0.01 | buy |
| HRT FINANCIAL LP | 0 | 124,063 | +124,063 | 0.00 | 0.01 | +0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 106,855 | +106,855 | 0.00 | 0.02 | +0.02 | buy |
| Jefferies Financial Group Inc. | 0 | 100,000 | +100,000 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 0 | 90,501 | +90,501 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 599,039 | 688,269 | +89,230 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 330,007 | 401,501 | +71,494 | 0.00 | 0.00 | +0.00 | buy |
| Weiss Asset Management LP | 0 | 66,273 | +66,273 | 0.00 | 0.01 | +0.01 | buy |
| TORONTO DOMINION BANK | 0 | 50,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| DCF Advisers, LLC | 140,000 | 189,736 | +49,736 | 0.53 | 0.84 | +0.31 | buy |
| Brevan Howard Capital Management LP | 0 | 49,235 | +49,235 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 126,972 | 175,741 | +48,769 | 0.01 | 0.03 | +0.02 | buy |
| ADAR1 Capital Management, LLC | 85,826 | 128,865 | +43,039 | 0.11 | 0.15 | +0.04 | buy |
| MARSHALL WACE, LLP | 0 | 41,716 | +41,716 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 4,593 | 45,495 | +40,902 | 0.00 | 0.06 | +0.05 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 36,674 | +36,674 | 0.00 | 0.07 | +0.07 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 242,652 | 278,227 | +35,575 | 0.01 | 0.01 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 17,563 | 52,563 | +35,000 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 216,901 | 251,604 | +34,703 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 91,241 | 125,455 | +34,214 | 0.04 | 0.06 | +0.02 | buy |
| Atom Investors LP | 0 | 32,362 | +32,362 | 0.00 | 0.03 | +0.03 | buy |
| Y-Intercept (Hong Kong) Ltd | 95,745 | 123,138 | +27,393 | 0.02 | 0.03 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,703,664 | 1,728,825 | +25,161 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 0 | 24,438 | +24,438 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS ADVISORS, LLC | 0 | 19,134 | +19,134 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 155,973 | 173,382 | +17,409 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 16,033 | +16,033 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 29,230 | 45,102 | +15,872 | 0.00 | 0.00 | +0.00 | buy |
| Quantessence Capital LLC | 0 | 13,094 | +13,094 | 0.00 | 0.05 | +0.05 | buy |
| INCEPTIONR LLC | 0 | 13,007 | +13,007 | 0.00 | 0.04 | +0.04 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 12,762 | +12,762 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 11,880 | +11,880 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 46,133 | 54,740 | +8,607 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 8,197 | +8,197 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 39,485 | 45,233 | +5,748 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 68,327 | 73,930 | +5,603 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 24,754 | 30,159 | +5,405 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 118,970 | 124,124 | +5,154 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 54,193 | 58,603 | +4,410 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 3,735 | +3,735 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 16,470 | 20,160 | +3,690 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 22,298 | 25,781 | +3,483 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 1,902 | 4,861 | +2,959 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 95,847 | 98,738 | +2,891 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 2,836 | 5,260 | +2,424 | 0.00 | 0.00 | +0.00 | buy |
| HANTZ FINANCIAL SERVICES, INC. | 1,031 | 3,187 | +2,156 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 1,842 | 3,947 | +2,105 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 9,972 | 12,066 | +2,094 | 0.03 | 0.04 | +0.01 | buy |
| NATIXIS | 0 | 1,912 | +1,912 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 1,879 | 3,328 | +1,449 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 1,227 | +1,227 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 19,899 | 20,846 | +947 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 638 | +638 | 0.00 | 0.00 | +0.00 | buy |
| Salomon & Ludwin, LLC | 0 | 587 | +587 | 0.00 | 0.00 | +0.00 | buy |
| GHP Investment Advisors, Inc. | 0 | 468 | +468 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 17,457 | 17,855 | +398 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 320 | +320 | 0.00 | 0.00 | +0.00 | buy |
| State of Tennessee, Department of Treasury | 30,721 | 30,993 | +272 | 0.00 | 0.00 | +0.00 | buy |
| Linden Thomas Advisory Services, LLC | 42,505 | 42,772 | +267 | 0.04 | 0.05 | +0.01 | buy |
| BESSEMER GROUP INC | 39 | 303 | +264 | 0.00 | 0.00 | +0.00 | buy |
| Blue Trust, Inc. | 0 | 222 | +222 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 362 | 575 | +213 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 59,426 | 59,626 | +200 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 2,409 | 2,567 | +158 | 0.00 | 0.00 | +0.00 | buy |
| Cedar Mountain Advisors, LLC | 0 | 88 | +88 | 0.00 | 0.00 | +0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 29,371 | 29,428 | +57 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 55 | +55 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 71,990 | 72,035 | +45 | 0.00 | 0.00 | +0.00 | buy |
| Wealthspire Advisors, LLC | 0 | 31 | +31 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 21 | +21 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 18 | +18 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,749 | 2,757 | +8 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 70,015 | 70,015 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BVF INC/IL | 2,740,141 | 2,740,141 | 0 | 0.77 | 1.30 | +0.53 | hold |
| MassMutual Private Wealth & Trust, FSB | 319 | 319 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 72,090 | 72,090 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FARMERS & MERCHANTS INVESTMENTS INC | 46 | 46 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JANUS HENDERSON GROUP PLC | 23,986 | 23,986 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Amundi | 11,408 | 11,408 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 64,184 | 64,184 | 0 | 0.01 | 0.03 | +0.02 | hold |
| DekaBank Deutsche Girozentrale | 31,800 | 31,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Diversified Trust Co | 16,200 | 16,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 222 | 222 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Swiss National Bank | 115,300 | 115,300 | 0 | 0.00 | 0.00 | +0.00 | hold |