| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 11,855,254 | 11,807,227 | -48,027 | 0.00 | 0.00 | +0.00 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 10,527,322 | 10,675,022 | +147,700 | 0.07 | 0.10 | +0.03 | buy |
| VANGUARD GROUP INC | 8,624,374 | 7,103,758 | -1,520,616 | 0.00 | 0.00 | +0.00 | sell |
| RTW INVESTMENTS, LP | 2,402,883 | 6,221,054 | +3,818,171 | 0.27 | 0.90 | +0.63 | buy |
| EcoR1 Capital, LLC | 6,144,767 | 6,144,767 | 0 | 2.86 | 3.46 | +0.60 | hold |
| STATE STREET CORP | 3,817,610 | 3,673,831 | -143,779 | 0.00 | 0.00 | +0.00 | sell |
| BVF INC/IL | 2,740,141 | 2,740,141 | 0 | 0.77 | 1.30 | +0.53 | hold |
| TCG Crossover Management, LLC | 2,452,138 | 2,452,138 | 0 | 2.20 | 1.41 | -0.79 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,703,664 | 1,728,825 | +25,161 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,760,184 | 1,693,292 | -2,066,892 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,780,570 | 1,588,963 | -191,607 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 180,905 | 1,273,000 | +1,092,095 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 1,655,690 | 1,246,280 | -409,410 | 0.45 | 0.43 | -0.01 | sell |
| UBS Group AG | 776,196 | 1,175,267 | +399,071 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 670,431 | 1,102,106 | +431,675 | 0.05 | 0.09 | +0.04 | buy |
| Nantahala Capital Management, LLC | 820,103 | 1,100,000 | +279,897 | 0.46 | 0.80 | +0.34 | buy |
| GOLDMAN SACHS GROUP INC | 716,392 | 1,017,453 | +301,061 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,025,398 | 900,837 | -124,561 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 579,300 | 810,200 | +230,900 | 0.01 | 0.02 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 938,993 | 753,829 | -185,164 | 0.00 | 0.00 | +0.00 | sell |
| JOHNSON & JOHNSON | 748,062 | 748,062 | 0 | 1.82 | 1.74 | -0.08 | hold |
| NORTHERN TRUST CORP | 715,867 | 712,201 | -3,666 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 346,934 | 702,574 | +355,640 | 0.00 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 599,039 | 688,269 | +89,230 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 439,843 | 629,376 | +189,533 | 0.01 | 0.01 | +0.01 | buy |
| PANAGORA ASSET MANAGEMENT INC | 488,892 | 621,029 | +132,137 | 0.02 | 0.03 | +0.01 | buy |
| BARCLAYS PLC | 654,397 | 600,345 | -54,052 | 0.00 | 0.00 | +0.00 | sell |
| Aberdeen Group plc | 558,810 | 558,810 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Deep Track Capital, LP | 549,439 | 549,439 | 0 | 0.14 | 0.18 | +0.04 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 92,614 | 532,202 | +439,588 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 220,268 | 481,168 | +260,900 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 485,000 | 460,003 | -24,997 | 0.03 | 0.03 | +0.01 | sell |
| Bank of New York Mellon Corp | 478,678 | 425,788 | -52,890 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 330,007 | 401,501 | +71,494 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 200,000 | 400,000 | +200,000 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 380,200 | 380,200 | 0 | 0.03 | 0.04 | +0.02 | hold |
| ALGERT GLOBAL LLC | 132,045 | 360,462 | +228,417 | 0.02 | 0.07 | +0.05 | buy |
| ROYAL BANK OF CANADA | 1,319,034 | 346,226 | -972,808 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 352,839 | 344,456 | -8,383 | 0.00 | 0.00 | +0.00 | sell |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 242,652 | 278,227 | +35,575 | 0.01 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 216,901 | 251,604 | +34,703 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 363,153 | 216,739 | -146,414 | 0.01 | 0.01 | -0.00 | sell |
| Woodline Partners LP | 843,296 | 193,117 | -650,179 | 0.04 | 0.01 | -0.02 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 55,600 | 190,389 | +134,789 | 0.00 | 0.00 | +0.00 | buy |
| DCF Advisers, LLC | 140,000 | 189,736 | +49,736 | 0.53 | 0.84 | +0.31 | buy |
| RHUMBLINE ADVISERS | 176,404 | 175,849 | -555 | 0.00 | 0.00 | +0.00 | sell |
| Jump Financial, LLC | 126,972 | 175,741 | +48,769 | 0.01 | 0.03 | +0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 155,973 | 173,382 | +17,409 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 209,375 | 166,142 | -43,233 | 0.00 | 0.00 | +0.00 | sell |
| Rhenman & Partners Asset Management AB | 165,750 | 165,750 | 0 | 0.16 | 0.22 | +0.05 | hold |
| AMERIPRISE FINANCIAL INC | 314,853 | 146,683 | -168,170 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 171,420 | 136,110 | -35,310 | 0.02 | 0.02 | +0.00 | sell |
| Nuveen, LLC | 134,051 | 134,051 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAR1 Capital Management, LLC | 85,826 | 128,865 | +43,039 | 0.11 | 0.15 | +0.04 | buy |
| WINTON GROUP Ltd | 91,241 | 125,455 | +34,214 | 0.04 | 0.06 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 118,970 | 124,124 | +5,154 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 124,063 | +124,063 | 0.00 | 0.01 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 95,745 | 123,138 | +27,393 | 0.02 | 0.03 | +0.02 | buy |
| Swiss National Bank | 115,300 | 115,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Susquehanna Portfolio Strategies, LLC | 0 | 106,855 | +106,855 | 0.00 | 0.02 | +0.02 | buy |
| Jefferies Financial Group Inc. | 0 | 100,000 | +100,000 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 335,493 | 99,902 | -235,591 | 0.03 | 0.02 | -0.01 | sell |
| Essex LLC | 105,961 | 99,861 | -6,100 | 0.16 | 0.21 | +0.05 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 95,847 | 98,738 | +2,891 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 104,650 | 95,107 | -9,543 | 0.00 | 0.00 | +0.00 | sell |
| SG Americas Securities, LLC | 0 | 90,501 | +90,501 | 0.00 | 0.00 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 121,137 | 87,544 | -33,593 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 96,301 | 86,818 | -9,483 | 0.00 | 0.00 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 101,722 | 85,736 | -15,986 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 68,327 | 73,930 | +5,603 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 72,090 | 72,090 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 71,990 | 72,035 | +45 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 70,015 | 70,015 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rafferty Asset Management, LLC | 90,599 | 69,876 | -20,723 | 0.00 | 0.00 | +0.00 | sell |
| Weiss Asset Management LP | 0 | 66,273 | +66,273 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 64,184 | 64,184 | 0 | 0.01 | 0.03 | +0.02 | hold |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 59,426 | 59,626 | +200 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 54,193 | 58,603 | +4,410 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 46,133 | 54,740 | +8,607 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 17,563 | 52,563 | +35,000 | 0.00 | 0.00 | +0.00 | buy |
| TORONTO DOMINION BANK | 0 | 50,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 49,235 | +49,235 | 0.00 | 0.01 | +0.01 | buy |
| Brooklyn Investment Group | 4,593 | 45,495 | +40,902 | 0.00 | 0.06 | +0.05 | buy |
| DEUTSCHE BANK AG\ | 39,485 | 45,233 | +5,748 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 29,230 | 45,102 | +15,872 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 44,683 | 44,680 | -3 | 0.00 | 0.00 | +0.00 | sell |
| Linden Thomas Advisory Services, LLC | 42,505 | 42,772 | +267 | 0.04 | 0.05 | +0.01 | buy |
| MARSHALL WACE, LLP | 0 | 41,716 | +41,716 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 61,752 | 40,568 | -21,184 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 50,562 | 40,201 | -10,361 | 0.00 | 0.01 | +0.00 | sell |
| Inspire Investing, LLC | 49,111 | 39,480 | -9,631 | 0.04 | 0.05 | +0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 36,674 | +36,674 | 0.00 | 0.07 | +0.07 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 43,265 | 36,650 | -6,615 | 0.00 | 0.00 | +0.00 | sell |
| State of Alaska, Department of Revenue | 42,351 | 35,888 | -6,463 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 40,353 | 35,090 | -5,263 | 0.00 | 0.00 | +0.00 | sell |
| Jain Global LLC | 38,981 | 34,781 | -4,200 | 0.00 | 0.01 | +0.00 | sell |
| ALPS ADVISORS INC | 38,399 | 34,033 | -4,366 | 0.00 | 0.00 | +0.00 | sell |
| Louisiana State Employees Retirement System | 33,300 | 32,800 | -500 | 0.00 | 0.01 | +0.00 | sell |
| Atom Investors LP | 0 | 32,362 | +32,362 | 0.00 | 0.03 | +0.03 | buy |
| DekaBank Deutsche Girozentrale | 31,800 | 31,800 | 0 | 0.00 | 0.00 | +0.00 | hold |