| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 575,000 | 2,402,883 | +1,827,883 | 0.17 | 0.84 | +0.67 | buy |
| BVF INC/IL | 850,000 | 2,288,760 | +1,438,760 | 0.50 | 1.78 | +1.28 | buy |
| EcoR1 Capital, LLC | 5,330,416 | 6,144,767 | +814,351 | 3.67 | 5.34 | +1.67 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 207,622 | 519,976 | +312,354 | 0.02 | 0.04 | +0.03 | buy |
| LOOMIS SAYLES & CO L P | 900,266 | 1,092,346 | +192,080 | 0.02 | 0.03 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 469,837 | 297,223 | +172,614 | 0.02 | 0.02 | 0.00 | sell |
| BRAIDWELL LP | 466,448 | 615,531 | +149,083 | 0.27 | 0.42 | +0.15 | buy |
| BAKER BROS. ADVISORS LP | 545,431 | 670,431 | +125,000 | 0.13 | 0.16 | 0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,929,062 | 4,036,412 | +107,350 | 0.01 | 0.01 | +0.00 | buy |
| TCG Crossover Management, LLC | 2,427,138 | 2,452,138 | +25,000 | 4.14 | 5.51 | +1.37 | buy |
| Birchview Capital, LP | 12,300 | 26,000 | +13,700 | 0.21 | 0.49 | +0.27 | buy |
| ALPS ADVISORS INC | 48,083 | 56,585 | +8,502 | 0.01 | 0.01 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 32,000 | 39,040 | +7,040 | 0.05 | 0.07 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,893 | 14,839 | +2,946 | 0.03 | 0.03 | +0.01 | buy |
| Woodline Partners LP | 843,325 | 845,916 | +2,591 | 0.14 | 0.13 | -0.01 | buy |
| PROFUND ADVISORS LLC | 15,320 | 13,416 | +1,904 | 0.01 | 0.01 | 0.00 | sell |
| Linden Thomas Advisory Services, LLC | 43,428 | 42,877 | -551 | 0.12 | 0.12 | +0.01 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 145,162 | 143,743 | -1,419 | 0.02 | 0.02 | +0.00 | sell |
| VIRTUS ADVISERS, LLC | 4,323 | 2,871 | -1,452 | 0.04 | 0.03 | -0.01 | sell |
| WINTON GROUP Ltd | 55,747 | 53,705 | -2,042 | 0.08 | 0.08 | +0.00 | sell |
| Bayesian Capital Management, LP | 10,816 | 8,716 | -2,100 | 0.03 | 0.02 | -0.00 | sell |
| BAILLIE GIFFORD & CO | 23,204 | 20,898 | -2,306 | 0.00 | 0.00 | +0.00 | sell |
| Inspire Investing, LLC | 20,530 | 17,489 | -3,041 | 0.04 | 0.04 | +0.00 | sell |
| DCF Advisers, LLC | 209,479 | 203,167 | -6,312 | 2.17 | 2.36 | +0.19 | sell |
| Rhenman & Partners Asset Management AB | 203,750 | 195,750 | -8,000 | 0.33 | 0.46 | +0.13 | sell |
| Nebula Research & Development LLC | 20,383 | 9,826 | -10,557 | 0.05 | 0.03 | -0.02 | sell |
| Advantage Alpha Capital Partners LP | 24,861 | 13,548 | -11,313 | 0.11 | 0.07 | -0.04 | sell |
| Rafferty Asset Management, LLC | 64,273 | 51,976 | -12,297 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 125,250 | 112,722 | -12,528 | 0.00 | 0.00 | +0.00 | sell |
| Essex LLC | 132,661 | 113,661 | -19,000 | 0.55 | 0.55 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 342,262 | 234,607 | -107,655 | 1.15 | 1.11 | -0.04 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 9,137,195 | 8,984,432 | -152,763 | 0.14 | 0.16 | +0.02 | sell |
| Deep Track Capital, LP | 800,000 | 500,000 | -300,000 | 0.51 | 0.43 | -0.08 | sell |