| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 11,028,103 | 12,201,617 | +1,173,514 | 0.00 | 0.01 | +0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 9,137,195 | 8,984,432 | -152,763 | 0.14 | 0.16 | +0.02 | sell |
| VANGUARD GROUP INC | 7,599,326 | 8,017,366 | +418,040 | 0.00 | 0.00 | +0.00 | buy |
| EcoR1 Capital, LLC | 5,330,416 | 6,144,767 | +814,351 | 3.67 | 5.64 | +1.97 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,929,062 | 4,036,412 | +107,350 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 3,119,290 | 3,200,913 | +81,623 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 2,427,138 | 2,452,138 | +25,000 | 4.14 | 5.51 | +1.37 | buy |
| RTW INVESTMENTS, LP | 575,000 | 2,402,883 | +1,827,883 | 0.17 | 0.84 | +0.67 | buy |
| BVF INC/IL | 850,000 | 2,288,760 | +1,438,760 | 0.50 | 1.78 | +1.28 | buy |
| Point72 Asset Management, L.P. | 3,120,229 | 2,177,081 | -943,148 | 0.22 | 0.14 | -0.08 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,455,350 | 1,634,876 | +179,526 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,399,235 | 1,501,532 | +102,297 | 0.01 | 0.01 | +0.00 | buy |
| LOOMIS SAYLES & CO L P | 900,266 | 1,092,346 | +192,080 | 0.02 | 0.03 | +0.01 | buy |
| UBS Group AG | 89,457 | 892,276 | +802,819 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 843,325 | 845,916 | +2,591 | 0.14 | 0.13 | -0.01 | buy |
| JOHNSON & JOHNSON | 748,062 | 748,062 | 0 | 3.52 | 4.45 | +0.93 | hold |
| NORTHERN TRUST CORP | 626,497 | 747,152 | +120,655 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 616,207 | 744,612 | +128,405 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 670,431 | 670,431 | 0 | 0.14 | 0.16 | +0.02 | hold |
| Finepoint Capital LP | 0 | 660,000 | +660,000 | 0.00 | 1.75 | +1.75 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 626,988 | 630,640 | +3,652 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 466,448 | 615,531 | +149,083 | 0.27 | 0.42 | +0.15 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 575,000 | 575,000 | 0 | 0.13 | 0.18 | +0.04 | hold |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 207,622 | 519,976 | +312,354 | 0.02 | 0.04 | +0.03 | buy |
| Deep Track Capital, LP | 800,000 | 500,000 | -300,000 | 0.51 | 0.43 | -0.08 | sell |
| Invesco Ltd. | 610,875 | 454,745 | -156,130 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 572,900 | 442,000 | -130,900 | 0.03 | 0.02 | -0.00 | sell |
| Bank of New York Mellon Corp | 418,566 | 437,152 | +18,586 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 401,013 | 401,013 | 0 | 0.26 | 0.35 | +0.09 | hold |
| GOLDMAN SACHS GROUP INC | 367,137 | 382,646 | +15,509 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 352,200 | 352,200 | 0 | 0.08 | 0.10 | +0.02 | hold |
| PRINCIPAL FINANCIAL GROUP INC | 291,916 | 340,145 | +48,229 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 155,568 | 330,745 | +175,177 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 332,876 | 321,308 | -11,568 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 469,837 | 297,223 | -172,614 | 0.02 | 0.02 | -0.01 | sell |
| AMERIPRISE FINANCIAL INC | 169,706 | 292,576 | +122,870 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 342,262 | 234,607 | -107,655 | 1.15 | 1.11 | -0.04 | sell |
| Russell Investments Group, Ltd. | 233,025 | 216,291 | -16,734 | 0.01 | 0.01 | +0.00 | sell |
| DCF Advisers, LLC | 209,479 | 203,167 | -6,312 | 2.17 | 2.36 | +0.19 | sell |
| MACQUARIE GROUP LTD | 200,000 | 200,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Rhenman & Partners Asset Management AB | 203,750 | 195,750 | -8,000 | 0.33 | 0.46 | +0.13 | sell |
| FRANKLIN RESOURCES INC | 188,480 | 195,452 | +6,972 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 166,936 | 191,514 | +24,578 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 175,520 | 175,520 | 0 | 0.01 | 0.01 | +0.00 | hold |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 131,157 | 174,309 | +43,152 | 0.01 | 0.02 | +0.00 | buy |
| RHUMBLINE ADVISERS | 152,257 | 170,000 | +17,743 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 216,859 | 147,823 | -69,036 | 0.00 | 0.00 | -0.00 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 145,162 | 143,743 | -1,419 | 0.02 | 0.02 | +0.00 | sell |
| Swiss National Bank | 120,000 | 123,600 | +3,600 | 0.00 | 0.00 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 116,369 | 122,897 | +6,528 | 0.00 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 130,354 | 121,063 | -9,291 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 555,987 | 119,521 | -436,466 | 0.01 | 0.00 | -0.01 | sell |
| CITIGROUP INC | 80,059 | 117,988 | +37,929 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 102,835 | 114,231 | +11,396 | 0.00 | 0.00 | +0.00 | buy |
| Essex LLC | 132,661 | 113,661 | -19,000 | 0.55 | 0.55 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 125,250 | 112,722 | -12,528 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 109,716 | 100,373 | -9,343 | 0.00 | 0.00 | +0.00 | sell |
| CANADA LIFE ASSURANCE Co | 75,245 | 83,535 | +8,290 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 206,022 | 83,241 | -122,781 | 0.05 | 0.02 | -0.03 | sell |
| ALLIANCEBERNSTEIN L.P. | 75,250 | 72,090 | -3,160 | 0.00 | 0.00 | +0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 63,905 | 70,715 | +6,810 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 52,754 | 59,130 | +6,376 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 58,226 | 58,126 | -100 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 37,913 | 58,041 | +20,128 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 48,083 | 56,585 | +8,502 | 0.01 | 0.01 | +0.00 | buy |
| WINTON GROUP Ltd | 55,747 | 53,705 | -2,042 | 0.08 | 0.08 | +0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 53,397 | +53,397 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 64,273 | 51,976 | -12,297 | 0.00 | 0.00 | -0.00 | sell |
| Linden Thomas Advisory Services, LLC | 43,428 | 42,877 | -551 | 0.12 | 0.12 | +0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 16,510 | 40,903 | +24,393 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 34,852 | 40,740 | +5,888 | 0.00 | 0.01 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32,705 | 40,355 | +7,650 | 0.00 | 0.00 | +0.00 | buy |
| State of Alaska, Department of Revenue | 35,286 | 39,773 | +4,487 | 0.01 | 0.01 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 39,737 | 39,304 | -433 | 0.00 | 0.00 | +0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 32,000 | 39,040 | +7,040 | 0.02 | 0.02 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 50,213 | 38,118 | -12,095 | 0.00 | 0.00 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 36,527 | 36,527 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLS FARGO & COMPANY/MN | 23,942 | 36,086 | +12,144 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 34,203 | 35,946 | +1,743 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 168,431 | 35,437 | -132,994 | 0.01 | 0.00 | -0.00 | sell |
| Amundi | 10,886 | 35,380 | +24,494 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 18,287 | 33,972 | +15,685 | 0.00 | 0.01 | +0.00 | buy |
| Louisiana State Employees Retirement System | 29,900 | 33,800 | +3,900 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 619,437 | 33,507 | -585,930 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 35,300 | 33,200 | -2,100 | 0.00 | 0.00 | +0.00 | sell |
| Illinois Municipal Retirement Fund | 26,396 | 33,198 | +6,802 | 0.01 | 0.01 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 31,942 | +31,942 | 0.00 | 0.27 | +0.27 | buy |
| DekaBank Deutsche Girozentrale | 31,800 | 31,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SG Americas Securities, LLC | 31,887 | 30,555 | -1,332 | 0.00 | 0.00 | +0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 49,459 | 30,204 | -19,255 | 0.00 | 0.00 | -0.00 | sell |
| State of Tennessee, Department of Treasury | 28,472 | 27,992 | -480 | 0.00 | 0.00 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 27,491 | +27,491 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 23,300 | 26,600 | +3,300 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 12,300 | 26,000 | +13,700 | 0.21 | 0.49 | +0.27 | buy |
| JANUS HENDERSON GROUP PLC | 23,986 | 23,986 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Allianz Asset Management GmbH | 15,900 | 23,900 | +8,000 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 32,196 | 23,638 | -8,558 | 0.00 | 0.00 | -0.00 | sell |
| Maryland State Retirement & Pension System | 20,881 | 23,567 | +2,686 | 0.01 | 0.01 | +0.00 | buy |
| YOUSIF CAPITAL MANAGEMENT, LLC | 19,032 | 20,976 | +1,944 | 0.00 | 0.01 | +0.00 | buy |
| BAILLIE GIFFORD & CO | 23,204 | 20,898 | -2,306 | 0.00 | 0.00 | +0.00 | sell |