| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 575,000 | 2,402,883 | +1,827,883 | 0.17 | 0.84 | +0.67 | buy |
| BVF INC/IL | 850,000 | 2,288,760 | +1,438,760 | 0.50 | 1.78 | +1.28 | buy |
| BlackRock, Inc. | 11,028,103 | 12,201,617 | +1,173,514 | 0.00 | 0.01 | +0.00 | buy |
| EcoR1 Capital, LLC | 5,330,416 | 6,144,767 | +814,351 | 3.67 | 5.64 | +1.97 | buy |
| UBS Group AG | 89,457 | 892,276 | +802,819 | 0.00 | 0.00 | +0.00 | buy |
| Finepoint Capital LP | 0 | 660,000 | +660,000 | 0.00 | 1.75 | +1.75 | buy |
| VANGUARD GROUP INC | 7,599,326 | 8,017,366 | +418,040 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 207,622 | 519,976 | +312,354 | 0.02 | 0.04 | +0.03 | buy |
| LOOMIS SAYLES & CO L P | 900,266 | 1,092,346 | +192,080 | 0.02 | 0.03 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,455,350 | 1,634,876 | +179,526 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 155,568 | 330,745 | +175,177 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 466,448 | 615,531 | +149,083 | 0.27 | 0.42 | +0.15 | buy |
| MORGAN STANLEY | 616,207 | 744,612 | +128,405 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 169,706 | 292,576 | +122,870 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 626,497 | 747,152 | +120,655 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,929,062 | 4,036,412 | +107,350 | 0.01 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,399,235 | 1,501,532 | +102,297 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 3,119,290 | 3,200,913 | +81,623 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 53,397 | +53,397 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 291,916 | 340,145 | +48,229 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 131,157 | 174,309 | +43,152 | 0.01 | 0.02 | +0.00 | buy |
| CITIGROUP INC | 80,059 | 117,988 | +37,929 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 31,942 | +31,942 | 0.00 | 0.27 | +0.27 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 27,491 | +27,491 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 2,427,138 | 2,452,138 | +25,000 | 4.14 | 5.51 | +1.37 | buy |
| Legal & General Group Plc | 166,936 | 191,514 | +24,578 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 10,886 | 35,380 | +24,494 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 16,510 | 40,903 | +24,393 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 37,913 | 58,041 | +20,128 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 418,566 | 437,152 | +18,586 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 152,257 | 170,000 | +17,743 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 18,287 | 33,972 | +15,685 | 0.00 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 367,137 | 382,646 | +15,509 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 12,300 | 26,000 | +13,700 | 0.21 | 0.49 | +0.27 | buy |
| Capula Management Ltd | 0 | 13,120 | +13,120 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 13,119 | +13,119 | 0.00 | 0.02 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 23,942 | 36,086 | +12,144 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 102,835 | 114,231 | +11,396 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 10,740 | +10,740 | 0.00 | 0.00 | +0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 0 | 10,600 | +10,600 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 10,408 | +10,408 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 10,227 | +10,227 | 0.00 | 0.01 | +0.01 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 9,949 | +9,949 | 0.00 | 0.07 | +0.07 | buy |
| SYON CAPITAL LLC | 0 | 9,745 | +9,745 | 0.00 | 0.02 | +0.02 | buy |
| Pathstone Holdings, LLC | 0 | 9,519 | +9,519 | 0.00 | 0.00 | +0.00 | buy |
| Teza Capital Management LLC | 0 | 9,150 | +9,150 | 0.00 | 0.03 | +0.03 | buy |
| ALTFEST L J & CO INC | 0 | 8,743 | +8,743 | 0.00 | 0.03 | +0.03 | buy |
| ALPS ADVISORS INC | 48,083 | 56,585 | +8,502 | 0.01 | 0.01 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 75,245 | 83,535 | +8,290 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 15,900 | 23,900 | +8,000 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32,705 | 40,355 | +7,650 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 32,000 | 39,040 | +7,040 | 0.02 | 0.02 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 188,480 | 195,452 | +6,972 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 63,905 | 70,715 | +6,810 | 0.00 | 0.00 | +0.00 | buy |
| Illinois Municipal Retirement Fund | 26,396 | 33,198 | +6,802 | 0.01 | 0.01 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 116,369 | 122,897 | +6,528 | 0.00 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 52,754 | 59,130 | +6,376 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 34,852 | 40,740 | +5,888 | 0.00 | 0.01 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 14,215 | 19,631 | +5,416 | 0.00 | 0.00 | +0.00 | buy |
| State of Alaska, Department of Revenue | 35,286 | 39,773 | +4,487 | 0.01 | 0.01 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,383 | 7,865 | +4,482 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 4,390 | +4,390 | 0.00 | 0.00 | +0.00 | buy |
| Louisiana State Employees Retirement System | 29,900 | 33,800 | +3,900 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 626,988 | 630,640 | +3,652 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 120,000 | 123,600 | +3,600 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 23,300 | 26,600 | +3,300 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 15,395 | 18,645 | +3,250 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 13,357 | 16,528 | +3,171 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,893 | 14,839 | +2,946 | 0.03 | 0.03 | +0.01 | buy |
| Maryland State Retirement & Pension System | 20,881 | 23,567 | +2,686 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 843,325 | 845,916 | +2,591 | 0.14 | 0.13 | -0.01 | buy |
| COMERICA BANK | 18,308 | 20,527 | +2,219 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 16,058 | 18,190 | +2,132 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 17,567 | 19,680 | +2,113 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 18,215 | 20,243 | +2,028 | 0.00 | 0.00 | +0.00 | buy |
| OREGON PUBLIC EMPLOYEES RETIREMENT FUND | 14,512 | 16,512 | +2,000 | 0.01 | 0.01 | +0.00 | buy |
| YOUSIF CAPITAL MANAGEMENT, LLC | 19,032 | 20,976 | +1,944 | 0.00 | 0.01 | +0.00 | buy |
| Corebridge Financial, Inc. | 34,203 | 35,946 | +1,743 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 13,217 | 14,940 | +1,723 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 2,704 | 4,041 | +1,337 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,763 | 7,045 | +1,282 | 0.00 | 0.01 | +0.00 | buy |
| Sterling Capital Management LLC | 142 | 1,182 | +1,040 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 3,123 | 3,936 | +813 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 11,655 | 12,166 | +511 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 1,639 | 2,147 | +508 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 534 | 804 | +270 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 927 | 1,069 | +142 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 1,017 | 1,141 | +124 | 0.00 | 0.00 | +0.00 | buy |
| FIFTH THIRD BANCORP | 382 | 479 | +97 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,236 | 2,332 | +96 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 585 | 680 | +95 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 407 | 485 | +78 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 65 | 115 | +50 | 0.00 | 0.00 | +0.00 | buy |
| Cornerstone Planning Group LLC | 0 | 38 | +38 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 0 | 35 | +35 | 0.00 | 0.00 | +0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 70 | 96 | +26 | 0.00 | 0.00 | +0.00 | buy |
| UMB Bank, n.a. | 129 | 137 | +8 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 130 | 130 | 0 | 0.00 | 0.00 | -0.00 | hold |