| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 11,807,227 | 11,927,218 | +119,991 | 0.00 | 0.00 | +0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 10,675,022 | 10,218,322 | -456,700 | 0.10 | 0.12 | +0.02 | sell |
| VANGUARD GROUP INC | 7,103,758 | 7,165,450 | +61,692 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 2,740,141 | 7,133,720 | +4,393,579 | 1.30 | 3.68 | +2.37 | buy |
| RTW INVESTMENTS, LP | 6,221,054 | 6,777,461 | +556,407 | 0.90 | 1.04 | +0.14 | buy |
| STATE STREET CORP | 3,673,831 | 4,507,254 | +833,423 | 0.00 | 0.00 | +0.00 | buy |
| EcoR1 Capital, LLC | 6,144,767 | 3,251,112 | -2,893,655 | 3.46 | 2.27 | -1.19 | sell |
| TCG Crossover Management, LLC | 2,452,138 | 2,452,138 | 0 | 1.41 | 1.24 | -0.17 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,728,825 | 1,752,918 | +24,093 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,693,292 | 1,601,762 | -91,530 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 900,837 | 1,508,727 | +607,890 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 1,273,000 | 1,308,088 | +35,088 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,588,963 | 1,249,288 | -339,675 | 0.00 | 0.00 | +0.00 | sell |
| BAKER BROS. ADVISORS LP | 1,102,106 | 1,102,106 | 0 | 0.09 | 0.10 | +0.01 | hold |
| GOLDMAN SACHS GROUP INC | 1,017,453 | 753,258 | -264,195 | 0.00 | 0.00 | -0.00 | sell |
| JOHNSON & JOHNSON | 748,062 | 748,062 | 0 | 1.74 | 2.06 | +0.32 | hold |
| Jefferies Financial Group Inc. | 100,000 | 720,440 | +620,440 | 0.01 | 0.09 | +0.08 | buy |
| Lynx1 Capital Management LP | 0 | 705,558 | +705,558 | 0.00 | 2.19 | +2.19 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 688,269 | 700,435 | +12,166 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 712,201 | 674,657 | -37,544 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 1,175,267 | 638,021 | -537,246 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 753,829 | 629,408 | -124,421 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 702,574 | 594,435 | -108,139 | 0.01 | 0.01 | +0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 621,029 | 583,778 | -37,251 | 0.03 | 0.03 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 810,200 | 506,600 | -303,600 | 0.02 | 0.02 | -0.00 | sell |
| TORONTO DOMINION BANK | 50,000 | 491,000 | +441,000 | 0.00 | 0.01 | +0.01 | buy |
| Erste Asset Management GmbH | 380,200 | 480,200 | +100,000 | 0.04 | 0.06 | +0.02 | buy |
| BRAIDWELL LP | 1,246,280 | 459,166 | -787,114 | 0.43 | 0.22 | -0.21 | sell |
| Hudson Bay Capital Management LP | 460,003 | 425,000 | -35,003 | 0.03 | 0.04 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 532,202 | 411,725 | -120,477 | 0.01 | 0.01 | -0.00 | sell |
| Bank of New York Mellon Corp | 425,788 | 410,650 | -15,138 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 600,345 | 359,235 | -241,110 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 344,456 | 340,326 | -4,130 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 481,168 | 321,808 | -159,360 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 401,501 | 303,979 | -97,522 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 629,376 | 268,737 | -360,639 | 0.01 | 0.01 | -0.01 | sell |
| Invesco Ltd. | 251,604 | 265,820 | +14,216 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 259,319 | +259,319 | 0.00 | 0.02 | +0.02 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 278,227 | 247,242 | -30,985 | 0.01 | 0.01 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 45,233 | 216,568 | +171,335 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 193,117 | 193,117 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Susquehanna Portfolio Strategies, LLC | 106,855 | 191,463 | +84,608 | 0.02 | 0.05 | +0.03 | buy |
| Trexquant Investment LP | 136,110 | 175,152 | +39,042 | 0.02 | 0.02 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 173,382 | 174,603 | +1,221 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 175,849 | 165,797 | -10,052 | 0.00 | 0.00 | +0.00 | sell |
| Rhenman & Partners Asset Management AB | 165,750 | 165,750 | 0 | 0.22 | 0.24 | +0.02 | hold |
| Nantahala Capital Management, LLC | 1,100,000 | 164,639 | -935,361 | 0.80 | 0.15 | -0.65 | sell |
| DCF Advisers, LLC | 189,736 | 154,736 | -35,000 | 0.84 | 0.78 | -0.06 | sell |
| AMERIPRISE FINANCIAL INC | 146,683 | 135,806 | -10,877 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 134,051 | 134,051 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SG Americas Securities, LLC | 90,501 | 128,345 | +37,844 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 360,462 | 124,400 | -236,062 | 0.07 | 0.03 | -0.04 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 166,142 | 119,789 | -46,353 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 115,300 | 119,600 | +4,300 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 23,663 | 112,275 | +88,612 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 86,818 | 112,271 | +25,453 | 0.00 | 0.00 | +0.00 | buy |
| Essex LLC | 99,861 | 98,661 | -1,200 | 0.21 | 0.27 | +0.06 | sell |
| Rafferty Asset Management, LLC | 69,876 | 97,749 | +27,873 | 0.00 | 0.01 | +0.00 | buy |
| FMR LLC | 73,930 | 92,883 | +18,953 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 125,455 | 88,038 | -37,417 | 0.06 | 0.05 | -0.01 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 87,717 | +87,717 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 95,107 | 82,942 | -12,165 | 0.00 | 0.00 | +0.00 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 87,544 | 82,828 | -4,716 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 54,740 | 79,667 | +24,927 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 85,736 | 77,802 | -7,934 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 72,090 | 72,090 | 0 | 0.00 | 0.00 | +0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 29,597 | 70,612 | +41,015 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 59,626 | 70,526 | +10,900 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 72,035 | 67,570 | -4,465 | 0.00 | 0.00 | +0.00 | sell |
| NEOS Investment Management LLC | 0 | 61,362 | +61,362 | 0.00 | 0.01 | +0.01 | buy |
| TEMA ETFS LLC | 0 | 60,457 | +60,457 | 0.00 | 0.07 | +0.07 | buy |
| ALPS ADVISORS INC | 34,033 | 58,639 | +24,606 | 0.00 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 58,603 | 58,530 | -73 | 0.00 | 0.00 | +0.00 | sell |
| CANADA LIFE ASSURANCE Co | 70,015 | 57,164 | -12,851 | 0.00 | 0.00 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 128,865 | 56,165 | -72,700 | 0.15 | 0.06 | -0.09 | sell |
| Point72 Asset Management, L.P. | 0 | 55,339 | +55,339 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 124,124 | 48,687 | -75,437 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 12,762 | 47,848 | +35,086 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 12,004 | 47,189 | +35,185 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 45,102 | 47,134 | +2,032 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 17,585 | 43,960 | +26,375 | 0.01 | 0.02 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 44,680 | 41,225 | -3,455 | 0.00 | 0.00 | +0.00 | sell |
| Linden Thomas Advisory Services, LLC | 42,772 | 40,963 | -1,809 | 0.05 | 0.06 | +0.01 | sell |
| MetLife Investment Management, LLC | 35,090 | 40,212 | +5,122 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 52,563 | 40,017 | -12,546 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 18,551 | 38,825 | +20,274 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 36,650 | 38,448 | +1,798 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 16,729 | 38,037 | +21,308 | 0.00 | 0.00 | +0.00 | buy |
| State of Alaska, Department of Revenue | 35,888 | 36,407 | +519 | 0.00 | 0.01 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 34,794 | +34,794 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 190,389 | 34,158 | -156,231 | 0.00 | 0.00 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 98,738 | 34,097 | -64,641 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 175,741 | 33,198 | -142,543 | 0.03 | 0.01 | -0.02 | sell |
| Louisiana State Employees Retirement System | 32,800 | 32,700 | -100 | 0.01 | 0.01 | +0.00 | sell |
| XTX Topco Ltd | 0 | 32,009 | +32,009 | 0.00 | 0.01 | +0.01 | buy |
| DekaBank Deutsche Girozentrale | 31,800 | 31,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cerity Partners LLC | 30,159 | 31,302 | +1,143 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,455 | 30,803 | +4,348 | 0.00 | 0.00 | +0.00 | buy |
| Inspire Investing, LLC | 39,480 | 30,676 | -8,804 | 0.05 | 0.04 | -0.00 | sell |
| Quinn Opportunity Partners LLC | 30,000 | 30,000 | 0 | 0.03 | 0.02 | -0.01 | hold |