| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 2,740,141 | 7,133,720 | +4,393,579 | 1.30 | 3.68 | +2.37 | buy |
| RTW INVESTMENTS, LP | 6,221,054 | 6,777,461 | +556,407 | 0.90 | 1.04 | +0.14 | buy |
| Erste Asset Management GmbH | 380,200 | 480,200 | +100,000 | 0.04 | 0.06 | +0.02 | buy |
| Susquehanna Portfolio Strategies, LLC | 106,855 | 191,463 | +84,608 | 0.02 | 0.05 | +0.03 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 98,738 | 34,097 | +64,641 | 0.00 | 0.00 | 0.00 | sell |
| Legal & General Group Plc | 1,273,000 | 1,308,088 | +35,088 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 69,876 | 97,749 | +27,873 | 0.00 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 17,585 | 43,960 | +26,375 | 0.01 | 0.02 | 0.00 | buy |
| ALPS ADVISORS INC | 34,033 | 58,639 | +24,606 | 0.00 | 0.01 | 0.00 | buy |
| Virtus Investment Advisers, LLC | 12,066 | 16,103 | +4,037 | 0.04 | 0.07 | +0.03 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,534 | 1,402 | -132 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 12,502 | 11,636 | -866 | 0.01 | 0.01 | +0.00 | sell |
| Essex LLC | 99,861 | 98,661 | -1,200 | 0.21 | 0.27 | +0.06 | sell |
| Linden Thomas Advisory Services, LLC | 42,772 | 40,963 | -1,809 | 0.05 | 0.06 | +0.01 | sell |
| Inspire Investing, LLC | 39,480 | 30,676 | -8,804 | 0.05 | 0.04 | -0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 36,674 | 19,708 | -16,966 | 0.07 | 0.05 | -0.02 | sell |
| DCF Advisers, LLC | 189,736 | 154,736 | -35,000 | 0.84 | 0.78 | -0.06 | sell |
| WINTON GROUP Ltd | 125,455 | 88,038 | -37,417 | 0.06 | 0.05 | -0.01 | sell |
| ADAR1 Capital Management, LLC | 128,865 | 56,165 | -72,700 | 0.15 | 0.06 | -0.09 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 10,675,022 | 10,218,322 | -456,700 | 0.10 | 0.12 | +0.02 | sell |
| BRAIDWELL LP | 1,246,280 | 459,166 | -787,114 | 0.43 | 0.22 | -0.21 | sell |
| Nantahala Capital Management, LLC | 1,100,000 | 164,639 | -935,361 | 0.45 | 0.08 | -0.36 | sell |
| EcoR1 Capital, LLC | 6,144,767 | 3,251,112 | -2,893,655 | 3.46 | 2.26 | -1.20 | sell |