| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 2,740,141 | 7,133,720 | +4,393,579 | 1.30 | 3.68 | +2.37 | buy |
| STATE STREET CORP | 3,673,831 | 4,507,254 | +833,423 | 0.00 | 0.00 | +0.00 | buy |
| Lynx1 Capital Management LP | 0 | 705,558 | +705,558 | 0.00 | 2.19 | +2.19 | buy |
| Jefferies Financial Group Inc. | 100,000 | 720,440 | +620,440 | 0.01 | 0.09 | +0.08 | buy |
| MORGAN STANLEY | 900,837 | 1,508,727 | +607,890 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 6,221,054 | 6,777,461 | +556,407 | 0.90 | 1.04 | +0.14 | buy |
| TORONTO DOMINION BANK | 50,000 | 491,000 | +441,000 | 0.00 | 0.01 | +0.01 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 259,319 | +259,319 | 0.00 | 0.02 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 45,233 | 216,568 | +171,335 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 11,807,227 | 11,927,218 | +119,991 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 380,200 | 480,200 | +100,000 | 0.04 | 0.06 | +0.02 | buy |
| CITIGROUP INC | 23,663 | 112,275 | +88,612 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 87,717 | +87,717 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 106,855 | 191,463 | +84,608 | 0.02 | 0.05 | +0.03 | buy |
| VANGUARD GROUP INC | 7,103,758 | 7,165,450 | +61,692 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 0 | 61,362 | +61,362 | 0.00 | 0.01 | +0.01 | buy |
| TEMA ETFS LLC | 0 | 60,457 | +60,457 | 0.00 | 0.07 | +0.07 | buy |
| Point72 Asset Management, L.P. | 0 | 55,339 | +55,339 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 29,597 | 70,612 | +41,015 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 136,110 | 175,152 | +39,042 | 0.02 | 0.02 | +0.01 | buy |
| SG Americas Securities, LLC | 90,501 | 128,345 | +37,844 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 12,004 | 47,189 | +35,185 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 1,273,000 | 1,308,088 | +35,088 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 12,762 | 47,848 | +35,086 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 34,794 | +34,794 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 32,009 | +32,009 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 29,031 | +29,031 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 69,876 | 97,749 | +27,873 | 0.00 | 0.01 | +0.00 | buy |
| Palumbo Wealth Management LLC | 0 | 27,090 | +27,090 | 0.00 | 0.10 | +0.10 | buy |
| PROFUND ADVISORS LLC | 17,585 | 43,960 | +26,375 | 0.01 | 0.02 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 86,818 | 112,271 | +25,453 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 54,740 | 79,667 | +24,927 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 34,033 | 58,639 | +24,606 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,728,825 | 1,752,918 | +24,093 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 16,729 | 38,037 | +21,308 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 18,551 | 38,825 | +20,274 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 19,306 | +19,306 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 73,930 | 92,883 | +18,953 | 0.00 | 0.00 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 17,200 | +17,200 | 0.00 | 0.02 | +0.02 | buy |
| Invesco Ltd. | 251,604 | 265,820 | +14,216 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 7,264 | 21,192 | +13,928 | 0.01 | 0.02 | +0.01 | buy |
| Centiva Capital, LP | 0 | 12,299 | +12,299 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 688,269 | 700,435 | +12,166 | 0.00 | 0.00 | +0.00 | buy |
| Entropy Technologies, LP | 0 | 11,966 | +11,966 | 0.00 | 0.01 | +0.01 | buy |
| NORGES BANK | 0 | 11,457 | +11,457 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 59,626 | 70,526 | +10,900 | 0.00 | 0.00 | +0.00 | buy |
| NorthCrest Asset Manangement, LLC | 0 | 10,464 | +10,464 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 6,460 | +6,460 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 5,277 | +5,277 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 35,090 | 40,212 | +5,122 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 12,722 | 17,791 | +5,069 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,455 | 30,803 | +4,348 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 115,300 | 119,600 | +4,300 | 0.00 | 0.00 | +0.00 | buy |
| Pinnacle Wealth Planning Services, Inc. | 0 | 4,238 | +4,238 | 0.00 | 0.01 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 12,066 | 16,103 | +4,037 | 0.04 | 0.07 | +0.03 | buy |
| Diversified Trust Co | 16,200 | 18,442 | +2,242 | 0.00 | 0.01 | +0.00 | buy |
| Quantinno Capital Management LP | 45,102 | 47,134 | +2,032 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 36,650 | 38,448 | +1,798 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 5,260 | 6,500 | +1,240 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 173,382 | 174,603 | +1,221 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 1,200 | +1,200 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 30,159 | 31,302 | +1,143 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 15,827 | 16,853 | +1,026 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,757 | 3,470 | +713 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 12,200 | 12,900 | +700 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 690 | +690 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 6,698 | 7,376 | +678 | 0.00 | 0.00 | +0.00 | buy |
| HANTZ FINANCIAL SERVICES, INC. | 3,187 | 3,857 | +670 | 0.00 | 0.00 | +0.00 | buy |
| State of Alaska, Department of Revenue | 35,888 | 36,407 | +519 | 0.00 | 0.01 | +0.00 | buy |
| GAMMA Investing LLC | 3,328 | 3,650 | +322 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 584 | 819 | +235 | 0.00 | 0.00 | +0.00 | buy |
| OREGON PUBLIC EMPLOYEES RETIREMENT FUND | 16,112 | 16,312 | +200 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 303 | 417 | +114 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 20,864 | 20,969 | +105 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 58 | 155 | +97 | 0.00 | 0.00 | +0.00 | buy |
| Sound Income Strategies, LLC | 0 | 43 | +43 | 0.00 | 0.00 | +0.00 | buy |
| Parkside Financial Bank & Trust | 16 | 57 | +41 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 41 | +41 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 21,858 | 21,887 | +29 | 0.00 | 0.00 | +0.00 | buy |
| UMB Bank, n.a. | 500 | 524 | +24 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| FLAGSHIP HARBOR ADVISORS, LLC | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 2,567 | 2,576 | +9 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 80 | 85 | +5 | 0.00 | 0.00 | +0.00 | buy |
| Dunhill Financial, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,885 | 5,885 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MassMutual Private Wealth & Trust, FSB | 319 | 319 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 72,090 | 72,090 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FARMERS & MERCHANTS INVESTMENTS INC | 46 | 46 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 1,102,106 | 1,102,106 | 0 | 0.09 | 0.10 | +0.01 | hold |
| JANUS HENDERSON GROUP PLC | 23,986 | 23,986 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 20,480 | 20,480 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GHP Investment Advisors, Inc. | 468 | 468 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIGNATUREFD, LLC | 55 | 55 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 31,800 | 31,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 222 | 222 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rhenman & Partners Asset Management AB | 165,750 | 165,750 | 0 | 0.22 | 0.24 | +0.02 | hold |
| Quinn Opportunity Partners LLC | 30,000 | 30,000 | 0 | 0.03 | 0.02 | -0.01 | hold |
| QUADRANT CAPITAL GROUP LLC | 638 | 638 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Versant Capital Management, Inc | 3,425 | 3,425 | 0 | 0.01 | 0.01 | +0.00 | hold |