| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| CITADEL ADVISORS LLC | 2,861,255 | 4,339,101 | +1,477,846 | 0.02 | 0.03 | +0.01 | buy |
| Ally Bridge Group (NY) LLC | 0 | 1,003,741 | +1,003,741 | 0.00 | 3.47 | +3.47 | buy |
| Tri Locum Partners LP | 0 | 978,793 | +978,793 | 0.00 | 2.11 | +2.11 | buy |
| Verition Fund Management LLC | 0 | 768,214 | +768,214 | 0.00 | 0.05 | +0.05 | buy |
| Laurion Capital Management LP | 42,424 | 747,827 | +705,403 | 0.01 | 0.13 | +0.12 | buy |
| Invesco Ltd. | 0 | 555,233 | +555,233 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 15,006 | 528,118 | +513,112 | 0.00 | 0.04 | +0.03 | buy |
| VANGUARD GROUP INC | 1,071,460 | 1,481,481 | +410,021 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 13,063 | 334,665 | +321,602 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 41,713 | 357,319 | +315,606 | 0.00 | 0.02 | +0.02 | buy |
| Ensign Peak Advisors, Inc | 301,533 | 591,311 | +289,778 | 0.00 | 0.01 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 250,000 | +250,000 | 0.00 | 0.01 | +0.01 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 173,320 | +173,320 | 0.00 | 0.70 | +0.70 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 145,284 | +145,284 | 0.00 | 0.60 | +0.60 | buy |
| HRT FINANCIAL LP | 0 | 98,525 | +98,525 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 50,700 | 143,900 | +93,200 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 259,416 | 343,322 | +83,906 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 325,995 | 406,121 | +80,126 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 78,251 | 157,703 | +79,452 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 112,634 | 190,986 | +78,352 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 599,975 | 676,554 | +76,579 | 0.03 | 0.04 | +0.00 | buy |
| Qube Research & Technologies Ltd | 55,449 | 131,902 | +76,453 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 33,170 | 109,405 | +76,235 | 0.00 | 0.00 | +0.00 | buy |
| Marathon Trading Investment Management LLC | 0 | 67,010 | +67,010 | 0.00 | 0.17 | +0.17 | buy |
| Man Group plc | 38,003 | 90,283 | +52,280 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 132,606 | 183,743 | +51,137 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 0 | 41,563 | +41,563 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 25,778 | +25,778 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 336,458 | 359,431 | +22,973 | 0.00 | 0.00 | +0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 22,820 | +22,820 | 0.00 | 0.02 | +0.02 | buy |
| OMERS ADMINISTRATION Corp | 0 | 22,200 | +22,200 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 109,180 | 126,180 | +17,000 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 15,400 | +15,400 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 144,678 | 159,597 | +14,919 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 14,042 | +14,042 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 13,900 | +13,900 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 11,928 | +11,928 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 11,670 | +11,670 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 11,400 | +11,400 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 10,718 | +10,718 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 12,279 | 20,531 | +8,252 | 0.01 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 43,900 | 50,900 | +7,000 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,362 | 8,921 | +6,559 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 653 | 5,710 | +5,057 | 0.00 | 0.01 | +0.01 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 3,700 | +3,700 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 16,737 | 20,187 | +3,450 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 29,045 | 32,118 | +3,073 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 28,795 | 31,459 | +2,664 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 0 | 1,375 | +1,375 | 0.00 | 0.00 | +0.00 | buy |
| VR Adviser, LLC | 2,575,593 | 2,576,093 | +500 | 0.93 | 0.76 | -0.16 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 296 | 296 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 12,757,562 | 12,757,562 | 0 | 1.49 | 1.40 | -0.10 | hold |
| LETKO, BROSSEAU & ASSOCIATES INC | 31,900 | 31,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PURA VIDA INVESTMENTS, LLC | 1,413,242 | 1,413,242 | 0 | 1.77 | 5.98 | +4.22 | hold |
| Clearline Capital LP | 119,128 | 119,128 | 0 | 0.07 | 0.07 | +0.00 | hold |
| Samsara BioCapital, LLC | 2,780,261 | 2,780,261 | 0 | 2.27 | 2.68 | +0.41 | hold |
| Heritage Wealth Management, Inc./Texas | 10,000 | 10,000 | 0 | 0.04 | 0.04 | +0.00 | hold |
| DLK Investment Management, LLC | 12,000 | 12,000 | 0 | 0.03 | 0.03 | +0.00 | hold |
| BARCLAYS PLC | 32,817 | 32,817 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMERICA BANK | 1,159 | 1,159 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 200 | 0 | -200 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 61,549 | 60,495 | -1,054 | 0.00 | 0.00 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 1,169 | 0 | -1,169 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 124,443 | 118,875 | -5,568 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 29,630 | 21,160 | -8,470 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 12,765 | 0 | -12,765 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 249,939 | 232,670 | -17,269 | 0.04 | 0.04 | -0.00 | sell |
| Bank of New York Mellon Corp | 18,621 | 0 | -18,621 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 141,800 | 86,800 | -55,000 | 0.02 | 0.01 | -0.00 | sell |
| 683 Capital Management, LLC | 69,869 | 0 | -69,869 | 0.04 | 0.00 | -0.04 | sell |
| Parkman Healthcare Partners LLC | 754,885 | 642,245 | -112,640 | 0.56 | 0.49 | -0.07 | sell |
| Ikarian Capital, LLC | 1,254,384 | 1,056,829 | -197,555 | 1.80 | 1.79 | -0.01 | sell |
| Point72 Asset Management, L.P. | 3,000,000 | 2,742,460 | -257,540 | 0.05 | 0.05 | +0.00 | sell |
| Rosalind Advisors, Inc. | 1,888,720 | 1,144,524 | -744,196 | 8.28 | 6.66 | -1.62 | sell |
| ARMISTICE CAPITAL, LLC | 1,088,000 | 0 | -1,088,000 | 0.15 | 0.00 | -0.15 | sell |
| Nantahala Capital Management, LLC | 4,050,218 | 2,820,982 | -1,229,236 | 2.12 | 1.72 | -0.41 | sell |
| Vestal Point Capital, LP | 3,000,000 | 800,000 | -2,200,000 | 1.67 | 0.41 | -1.25 | sell |